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Application of Cole-Cole model to transformer oil-paper insulation considering distributed dielectric relaxation

High Voltage 2019年第1期4卷 72-79页

作者： sandip kumar ojha Prithwiraj Purkait Biswendu Chatterjee Sivaji Chakravorti Department of Electrical Engineering Haldia Institute of TechnologyHaldia721657West BengalIndia Department of Electrical Engineering St.Thomas'College of Engineering&TechnologyKolkata700023West BengalIndia Electrical Engineering Department Jadavpur UniversityKolkata700032West BengalIndia Electrical Engineering Department Currently at NIT Calicut on lien from Jadavpur UniversityKolkata700032West BengalIndia

Researchers have been exploring dielectric testing techniques both in time and frequency domain for insulation condition assessment of oil-paper insulated *** a practical dielectric system,dipoles are found to behave according to a distribution of elementary Debye relaxation *** distribution density functions have been proposed to characterise such many-body interaction ***-Cole diagrams can be one of the methods for studying the nature of frequency dependency of dielectric materials of complex ***-Cole plots are commonly used for characterising different materials such as dielectric mixtures,ionic liquids,cable insulating oil,polar liquids *** scope of its application for assessing transformer oil-paper insulation considering distributed relaxation process has not been explored *** present contribution discusses mathematical formulations used for transforming the experimentally obtained time domain dielectric response test data to distribution domain and further to frequency domain for obtaining the Cole-Cole *** about the influence of various operating conditions and insulation status on the Cole-Cole diagram have been reported in this *** of tests on field transformers are also *** paper attempts to employ the features of Cole-Cole diagrams as potential indicators for analysing condition of the oil-paper insulation considering distributed relaxation process.

关键词： properties structure process

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Adaptive sampling for generalized probabilistic roadmaps

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控制理论与应用（英文版） 2012年第1期10卷 1-10页

作者： sandip kumar Suman CHAKRAVORTY Department of Aerospace Engineering Texas A&M University College Station

In this paper, an adaptive sampling strategy is presented for the generalized sampling-based motion plan- ner, generalized probabilistic roadmap （GPRM）. These planners are designed to account for stochastic map and model uncertainty and provide a feedback solution to the motion planning problem. Intelligently sampling in this framework can result in large speedups when compared to naive uniform sampling. By using the information of transition probabilities, encoded in these generalized planners, the proposed strategy biases sampling to improve the efficiency of sampling, and increase the overall success probability of GPRM. The strategy is used to solve the motion planning problem of a fully actuated point robot and a 3-DOF fixed-base manipulator on several maps of varying difficulty levels, and results show that the strategy helps solve the problem efficiently, while simultaneously increasing the success probability of the solution. Results also indicate that these rewards increase with an increase in map complexity.

关键词： Adaptive sampling GPRM Probabilistic roadmaps (PRM) Stochastic maps Model uncertainty Linkmanipulator

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Removal efficiency of fluoride by novel Mg-Cr-Cl layered double hydroxide by batch process from water

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Journal of Environmental Sciences 2013年第5期25卷 993-1000页

作者： sandip Mandal Swagatika Tripathy Tapswani Padhi Manoj kumar Sahu Raj Kishore Patel Department of Chemistry National Institute of TechnologyRourkela 769 008India

The fluoride ion removal from aqueous solution using synthesized Mg-Cr-Cl layered double hydroxide has been ***-Cr-Cl was characterized by X-ray powder diffraction,Fourier-transform infrared,thermo-gravimetric analysis,differential thermal analysis,and scanning electron *** experiments were carried out in batch mode as a function of adsorption dosages,contact time,pH,and initial fluoride concentration to get optimum adsorption *** adsorption kinetic study showed that the adsorption process followed first order *** fluoride removal was 88.5% and 77.4% at pH 7 with an adsorbent dose of 0.6 g/100 mL solution and initial fluoride concentration of 10 mg/L and 100 mg/L,*** equilibrium was established at 40 *** experiment data were fitted well with Langmuir isotherm with R 2 = *** constants were also measured and concluded that the adsorption process was spontaneous and endothermic in *** removal percentage decreased slowly with increasing *** process is suitable for industrial *** regeneration of the material is not possible.

