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Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review

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World Journal of Clinical Oncology 2020年第1期11卷 31-42页

作者： Rogelio González-González sandra lópez-verdín Jesús lavalle-Carrasco nelly Molina-Frechero Mario Isiordia-Espinoza Ramón G Carreón-Burciaga Ronell Bologna-Molina Department of Research School of DentistryUniversidad Juárez del Estado de DurangoDurango 34000Mexico Research Institute of Dentistry Health Science CenterUniversidad de GuadalajaraGuadalajara 4430Mexico Department of Health Care Xochimilco UnitUniversidad Autónoma Metropolitana XochimilcoMéxico 04960Mexico Department of Clinics Biomedical Sciences DivisionCentro Universitario de los AltosUniversidad de GuadalajaraTepetitlán de Morelos 47620Mexico Molecular Pathology Area School of DentistryUniversidad de la RepúblicaMontevideo 11600Uruguay

BACKGROUnD Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment *** signaling pathways that participate in the progression of these tumors have been identified.B-raf proto-oncogene serine/threonine kinase(BRAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell *** gene mutations have been identified in ameloblastomas,of which the BRAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its *** therapies have been used as an alternative in the case of resistance or contraindications to conventional *** To document the presence of BRAF V600E and additional mutations,their behavior,and targeted therapies in these *** An electronic literature search was conducted according to PRISMA guidelines in PubMed/MEDlInE,Cochrane,EMBASE,and Springerlink using the terms“ameloblastomas”,“BRAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO *** criteria were articles in English,published not more than 10 years ago,and studies with laboratory works related to BRAF *** were evaluated by two independent reviewers and retrieved for full-text *** EBlIP Critical Appraisal Checklist was used to evaluate the quality of the eligible *** statistical analysis was *** Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this *** analysis registered 521 conventional ameloblastomas(AM),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(MA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatom

关键词： Ameloblastoma B-raf proto-oncogene serine/threonine kinase B-raf protooncogene serine/threonine kinase V600E Additional mutations Targeted therapies

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Exploring seven hundred years of transhumance, climate dynamic, fire and human activity through a historical mountain pass in central Spain

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Journal of Mountain Science 2016年第7期13卷 1139-1153页

作者： José Antonio lópez-SáEZ Francisca AlBA-SánCHEZ sandra ROBlES-lópez Sebastián PéREZ-DíAZ Daniel ABEl-SCHAAD Silvia SABARIEGO-RUIZ Arthur GlAIS Research Group Archaeobiology Institute of History CSIC Dept.Botany Faculty of Sciences University of Granada Dept.of Plant Biology Faculty of Biology Complutense University lETG CAEn GEOPHEn-UMR 6554 CnRS University of Caen-Normandie

A high-altitude peat sequence from the heart of the Spanish Central System(Gredos range) was analysed through a multi-proxy approach to determine the sensitivity of high-mountain habitats to climate, fire and land use changes during the last seven hundred years, providing valuable insight into our understanding of the vegetation history and environmental changes in a mountain pass close to a traditional route of transhumance. The pollen data indicate that the vegetation was dominated by shrublands and grasslands with scattered pines in high-mountain areas, while in the valleys cereals, chestnut and olive trees were cultivated. Strong declines of high-mountain pines percentages are recorded at 1540, 1675, 1765, 1835 and 1925 cal AD, which may be related to increasing grazing activities and/or the occurrence of anthropogenic fires. The practice of mountain summer farming and transhumance deeply changed and redesigned the landscape of the high altitudes in central Spain(Gredos range) since the Middle Ages, although its dynamics was influenced in some way by climate variability of the past seven centuries.

关键词： Climate and human impacts Fire late Holocene Gredos range Vegetation history

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The anthocyanin's role on the food metabolic pathways,color and drying processes:An experimental and theoretical approach

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Food Bioscience 2022年第3期47卷 91-110页

作者： sandra Peñaloza Cornelio Delesma Jesús Muñiz lópez-Ortiz A. Instituto de Energías Renovables Universidad Nacional Autónoma de MéxicoPriv.Xochicalco s/nCol.CentroTemixco62580MorelosMexico

This review is intended to cover the works related to the anthocyanin behavior in food that is subjected to *** experimental and theoretical results available in scientific literature are *** increase in anthocyanin concentration has been observed upon thermal ***,a conclusive explanation is still *** accessible studies suggest an increase in concentration during maturations,which could be related to the enzymatic *** possible enzymes involved in such a procedure have also been covered,including their role played in the *** possible activation mechanisms and the related factors such as temperature,pH,oxygen contents and the presence of UV-light irradiation were also ***,the metabolic pathways were also explored including experimental evaluation and theoretical models based on atomistic methodologies such as density functional theory(DFT).This review is aimed to provide a comprehensive overview of the probable mechanisms behind the increase of anthocyanin concentration during drying.

