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Family Medicine and Community Health 2015年第2期3卷 48-53页

作者： sandra j.gonzalez Maria C.Mejia de Grubb Roger j.Zoorob Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

The reciprocal relationship between mental and physical health is well ***,untreated,and poorly managed mental health conditions are associated with numerous physical health complications,poor treatment adherence,and decreased quality of *** growing evidence regarding the importance of effectively addressing these conditions in primary care,the rates of identification remain low and follow-up and management by primary care providers has been *** objective of this review was to demonstrate the role of Patient-Centered Medical Home(PCMH)and mental health integration in addressing comprehensive health care needs in primary care patients,and to describe common barriers and facilitators to the implementation of these types of programs.

关键词： Patient-centered medical home integrated primary care health care service delivery mental health chronic disease management behavioral health integration

Primary and secondary prevention of colorectal cancer: An evidence- based review

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Family Medicine and Community Health 2017年第1期5卷 78-84页

作者： sandra j.gonzalez Maria C.Mejia de Grubb Robert S.Levine Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA

Colorectal cancer (CRC) is a common cancer that affects one in three men and one in four women worldwide. Late-stage detection is associated with significantly lower 5-year survival rates. Although it is well established that CRC mortality rates have decreased in the past several decades, adoption of routine screening continues to lag behind screening for other common cancers such as cervical and breast cancer. The decrease in overall rates has been attributed, in part, to improved primary and secondary prevention efforts, including smoking prevention and cessation programs, nutritional counseling, and the use of evidence-based screening protocols, as well as access to better treatment. Despite the increased screening rates, it is estimated that at least one-third of eligible people do not receive appropriate screening. The objective of this review is to describe the current epidemiology of CRC and to demonstrate effective primary and secondary prevention strategies for the primary care provider.

关键词： Colorectal cancer adenocarcinoma modifiable risk factors primary prevention secondary prevention primary care

Temporal trends in colorectal cancer incidence among Asian American populations in the United States, 1994-2013

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Family Medicine and Community Health 2017年第1期5卷 56-64页

作者： Haijun Wang Maria C.Mejia de Grubb sandra j.gonzalez Mohamad Sidani jianping Ma Roger j.Zoorob Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Shenzhen Nanshan Center for Chronic Disease Control ShenzhenGuangdongChina

Objective:To investigate the incidence and trends in colorectal cancer(CRC)among Asian American populations in the United ***:CRC incidence data from 1994 through 2013 were obtained from 13 Surveillance,Epidemiology,and End Results ****Stat and IBM SPSS Statistics were ***:The age-adjusted incidence of CRC among Asian Americans decreased from 45.6 per 100,000 in 1994 to 33.0 per 100,000 in 2013,with the annual percent change being−1.8%(P<0.05).The incidences were higher for men,the elderly(aged 60 years or older),and several geographic *** those younger than 70 years,the rectal site was more affected compared with those aged 70 years or older,in whom the proximal site were more *** patients presented with localized and regional ***,80 years or older,in situ stage,and some geo-graphic areas such as Connecticut and California experienced significant incidence decreases in the 20-year observation ***:Although CRC incidence has declined among Asian American populations in the United States in the past 2 decades,there are persistent differences by age and geographic *** research is needed to guide the design and implementation of tailored strategies to reduce CRC outcome differences across Asian American populations.

关键词： Colorectal cancer proximal colon distal colon rectal cancer incidence trend

Study on Blood Cell Immune Response in Water Buffaloes Infected Acutely with F. hepatica

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Agricultural Sciences in China 2002年第2期1卷 221-226页

作者： Award Daugschies j.gonzalez-Gallego Institute of Parasitology Hannover School of Veterinary Medicine Bunteweg 17 D-30559 Hannover GermanyDepartment of Physiology Pharmacology and Toxicology University of Leon Leon 24071 Spain

Action mechanism of blood cell immune response in water buffaloes against acute infection with F. Hepatica was studied. The results showed that after water buffaloes were infected, the total levels of WBC surpassed control group during whole infection period; Eosinophiles (%) of DC were higher than control group at the 2nd week until 19th week, and then dropped and was close to control group; Neutrophiles(%) was low or significantly lower than control group within the 5 - 16th weeks; The total levels of lymphocytes (%) was lower than control group during the whole infection period; T-lymphocytes (%) dropped significantly, but B-lymphocytes(%) had opposite changes from the first week of infection, and they were close to the control group after 11 weeks; RBC-CR] and RBC-IC rosette rates dropped and rose during 2 - 16 and 2-18 weeks, respectively, and then approached the same between both groups. It was suggested that the violent changes of specific and nonspecific immune responses in water buffaloes with acute F. hepatica infection are related with the mechanism against infection with F. hepatica together.

