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Human endogenous Retrovirus Type W envelope from Multiple Sclerosis Demyelinating Lesions Shows Unique Solubility and Antigenic Characteristics

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Virologica Sinica 2021年第5期36卷 1006-1026页

作者： Benjamin Charvet Justine Pierquin Joanna Brunel Rianne Gorter Christophe Que´tard Branka Horvat sandra Amor Jacques Portoukalian Herve´Perron GeNeuro Innovation Lyon 69008France CIRI International Center for Infectiology ResearchINSERM U1111CNRS UMR5308University of LyonENS LyonFrance Universite´Claude Bernard Lyon 1 Lyon 69000France Department of Pathology Amsterdam UMCLocation VUMC1007 MB AmsterdamThe Netherlands ProteinSimple Abingdon OX143NBUK Centre for Neuroscience and Trauma Blizard InstituteBarts and London School of Medicine and DentistryQueen Mary University of LondonLondon E12ATUK

In multiple sclerosis(MS),human endogenous retrovirus W family(HeRV-W)envelope protein,pHeRV-W eNV,limits remyelination and induces microglia-mediated *** better understand its role,we examined the soluble pHeRV-W antigen from MS brain lesions detected by specific ***-chemical and antigenic characteristics confirmed differences between pHeRV-W eNV and ***-W eNV monomers and trimers remained associated with membranes,while hexamers self-assembled from monomers into a soluble macrostructure involving sulfatides in MS *** hexamers are stabilized by internal hydrophobic bonds and external hydrophilic ***-W studies in MS also suggest that this diffusible antigen may correspond to a previously described highmolecular-weight neurotoxic factor secreted by MS B-cells and thus represents a major agonist in MS *** methods are now needed to identify encoding HeRV provirus(es)in affected cells *** properties and origin of MS brain pHeRV-W eNV soluble antigen will allow a better understanding of the role of HeRVs in MS *** present results anyhow pave the way to an accurate detection of the different forms of pHeRV-W eNV antigen with appropriate conditions that remained unseen until now.

关键词： Multiple sclerosis(MS) Brain Antigen HeRV-W envelope endogenous retrovirus MSRV-eNV Syncytin Demyelination Lipids Glycolipids Sulfatides Oligomer Hexamer

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Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity

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Bioactive Materials 2021年第12期6卷 4342-4359页

作者： Sophia Hauck Paula Zager Norbert Halfter elke Wandel Marta Torregrossa Ainur Kakpenova sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze sandra Franz Department of Dermatology Venerology und AllergologyLeipzig University04103LeipzigGermany Institute of Materials Science Max Bergmann Center for BiomaterialsTechnische Universitǎt Dresden01069DresdenGermany Biomaterials Department INNOVENT e.V.JenaGermany

Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic *** of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic *** we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound *** sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in *** further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo *** a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the *** is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation *** in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one *** immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound *** sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure.

关键词： 4-6):sulfated hyaluronan Macrophages Immunomodulation Chronic wounds Hydrogel Skin inflammation

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Neural activation while perceiving biological motion in dynamic facial expressions and point-light body action animations

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Neural Regeneration Research 2010年第14期5卷 1076-1083页

作者： Lorna García Pentón Alejandro Pérez Fernández María A.Bobes León Yanely Acosta Ymas Lídice Galán García Yasser Iturria-Medina sandra e.Leh Mitchell Valdés-Sosa Cognitive Neuroscience Laboratory Faculty of PsychologyUniversidad Diego Portales Basque Center on Cognition Brain and Language Cognitive Department Cuban Neuroscience Center Neuroimaging Department Cuban Neuroscience Center Montreal Neurological Institute & Hospital

BACKGROUND： The interpretation of non-verbal social signals relies heavily on the ability to perceive biological motion. The posterior superior temporal sulcus is an important part of a network involved in biological motion processing. However, the underlying functional organization remains poorly understood. Several studies have suggested topographical representation of motion from different body parts within this region. However, other studies have shown that the posterior superior temporal sulcus responds equally to any body part. OBJeCTIVe： Through the use of functional magnetic resonance imaging, the effects of socially relevant biological motion stimuli to activate a specific cortical area within posterior superior temporal sulcus, even if different body parts are involved in motion, will be analyzed. DeSIGN, TIMe AND SeTTING： A functional magnetic resonance imaging, block-design was performed at the Magnetic Resonance Imaging, Surgical Medical Investigation Center, Havana, Cuba between 2004 and 2005. PARTICIPANTS： Thirteen healthy volunteers, from 19 to 55 years of age and compris!ng eight males and five females, were included in the study. MeTHODS： A conjunction analysis of responses to natural, dynamic, fearful, facial expressions and point-light, body-motion animations. MAIN OUTCOMe MeASUReS： The corresponding functionally specialized areas, as well as neural areas significant for both types of stimuli, were identified. ReSULTS： One region within the posterior superior temporal sulcus of the right hemisphere was equally activated by facial and body complex motion. CONCLUSION： A site of common neural activity existed within the posterior superior temporal sulcus, which was not specific to a biological motion type. In addition, the activity was not related to a topographically organized body-part map, which suggested high-level visual representation of biological motion in this region.

