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Optimizing bone marrow harvesting sites for enhanced mesenchymal stem cell yield and efficacy in knee osteoarthritis treatment

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World Journal of Methodology 2025年第2期15卷 92-107页

作者： Arulkumar Nallakumarasamy sandeep Shrivastava Ravi Velamoor Rangarajan Naveen Jeyaraman Avinash Gandi Devadas Swaminathan Ramasubramanian Madhan Jeyaraman Department of Orthopaedics Datta Meghe Institute of Higher Education and ResearchWardha 442004MaharashtraIndia Department of Regenerative Medicine Mother Cell Regenerative CentreTiruchirappalli 620017Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia

Knee osteoarthritis(OA)is a debilitating condition with limited long-term treatment *** therapeutic potential of mesenchymal stem cells(MSCs),particularly those derived from bone marrow aspirate concentrate,has garnered attention for cartilage repair in *** the iliac crest is the traditional site for bone marrow harvesting(BMH),associated morbidity has prompted the exploration of alternative sites such as the proximal tibia,distal femur,and proximal *** paper reviews the impact of different harvesting sites on mesenchymal stem cell(MSC)yield,viability,and regenerative potential,emphasizing their relevance in knee OA *** iliac crest consistently offers the highest MSC yield,but alternative sites within the surgical field of knee procedures offer comparable MSC characteristics with reduced *** integration of harvesting techniques into existing knee surgeries,such as total knee arthroplasty,provides a less invasive approach while maintaining thera-peutic ***,variability in MSC yield from these alternative sites underscores the need for further research to standardize techniques and optimize clinical *** directions include large-scale comparative studies,advanced characterization of MSCs,and the development of personalized harvesting ***,the findings suggest that optimizing the site of BMH can significantly influence the quality of MSC-based therapies for knee OA,enhancing their clinical utility and patient outcomes.

关键词： Knee Osteoarthritis Mesenchymal stem cells Bone marrow harvest Regenerative medicine

Immunohistochemical expression of matrix metalloproteinase-9 and 13 in oral squamous cell carcinoma and their role in predicting lymph node metastasis

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World Journal of Methodology 2025年第2期15卷 108-116页

作者： Bhari Sharanesha Manjunatha Keshav T Handge Vandana sandeep Shah Yasser Eid Al-Thobaiti Deepak Gowda Sadashivappa Pateel Department of Basic Oral Medicine and Allied Dental Sciences Taif UniversityAt`Taif 26571MakkahSaudi Arabia Department of Oral and Maxillofacial Pathology Dr.Vasantrao Pawar Medical CollegeHospital and Research CentreNashik 423101MaharashtraIndia Department of Oral Pathology and Microbiology KM Shah Dental College and HospitalSumandeep VidyapeethVadodara 391760GujaratIndia Department of Oral and Maxillofacial Surgery and Diagnostic Sciences Faculty of DentistryTaif UniversityAl-Haweiah 26571 MakkahSaudi Arabia Department of Oral Pathology and Microbiology Faculty of DentistryMAHSA UniversitySelangor 42610Malaysia

BACKGROUND One of the main characteristics of oral squamous cell carcinoma(OSCC)is that it metastasizes to cervical lymph nodes frequently with a high degree of local invasiveness.A primary feature of malignant tumors is their penetration of neighboring tissues,such as lymphatic and blood arteries,due to the tumor cells'capacity to break down the extracellular matrix(ECM).Matrix metalloproteinases(MMPs)constitute a family of proteolytic enzymes that facilitate tissue remo-deling and the degradation of the ***-9 and MMP-13 belong to the group of extracellular matrix degrading enzymes and their expression has been studied in OSCC because of their specific ***-13,a collagenase family member,is thought to play an essential role in the MMP activation cascade by breaking down the fibrillar collagens,whereas MMP-9 is thought to accelerate the growth of *** MMP-13 expression has been associated with tumor behavior and patient prognosis in a number of malignant *** authors wish to thank Jadhav KB for his valuable opinion during the preparation of the manuscript.

