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国际医学放射学杂志 2016年第3期 323-324页

作者： P.Lindberg K.sanchez F.Ozcan F.Rannou S.Poiraudeau A.Feydy 吴龙 FR 3636 Neurosciences Universite Paris DescartesSorbonne Paris Cite

摘要目的探讨常规MRI无脊髓损伤的颈椎病病人的脊髓结构。方法采用横断面研究,对常规MRI无脊髓损伤的颈椎病病人和健康对照者行脊髓扩散张量成像(DTI)、精确握力和足被动追踪任务以及包括神经系统体征评估在内的临床检查。在多个颈椎水... 详细信息

摘要目的探讨常规MRI无脊髓损伤的颈椎病病人的脊髓结构。方法采用横断面研究,对常规MRI无脊髓损伤的颈椎病病人和健康对照者行脊髓扩散张量成像(DTI)、精确握力和足被动追踪任务以及包括神经系统体征评估在内的临床检查。在多个颈椎水平(C1-C5)对外侧和内侧脊髓白

关键词：无脊髓损伤脊髓脑颈椎病 DTI 病人 MRI 常规

3例阴茎透明细胞癌:一种与HPV相关的鳞状细胞癌变异亚型的报道

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临床与实验病理学杂志 2017年第2期33卷 173-173页

作者： sanchez D F Rodriguez I M Piris A 魏建国许春伟浙江省绍兴市人民医院病理科绍兴312000 解放军307医院病理科北京100071

目前文献报道的阴茎透明细胞癌起源于皮肤附属器的腺体。作者介绍了3例形态学独特的阴茎肿瘤，该肿瘤具有明显的透明细胞特点，但并非起源于阴茎皮肤，而是起源于龟头表面鳞状上皮的黏膜组织。作者对其临床及病理学特征进行分析。免疫... 详细信息

目前文献报道的阴茎透明细胞癌起源于皮肤附属器的腺体。作者介绍了3例形态学独特的阴茎肿瘤，该肿瘤具有明显的透明细胞特点，但并非起源于阴茎皮肤，而是起源于龟头表面鳞状上皮的黏膜组织。作者对其临床及病理学特征进行分析。免疫组化检测GATA3及p16的表达。采用原位杂交法检测3例阴茎透明细胞癌的HPV表达情况，其中1例全组织切片进行聚合酶链反应。

关键词：透明细胞癌阴茎肿瘤 HPV 鳞状细胞癌免疫组化检测亚型变异聚合酶链反应

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β5整合素在造血细胞上的表达及其与细胞增殖和诱导凋亡的作用

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中国病理生理杂志 2000年第10期16卷 176-176页

作者：殷莲华,赵新永,付四清,Felix Garacia-sanchez,Deisse roth 上海医科大学病理生理学教研室!上海200032 上海医科大学病理生理学教研室!上海200032 SectionofMedicalOncology YaleUniversitySchoolofMedicine NewHaven CT06520-8023 SectionofMedicalOncology YaleUniversitySchoolofMedicine NewHaven CT06520-8023

目的:整合素(integrins)是一类广泛存在于细胞表面的糖蛋白.在造血细胞的整合素由α和β两个亚基组成,参与细胞与胞外基质、细胞骨架的莲接,并通过酪氨酸和丝氨酸蛋白激酶系统介导细胞信息的传递.αvβ5的过度表达与肿瘤转移及血管形成... 详细信息