关键词： Water buffalo Fasciola hepatica Infection Blood cell Immune response

Nuclear receptors and non-alcoholic fatty liver disease:An update

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Liver Research 2020年第2期4卷 88-93页

作者： Xiao Yang Frank j.gonzalez Min Huang Huichang Bi Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouChina Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNIHBethesdaMDUSA

Non-alcoholic fatty liver disease(NAFLD)has become the leading cause of chronic liver disease in adults and children *** symptoms of NAFLD range from simple steatosis and non-alcoholic stea-tohepatitis(NASH)to hepatic fibrosis or cirrhosis,even ultimately develops to hepatocellular *** receptors(NRs)are a superfamily of ligand-activated transcription factors,most of which are ligand-activated that control cellular homeostasis in the liver and other tissues.A growing number of studies demonstrated the important role of NRs in *** this review,the current findings on the role of NRs in NAFLD are summarized and future perspectives to target NRs for NAFLD are discussed.

关键词： Nuclear receptors(NRs) Non-alcoholic fatty liver disease(NAFLD) Pregnane X receptor(PXR) Constitutive androstane receptor(CAR) Farnesoid X receptor(FXR) Peroxisome proliferator activated receptor (PPAR) Liver X receptor(LXR)

Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence

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journal of Pharmaceutical Analysis 2021年第3期11卷 340-350页

作者： Huizhen Zhang Yongtao Wang Lihuan Guan Yixin Chen Panpan Chen jiahong Sun Frank j.gonzalez Min Huang Huichang Bi Guangdong Provincial Key Laboratory of New Drug Design and Evaluation School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD20892USA

Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C(CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic analysis of PANC-1,MDA-MB-231, HCT-116 and A549 cancer cells was conducted after siRNA depletion of CPT1C. Cellular lipotoxicity was further confirmed by lipotoxicity assays. Significant changes were found in the lipidome of CPT1C-depleted cells, including major alterations in fatty acid, diacylglycerol, triacylglycerol, oxidative lipids, cardiolipin, phosphatidylglycerol, phosphatidylcholine/phosphatidylethanolamine ratio and sphingomyelin. This was coincident with changes in expressions of mRNAs involved in *** and biochemical analyses revealed higher lipid accumulation and increased malondialdehyde and reactive oxygen species, signatures of lipid peroxidation and oxidative stress. Reduction of ATP synthesis, loss of mitochondrial transmembrane potential and down-regulation of expression of mitochondriogenesis gene m RNAs indicated mitochondrial dysfunction induced by lipotoxicity, which could further result in cellular senescence. Taken together, this study demonstrated CPT1C plays a critical role in the regulation of cancer cell lipotoxicity and cell senescence, suggesting that inhibition of CPT1C may serve as a new therapeutic strategy through induction of tumor lipotoxicity and senescence.

关键词： Lipidomics Lipid accumulation Lipid peroxidation Oxidative stress Mitochondrial dysfunction Anticancer target

Energy spectrum of an electron confined in the hexagon-shaped quantum well

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Science China(Technological Sciences) 2009年第1期52卷 15-18页

作者： Yu.V.VOROBIEV V.R.VIEIRA P.P.HORLEY P.N.GORLEY j.gonzalez-HERNANDEZ CINVESTAV Unidad Querétaro Libramiento Norponiente#2000 Centro de Física das Interaccoes Fundamentais Av.Rovisco Pais Yuri Fedkovych Chernivtsi National University 2 Kotsyubynsky str. CIMAV 120 Miguel de Cervantes

Considering the hexagonal-shaped quantum-scale formations on the surface of thin semiconductor films, a methodology was developed to obtain the analytical solution of the Schrdinger equation when impenetrable walls of a quantum well are treated as mirrors. The results obtained allowed the calculation of the space probability distributions and the energy spectrum of the particle confined in a hex-agonal-shaped well.