关键词： layered double hydroxide(LDH) fluoride adsorbents

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Impact of metal oxide nanoparticles on cotton(Gossypium hirsutum L.):a physiological perspective

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Journal of Cotton Research 2021年第2期4卷 169-187页

作者： SINGH BRAR Ravinderdeep kumar Avneesh KAUR Simranjeet SAHA sandip kumar Anuj kumar Sandeep Department of Chemistry Akal UniversityTalwandi SaboBathindaPunjab151302India Department of Botany Akal UniversityTalwandi SaboBathindaPunjab151302India Indian Agricultural Statistics Institute DelhiIndia

Cotton production substantiated a crucial part in the escalating economic development of many *** realize the increasing global demand for cotton,the emphasis should be laid on to improve cotton fiber growth and *** bioengineered transgenic cotton proved expedient in resolving inadequacies of conventional cotton,but still required improvements to encounter heightened demand of textile *** possible solution pertaining to this has been provided by nanoscience in the form of metal or metal oxide *** metal oxide nanoparticles have easy access to the various parts of cotton plants through its transportation system,and thus significantly influence several parameters relative to the growth and production of cotton *** review summarizes the distribution and accumulation of metal oxide nanoparticles in cotton plant and its impact on different plant growth-promoting factors,which resulted in the improved cotton yields.

关键词： Cotton Bt-transgenic Nanoparticles Metal oxide nanoparticles Phytohormones Superoxide dismutase Nutrient element

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Analysis of risk factors contributing to road traffic accidents in a tertiary care hospital. A hospital based cross-sectional study

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Chinese Journal of Traumatology 2020年第3期23卷 159-162页

作者： sandip kumar Mahima Dhiraj kumar Srivastava Pradip Kharya Neha Sachan K.Kiran Department of Community Medicine UPUMSSaifaiEtawah206130India

Purpose: Road traffic accidents (RTAs) are a public health issue and cost a lot to individuals, families, communities and nations. Trauma care systems in India are at a nascent stage of development. There is gross disparity between trauma services available in various parts of the country. Rural area in India has inefficient services for trauma care, due to the varied topography, financial constraints, and lack of appropriate health infrastructure. The present study is to study the trends of occurrence of RTA cases by month, week and time of accident occurrence as well as to research the types of vehicle involved in accidents and other various risk factors related to ***: During 1st January 2017 to 31st December 2017, a hospital-based and cross-sectional study of RTA victims was conducted. The patients were admitted in emergency department of Uttar Pradesh University of Medical Sciences, Saifai, Etawah, when stabilized, they were shifted to the orthopaedics and surgery ***: In the study, 654 road accident victims were included, of which the majority were males (77.5%) and the most of them belonged to rural (67%). RTA victims according to the month of occurrence majority were found in January (12.5%) and evening was time of a day with maximum accidents (32.1%). Mortality cases of RTA victims based on type of road user and it shows decreasing trend of mortality of motor-cyclists (54.2%) followed by pedestrian (25.1%).Conclusion: There should be control over people driving vehicles under the influence of alcohol and drivers over-speeding and rash driving on urban roads as well as rural village roads.

关键词： Road traffic accidents Risk factors Tertiary care hospital

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Pathological abnormalities in splenic vasculature in non-cirrhotic portal hypertension:Its relevance in the management of portal hypertension

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World Journal of Gastrointestinal Surgery 2020年第1期12卷 1-8页

作者： Shahana Gupta Biju Pottakkat Surendra kumar Verma Raja Kalayarasan sandip Chandrasekar A Ajith Ananthakrishna Pillai Department of Surgical Gastroenterology JIPMERPondicherry 605006India Department of Pathology JIPMERPondicherry 605006India Department of Cardiology JIPMERPondicherry 605006India

BACKGROUND Portal hypertension(PH)is associated with changes in vascular structure and function of the portosplenomesenteric system(PSMS).This is referred to as portal hypertensive *** abnormalities of PSMS has been described in the literature for cirrhotic *** portal pressure and hyperdynamic circulation are thought to be the underlying cause of this *** view of this,it is expected that pathological changes in splenic and portal vein similar to those reported in cirrhotic patients with PH may also be present in patients with non-cirrhotic PH(NCPH).AIM To investigate pathological abnormalities of splenic vein in patients with NCPH,and suggest its possible implications in the management of *** A prospective observational study was performed on 116 patients with NCPH[Extrahepatic portal vein obstruction(EHPVO):53 and non-cirrhotic portal fibrosis(NCPF):63]who underwent proximal splenorenal shunt(PSRS),interposition shunt or splenectomy with devascularization in JIPMER,Pondicherry,India,a tertiary level referral center,between *** patients were evaluated by Doppler study of PSMS,computed tomography portovenogram and upper gastrointestinal *** acoustic resonance forced impulse(ARFI)scan and abdomen ultrasound were done for all cases to exclude *** and histopathological assessment of the harvested splenic vein was performed in *** study group was divided into delayed and early presentation based on the median duration of symptoms(i.e.108 mo).RESULTS The study group comprising of 116 patients[77(66%)females and 39(34%)males]with NCPH had a median age of 22 *** duration of symptoms was 108 *** most common presentation in both EHPVO and NCPF patients was upper gastrointestinal bleeding(hematemesis and melena).The ARFI scan revealed a median score of 1.2(1.0-1.8)m/s for EHPVO and 1.5(0.9-2.8)m/s for *** was performed in 84 patients(two of whom underwent interpos

