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Special Considerations in the Management of Autoimmune Hepatitis in COVID-19 Hotspots:A Review

Journal of Clinical and Translational Hepatology 2021年第4期9卷 568-575页

作者： Deepak Madhu sanchit sharma Ashish Agarwal Anoop Saraya Department of Gastroenterology Aster MIMS CalicutKeralaIndia Department of Gastroenterology Caritas HospitalKottayamKeralaIndia Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew DelhiIndia Department of Gastroenterology All India Institute of Medical SciencesJodhpurRajasthanIndia

The ongoing coronavirus disease-2019(COVID-19)pandemic has necessitated special considerations in the management of *** way presence of pre-existing diseases or treatment for it predisposes to,alters course of,and changes the management of COVID-19,is of relevance and is being extensively *** hepatitis(AIH)is unique in that it is an autoimmune disease mandating treatment with immunosuppressive drugs,as well as a liver disease with potential for varying degrees of underlying *** use of immunosuppressive drugs could alter the risk of acquiring COVID-19,the clinical course and severity of COVID-19 and the degree of underlying liver fibrosis could alter the clinical outcomes of patients with *** this review,we try to summarize key areas relevant in understanding and improving the clinical care of patients with AIH in the current *** considerations required in the management of patients with AIH in COVID-19 hotspots have been outlined based on the current evidence.

关键词： Hepatitis Autoimmune Liver cirrhosis COVID-19 SARS-CoV-2 infection Immunosuppressive agents

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A neutronic experiment to support the design of an Indian TBM shield module for ITER

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Plasma Science and Technology 2019年第6期21卷 147-152页

作者： H L SWAMI M ABHANGI sanchit sharma S TIWARI A N MISTRY V VASAVA V MEHTA S VALA C DANANI V CHAUDHARI P CHAUDHURI Institute for Plasma Research Gandhinagar Gujarat 382428 India Homi Bhabha National Institute(HBNI) Anushaktinagar Mumbai 400094 India Pandit Deendayal Petroleum University Gandhinagar Gujarat 382007 India

A shield module is associated with an Indian Test Blanket Module (TBM) in ITER to limit the radiation doses in port inter-space *** shield module is made of stainless steel plates and water *** is identified as an important component for radiation protection because of its radiation exposure control *** radiation protection classification leads to more assurance of the component *** order to validate and verify the design of the shield module,a neutronic laboratory-scale experiment is designed and *** experiment is planned by considering the irradiation under a neutron source of 14 MeV and yields of 1010 n *** reference neutron spectrum of the ITER TBM shield module has been achieved through optimization of the neutron source spectrum by a combination of steel and lead *** neutron spectrum and flux are measured using a multiple foil activation technique and neutron dose-rate meter LB 6411 (He-3 proton recoil counter with polyethylene),*** neutronic design simulation is assessed using MCNP5 and FENDL 2.1 crosssection *** paper covers neutronic design,irradiation and the outcome of the experiment in detail.

关键词： TBM shield module neutronic experiment ITER MCNP neutron attenuation

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