关键词： human movement body movement dynamic faces emotional expressions common neural activation overlapped activations

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Biocompatibility and electrochemical evaluation of ZrO_(2) thin films deposited by reactive magnetron sputtering on MgZnCa alloy

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Journal of Magnesium and Alloys 2021年第6期9卷 2019-2038页

作者： Benjamín Millán-Ramos Daniela Morquecho-Marín Phaedra Silva-Bermudez David Ramírez-Ortega Osmary Depablos-Rivera Julieta García-López Mariana Fernández-Lizárraga JoséVictoria-Hernández Dietmar Letzig Argelia Almaguer-Flores sandra e.Rodil Instituto de Investigaciones en Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado en Ciencia e Ingeniería de Materiales Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Unidad de Ingeniería de Tejidos Terapia Celular y Medicina RegenerativaInstituto Nacional de Rehabilitación Luis Guillermo IbarraCDMX 14389Mexico Posgrado en Ciencias Médicas Odontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico Instituto de Ciencias Aplicadas y Tecnologia Universidad Nacional Autónoma de MéxicoCDMX 04510Mexico Posgrado de Doctorado en Ciencias en Biomedicina y Biotecnología Molecular Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalCDMX 11340Mexico Institute of Material and Process Design Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Magnesium Innovation Centre MagIC Helmholtz-Zentrum GeesthachtMax-Planck-Strasse 1Geesthacht 21502Germany Laboratorio de Biointerfases Facultad de OdontologíaDivisión de Estudios de Posgrado e InvestigaciónUniversidad Nacional Autónoma de MéxicoCDMX 04510Mexico

Biodegradable magnesium alloys are promising candidates for temporary fracture fixation devices in orthopedics;nevertheless,its fast degradation rate at the initial stage after implantation remains as one of the main challenges to be ***_(2)-based coatings to reduce the degradation rate of the Mg-implants are an attractive solution since they show high biocompatibility and *** this work,the degradation,cytotoxicity,and antibacterial performance of ZrO_(2)thin films deposited by magnetron sputtering on a Mg-Zn-Ca alloy was ***-term degradation of ZrO_(2)-coated and uncoated samples was assessed considering electrochemical techniques and H_(2)evolution(gas chromatography).Additionally,long term degradation was assessed by mass-loss *** results showed that a 380 nm ZrO_(2)coating reduces the degradation rate and H_(2)evolution of the alloy during the initial 3 days after immersion but allows the degradation of the bare alloy for the *** ZrO_(2)coating does not compromise the biocompatibility of the alloy and permits better cell adhesion and proliferation of mesenchymal stem cells directly on its surface,in comparison to the bare ***,the ZrO_(2)coating prevents the adhesion and biofilm formation of ***.

关键词： Zirconium dioxide Magnetron sputtering Short-term degradation H_(2)evolution

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enabling Virtual Met Masts for wind energy applications through machinelearning-methods

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energy and AI 2023年第1期11卷 26-42页

作者： sandra Schwegmann Janosch Faulhaber Sebastian Pfaffel Zhongjie Yu Martin Dörenkämper Kristian Kersting Julia Gottschall Fraunhofer IWeS Küpkersweg 7026129 OldenburgGermany Fraunhofer Iee Königstor 5934119 KasselGermany Technical University of Darmstadt Karolinenplatz 564289 DarmstadtGermany Hessian Center for AI(hessian.AI) Mornewegstraße 3064293 DarmstadtGermany