关键词： Portal hypertensive vasculopathy Non-cirrhotic portal hypertension Splenic vasculature Hyperdynamic circulation Shunt surgery

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Property mapping of polycrystalline diamond coatings over large area

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Journal of Advanced Ceramics 2014年第1期3卷 56-70页

作者： Awadesh kumar MALLIK sandip BYSAKH Monjoy SREEMANY Sudakshina ROY Jiten GHOSH Soumyendu ROY Joana Catarina MENDES Jose GRACIO Someswar DATTA CSIR-Central Glass&Ceramic Research Institute Kolkata 700032West BengalIndia Department of Physics Indian Institute of Technology BombayPowaiMumbai 400076MaharashtraIndia Instituto de Telecomunicações Campus Universitário de Santiago3810-193Portugal Nanotechnology Research Division Centre for Mechanical Technology and AutomationUniversity of Aveiro3810-193Portugal

Large-area polycrystalline diamond(PCD)coatings are important for fields such as thermal management,optical windows,tribological moving mechanical assemblies,harsh chemical environments,biological sensors,*** plasma chemical vapor deposition(MPCVD)is a standard technique to grow high-quality PCD films over large area due to the absence of contact between the reactive species and the filament or the chamber ***,the existence of temperature gradients during growth may compromise the desired uniformity of the final diamond *** the present work,a thick PCD coating was deposited on a 100-mm silicon substrate inside a 915-MHz reactor;the temperature gradient resulted in a non-uniform diamond *** attempt was made to relate the local temperature variation during deposition and the different properties of the final *** was found that there was large instability inside the system,in terms of substrate temperature(as high asΔT=212℃),that resulted in a large dispersion of the diamond coating’s final properties:residual stress(-15.8 GPa to+6.2 GPa),surface morphology(octahedral pyramids with(111)planes to cubo-octahedrals with(100)flat top surfaces),thickness(190μm to 245μm),columnar growth of diamond(with appearance of variety of nanostructures),nucleation side hardness(17 GPa to 48 GPa),quality(Raman peak FWHM varying from 5.1 cm^(-1) to 12.4 cm^(-1) with occasional splitting).This random variation in properties over large-area PCD coating may hamper reproducible diamond growth for any meaningful technological application.

关键词： plasma-enhanced chemical vapor deposition(CVD) diamond film mechanical properties nanostructures

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Discovery and preclinical development of ⅢM-160, a Bergenia ciliatabased anti-inflammatory and anti-arthritic botanical drug candidate

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Journal of Integrative Medicine 2019年第3期17卷 192-204页

作者： sandip B.Bharate Vikas kumar Sonali S.Bharate Bikarma Singh Gurdarshan Singh Amarinder Singh Mehak Gupta Deepika Singh Ajay kumar Surjeet Singh Ram A.Vishwakarma Medicinal Chemistry Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research PK-PD Toxicology & Formulation Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Biodiversity and Applied Botany Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research Quality Control and Quality Assurance Division Indian Institute of Integrative Medicine Council of Scientific and Industrial Research

Objective: Bergenia ciliata(Haw.) Sternb. is used in the Indian traditional system of medicine to treat various ailments including rheumatism and to heal wounds. The objective of the present study was to perform a preclinical characterization of the B. ciliata-based botanical extract ***: ⅢM-160 was chemically standardized and analyzed for heavy metal content, aflatoxins,pesticides and microbial load. The in vitro and in vivo efficacies were determined in suitable models of inflammation, arthritis and nociception. An acute oral toxicity study was performed in Swiss albino mice.A suitable oral formulation was developed and ***: Bergenin was found to be the major component(9.1% w/w) of ⅢM-160. The botanical lead displayed inhibition of lipopolysaccharide-induced production of proinflammatory cytokines in THP-1 cells, with selectivity toward interleukin-6(IL-6) and had an excellent safety-window. It showed anti-inflammatory, anti-arthritic and antinociceptive activity in animal models and was not toxic at oral doses up to 2 g/kg in Swiss-albino mice. The gastroretentive, sustained-release capsule formulation showed sustained-release of the bergenin over the period of 24 h, resulting in improved plasma-exposure of bergenin in Sprague–Dawley ***: The dual-activity of IL-6 inhibition and antinociception marks the suitability of ⅢM-160 for treating rheumatoid arthritis. This study will serve as the benchmark for further research on this botanical formulation.

