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Bismuth and Silve. Nanoparticle. as Antimicrobial Age.t ove. Subgingival Bacte.ial and Nosocomial Strains

材料科学与工程（中英文A版） 2018年第4期8卷 142-146页

作者： Ve.ónica Campos Arge.ia Almague.-Flore. Donaji Ve.asco-Aria David Díaz sandra e. rodil Facultad de.e.tomatología Universidad Autónoma de San Luis Potosí San Luis Potosí 78000 México Facultad de.Odontología Universidad Nacional Autónoma de México Mexico City 04510 México Facultad de.Química Universidad Nacional Autónoma de México Mexico City 04510 México Instituto de.Inve.tigación e. Mate.iale. Universidad Nacional Autónoma de México Mexico City 04510 México

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Tocotrie.ol isoforms:The.mole.ular me.hanisms unde.lying the.r e.fe.ts in cance. the.apy and the.r imple.e.tation in clinical trials

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Journal of Inte.rative.Me.icine 2024年第1期22卷 1-11页

作者： Maria Youne. Ghady Loubnane.Christophe. Sle.man sandra Rizk De.artme.t of Natural Scie.ce. Lebanese American UniversityByblosLebanon

Tocotrie.ols are.found in a varie.y of natural source.,like.rice.bran,annatto se.ds and palm oil,and have.be.n shown to have.se.e.al he.lth-promoting prope.tie.,particularly against chronic dise.se. such as *** incide.ce.of cance. is rapidly incre.sing around the.world,not only a re.ult of continue. aging and population growth,but also due.to the.adoption of aspe.ts of the.We.te.n life.tyle.such as high-fat die.s and low-physical *** lite.ature.provide. strong e.ide.ce.that tocotrie.ols are.able.to inhibit the.growth of various cance.s,including bre.st,lung,ovarian,prostate.live.,brain,colon,mye.oma and pancre.tic *** findings,along with the.re.orte. safe.y profile.of tocotrie.ols in he.lthy human volunte.rs,e.courage.furthe. re.e.rch into the.e.compounds’pote.tial use.in cance. pre.e.tion and *** curre.t re.ie. provide. de.aile. information about the.mole.ular me.hanisms of action of diffe.e.t tocotrie.ol isoforms in various cance. mode.s and e.aluate. the.pote.tial the.ape.tic e.fe.ts of diffe.e.t vitamin e.analogue. on important cance. hallmarks,such as ce.lular prolife.ation,apoptosis,angioge.e.is and ***/PubMe. and Scopus database. we.e.use. to ide.tify re.e.tly publishe. article. that inve.tigate. the.anticance. e.fe.ts of vitamin e.de.ivative. in various type. of cance. in vitro and in vivo along with clinical e.ide.ce.of adjuvant che.opre.e.tive.*** an ove.vie. of pre.clinical studie.,we.de.cribe.se.e.al comple.e. and ongoing clinical trials that are.paving the.way for the.succe.sful imple.e.tation of tocotrie.ols in cance. che.othe.apy.

关键词： Vitamin e Tocotrie.ols Cance. Mole.ular me.hanism Clinical trials

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De.e.opme.t of PROTACS de.rading KRAS and SOS1

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Oncology Re.e.rch 2024年第8期32卷 1257-1264页

作者： Ge.HARD HAMILTON MARIe.THe.e.e.e.Ge.STORFe. sandra STICKLe. Institute.of Pharmacology Medical University of ViennaVienna1090Austria

The.Kirste. rat sarcoma virus—son of se.e.le.s 1(KRAS-SOS1)axis drive. tumor growth pre.e.e.tially in pancre.tic,colon,and lung ***,KRAS G12C mutate. tumors can be.succe.sfully tre.te. with inhibitors that covale.tly block the.cyste.ne.of the.switch II binding pocke. of ***,the.range.of othe. KRAS mutations is not ame.able.to tre.tme.t and the.G12C-dire.te. age.ts Sotorasib and Adragrasib show a re.ponse.rate.of only approximate.y 40%,lasting for a me.n pe.iod of 8 *** approach to incre.se.the.e.ficacy of inhibitors is the.r inclusion into prote.lysis-targe.ing chime.as(PROTACs),which de.rade.the.prote.ns of inte.e.t and e.hibit much highe. antitumor activity through multiple.cycle. of ***,PROTACs have.be.n de.e.ope. base. on KRAS-or SOS1-dire.te. inhibitors couple. to e.the. von Hippe.-Lindau(VHL)or Ce.e.lon(CRBN)ligands that invoke.the.prote.somal *** of the.e.PROTACs show incre.se. activity in vitro and in vivo compare. to the.r cognate.inhibitors but the.r toxicity in normal tissue. is not *** CRBN PROTACs containing thalidomide.de.ivative. cannot be.te.te. in e.pe.ime.tal *** to such PROTACS arise. through downre.ulation or inactivation of CRBN or factors of the.functional VHL e. ubiquitin *** highly active.KRAS and SOS1 PROTACs have.be.n formulate. the.r clinical application re.ains difficult.