As wind is the basis of all wind energy projects, a precise knowledge about its availability is needed. For ananalysis of the site-specific wind conditions, Virtual Meteorological Masts (VMMs) are frequently used. VMMsmake use of site calibrated numerical data to provide precise wind estimates during all phases of a wind energyproject. Typically, numerical data are used for the long-term correlation that is required for estimating theyield of new wind farm projects. However, VMMs can also be used to fill data gaps or during the operationalphase as an additional reference data set to detect degrading sensors. The value of a VMM directly dependson its ability and precision to reproduce site-specific environmental conditions. Commonly, linear regressionis used as state of the art to correct reference data to the site-specific conditions. In this study, a frameworkof 10 different machine-learning methods is tested to investigated the benefit of more advanced methods ontwo offshore and one onshore site. We find significantly improving correlations between the VMMs and the reference data when using more advanced methods and present the most promising ones. The K-NearestNeighbors and AdaBoost regressors show the best results in our study, but Multi-Output Mixture of GaussianProcesses is also very promising. The use of more advanced regression models lead to decreased uncertainties;hence those methods should find its way into industrial applications. The recommended regression models canserve as a starting point for the development of end-user applications and services.

关键词： Virtual Met Mast(VMM) Wind power Machine learning Reanalysis data Site assessment Weather Research and Forecasting Model(WRF) Measure-Correlate-Predict(MCP)

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GSTM3, but not IZUMO1, is a cryotolerance marker of boar sperm

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Journal of Animal Science and Biotechnology 2019年第4期10卷 931-941页

作者： Marc Llavanera Ariadna Delgado-Bermúdez Beatriz Fernandez-Fuertes sandra Recuero Yentel Mateo Sergi Bonet Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction (Techno Sperm) Unit of Cell Biology Department of Biology Institute of Food and Agricultural Technology University of Girona

Background: Cryopreservation is currently the most efficient method for long-term preservation of mammalian gametes and is extensively used in swine artificial insemination(AI) centres. However, it is well-known that cryopreservation procedures induce changes in the water phase in both intra and extracellular compartments,which alter the content and localisation of several proteins and ends up curtailing the structural integrity of functional sperm(i.e., cryoinjuries). Alterations and deficiencies of sperm-oocyte binding proteins during gamete recognition are one of the causes of reproductive failure both in vitro and in vivo. In this sense, characterisation of cryopreservation effects upon oocyte-binding proteins of sperm, such as IZUMO1 and GSTM3, is essential when assessing the impact of this technique in swine ***: Cryopreservation was found to induce changes in the localisation of IZUMO1 and GSTM3 in boar ***, the relative content of both proteins was not altered after thawing. Furthermore, whereas IZUMO1 content was found not to be related to the cryotolerance of boar sperm, GSTM3 content was observed to be higher in poor(PFe) than in good(GFe) freezability ejaculates in both pre-frozen(1.00 INT·mm^2± 0.14 INT·mm^2 vs.0.72 INT·mm^2± 0.15 INT·mm^2;P ed(0.96 INT·mm^2± 0.20 INT·mm^2 vs. 70 INT·mm^2± 0.19 INT·mm^2;P es. Moreover, GSTM3 levels were found to be higher in those spermatozoa that exhibited low mitochondrial activity, high reactive oxygen species(ROS) production, and high membrane lipid disorder postthaw(P e difference in GSTM3 content between GFe and PFe, together with this protein having been found to be related to poor sperm quality post-thaw, suggests that it could be used as a cryotolerance marker of boar spermatozoa. Furthermore, both IZUMO1 and GSTM3 relocate during cryopreservation, which could contribute to the reduced fertilising capacity of frozen-thawed boar

关键词： Boar Cryopreservation GSTM3 IZUMO1 ROS Sperm

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A role for the Tgf-β/Bmp co-receptor endoglin in the molecular oscillator that regulates the hair follicle cycle

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Journal of Molecular Cell Biology 2019年第1期11卷 39-52页

作者： Maria I.Calvo-Sanchez sandra Fernandez-Martos elisa Carrasco Gema Moreno-Bueno Carmelo Bernabeu Miguel Quintanilla Jesus espada Instituto de Investigaciones Biomedicas'Alberto Sols' Consejo Superior de Investigaciones Cientificas(CSIC)-Departamento de BioqufmicaUniversidad Autonoma de Madrid(UAM)Madrid 28029Spain Instituto de Investigaciones Biosanitarias Facultad de Ciencias ExperimentalesUniversidad Francisco de Vitoria(UFV)Pozuelo de Alarcon 28223Spain Centro de Investigacion Biomedica en Red de Cancer(CIBeRONC) Spain Centro de Investigaciones Biologicas Consejo Superior de Investigaciones Cientificas(CSIC)and Centro de Investigacion Biomedica en Red de Enfermedades Raras(CIBERER)Madrid 28040Spain Centro Integrativo de Biologfa y Quimica Aplicada Universidad Bernardo O'HigginsSantiago 8370854Chile Instituto Ramon y Cajal de Investigacion Sanitaria(IRYCIS) Hospital Universitario Ramon y CajalMadridSpain

