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Systematic Screening of the Serotonin Receptor 1A (5-HT1A) Gene in Chronic Tinnitus

Journal of Otology 2006年第2期1卷 83-85页

作者： Kleinjung T Langguth B Fischer B Hajak G Eichhammer P sand pg Departments of Otorhinolaryngology University of Regensburg Departments of Psychiatry University of Regensburg

Objective Chronic tinnitus is a highly prevalent condition and has been hypothesized to result from an innate disturbance in central nervous serotonergic transmission. Given the frequent comorbidity with major depression and anxiety, we argue that candidate genes for these disorders are likely to overlap. The present study addresses the gene encoding for the 5-HT1A receptor as a putative risk factor for tinnitus. Methods In 88 subjects with a diagnosis of chronic subjective tinnitus who underwent a detailed neurootological examination, the entire 5-HT1A gene was amplified using overlapping PCR products. Amplicons were custom sequenced bidirectionally and were screened for variants in multiple alignments against the human genome reference. Results We identified a synonymous C > T exchange at residue 184 (Pro) in 7/88 subjects, but detected no missense variants in the population under study. Specifically, the following residues were fully conserved: 16 (Pro), 22(Gly), 28(Ile), 98 (Val), 220(Arg), 267 (Val), 273 (Gly), and 418 (Asn). Discussion The present data count against the causation of chronic tinnitus by a change in the 5-HT1A receptor’s amino acid sequence. However, the allele frequency for the 184Pro minor allele (0.04) reached twice the frequency reported in control cohorts from the same ethnicity. Additional investigations are invited to clarify the role of the 5-HT1A polymorphism in larger samples, and to control for comorbid affective disorders.

关键词： 5-HT1A Gene Tinnitus

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3D reservoir characterization of the Mangahewa Formation,Mangahewa Field,Taranaki Basin,New Zealand

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Energy Geoscience 2024年第2期5卷 152-170页

作者： Dk Nurulnazihah pg Norsahminan Md Aminul Islam Surya Tejasvi Thota Mohamed Ragab Shalaby Department of Geosciences Faculty of ScienceUniversiti Brunei DarussalamJalan Tungku LinkGadong BE1410Brunei Darussalam

The Mangahewa Formation is the primary reservoir target in the Mangahewa Field in the Taranaki Basin,New *** formation is distinguished by its marginal marine substantial tight-sand reservoir,having thickness exceeding 800 *** aim of this study is to assess the reservoir properties of the Mangahewa Formation through 3D reservoir modeling,employing 3D seismic data,core data,and well data from the Mangahewa *** variance attributes,the faults and horizons have been identified successfully within the *** majority of the interpreted faults exhibit dip angles exceeding 60°,with a maximum displacement of 118 *** detect direct hydrocarbon indicators,root-mean-square amplitude seismic attribute,envelope,and generalized spectral decomposition techniques have been ***,four lithofacies,comprising 78.3%sandstone,9.2%siltstone,9.5%claystone,and 3.0%coal have been established by utilizing the Sequential Indicator Simulation(SIS)algorithm to create a lithofacies model.A property model has been generated using the Sequential Gaussian Simulation(SGS)*** evaluation indicates that the Mangahewa Formation exhibits reservoir qualities ranging from fair to good,with porosity levels between 8%and 11%,permeability averaging up to 10 mD,variable shale volumes,and hydrocarbon saturation in the range of 40%-50%.This study's methodologies and findings can serve as a valuable foundation for similar investigations in other tightsand gas fields located in different regions.

关键词： Marginal marine Tight-sand reservoir Mangahewa formation Mangahewa gas-condensate field Northern taranaki basin

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