关键词： Matrix metalloproteinases Oral squamous cell carcinoma Tumor staging Immunohistochemistry Invasion Lymph node metastasis TNM stage

Contributions of type II and Ib/c supernovae to Galactic chemical evolution

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Research in Astronomy and Astrophysics 2014年第6期14卷 693-704页

作者： sandeep Sahijpal Department of Physics Panjab University

Type II and Ib/c supernovae （SNe II and Ib/c） have made major stellar nu- cleosynthetic contributions to the inventories of stable nuclides during chemical evolu- tion of the Galaxy. A case study is performed here with the help of recently developed numerical simulations of Galactic chemical evolution in the solar neighborhood to un- derstand the contributions of SNe II and Ib/c by comparing the stellar nucleosynthetic yields obtained by two leading groups in this field. These stellar nucleosynthetic yields differ in terms of their treatment of stellar evolution and nucleosynthesis. The formu- lation describing Galactic chemical evolution is developed with the recently revised solar metallicity of -0.014. Furthermore, the recent nucleosynthetic yields of stellar models based on the revised solar metallicity are also used. The analysis suggests that it could be difficult to explain, in a self-consistent manner, the various features asso- ciated with the elemental evolutionary trends over Galactic timescales by any single adopted stellar nucleosynthetic model that incorporates SNe II and Ib/c.

关键词： Sun: abundances - stars: evolution - stars: supernovae - Galaxy:abundance - Galaxy: formation - Galaxy: evolution - nucleosynthesis

Protracted zircon growth in migmatites and In situ melt of Higher Himalayan Crystallines:U-Pb ages from Bhagirathi valley, NW Himalaya,India

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Geoscience Frontiers 2019年第3期10卷 793-809页

作者： sandeep Singh Department of Earth Sciences Indian Institute of Technology Roorkee

The Higher Himalayan Crystallines(HHC), in western Garhwal, Uttarakhand are located in a regionalscale intracontinental ductile shear zone(15-20 km wide) bounded by the Main Central Thrust at the base, and the South Tibetan Detachment System at the top. The migmatite zone in the centre has the highest grade of metamorphism in the NW Himalayas and show evidence of flowage. Zircons extracted from samples of metasediment, migmatite, biotite granite and in situ partial melt(tourmaline-bearing leucogranite) along the Bhagirathi Valley, preserve U-Pb isotopic evidence of magmatic history, magma source and effects of the Himalayan orogeny in the region. Three distinct periods of zircon growth in the leucogranite record the episodic influx of magma between 46 Ma and 20 Ma indicating a time span of more than 25 Ma between the onset of fluid-fluxed partial melting in the mid-crustal intracontinental shear zone and the emplacement of the magma into the upper crust in a post-collisional extensional setting. Metamorphic zircon growth was initiated about 46 Ma, when the partial melts were generated as the migmatite zone was exhumed.

关键词： Himalayas Crustal anatexis Zircon SHRIMP U-Pb dating Migmatites Granites

Linear and nonlinear propagation characteristics of multi-Gaussian laser beams

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Chinese Physics B 2020年第11期29卷 370-379页

作者： Naveen Gupta sandeep Kumar Lovely Professional University PhagwaraIndia

Theoretical investigation on the propagation characteristics of a new class of laser beams known as multi Gaussian(M.G)laser beams has been *** investigate the linear characteristics,propagation of the laser beam in vacuum has been ***,the nonlinear characteristics have been investigated in *** nonlinearity of the plasma has been modeled by relativistic mass nonlinearity of the plasma electrons in the field of laser *** is based on finding the semi analytical solution of the wave equation for the slowly varying envelope of the laser ***,the dynamical evolutions of the beam width and longitudinal phase of the laser beam have been investigated in detail.

