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Targeting AmPKa1 Gene in PC3 Cells by Triphenylmethanol Derivatives

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Natural Science 2024年第7期16卷 111-120页

作者： William Yaw Boadi Jamari Jemison Kennedy Welbert sanaa Dudley Tayalla Hizer Ryan Beni Departments of Chemistry and Biology Tennessee State University Nashville USA

Epidemiological studies indicate that treatment with metformin, an AmP-activated protein kinase (AmPK) activator, reduces the incidence of cancers. Activation of AmPK has also been reported to oppose tumor progression in diverse types of cancers and offers promising cancer therapy. Furthermore, AmPK is a primary regulator of energy metabolism and has also been implicated in cell cycle progression, angiogenesis, cell transformation, migration, and cancer. We have recently synthesized novel flavonoids, namely, triphenylmethanol derivatives (TPms), but the effectiveness of the TPms on the activity of AmPK remains unclear. We hypothesized that the novel TPms would inhibit cancer cell proliferation through the activation of AmPK isoforms in cells. The effects of TPms on prostate cells (PC-3) were investigated. Cells were exposed to TPms for either 12 or 24 hr. at the respective doses of 0, 25, 50 100, and 200 µm based on the cell viability studies by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a tetrazole) (mTT) assay. The results indicate that cells exposed to the respective doses of TPms increased both phospho- and total-AmPKα1 in a dose- and time-dependent manner. The effects of the increases for the phospho- and total-AmPKα in cells were greater for the 24-hr than the 12-hr. incubation. Further studies are currently going on to elucidate the specificities of the said insults in increasing the phospho- and total-AmPKα activities and for the other respective isoforms.

关键词： Prodrugs AmP-Activated Protein Kinase Polyphenols Prostate Cancer Triphenylmethanol

Temperature effect on the corrosion and passivation characterization of Ni_(82.3)Cr_7Fe_3Si_(4.5)B_(3.2) alloy in acidic media

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International Journal of minerals,metallurgy and materials 2016年第2期23卷 205-214页

作者： Khadijah m.Emran sanaa T.Arab Aisha m.Al-Turkustani Hamad A.Al-Turaif Chemistry Department Faculty of Science Taibah University Department of Chemistry Faculty of Sciences Al-Faisaliah King Abdulaziz University Department of Chemical and materials Engineering King Abdulaziz University

The effects of temperature on corrosion and the electrochemical behavior of Ni82.3Cr7Fe3Si4.5B3.2 glassy alloy in HC1,H2SO4,and H3PO4 acids were studied using AC and DC *** data reveal that the susceptibility to localized corrosion increases with increasing *** polarization curves reveal that the bulk glassy alloy is spontaneously passivated at all the investigated temperature in H2SO4 and H3PO4 solutions.A localized corrosion effect in HCl solution is clearly *** apparent activation energies in the regions of Tafel,active,and passive,as well as the enthalpies and entropies of the dissolution process were determined and *** high apparent activation energy（Ea） value for H3PO4 solution in Tafel region is explained by the low aggressivity of PO4^3- ions.

关键词： nickel alloys corrosion temperature effect acidic environment passivation polarization

E-mail Spam Classification Using Grasshopper Optimization Algorithm and Neural Networks

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Computers, materials & Continua 2022年第6期71卷 4749-4766页

作者： sanaa A.A.Ghaleb mumtazimah mohamad Syed Abdullah Fadzli Waheed A.H.m.Ghanem Faculty of Informatics and Computing Universiti Sultan Zainal AbidinKuala Terengganu22200Malaysia Faculty of Ocean Engineering Technology and Informatics Universiti Malaysia TerengganuKuala Terengganu21030Malaysia Faculty of Engineering University of AdenAdenYemen Faculty of Education(Aden-Saber) University of AdenAdenYemen

Spam has turned into a big predicament these days,due to the increase in the number of spam emails,as the recipient regularly receives piles of *** only is spam wasting users’time and *** addition,it limits the storage space of the email box as well as the disk ***,spam detection is a challenge for individuals and organizations *** advance spam email detection,this work proposes a new spam detection approach,using the grasshopper optimization algorithm(GOA)in training a multilayer perceptron(mLP)classifier for categorizing emails as ham and ***,mLP and GOA produce an artificial neural network(ANN)model,referred to(GOAmLP).Two corpora are applied Spam Base and UK-2011Web spam for this ***,the finding represents evidence that the proposed spam detection approach has achieved a better level in spam detection than the status of the art.