目的:整合素(integrins)是一类广泛存在于细胞表面的糖蛋白.在造血细胞的整合素由α和β两个亚基组成,参与细胞与胞外基质、细胞骨架的莲接,并通过酪氨酸和丝氨酸蛋白激酶系统介导细胞信息的传递.αvβ5的过度表达与肿瘤转移及血管形成有关.αvβ3也已证实与血管形成时的能动性调节及肿瘤的转移有关.αvβ3和αvβ5均可作用在摄取腺病毒易感的细胞,因而αvβ3和αvβ5的上调可引起腺病毒与易感细胞再结合增加.为研究αvβ5的功能及其对血源性细胞的作用,我们成功的构建了逆转录病毒载体系统和四环素控制下的诱导表达载体系统,并研究其对造血细胞整合素表达时细胞凋亡和增殖的影响;方法:用去除血清的方法,观察血源性细胞凋亡和分化时αvβ5和αvβ3的变化;用抗αvβ5单克隆抗体封闭血源性细胞上的αvβ5时,观察它们对凋亡和增殖的影响.结果和结论:用pGβ5CHT载体转导造血细胞,β5 cDNA未得到表达,用无血清培养诱导血源性细胞分化和凋亡时,αvβ5和αvβ3发生不平衡表达,αvβ5表达升高,αvβ3表达下降,与有血清培养相比,αvβ5和αvβ3比例是增加的,与K562相比,αvβ5对αvβ3的比例从有血清1.146升到无血清1.370,BV173细胞从0.147到0.464,U937从0.188到0.370,HL60从0.220到0.610,这些结果提示αvβ5的表达增加可促进无血清培养细胞的凋亡;用抗αvβ5单抗隆抗体封闭U937细胞,发现U937细胞的磷脂酰丝氨酸密度显著下降,这提示封闭细胞表面αvβ5可抑制细胞无血清引起的细胞凋亡;K562细胞β5表达水平的增加可抑制细胞的增殖.通过对β5反义转录单位的诱导表达研究发现,四环素可阻止tet/vp 16调控的反义β5基因的表达,从而导致外源性和内源性β5基因的表达,β5基因表达的提高可抑制细胞增殖,因而反义β5表达的缺乏与β5表达水平的增加及细胞生长抑制有关.

关键词：造血细胞整合素血源性

A Practical Backside Technology for Indium Phosphide MMICs

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Journal of Semiconductors 2001年第12期22卷 1497-1500页

作者：李拂晓杨乃彬南京电子器件研究所南京210016

A wet etching process for backside via holes suitable for use on InP MMICs technologies is developed for indium phosphide *** is used to mount InP wafer onto glass *** Ta film is utilized as etch ***+H 3PO 4 solution realised a etch until a depth of 100μ*** is demonstrated that the wet etching backside process is controllable with large latitudes.

关键词： indium phosphide MMICs backside process

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Patients Body Modeling:A Practical Theoretical Experience in Plastic Surgery

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Modern Plastic Surgery 2019年第3期9卷 52-58页

作者： Jose Humberto Cardoso Resende Issacar de Oliveira Costa Pedro Fernando Huertas Granobles Rolando Arturo Romero Balcazar Guilherme Bahia de Carvalho Hugo Rojas Perdomo Edmar Moreira Lisboa Mohamad Youssef Mohsen Alváro sanchez Vargas Nebia Maria Almeida de Figueiredo UNIREDENTOR University Rio de JaneiroBrazil UNIRIO University Rio de JaneiroBrazil

This research is an active pedagogical experience with surgeons who are specialized in reconstructive plastic surgery and nursing. The guiding questions were the statements of each Surgeon’s clients and what they think about them. Modeling the imaginary bodies of the patients and identify what they built in their minds, highlighting topics and the discussion about the practice made in clay modeling. Eight bodies were modeled, with six bodies with all the senses and two incomplete bodies with only the regions of the breasts and buttocks. It was concluded that there are diverse issues emerging such as gender, ethics, care, spirituality and dream as the fulfillment of the wishes of the patients. Where in the body can these surgeons act to improve the patients’ physical and quality of life? There is an important theme when we are generally welcoming women into an anamnesis that considers their body as a whole, but what is their expectation for each patient? This paper showed the importance of the preoperative evaluation of this whole, for the indication of repairs or contraindications of procedures that aim to improve the physical of the patients, with possible bodily surgical modifications as a form of modeling through liposuction, grafting or excision with lipectomy and withdrawal of excess skin to mitigate the effects of the transformations that deform the physical and end up harming the human relationship, especially women. This is a qualitative method showing the meanings of the bodies of the women represented in the modeling by the Surgeons. However, some surgeons stand out by the look of their practice, as greater sensitivity looking at the body as a whole, spiritual and emotional. They need to use their skills as surgical art and gift, to try to achieve a means, but not an end.

关键词： Modeling Bodies Surgery Plastic Art

流行性出血热病毒R22株cDNA克隆及其特异性鉴定

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病毒学报 1988年第3期 208-212页

作者：杭长寿 sanchez A 陈思毅 Kiley M. P David D.A. McCormick J.B. 宋干中国预防医学科学院病毒学研究所美国疾病控制中心

用家鼠型流行性出血热病毒R22株RNA,经polyA接尾,以Oligo-dT做引物,合成cDNA。用pUC18为载体转染*** Mc1061,建立cDNA克隆。再经菌落杂交,选择病毒特异性的5个阳性克隆制成缺口翻译探针,与病毒RNA3个片段进行反杂交,确定RNA片段的特异... 详细信息