关键词： self-focusing multi Gaussian self phase modulation self-channeling

Micromechanical experiments using a new inter-granule loading apparatus on gravel to ballast-sized materials

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Friction 2020年第1期8卷 70-82页

作者： Chitta Sai sandeep Kostas SENETAKIS City University of Hong Kong Hong Kong SARChina

Micromechanical and tribological studies of geological materials with a particular focus on their contact-mechanics behavior at the grain scale are currently a major interest in the engineering and geoscience disciplines. In this study, a new robust micromechanical apparatus developed at the City University of Hong Kong is described;it is capable of conducting inter-granule(or inter-particle) loading tests on fine gravel to ballast-sized materials of sizes as small as 5-10 mm to granules(or ballast) as big as 50 mm. The focus of our study is the description of the major technical features of the new apparatus and its performance and repeatability in conducting experiments on reference grains of chrome steel balls and glass balls;in addition, we conducted a preliminary set of experiments on crushed granitic rock, which is a material widely used in geotechnical and transportation infrastructure. The representative results of these experiments are presented in terms of the normal force-displacement relationship, friction, and tangential stiffness. The newly developed large-size apparatus is further compared with a well-established apparatus that can conduct micromechanical tests on sand-sized materials.

关键词： experimental micromechanics contact mechanics linear bearings inter‐particle friction granite debris flow ballast

Piecewise linear programming approach to solve multi-objective matrix games with I-fuzzy goals

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Journal of Control and Decision 2021年第1期8卷 1-13页

作者： sandeep Kumar Department of Mathematics Ch.Charan Singh UniversityMeerut 250004Uttar PradeshIndia

The intuitionistic fuzzy set(I-fuzzy set)plays an effective role in game theory when players face‘neither this nor that’situation to set their *** study presents a maxmin–minmax solution to multi-objective two person zero-sum matrix games with I-fuzzy *** this article,a class of piecewise linear membership and non-membership functions for I-fuzzy goals is *** functions are more effective in real games because marginal rate of increase(decrease)of such membership functions(non-membership functions)is different in different intervals of tolerance ***,one numerical example is given to examine the effectiveness and advantages of the proposed results.

关键词： Intuitionistic fuzzy set multi-objective matrix game I-fuzzy goals maxmin-minmax solution piecewise linear function

2P3FL:A Novel Approach for Privacy Preserving in Financial Sectors Using Flower Federated Learning

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 2035-2051页

作者： sandeep Dasari Rajesh Kaluri School of Computer Science Engineering and Information Systems Vellore Institute of TechnologyVellore632014India

The increasing data pool in finance sectors forces machine learning(ML)to step into new *** data has significant financial implications and is *** users data from several organizations for various banking services may result in various intrusions and privacy *** a result,this study employs federated learning(FL)using a flower paradigm to preserve each organization’s privacy while collaborating to build a robust shared global ***,diverse data distributions in the collaborative training process might result in inadequate model learning and a lack of *** address this issue,the present paper proposes the imple-mentation of Federated Averaging(FedAvg)and Federated Proximal(FedProx)methods in the flower framework,which take advantage of the data locality while training and guaranteeing global *** improves the privacy of the local *** analysis used the credit card and Canadian Institute for Cybersecurity Intrusion Detection Evaluation(CICIDS)***,recall,and accuracy as performance indicators to show the efficacy of the proposed strategy using FedAvg and *** experimental findings suggest that the proposed approach helps to safely use banking data from diverse sources to enhance customer banking services by obtaining accuracy of 99.55%and 83.72%for FedAvg and 99.57%,and 84.63%for FedProx.

关键词： Federated learning FedAvg FedProx flower framework privacy preservation financial sectors

Insoluble drug delivery strategies: review of recent advances and business prospects

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Acta Pharmaceutica Sinica B 2015年第5期5卷 442-453页

作者： sandeep Kalepu Vijaykumar Nekkanti Department of Pharmaceutical Technology Shri Vishnu College of Pharmacy College of Pharmaceutical Sciences Western University of Health Sciences

The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve ef fi cacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical *** review covers the recent advances in the fi eld of insoluble drug delivery and business prospects.

关键词： Bioavailability Cocrystals Solubility Inclusion complexation Nanoparticles Self-emulsifying formulations Proliposomes