关键词： quantum well Schrodinger equation wave function hexagon reflection boundary conditions impenetrable walls

Analytical methodologies for sensing catechol-O-methyltransferase activity and their applications

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journal of Pharmaceutical Analysis 2021年第1期11卷 15-27页

作者： Fang-Yuan Wang Ping Wang Dong-Fang Zhao Frank j.gonzalez Yu-Fan Fan Yang-Liu Xia Guang-Bo Ge Ling Yang Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai201203China School of Life Science and Medicine Dalian University of TechnologyPanjin124221China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMDUSA

Mammalian catechol-O-methyltransferases(COMT)are an important class of conjugative enzymes,which play a key role in the metabolism and inactivation of catechol neurotransmitters,catechol estrogens and a wide range of endobiotics and xenobiotics that bear the catechol ***,COMT inhibitors are used in combination with levodopa for the treatment of Parkinson’s disease in clinical *** crucial role of COMT in human health has raised great interest in the development of more practical assays for highly selective and sensitive detection of COMT activity in real samples,as well as for rapid screening and characterization of COMT inhibitors as drug *** review summarizes recent advances in analytical methodologies for sensing COMT activity and their *** lists of biochemical assays for measuring COMT activity,including the probe substrates,along with their analytical conditions and kinetic parameters,are ***,the challenges and future perspectives in the field,such as visualization of COMT activity in vivo and in situ,are ***,this review article overviews the practical assays for measuring COMT activities in complex biological samples,which will strongly facilitate the investigations on the relevance of COMT to human diseases and promote the discovery of COMT inhibitors via high-throughput screening.

关键词： Catechol-O-Methyltransferase(COMT) Enzymatic activity Probe substrate COMT inhibitor High-throughput screening

A collaborative effort of China incombating COVID-19

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Global Health Research and Policy 2020年第1期5卷 87-89页

作者： Mohamed S.Bangura Maria j.gonzalez Nasra M.Ali Ran Ren Youlin Qiao School of Public Health Dalian Medical UniversityDalian 116044China Dalian Maternal and Child Health Hospital Dalian 116033China Global Health Research Center Dalian Medical UniversityDalian 116044China Department of Cancer Epidemiology National Cancer Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 10002China

A novel coronavirus(COVID-19)was firstly identified in Wuhan by the end of *** has implemented a seriesof preventive measures to deter COVID-19 spread and its consequences since the beginning of the ***,the expansion of COVID-19 has been slowed down significantly through the effort of all contributors,including governments,nongovernments,and civil *** collaborators have been actively involved incombating the epidemic,using their respective strengths to play their *** has mitigated the number ofcases due to the mobilization of the whole society and collaborators joining collective efforts and actions insolidarity to tackle and conquer the *** date,China has continued to implement actions to control anyresurgence of new cases of COVID-19 and keep its population *** people’s united effort against the virus hasenhanced a great insight into China,and it might serve as a model to the global community in fighting the COVID-19 pandemic in terms of coordination,solidarity,decisiveness,and leadership.

关键词： Collaborative effort COVID-19 Multisectoral China

Crosstalk between CYP2E1 and PPARα substrates and agonists modulate adipose browning and obesity

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2224-2238页

作者： Youbo Zhang Tingting Yan Tianxia Wang Xiaoyan Liu Keisuke Hamada Dongxue Sun Yizheng Sun Yanfang Yang jing Wang Shogo Takahashi Qiong Wang Kristopher W.Krausz Changtao jiang Cen Xie Xiuwei Yang Frank j.gonzalez State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Laboratory of Metabolism Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892USA School of Life Science and Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physiology and Pathophysiology School of Basic Medical SciencesPeking Universitythe Key Laboratory of Molecular Cardiovascular ScienceMinistry of EducationBeijing 100191China

Although the functions of metabolic enzymes and nuclear receptors in controlling physiological homeostasis have been established, their crosstalk in modulating metabolic disease has not been *** ablation of the xenobiotic-metabolizing cytochrome P450 enzyme CYP2 E1 in mice markedly induced adipose browning and increased energy expenditure to improve obesity. CYP2 E1 deficiency activated the expression of hepatic peroxisome proliferator-activated receptor alpha(PPARa) target genes,including fibroblast growth factor(FGF) 21, that upon release from the liver, enhanced adipose browning and energy expenditure to decrease obesity. Nineteen metabolites were increased in Cyp2 e1-null mice as revealed by global untargeted metabolomics, among which four compounds, lysophosphatidylcholine and three polyunsaturated fatty acids were found to be directly metabolized by CYP2 E1 and to serve as PPARa agonists, thus explaining how CYP2 E1 deficiency causes hepatic PPARa activation through increasing cellular levels of endogenous PPARa agonists. Translationally, a CYP2 E1 inhibitor was found to activate the PPARa-FGF21-beige adipose axis and decrease obesity in wild-type mice, but not in liver-specific Pparanull mice. The present results establish a metabolic crosstalk between PPARa and CYP2 E1 that supports the potential for a novel anti-obesity strategy of activating adipose tissue browning by targeting the CYP2 E1 to modulate endogenous metabolites beyond its canonical role in xenobiotic-metabolism.

关键词： CYP2E1 PPARa FGF21 Metabolic enzyme Nuclear receptor Obesity