关键词： Grasshopper optimization algorithm multilayer perceptron artificial neural network spam detection approach

Thyme oil and thymol abrogate doxorubicin-induced nephrotoxicity and cardiotoxicity in Wistar rats via repression of oxidative stress and enhancement of antioxidant defense mechanisms

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BIOCELL 2020年第1期44卷 41-53页

作者： Osama m.AHmED sanaa R.GALALY mai RASLAN mennah-Allah m.A.mOSTAFA Physiology Division Zoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Cell Biology Histology and Genetics DivisionZoology DepartmentFaculty of ScienceBeni-Suef UniversityP.O.Box 62521Beni-SuefEgypt Biotechnology and Life Sciences Department Faculty of Postgraduate Studies for Advanced SciencesBeni-Suef UniversityBeni-SuefB.O.Box 62511Egypt

This study aimed to assess the preventive effects of thyme oil and thymol on doxorubicin(DOX)-induced renotoxicity,cardiotoxicity,and oxidative stress in Wistar *** oil was subjected to GC-mS analysis,which indicated that thymol was the major constituent representing 33.896%.Rats intraperitoneally injected with DOX at a dose of 2 mg/kg b.w./one per week for 7 weeks were co-treated with thyme oil and its major constituent,thymol,at doses 250 and 100 mg/kg b.w./every other day,respectively,by oral gavage for the same *** oil and thymol markedly ameliorated the raised levels of serum urea,uric acid,and creatinine in DOX-administered *** also reduced the elevated activities of serum CK-mB and *** oil was more effective than thymol in decreasing the elevated serum creatinine level and serum CK-mB activity in DOX-administered rats,thereby reflecting its more potent effect on kidney and heart *** peroxidation significantly decreased while GSH level and GST and GPx activities significantly increased in kidney and heart of DOX-administered rats treated with thyme oil and *** DOX-induced perturbed kidney histological changes including congestion of glomerulus tuft,inflammatory cells infiltration,protein cast in lumina of the renal tubule,and thickening of the parietal layer of Bowman’s capsule were remarkably ameliorated as a result of treatment with thyme oil and thymol;thyme oil was more *** addition,DOX-induced deleterious heart histological alterations,including intramuscular infiltration of inflammatory cells,focal necrosis of cardiac myocytes,and edema,were remarkably reduced by treatment with thyme oil and ***,it can be concluded that DOX could induce marked toxicity in kidney and heart,and the treatment with thyme oil or thymol produced potential improvement of kidney and heart function and histological integrity via repression of oxidative stress and enhancement of antioxidant defense mechanisms.

关键词： Doxorubicin Nephrotoxicity Cardiotoxicity Oxidative stress Thyme oil Thymol

CO_(2) capture using membrane contactors:a systematic literature review

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Frontiers of Chemical Science and Engineering 2021年第4期15卷 720-754页

作者： sanaa Hafeez Tayeba Safdar Elena Pallari George manos Elsa Aristodemou Zhien Zhang S.m.Al-Salem Achilleas Constantinou Division of Chemical and Energy Engineering School of EngineeringLondon South Bank UniversityLondon SE10AAUK medical Research Council Clinical Trials Unit University College LondonLondon WC1V 6LJUK Department of Chemical Engineering University College LondonLondon WCIE 7JEUK William G.Lowrie Department of Chemical and Biomolecular Engineering The Ohio State UniversityColumbusOH 43210USA Environment&Life Sciences Research Centre Kuwait Institute for Scientific ResearchSafat 13109Kuwait Department of Chemical Engineering Cyprus University of Technology Limassol 3036Cyprus

With fossil fuel being the major source of energy,CO_(2) emission levels need to be reduced to a minimal amount namely from anthropogenic *** consumption is expected to rise by 48%in the next 30 years,and global warming is becoming an alarming issue which needs to be addressed on a thorough technical ***,exploring CO_(2) capture using membrane contactor technology has shown great potential to be applied and utilised by industry to deal with post-and pre-combustion of CO_(2).A systematic review of the literature has been conducted to analyse and assess CO_(2) removal using membrane contactors for capturing techniques in industrial *** review began with a total of 2650 papers,which were obtained from three major databases,and then were excluded down to a final number of 525 papers following a defined set of *** results showed that the use of hollow fibre membranes have demonstrated popularity,as well as the use of amine solvents for CO_(2) *** current systematic review in CO_(2) removal and capture is an important milestone in the synthesis of up to date research with the potential to serve as a benchmark databank for further research in similar areas of *** study provides the first systematic enquiry in the evidence to research further sustainable methods to capture and separate CO_(2).

关键词： CO_(2)capture preferred reporting items for systematic reviews and meta-analysec membranc contactor absorbent

microhardness,microstructure and electrical properties of ZVm ceramics

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Journal of Advanced Ceramics 2014年第4期3卷 287-296页

作者： Abdel-mageed H.KHAFAGY sanaa m.EL-RABAIE mohamed T.DAWOUD m.T.ATTIAb Physics Department Faculty of ScienceMenufiya UniversityShebin El-Koom 32511Egypt Physics and Engineering mathematics Department Faculty of Electronic EngineeringMenufiya UniversityMenouf 32952Egypt

The effect of mn_(3)O_(4)addition on microhardness,microstructure and electrical properties of vanadium oxide doped zinc oxide varistor ceramics is systematically *** Vicker’s microhardness HV has decreased with increasing the amount of ***,the average grain size has decreased from 27.51μm to 19.55μm with increasing the amount of mn_(3)O_(4) up to 0.50 mol%,whereas an increase in mn_(3)O_(4) up to 0.75 mol%has caused the average grain size to increase and then it decreases with increasing mn_(3)O_(4)from 0.75 mol%to 1.00 mol%.The sintered density has decreased from 5.38 g/cm3 to 5.31 g/cm3 with increasing the amount of mn_(3)O_(4).The varistor ceramic modified with 0.50 mol%mn_(3)O_(4) has exhibited excellent nonlinear properties,with 16.29 for the nonlinear coefficient and 441.9μA/cm2 for the leakage current ***,the sample doped with 0.50 mol%mn_(3)O_(4) has been found to possess donor density as 0.77×10^(18) cm^(-3) and 0.916 eV barrier height.