关键词： Anthocyanin Metabolic pathway PAl CHS UFGT HPlC Theoretical model

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Biocompatibility and electrochemical evaluation of ZrO_(2) thin films deposited by reactive magnetron sputtering on MgZnCa alloy

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Journal of Magnesium and Alloys 2021年第6期9卷 2019-2038页

作者： Benjamín Millán-Ramos Daniela Morquecho-Marín Phaedra Silva-Bermudez David Ramírez-Ortega Osmary Depablos-Rivera Julieta García-lópez Mariana Fernández-lizárraga JoséVictoria-Hernández Dietmar letzig Argelia Almaguer-Flores sandra E.Rodil Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado en Ciencia e Ingeniería de Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina RegenerativaInstituto Nacional de Rehabilitación Luis Guillermo IbarraCDMX 14389Mexico Posgrado en Ciencias Médicas Odontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico Instituto de Ciencias Aplicadas y Tecnologia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCDMX 11340Mexico Institute of Material and Process Design Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Magnesium Innovation Centre MagIC Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany laboratorio de Biointerfases Facultad de OdontologíaDivisión de Estudios de Posgrado e InvestigaciónUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be ***_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and *** this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was ***-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss *** results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the *** ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare ***,the ZrO_(2)coating prevents the adhesion and biofilm formation of ***.

关键词： Zirconium dioxide Magnetron sputtering Short-term degradation H_(2)evolution

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HP0953-hypothetical virulence factor overexpresion and localization during Helicobacter pylori infection of gastric epithelium

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World Journal of Gastroenterology 2022年第29期28卷 3886-3902页

作者： nancy K Arteaga-Resendiz Gerardo E Rodea Rosa María Ribas-Aparicio Alma l Olivares-Cervantes Juan Arturo Castelán-Vega Joséde Jesús Olivares-Trejo sandra Mendoza-Elizalde Edgar O lópez-Villegas Christian Colín Pamela Aguilar-Rodea Alfonso Reyes-lópez Marcela Salazar García norma Velázquez-Guadarrama laboratorio de Investigación en Enfermedades Infecciosas Hospital Infantil de México Federico GómezMexico City 06720Mexico Posgrado en Biomedicina y Biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico laboratorio de Adquisición de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico laboratorio Central de Microscopía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Centro de estudios económicos y sociales en salud Hospital Infantil de México Federico GómezMexico City 06720Mexico laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUnD The high prevalence and persistence of Helicobacter pylori(H. pylori) infection, as well as the diversity of pathologies related to it, suggest that the virulence factors used by this microorganism are varied. Moreover, as its proteome contains 340hypothetical proteins, it is important to investigate them to completely understand the mechanisms of its virulence and survival. We have previously reported that the hypothetical protein HP0953 is overexpressed during the first hours of adhesion to inert surfaces, under stress conditions, suggesting its role in the environmental survival of this bacterium and perhaps as a virulence *** To investigate the expression and localization of HP0953 during adhesion to an inert surface and against gastric(AGS) *** Expression analysis was performed for HP0953 during H. pylori adhesion. HP0953 expression at 0,3, 12, 24, and 48 h was evaluated and compared using the Kruskal-Wallis equality-of-populations rank test. Recombinant protein was produced and used to obtain polyclonal antibodies for immunolocalization. Immunogold technique was performed on bacterial sections during adherence to inert surfaces and AGS cells, which was analyzed by transmission electron microscopy. HP0953 protein sequence was analyzed to predict the presence of a signal peptide and transmembrane helices, both provided by the ExPASy platform, and using the GlYCOPP platform for glycosylation sites. Different programs, via, I-TASSER, RaptorX, and HHalign-Kbest, were used to perform three-dimensional *** HP0953 exhibited its maximum expression at 12 h of infection in gastric epithelium *** technique revealed HP0953 localization in the cytoplasm and accumulation in some peripheral areas of the bacterial body, with greater expression when it is close to AGS *** analysis revealed the presence of a signal peptide that interacts with the transmembrane region and then allows the release of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Persistence

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Erratum to:Aqueous extracts from Tenebrio molitor larval and pupal stages inhibit early hepatocarcinogenesis in vivo

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第4期24卷 371-372页

作者： Dulce María Moreno-García Armando Zepeda-Bastida Juan Ocampo-lópez Brisa Rodope Alarcón-Sánchez Osiris Germán Idelfonso-García sandra Rosas-Madrigal Diana Ivette Aparicio-Bautista Julio Isael Pérez-Carreón Saúl Villa-Treviño Jaime Arellanes-Robledo laboratory of liver Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Institute of Agricultural Sciences Autonomous University of Hidalgo State-ICAP-UAEHHidalgo43600Mexico Department of Cell Biology Center for Research and Advanced Studies of the National Polytechnic Institute-CINVESTAV-IPNCDMX07360Mexico laboratory of Cardiovascular Diseases National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Proteomics Unit National Institute of Genomic Medicine-INMEGENCDMX14610Mexico Directorate of Cátedras National Council of Science and Technology-CONACYTCDMX03940Mexico