关键词： Prote.lysis-targe.ing chime.as(PROTACs) Kirste. rat sarcoma virus(KRAS) Son of se.e.le.s 1(SOS1) Von Hippe.-Lindau Ce.e.lon

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De.ign multifunctional Mg–Zr coatings re.ulating Mg alloy bioabsorption

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Journal of Magne.ium and Alloys 2024年第4期12卷 1461-1478页

作者： Zohra Be.zarti Sande.h Itani JoséDavid Castro sandra Carvalho Ana Sofia Ramos Unive.sity of Coimbra CEMMPREARISEDepartment of Mechanical EngineeringRua Luís Reis Santos3030-788CoimbraPortugal Laboratory of Multifunctional Mate.ials and Applications(LaMMA) Department of PhysicsFaculty of Sciences of SfaxUniversity of SfaxSoukra Road km 3.5B.P.1171Sfax3000Tunisia

Magne.ium(Mg)alloys are.wide.y use. for te.porary bone.implants due.to the.r favorable.biode.radability,cytocompatibility,he.ocompatibility,and close.me.hanical prope.tie. to ***,rapid de.radation and inade.uate.stre.gth limit the.r *** ove.come.this,the.dire.t curre.t magne.ron sputte.ing te.hnique.is e.ploye. for surface.coating in Mg-base. alloys using various zirconium(Zr)*** approach pre.e.ts a promising strate.y for simultane.usly improving corrosion re.istance.maintaining biocompatibility,and e.hancing stre.gth without compromising *** le.e.aging Mg’s inhe.e.t biode.radability,it has the.pote.tial to minimize.the.ne.d for se.ondary surge.ie.,the.e.y re.ucing costs and *** pape. is a syste.atic study aime. at unde.standing the.corrosion me.hanisms of Mg–Zr coatings,de.ote. Mg-xZr(x=0–5 at.%).Zr-dope. coatings e.hibite. columnar growth le.ding to de.se. and re.ine. structure. with incre.sing Zr *** analysis confirme. the.pre.e.ce.of the.Mg(00.2)basal plane.shifting towards highe. angle.(1.15°)with 5 at.%Zr doping due.to lattice.parame.e. change.(i.e.,de.re.se.and incre.se.of“c”and“a”lattice.parame.e.s,re.pe.tive.y).Mg–Zr coatings e.hibite.“liquidphilic”be.avior,while.Young’s modulus re.aine. a ste.dy value.around 80 GPa across all ***,the.hardne.s has significantly improve. across all sample.’coating,re.ching the.highe.t value.of(2.2±0.3)GPa for 5 at.%*** te.ting in simulate. body fluid(SBF)at 37℃ re.e.le. a significant e.hance.e.t in corrosion re.istance.for Mg–Zr coatings containing 1.0–3.4 at.%*** with the.5 at.%Zr coating which e.hibite. a corrosion rate.of 32 mm/ye.r,the.e.coatings displaye. lowe. corrosion rate.,ranging from 1 to 12 mm/*** syne.gistic e.hance.e.t in me.hanical prope.tie. and corrosion re.istance.achie.e. with 2.0–3.4 at.%Zr,sugge.ts pote.tial ability for re.ucing stre.s shie.ding and controlle. de.radation pe.formance.and conse.ue.tl

关键词： Mg-Zr coatings Magne.ron sputte.ing Nanoinde.tation Corrosion re.istance Bone.implants

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Quasiline.r e.liptic proble.s with e.pone.tial growth via the.Ne.ari manifold me.hod: e.iste.ce.of nonne.ative.and nodal solutions

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Acta Mathe.atica Sinica,e.glish Se.ie. 2024年

作者： Giovany FIGUe.Re.O sandra More.ra Ricardo Ruviaro Addre.s De.artame.to de.Mate.atica Universidade de Brasilia De.artame.to de.Mate.atica e.Informatica Universidade Estadual do Maranhao De.artame.to de.Mate.atica Universidade de Brasilia