关键词： Botanical preclinical candidate UIM-160 Bergenia ciliata Arthritis Gastroretentive sustained release formulation Bergenin

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BMP与后纵韧带骨化症易患性的研究进展

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中国修复重建外科杂志 2012年第10期26卷 1255-1258页

作者：方钊孙天威 sandip kumar Yadav 南开大学人民医院脊柱外科天津300121 天津医科大学天津市人民医院脊柱外科

目的综述BMP与后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)易患性的研究进展。方法查阅近年国内外有关BMP与OPLL易患性的相关参考文献并进行总结。结果 BMP基因的单核苷酸多态性(single nucleotide poly... 详细信息

目的综述BMP与后纵韧带骨化症(ossification of the posterior longitudinal ligament,OPLL)易患性的研究进展。方法查阅近年国内外有关BMP与OPLL易患性的相关参考文献并进行总结。结果 BMP基因的单核苷酸多态性(single nucleotide polymorphisms,SNPs)产生微效累加效应增加对OPLL的易感性,多种环境因素可通过增加BMPs基因的表达,促进OPLL的发生、发展。结论 BMPs易感基因的SNPs可促进个体对OPLL的易感性,SNPs的累加效应及与环境因素的相互作用则可影响个体对OPLL易患性的高低。

关键词：后纵韧带骨化症 BMP 单核苷酸多态性易感性易患性

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In vitro and in vivo anticancer potential and molecular targets of the new colchicine analog ⅢM-067

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Journal of Integrative Medicine 2023年第1期21卷 62-76页

作者： Sumera Malik Mubashir J.Mintoo Chilakala Nagarjuna Reddy Rajesh kumar Pankul Kotwal sandip BBharate Utpal Nandi Dilip M.Mondhe Sanket K.Shukla Pharmacology Division Council of Scientific and Industrial Research(CSIR)-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia Academy of Scientific&Innovative Research(AcSIR) Ghaziabad 201002Uttar PradeshIndia Medicinal Chemistry Division CSIR-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia Pharmacokinetics-Pharmacodynamics(PK-PD) Toxicology DivisionCSIR-Indian Institute of Integrative MedicineJammu 180001Jammu&KashmirIndia

Objective: The current study evaluated various new colchicine analogs for their anticancer activity and to study the primary mechanism of apoptosis and in vivo antitumor activity of the analogs with selective anticancer properties and minimal toxicity to normal ***: Sulforhodamine B(SRB) assay was used to screen various colchicine analogs for their in vitro cytotoxicity. The effect of N-[(7S)-1,2,3-trimethoxy-9-oxo-10-(pyrrolidine-1-yl)5,6,7,9-tetrahydrobenzo[a] heptalene-7-yl] acetamide(ⅢM-067) on clonogenicity, apoptotic induction, and invasiveness of A549 cells was determined using a clonogenic assay, scratch assay, and staining with 4’,6-diamidino-2-phenylindole(DAPI) and annexin V/propidium iodide. Mitochondrial membrane potential(MMP) and reactive oxygen species(ROS) levels were observed using fluorescence microscopy. Western blot analysis was used to quantify expression of proteins involved in apoptosis, cell cycle, and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR) signaling. Pharmacokinetic and in vivo efficacy studies against Ehrlich ascites carcinoma(EAC) and Ehrlich solid tumor models were conducted using Swiss albino ***: ⅢM-067 showed potent cytotoxicity and better selectivity than all other colchicine analogs screened in this study. The selective activity of ⅢM-067 toward A549 cells was higher among other cancer cell lines,with a selectivity index(SI) value of 2.28. ⅢM-067 demonstrated concentration-and time-dependent cytotoxicity against A549 cells with half-maximal inhibitory concentration values of 0.207, 0.150 and0.106 μmol/L at 24, 48 and 72 h, respectively. It also had reduced toxicity to normal cells(SI > 1) than the parent compound colchicine(SI = 1). ⅢM-067 reduced the clonogenic ability of A549 cells in a dose-dependent manner. ⅢM-067 enhanced ROS production from 24.6% at 0.05 μmol/L to 82.1% at 0.4 μmol/L and substantially decreased the MMP(100% in control to 5.6% at 0.4 μmol

关键词： Colchicine 1IIM-067 Apoptosis Antineoplastic agents Carcinoma Ehrlich tumor A549 cells

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