Following an Assessment by the Autonomous University of Hidalgo State and the national Institute of Genomic Medicine,this erratum corrects the authorship of this article by adding Dulce Maria MOREnO-GARCiA as the first *** published article(Zepeda-Bastida et al.,2021)has now been updated with the corrected authorship,author contributions,and acknowledgments,which may be seen in this erratum.

关键词： larval adding corrected

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Scientific guidelines for preclinical research on potentised preparations manufactured according to current pharmacopoeias-the PrePoP guidelines

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Journal of Integrative Medicine 2024年第5期22卷 533-544页

作者： Alexander l.Tournier leoni V.Bonamin Susann Buchheim-Schmidt Steven Cartwright Christoph Dombrowsky Paul Doesburg Carla Holandino Maria Olga Kokornaczyk Everine Bvan de Kraats Jesús Antonio lópez-Carvallo Papiya nandy JoséManuel Mazón-Suástegui Fateme Mirzajani Bernard Poitevin Claudia Scherr Karin Thieves sandra Würtenberger Stephan Baumgartner Institute of Complementary and Integrative Medicine University of Bern3010 BernBernSwitzerland Institute of Integrative Medicine Witten/Herdecke University58455 WittenNorth Rhine–WestphaliaGermany Homeopathy Research Institute London SW74EFUnited Kingdom Graduate Program on Environmental and Experimental Pathology Paulista UniversitySão Paulo 01504-000São PauloBrazil Department of Medical Science Deutsche Homöopathie-Union DHU-Arzneimittel GmbH&Co.KG76227 KarlsruheBaden-WürttembergGermany Cherwell laboratory for Fundamental Research in Homeopathy Oxford OX28NUOxforeshireUnited Kingdom Society for Cancer Research Hiscia Research Institute4144 ArlesheimBaselSwitzerland laboratório Multidisciplinar de Ciências Farmacêuticas Universidade Federal do Rio de JaneiroRio de Janeiro 21941-902Rio de JaneiroBrazil World Water Community Rotterdam 3029AKthe Netherlands Departamento de Acuicultura Facultad de Ciencias del MarUniversidad Católica del Norte1790437 CoquimboElquiChile Centre for Interdisciplinary Research and Education KolkataWest Bengal 700068West BengalIndia laboratorio de Homeopatía Acuícola y Semillas Marinas Centro de Investigaciones Biológicas del NoroesteLa Paz 23096Baja California SurMexico Protein Research Center Shahid Beheshti UniversityTehran ***Iran Department of Medical laboratory Science College of ScienceKnowledge University44001 ErbilErbilIraq SociétéSavante d’Homéopathie 75009 ParisFrance Sola Salus Institute for Homeopathic Research52511 GeilenkirchenNorth Rhine–WestphaliaGermany Scientific Society for Homeopathy 06366 KöthenSaxony-AnhaltGermany

Objective Pharmacopoeias regulate the manufacture of potentised pharmaceutical preparations used in different branches of complementary and integrative *** physicochemical properties and biological activity of these preparations are often investigated in preclinical research,yet no guidelines for experimental research currently exist in this *** present PrePoP guidelines aim to provide recommendations to promote high-quality,statistically sound,and reproducible preclinical research on potentised *** Input was gathered from researchers nominated by the relevant scientific societies using a simplified Delphi consensus approach covering the most relevant aspects of basic research methodology in the field including appropriate controls,sample preparation and handling,and *** three rounds of feedback,a consensus was finally reached on the most important aspects and considerations for conducting high-quality research on potentised *** We present a series of recommendations on a range of topics including experimental controls,system stability,blinding and randomisation,environmental influences,and procedures for the preparation of potentised samples and controls,and we address some specific challenges of this research *** This expert consensus process resulted in a robust set of methodological guidelines for research on potentised preparations and provides a valuable framework that will inform and improve the quality of subsequent research in this emerging field.

关键词： Research guidelines Fundamental research Basic research Complementary and integrative medicine Potentisation Potentised preparations

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Microbiological Quality of Asadero Cheese Manufactured with a Plant Based Coagulant from <i>Solanum elaeagnifolium</i>

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Food and nutrition Sciences 2013年第7期4卷 75-81页

作者： nina del Rocío Martínez-Ruiz sandra Flores Enriquez Rosa Emma Vázquez-nájera José Alberto lópez-Díaz Departamento de Ciencias Químico Biológicas Instituto de Ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Ciudad Juárez México Departamento de Ciencias Químico Biológicas Instituto de Ciencias Biomédicas Universidad Autónoma de Ciudad Juárez Ciudad Juárez México.