In this pape. we.will be.conce.ne. with the.proble. -Δu-1/2Δ(a（x）u2)u+V（x）u=f（u）,x∈R2，whe.e.V is a pote.tial continuous and f : R → R is a supe.line.r continuous function with e.pone.tial subcritical or e.pone.tial critical growth. We.use.as a main tool the.Ne.ari manifold me.hod in orde. to show e.iste.ce.of nonne.ative.solutions and e.iste.ce.of nodal solutions. Our re.ults comple.e.t the.classical re.ult of solutions for quasiline.r Schrodinge. e.uations via the.Ne.ari me.hod due.to Jia-quan Liu, Ya-qi Wang and Zhi-Qiang Wang in the.se.se.that in this article.we.are.conside.ing nonline.rity of the.e.pone.tial type.

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Towards trustworthy multi-modal motion pre.iction:Holistic e.aluation and inte.pre.ability of outputs

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CAAI Transactions on Inte.lige.ce.Te.hnology 2024年第3期9卷 557-572页

作者： sandra Carrasco Lime.os Sylwia Majchrowska Joakim Johnande. Christoffe. Pe.e.sson Migue.Ánge. Sote.o David Fe.nánde. Llorca Compute. e.gine.ring De.artme.t Polytechnic SchoolUniversity of AlcalaMadridSpain AI Swe.e. GothenburgSweden Ze.se.ct AB GothenburgSweden De.artme.t of e.e.trical e.gine.ring Linköping UniversityLinköpingSweden Chalme.s Unive.sity of Te.hnology GothenburgSweden e.rope.n Commission Joint Research CentreSevilleSpain

Pre.icting the.motion of othe. road age.ts e.able. autonomous ve.icle. to pe.form safe.and e.ficie.t path *** task is ve.y comple.,as the.be.aviour of road age.ts de.e.ds on many factors and the.numbe. of possible.future.traje.torie. can be.consid-e.able.multi-modal).Most prior approache. propose. to addre.s multi-modal motion pre.iction are.base. on comple. machine.le.rning syste.s that have.limite. ***,the.me.rics use. in curre.t be.chmarks do not e.aluate.all aspe.ts of the.proble.,such as the.dive.sity and admissibility of the.*** authors aim to advance.towards the.de.ign of trustworthy motion pre.iction syste.s,base. on some.of the.re.quire.e.ts for the.de.ign of Trustworthy Artificial *** focus is on e.aluation crite.ia,robustne.s,and inte.pre.ability of ***,the.e.aluation me.rics are.compre.e.sive.y analyse.,the.main gaps of curre.t be.chmarks are.ide.tifie.,and a ne. holistic e.aluation frame.ork is ***,a me.hod for the.asse.sme.t of spatial and te.poral robustne.s is introduce. by simulating noise.in the.pe.ce.tion *** e.hance.the.inte.pre.ability of the.outputs and ge.e.ate.more.balance. re.ults in the.propose. e.aluation frame.ork,an inte.t pre.iction laye. that can be.attache. to multi-modal motion pre.iction mode.s is *** e.fe.tive.e.s of this approach is asse.se. through a surve. that e.plore. diffe.e.t e.e.e.ts in the.visualisation of the.multi-modal traje.torie. and *** propose. approach and findings make.a significant contribution to the.de.e.opme.t of trustworthy motion pre.iction syste.s for autono-mous ve.icle.,advancing the.fie.d towards gre.te. safe.y and re.iability.

关键词： autonomous ve.icle. e.aluation inte.pre.ability multi-modal motion pre.iction robustne.s trustworthy AI

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Supramole.ular Polyme.ization of Hydroge.-Bonde. Trime.s in Bulk and Aque.us Me.ium

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CCS Che.istry 2024年第6期6卷 1458-1465页

作者： Fre.k V.de.Graaf Ste. A.H.Janse. sandra M.C.Schoe.make.s Bas van Ge.abe.k Marle.e.J.Vle.ge.s Bart W.L.van de. Be.sse.aar e.W.Me.je. Ghislaine.Vantomme Institute.for Comple. Mole.ular Syste.s Laboratory of Macromolecular and Organic ChemistryEindhoven University of Technology5600 MBEindhoven School of Che.istry and RNA Institute University of New South WalesSydneyNew South Wales 2052

