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Evaluation of CD64 Index in HBV and in Chronic HCV Infections

Open Journal of Gastroenterology 2017年第6期7卷 173-186页

作者： Hasan Sedeek Mahmoud sanaa shaker aly Heba Ahmed Osman Asmaa Mohamed Zahran Muhammad Abbas El Masry Tropical Medicine and Gastroenterology Department Qena Faculty of Medicine South Valley University Qena Egypt Clinical and Chemical Pathology Department Qena Faculty of Medicine South Valley University Qena Egypt Oncological Clinical Pathology Department South Egypt Cancer Institute Assiut University Assiut Egypt Internal Medicine Department Division of Gastroenterology Assiut Faculty of Medicine Assiut Egypt

Background and aims: CD64 [Fc gamma receptor 1 (FcγRI)] is a promising biomarker used in predicting severe bacterial infection. The study was designed to assess their level in all stages of HBV infection and in chronic HCV infection before and after treatment with direct acting antiviral therapy as a possible biomarker of inflammation. Patients and methods: A case-control study was conducted, 50 patients with different disease stages of HBV infection (10 acute, 15 chronic hepatitis, 15 liver cirrhosis (LC) and 10 with hepatocellular carcinoma (HCC)), twenty patients with chronic HCV and 15 as a control group. Laboratory and imaging studies were evaluated. The levels of CD64 expressions in peripheral blood and CD64 Index were measured for all patients by flowcytometry using fluorescein isothiocyanate (FITC)-conjugated anti-CD64 monoclonal antibody. Results: The levels of CD64 expressions in peripheral blood and CD64 index were significantly higher in patients with HBV and HCV than in control group (P value = 0.01, 0.01 and 0.000, 0.000 respectively). They were increased significantly with disease progression in patients with HBV infection, acute hepatitis B infection showed the highest values. Their levels were significantly decreased in patients with HCV infection post treatment than before treatment. Conclusions: The levels of CD64 expressions in peripheral blood and CD64 index are considered good biomarkers of inflammation in viral hepatitis both B and C and could detect disease progression and also suppression of inflammation after antiviral therapy.

关键词： CD64 HBV HCV

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Dietary supplementation of some antioxidants against hypoxia

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World Journal of Gastroenterology 2012年第44期18卷 6379-6386页

作者： sanaa Ahmed Ali Hanan Farouk aly Lilla Mohammed Faddah Zeenat F Zaidi Department of Therapeutic Chemistry Division of Pharmaceutical and Drug IndustriesNational Research CenterCairo 12622Egypt Department of Pharmacology College of PharmacyKing Saud UniversityRiyadh 11495Saudi Arabia Department of Anatomy Faculty Of MedicineKing Saud UniversityRiyadh 11495Saudi Arabia

The present study aims to clarify the protective effect of supplementation with some antioxidants,such as idebenone(200 mg/kg,ip),melatonin(10 mg/kg,ip) and arginine(200 mg/kg,ip) and their combination,on liver function(***,albumin,alanine aminotransferase,aspartate aminotransferase and alkaline phosphatase),energetic parameters(adenosine triphosphate,adenosine diphosphate,adenosine monophosphate,inorganic phosphate,total adenylate,adenylate energy charge and potential phosphate).The effect on glycolytic and glycogenolytic enzymes(glucose,glycogen,glycogen phosphorylase,pyruvate kinase and phosphofructokinase against hypoxia) was also *** drugs were administered 24 and 1 h prior sodium nitrite *** biochemical parameters were estimated 1 h after sodium nitrite *** of sodium nitrite(75 mg/kg,sc) produced a significant disturbance in all biochemical parameters of liver function,energetic parameters and glycolytic and glycogenolytic *** damage was confirmed by histopathological examination of the liver as compared to *** marked changes in hepatic cells induced by sodium nitrite were completely abolished by pretreatment with the drug combination,suggesting potential protection against sodium nitrite-induced *** could be concluded that a combination of both idebenone and melatonin or idebenone and arginine provides potential protection against sodium nitrite-induced hypoxia by improving biochemical parameters and preserving liver histology.

关键词：缺氧保护抗氧化剂糖原磷酸化酶谷丙转氨酶碱性磷酸酶三磷酸腺苷组织病理学检查亚硝酸钠

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埃及东北地区夏季暴露尸体上常见嗜尸性昆虫种类的鉴定(英文)

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中南大学学报（医学版） 2013年第1期38卷 1-6页

作者： sanaa Mohamed aly 文继舫王翔蔡继峰刘钦来钟鸣中南大学基础医学院法医学系长沙410013 苏伊士运河大学医学院法医学与临床毒理学系

目的:首次鉴定埃及东北地区(东经32°15'和北纬30°36')常见嗜尸性昆虫种类及记录其演替规律。方法:观察被置于一空地上的动物尸体在夏季60 d内的腐败过程,同时捕捉出现的昆虫及记录每日的环境温度(最高及最低温度)和相对湿度(RH)。利... 详细信息

目的:首次鉴定埃及东北地区(东经32°15'和北纬30°36')常见嗜尸性昆虫种类及记录其演替规律。方法:观察被置于一空地上的动物尸体在夏季60 d内的腐败过程,同时捕捉出现的昆虫及记录每日的环境温度(最高及最低温度)和相对湿度(RH)。利用已知嗜尸性昆虫鉴别要点对所收集的昆虫进行分类及鉴定。结果:在研究期间的最高和最低的环境温度的均值分别为34.85℃和29.2℃,相对湿度的均值为53.5%。尸体的腐败过程主要分为4个阶段:新鲜期、肿胀期、腐败期和干化期。收集到的昆虫大部分为双翅目、鞘翅目和膜翅目昆虫。经形态学鉴定双翅目包括四科昆虫(家蝇科、厕蝇科、丽蝇科和麻蝇科),鞘翅目包括两科昆虫(皮蠹科和阎魔虫科),膜翅目仅包括厨蚁属小黑蚁。结论:为进一步研究埃及地区不同季节的嗜尸性昆虫演替奠定了基础。

关键词：法医昆虫学演替腐败节肢动物种类鉴定

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