The hair follicle is a biological oscillator that alternates growth,regression,and rest phases driven by the sequential activation of the proliferation differentiation programs of resident stem cell *** activation of hair follicle stem cell niches and subsequent entry into the growing phase is mainly regulated by Wnt/β-catenin signalling,while regression and resting phases are mainly regulated by Tgf-β/Bmp/Smad activity.A major question still unresolved is the nature of the molecular switch that dictates the coordinated transition between both signalling *** we have focused on the role of endoglin(eng),a key co-receptor for members of the Tgf-β/Bmp family of growth *** an eng haploinsufficient mouse model,we report that eng is required to maintain a correct follicle cycling pattern and for an adequate stimulation of hair follicle stem cell *** further report thatβ-catenin binds to the eng promoter depending on Bmp ***,we show thatβ-catenin interacts with Smad4 in a Bmp/eng-dependent context and both proteins act synergistically to activate eng promoter *** observations point to the existence of a growth/rest switching mechanism in the hair follicle that is based on an eng-dependent feedback cross-talk between Wnt/β-catenin and Bmp/Smad signals.

关键词： endoglin hair follicle skin stem cells Wnt/β-catenin Tgf-β/Bmp/Smad

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Root proliferation in native perennial grasses of arid Patagonia,Argentina

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Journal of Arid Land 2014年第2期6卷 195-204页

作者： Yanina A TORReS Carlos A BUSSO Oscar A MONTeNeGRO Leticia ITHURRART Hugo D GIORGeTT Gustavo RODRíGUeZ Diego BeNTIVeGNA Roberto e BReVeDAN Osvaldo A FeRNáNDeZ María M MUJICA sandra S BAIONI José eNTíO María N FIOReTTI Guillermo TUCAT Agronomy Department National University of the South and CERZOS (CONICET) experimental Farm eeA INTA Patagones Ministery of Agrarian Issues Faculty of Agrarian Sciences National University of La Plata

Pappophorum vaginatum is the most abundant C4 perennial grass desirable to livestock in rangelands of northeastern Patagonia, Argentina. We hypothesized that （1） defoliation reduce net primary productivity, and root length density and weight in the native species, and （2） root net primary productivity, and root length density and weight, are greater in P. vaginatum than in the other, less desirable, native species （i.e., Aristida spegazzinfi, A. subulata and Sporobolus cryptandrus）. Plants of all species were either exposed or not to a severe defoliation twice a year during two growing seasons. Root proliferation was measured using the cylinder method. Cylindrical, iron structures, wrapped up using nylon mesh, were buried diagonally from the periphery to the center on individual plants. These structures, initially filled with soil without any organic residue, were dug up from the soil on 25 April 2008, after two successive defoliations in mid-spring 2007. During the second growing season （2008-2009）, cylinders were destructively harvested on 4 April 2009, after one or two defoliations in mid- and/or late-spring, respectively. Roots grown into the cylinders were obtained after washing the soil manually. Defoliation during two successive years did reduce the study variables only after plants of all species were defoliated twice, which supported the first hypothesis. The greater root net primary productivity, root length den- sity and weight in P. vaginatum than in the other native species, in support of the second hypothesis, could help to explain its greater abundance in rangelands of Argentina.

关键词： Aristida species competitive ability Pappophorum vaginatum Sporobolus cryptandrus warm-season perennial grasses

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微生物与矿物建筑材料的相互作用(英文)

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硅酸盐学报 2014年第5期42卷 563-567页

作者： Nele De BeLIe WANG Jianyun Willem De MUYNCK sandra MANSO BLANCO Ignacio SeGURO PeReZ Magnel Laboratory for Concrete Research Ghent University Belgium Laboratory of Microbial ecology and Technology Ghent University Belgium Departamento de Ingenieria de la Construccion Universitat Politecnica de Catalunya Campus Nord Spain

综合介绍了比利时根特大学Magnel实验室与其他合作单位关于微生物与建筑材料（混凝土和石材）之间相互作用的研究概况。第一个研究课题是生物硫酸腐蚀，主要研究混凝土下水道系统和储肥设施的侵蚀。整个过程可用纯化学或微生物侵蚀实验... 详细信息