In Chihuahua, north Mexico, the berries of Solanum elaeagnifolium (trompillo or silverleaf nightshade) have been used in the manufacture of artisanal filata-type asadero cheese. Solanum elaeagnifolium is a wild plant that possesses proteases in its fruit;those enzymes exhibit general proteolytic activities, which are useful in traditional asadero cheesemaking as a rennet substitute. These type of cheese is softer than those made with rennin or chymosin due to their water content and proteolysis. Thus, the aim of this work was to explore microbiological susceptibility of asadero cheese made with an extract from ripe berries and compared with those elaborated with commercial rennet. Crude extract of such fruit was obtained by salting out with ammonium sulfate (40%). Cheeses were obtained by a standardized process only changing the enzyme, packaged in plastic bag or vacuum bag and storage at 4℃ -?6℃. The study included the analysis of spoilage bacteria (total aerobic count, yeasts and molds), indicators of hygiene (total coliforms and E. coli) and fecal contamination (fecal coliforms) after 1, 7, 14, 21 and 28 days of production. Although cheese made with S. elaeagnifolium had lower microbial growth, the aerobic count and yeasts and molds count of all cheese samples showing a 28 days shelf life. Total coliforms, in limits beyond the established ones by the Mexican legislation for human consumption with no effect of the enzyme type used for production, as well as for fecal coliforms. Differences were detected just for packaged method, suggesting that good manufacturing practices take place not the plant coagulant.

关键词： Milk Coagulation Plant Coagulant Silverleaf nightshade Trompillo Microbiological Quality

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Strategies for the Extraction, Purification and Amplification of Metagenomic DnA from Soil Growing Sugarcane

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Advances in Biological Chemistry 2014年第4期4卷 281-289页

作者： luis Raúl Gutiérrez-lucas Juan José Montor-Antonio nohemí Gabriela Cortés-lópez sandra del Moral División de Estudios de Posgrado Universidad del Papaloapan Tuxtepec México Instituto de Biotecnología. Universidad del Papaloapan Tuxtepec Oaxaca México

Recently, studies were initiated to investigate the metagenome, which represents the genomes of cultured and uncultured microbes, as a rich source for isolation of many novel genes. The meta-genomic approach originated from the molecular analysis of microbial communities, which revealed that the majority of microorganisms in nature were not cultivable by standard culturing techniques. Therefore, most microorganisms in nature have not been characterized. Although numerous methods have been reported for direct DnA isolation and purification from microorganisms in soil, the sample preparation procedures and experimental conditions used in different studies vary widely. Soils are therefore one of the most challenging environmental matrices from which to obtain microbial DnA that will support PCR. The Papaloapan River is the second largest river basin in México. For the climatic conditions of this region, there is great diversity in plants, animals and microorganisms. In the Papaloapan region different fruits are grown, however, the main crops are sugarcane and pineapple. In this work the extraction of DnA from soils of sugarcane cultivation was performed. We used PCR tests to assess the quality of DnA extracted from soil by amplifying the 16S rDnA gene. Changes in both protocols were performed;satisfactory results were obtained as to the quality of DnA and gene amplification. These results will allow continuing the metagenomic studies, such as sequencing, library construction and identification of enzymes cellulase and amylase activity. It is the first time these studies were performed in the Papaloapan region.

关键词： Metagenomic Soil DnA Metagenome Papaloapan Basin

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为什么不?

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城市环境设计 2016年第5期 372-373页

作者： sandra González álvarez Miguel Comesa?a Alonso Alberto Fuentes Valcárcel Ramón lópez González Maite Fraga lamas

瓦尔特·本雅明《拱廊街计划》一书中对19世纪的中心——巴黎的技术、商业、社会和艺术空间发展的描述让我们有这样的疑问:什么是购物广场?它的现状如何?未来会怎样?这些问题让我们不再满足于已有知识体系对于商业广场的认知,从而踏入... 详细信息

瓦尔特·本雅明《拱廊街计划》一书中对19世纪的中心——巴黎的技术、商业、社会和艺术空间发展的描述让我们有这样的疑问:什么是购物广场?它的现状如何?未来会怎样?这些问题让我们不再满足于已有知识体系对于商业广场的认知,从而踏入寻求未来商业模式的旅程。"回归历史就意味着引用历史。"因此我们展望未来:21世纪的商业广场赋予我们怎样的想象?如何缝合多种功能板块?建筑如何作为公共花园存在于城市?这些问题不断碰撞、摩擦,使我们得到拓展视野、超乎想象的惊喜结果。

关键词：商业广场

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