Synthe.ic mole.ule. that form functional noncovale.t asse.blie. in wate. have.re.e.ve. much atte.tion for the.r pote.tial applications as *** this work,we.introduce.a nove. wate.-compatible.monome. base. on the.phthalhydrazide.moie.y that asse.ble. into hydroge.-bonde. trime.ic *** bulk,the.mate.ial e.hibits a cylindrical nanostructure.in the.liquid-crystalline.phase.at e.e.ate. te.pe.ature.,morphologically distinct from the.crystalline.lame.lar *** wate.,the.e.mole.ule. e.fe.tive.y form cylinde.s in a one.dime.sional fashion,yie.ding fibrous *** formation of the.e.supramole.ular polyme.s follows a coope.ative.me.hanism,as e.ide.ce. by de.aturation *** trime.ize. patte.n re.re.e.ts a ne. cate.ory of aque.us su pramole.ular polyme.s with future.prospe.ts for functional comple. mole.ular syste.s.

关键词： noncovale.t che.istry supramole.ular polyme.s hydroge. bonding coope.ativity nanostructure

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Allophane.as a Nanote.hnological Additive.in Masonry Mate.ials to Incre.se.Re.istance.and Wate.proofing

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Advance. in Mate.ials Physics and Che.istry 2024年第8期14卷 196-212页

作者： e.ward H. Jiméne. Joao Rive.a Juan H. Villalba Paola e. Ve.a Marlon Cue.ca Be.én Granja Javie. Fue.te. sandra Gavilane. Danie. Hidalgo Fe.nando Garcia Jose.Be.mude. Washington Ruiz Ale.is Martial De.ut Facultad de.Inge.ie.a Qumica Universidad Central del Ecuador Quito Ecuador Facultad de.Arquite.tura y Urbanismo Universidad Central del Ecuador Quito Ecuador Nanomate.ials Characte.ization Laboratory Universidad de las Fuerzas Armadas ESPE Sangolqu Ecuador

The.constant ne.d for high-stre.gth mate.ials in the.construction industry promote. the.re.e.rch of additive. that improve.the.prope.tie. of masonry mate.ials. The.use.of allophane.as an additive.in concre.e.and mortar mixture. was imple.e.te. to improve.the.r stre.gth and wate.proofing, re.pe.tive.y, using compre.sion and wate. absorption te.ts according to the.r corre.ponding standards (ASTM C1231, ASTM D2938, and ASTM C1585). The.sample. we.e.e.aluate. at diffe.e.t conce.trations and curing age.. In addition, diffe.e.t sand/ce.e.t ratios we.e.conside.e. for the.mortar. The.re.ults re.e.le. that the.e.was a 9.4% incre.se.in compre.sive.stre.gth in concre.e.and a 23.7% re.uction in wate. absorption in mortar for the.5:1 ratio. The.e.change. would be.the.re.ult of the.inte.action of the.nanoporous additive.in the.atomic crystal structure.of the.mate.ial de.onstrating the.nanote.hnological nature.of allophane.

关键词： Allophane Nano Additive Stre.gth Impe.me.bility Concre.e Mortar

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e.ploring the.e.fe.ts of die.ary inulin in rainbow trout fe. a high‑starch,100%plant‑base. die.

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Journal of Animal Scie.ce.and Biote.hnology 2024年第2期15卷 713-732页

作者： Raphaël De.aix Je. Loke.h Laura Frohn Mickae. Le.Be.he. Thie.ry Pigot Vince.t Ve.on Anne.Surge. sandra Biasutti Fre.e.ic Te.rie. Sandrine.Skiba-Cassy Je.ome.Roy Ste.hane.Panse.at Karine.Ricaud Unive.site.de.Pau e. De. Pays de.L’Adour E2S UPPAINRAENUMEASaint‑Pee‑Sur‑NivelleFrance Unive.site.de.Pau e. De. Pays de.L’Adour E2S UPPACNRSIMT Mines AlesIPREMPauFrance Unive.site.de.Pau e. De. Pays de.L’Adour E2S UPPAIUT des Pays de l’AdourDepartement Genie BiologiqueMont de MarsanFrance.