用家鼠型流行性出血热病毒R22株RNA,经polyA接尾,以Oligo-dT做引物,合成cDNA。用pUC18为载体转染*** Mc1061,建立cDNA克隆。再经菌落杂交,选择病毒特异性的5个阳性克隆制成缺口翻译探针,与病毒RNA3个片段进行反杂交,确定RNA片段的特异性。结果表明,3个克隆为中(M)片段的cDNA,另两个分别为大(L)和小(S)片段cDNA。核苷酸序列分析证明,克隆的DNA中含病毒特异的核苷酸序列。

关键词：流行性出血热病毒 cDNA克隆 DNA序列分析

The Usefulness of Magnetic Resonance Imaging in the Preoperative Study and Postoperative Control in the Laparoscopic Treatment of the Incisional Hernia

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Surgical Science 2015年第8期6卷 376-382页

作者： J.C.Martín del Olmo Luis García-Vallejo Jose Nunez Gestal Pablo Concheiro Coello Francisco Blanco Antona Miguel Toledano Trincado Javier sanchez Gonzalez M.Luz Martín Esteban L.Colao Carlos Vaquero Puerta Miguel Carbajo Surgery Department Medina del Campo HospitalValladolidSpain Surgery Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Radiology Department CHUSCalle Rua de Ramon BaltarSantiago de CompostelaSpain Department of General and Digestive Surgery Medina del Campo HospitalValladolidSpain Surgery Department University of ValladolidValladolidSpain CEOAD ValladolidSpain

Background and Objectives: The aim of this study is to evaluate the usefulness of Magnetic Resonance Imaging (MRI) for planning surgery and postoperative control of complex cases of abdominal wall hernia. Methods: Included in a prospective data base with more than 350 patients treated in two centers, a prospective study over ten patients with complex incisional hernias was designed. In all cases, preoperative diagnosis study and postoperative imaging control by MR Imaging were established. In the early and late follow-up controls, local and general complications were specifically noted and studied by MRI in each case. Results: The preoperative MRI was effective method for an adequate understanding of the defects and hernia sack content. In the postoperative control, the MRI was useful in the follow-up of the mesh integration, detection of complications and diagnosis of the relapsing. Conclusion: In our experience the MRI test is specially recommended in the preoperative workup of complex cases of incisional hernia.

关键词： Incisional Hernia MR Imaging Laparoscopic Eventroplasty

Respiratory Muscle Strength Evaluation in Healthy Adult and Elderly Women—Respiratory Muscle Strength Assessment in Adult and Elderly

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Health 2018年第8期10卷 1031-1036页

作者： Maria Clara de Souza Pereira Gama Maciel Cássio Daniel Araújo da Silva Fernanda Figueiroa sanchez Jamilly Reboucas Demosthenes Marques Pablo Costa Cortez Camila Miriam Suemi Sato Barros do Amaral Naylla Morais de Souza Roberta Lins Goncalves Federal University of Amazonas-UFAM ManausBrazil

Measurement of respiratory muscle strength is performed through static measurements of maximal respiratory pressures and is an important tool for determining the existence and prognosis of neuromuscular and pulmonary disorders, such as weakness or fatigue of this musculature. Objectives: To evaluate and compare respiratory muscle strength among healthy adult and elderly women. Methods: A total of 163 healthy women were recruited through convenience sampling at the family centers of the city of Manaus (AM, Brazil), divided into two groups: adult women (age 20 - 59 years) and elderly women (over 60 years of age). The evaluation was performed by Manovacuometry, in order to measure the maximum inspiratory pressure (MIP) and maximum expiratory pressure (MEP). For statistical analysis we used the Student’s T test, considering significant p value ≤ 0.05. Results: The final sample consisted of 116 adult women and 47 elderly women. The mean age in the group of women between 20 - 59 years was 44.5 ± 12 and the elderly group was 65 ± 6.6. MIP values in adult women were significantly higher when compared to the elderly (−108 ± 5.3 cmH2O × −79.5 ± 4 cmH2O, p = 0.0014, respectively). The same behavior was observed in the evaluation of MEP (87.1 ± 2.9 cmH2O in adults and 69.8 ± 3.5 cmH2O in the elderly;p = 0.0008). Conclusion: The results indicate that inspiratory and expiratory muscle strength is lower in older women, suggesting that the aging process tends to interfere with those muscles, resulting in altered respiratory system function.

关键词： Muscular Strength Evaluation Respiratory Muscles Aging