综合介绍了比利时根特大学Magnel实验室与其他合作单位关于微生物与建筑材料（混凝土和石材）之间相互作用的研究概况。第一个研究课题是生物硫酸腐蚀，主要研究混凝土下水道系统和储肥设施的侵蚀。整个过程可用纯化学或微生物侵蚀实验来模拟。利用化学硫酸实验来模拟侵蚀过程的缺点是忽视了混凝土本身的杀菌效果。微生物实验结果表明使用具有高度中和能力的材料可限制生物腐蚀的发生。因此，生物硫酸侵蚀模型中不但需要考虑耐久性（如孔隙率），也需要把混凝土碱性列为参数之一。第二个研究课题是细菌在胶结固化和混凝土自修复中的应用。细菌诱导产生的碳酸钙用于水泥基材料和石灰石的表面防护。研究表明：沉积在表面的生物碳酸钙可有效降低混凝土吸水率、碳化和氯离子侵蚀；还能提高混凝土抗冻融性能。多孔石灰石表面固化深度可达到30mm甚至更多，固结区的强度可增加300％。与此同时，微生物碳酸钙也被应用于混凝土裂缝自修复。细菌先被固载于硅藻土或微胶囊内，然后加入到混凝土中与其一起搅拌。结果显示：加有硅藻土固载的细菌的砂浆试块上0．15～O．17mitt宽的裂缝可在40d内被细菌诱导产生的碳酸钙完全修复；而加有微胶囊固载的细菌的试块上1rnm宽的裂缝可以在3周内自修复完毕。微生物在混凝土中的另一个应用是创造绿色生态混凝土墙壁。这种混凝土墙壁经过特殊设计获得特定的微观结构和生物兼容性，从而可充当生物生长的基体。为了适于生物生长，使用低pH值的磷酸镁水泥混凝土和碳化水泥混凝土，并对其他影响生物兼容性的因素如混凝土孔隙率、表面粗糙度等进行了优化研究。

关键词：生物侵蚀生物固化碳酸钙沉淀自修复生态墙壁

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Methylation changes at the GNAS imprinted locus in pancreatic cystic neoplasms are important for the diagnosis of malignant cysts

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World Journal of Gastrointestinal Oncology 2020年第9期12卷 1056-1064页

作者： sandra Faias Marlene Duarte Luísa Pereira Paula Chaves Marília Cravo Antonio Dias Pereira Cristina Albuquerque Department of Gastroenterology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Faculty of Health Sciences University of Beira InteriorCovilhã6200-506Portugal Unidade de Investigação em Patobiologia Molecular(UIPM) Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Centro de Matemática e Aplicações(CMA-UBI) Universidade da Beira InteriorCovilhã6200-506Portugal Department of Pathology Instituto Português de Oncologia de Lisboa Francisco GentilEPELisboa 1099-023Portugal Department of Gastroenterology Hospital BeatrizÂngeloLoures 2674-514Portugal

BACKGROUND Guanine nucleotide-binding protein,alpha stimulating(GNAS)mutations are characteristic of intraductal papillary mucinous neoplasms(IPMNs).Pancreatic ductal adenocarcinomas(PDACs)harboring GNAS mutations originate in *** is a complex imprinted locus that produces five transcripts regulated by differential methylated regions,NeSP55,GNASAS,GNASXL,GNAS1A,and *** To evaluate if methylation changes in the differential methylated regions of GNAS locus contributed to malignant progression of pancreatic *** GNAS locus methylation was analyzed in archival pancreatic cyst fluid(PCF)obtained by endoscopic ultrasound with fine-needle aspiration by methylation specific–multiplex ligation dependent probe *** were normalized and analyzed using *** *** Fifty-two PCF samples obtained by endoscopic ultrasound with fine-needle aspiration and previously characterized for KRAS and GNAS mutations were *** final diagnoses were surgical(11)and clinicopathological(41),including 30 benign cysts,14 pre-malignant cyst,and eight malignant *** changes at NeSP55,GNASAS,GNAS1A,and especially GNASXL were more frequent in malignant cysts,and NeSP55 and GNASAS were useful for diagnosis.A combined variable defined as“GNAS locus methylation changes”was significantly associated with malignancy(6/8 malignant cysts and only 2/20 benign cysts)and improved *** in both maternally(NeSP55)and paternally(GNASXL)derived promoters was found in 3/3 *** This is the first study to identify methylation changes in the GNAS locus,improving the diagnosis of malignant pancreatic cysts and suggesting a role in progression to PDAC.

关键词： Intraductal papillary mucinous neoplasms Pancreas cyst Methylation Biomarker GNAS locus Pancreatic neoplasm

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