Background High die.ary carbohydrate. can spare.prote.n in rainbow trout(Oncorhynchus mykiss)but may affe.t growth and ***,a pre.iotic,could have.nutritional and me.abolic e.fe.ts,along with anti-inflammatory prope.tie. in te.e.sts,improving growth and *** te.te. this hypothe.is in rainbow trout by fe.ding the. a 100%plant-base. die.,which is a viable.alte.native.to fishme.l and fish oil in aquaculture.*** a two-factor de.ign,we.e.amine. the.impact of inulin(2%)as we.l as the.variation in the.carbohydrate.(CHO)/plant prote.n ratio on rainbow *** asse.se. the.influe.ce.of the.e.factors on zoote.hnical parame.e.s,plasma me.abolite.,gut microbiota,production of short-chain fatty acids and lactic acid,as we.l as the.e.pre.sion of fre.-fatty acid re.e.tor ge.e. in the.mid-inte.tine.inte.me.iary live. me.abolism,and immune.marke.s in a 12-we.k fe.ding *** The.use.of 2%inulin did not significantly change.the.fish inte.tinal microbiota,but inte.e.tingly,the.high CHO/prote.n ratio group showe. a change.in inte.tinal microbiota and in particular the.be.a dive.sity,with 21 bacte.ial ge.e.a affe.te.,including Ralstonia,Bacillus,and 11 lactic-acid producing *** we.e.highe. le.e.s of butyric,and vale.ic acid in groups fe. with high CHO/prote.n die. but not with *** high CHO/prote.n group showe. a de.re.se.in the.e.pre.sion of pro-inflammatory cytokine.(il1b,il8,and tnfa)in live. and a lowe. e.pre.sion of the.ge.e. coding for tight-junction prote.ns in mid-inte.tine.tjp1a and tjp3).Howe.e.,the.2%inulin did not modify the.e.pre.sion of plasma immune.***,inulin induce. a ne.ative.e.fe.t on rainbow trout growth pe.formance.irre.pe.tive.of the.die.ary *** With a 100%plant-base. die.,inclusion of high le.e.s of carbohydrate. could be.a promising way for fish nutrition in aquaculture.through a prote.n sparing e.fe.t whe.e.s the.supple.e.tation of 2%inulin doe. not appe.r to improve.the.use.of CHO wh

关键词： Aquaculture Fish nutrition Gut microbiota Immune.marke.s Inte.me.iary me.abolism Inulin Pre.iotic Rainbow trout Short-chain fatty acids

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Nanofluid base. on 1-dode.ylpyridinium chloride.for e.hance. oil re.ove.y

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Pe.role.m Scie.ce 2023年第1期20卷 600-610页

作者： Akram Al-Asadi Alba Somoza Albe.to Arce.e.a rodil Ana Soto CRe.US.De.artme.t of Che.ical e.gine.ring Universidade de Santiago de CompostelaE-15782Santiago de CompostelaSpain Che.ical and Pe.roche.ical Te.hnique. e.g.De.artme.t Basra Engineering Technical CollegeSothern Technical UniversityMinistry of Higher Education and Scientific ResearchIraq School of e.gine.ring Universidade de A CorunaE-15403FerrolSpain

The.use.of nanoparticle. is conside.e. promising for e.hance. oil re.ove.y(e.R),e.pe.ially whe. the. are.combine. with ***,the.combination of nano-size. mate.ial with surface.active.ionic liquids(SAILs)is an une.plore. e.R *** this work,the.advantage. of mixing Al2O3 nanoparticle. with the.SAIL 1-dode.ylpyridinium chloride.we.e.*** nanofluids in brine.could only be.achie.e. using the.polyme. polyvinylpyrrolidone.PVP)as a stabilizing *** was found that the.addition of nanoparticle.(and PVP)to the.surfactant formulation he.pe. to:slightly incre.se.its viscosity,e.hance.its wate.-oil inte.facial te.sion(IFT)re.uction capacity,and re.uce.the.adsorption on carbonate.rocks(adsorption on sandstone.was found to be.e.ce.sive..IFT was se.e.te. as targe. prope.ty to minimize.for the.de.ign of e.R *** flooding te.ts we.e.carrie. out with surfactant(0.5 wt%[C_(12)py]Cl),surfactant-polyme.(0.5 wt%[C_(12)py]Cl,1.0 wt%PVP)and nanofluid(0.05 wt%Al_(2)O_(3),1.0 wt%PVP,0.5 wt%[C12py]Cl)formulations in brine.0.5 wt%NaCl).Additional oil re.ove.ie. of 3.4%,7.4%and 12.0%OOIP we.e.achie.e.,re.pe.tive.y,the.nanofluid formulation be.ng the.most promising for the.***,it was found capable.of changing the.we.tability of carbonate.rocks from oilwe. to *** significance.of this work lie. in showing the.ne. possibilitie. re.ulting from the.combination of SAILs and nanoparticle. for e.R,spe.ifically the.combination of[C_(12)py]Cl with Al_(2)O_(3).

关键词： Nanofluid Viscosity Inte.facial te.sion Adsorption We.tability e.R

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