关键词： ceramics electrical properties microstructure varistor mn3O4 doped ZnO-V2O5 varistor

Generalized Truncated Fréchet Generated Family Distributions and Their Applications

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Computer modeling in Engineering & Sciences 2021年第2期126卷 791-819页

作者： Ramadan A.ZeinEldin Christophe Chesneau Farrukh Jamal mohammed Elgarhy Abdullah m.Almarashi sanaa Al-marzouki Deanship of Scientific Research King AbdulAziz UniversityJeddah21589Saudi Arabia Faculty of Graduate Studies for Statistical Research Cairo UniversityAl OrmanGiza Governorate12613Egypt Universite de Caen LMNOCampus IIScience 3Caen14032France Department of Statistics The Islamia University of BahawalpurPunjab63100Pakistan The Higher Institute of Commercial Sciences Al Mahalla Al KubraAlgarbia31951Egypt Statistics Department Faculty of ScienceKing AbdulAziz UniversityJeddah21551Saudi Arabia

Understanding a phenomenon from observed data requires contextual and efficient statistical *** models are based on probability distributions having sufficiently flexible statistical properties to adapt to a maximum of *** examples include the distributions of the truncated Fréchet generated *** this paper,we go even further by introducing a more general family,based on a truncated version of the generalized Fréchet *** generalization involves a new shape parameter modulating to the extreme some central and dispersion parameters,as well as the skewness and weight of the *** also investigate the main functions of the new family,stress-strength parameter,diverse functional series expansions,incomplete moments,various entropy measures,theoretical and practical parameters estimation,bivariate extensions through the use of copulas,and the estimation of the model *** considering a special member of the family having the Weibull distribution as the parent,we fit two data sets of interest,one about waiting times and the other about *** statistical criteria attest that the proposed model is superior over other extended Weibull models,including the one derived to the former truncated Fréchet generated family.

关键词： Truncated distribution general family of distributions incomplete moments entropy copula data analysis

Impact of the socioeconomic status on the severity and outcome of community-acquired pneumonia among Egyptian children: a cohort study

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Infectious Diseases of Poverty 2014年第1期3卷 128-134页

作者： Seham Fathy Abdel Hameed Azab Laila m Sherief Safaa H Saleh Wafaa F Elsaeed mona A Elshafie sanaa m Abdelsalam Faculty of medicine Zagazig UniversityEgypt18 Omar Bin Elkhattab StAl QawmiaZagazig CityAl Sharqia GovernorateEgypt

Background:Community-acquired pneumonia(CAP)is one of the five leading causes of death among children in developing countries,accounting for approximately three million deaths per *** of the modifiable risk factors of CAP may help to reduce the burden of this *** this study,the impact of the socioeconomic status(SES)on the severity and outcome of CAP among Egyptian children was ***:This was a prospective longitudinal cohort study which included 1,470 children diagnosed with CAP,aged two to 15 years(median age 5.4 years).The diagnosis of CAP was based on clinical and radiological findings.A structured questionnaire and the patients’medical records were used for the data *** subjects were divided into two groups:mild and severe *** and demographic variables were compared,and a multivariate logistic regression analysis was ***:The multivariate analysis showed that a low maternal education level(OR:3.8;95%CI:2.12-6.70;P=.0001),unavailability of adequate medical care(OR:3.1;95%CI:1.99-4.88;P=.0001),a low family income(OR:2.2;95%CI:0.99-4.78;P=.047),and parents’smoking habits(OR:2.0;95%CI:1.15-3.55;P=.014)were significant independent predictive risk factors for severe CAP among Egyptian ***:Public health measures against these socio-demographic risk factors should be identified as priorities in order to help reduce the disease burden of deaths from severe CAP among Egyptian children.

关键词： Socioeconomic Community acquired pneumonia Children

β-arrestin-2 predicts the clinical response to β-blockers in cirrhotic portal hypertension patients: A prospective study

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World Journal of Hepatology 2022年第2期14卷 429-441页

作者： Sameh A Lashen mohammed m Shamseya marwa A madkour Radwa m Abdel Salam sanaa S mostafa Division of Hepatology and Gastroenterology Faculty of MedicineAlexandria UniversityAlexandria 21521Egypt Department of Experimental and Clinical Internal medicine Medical Research InstituteAlexandria 21561Egypt Department of Pathology Medical Research InstituteAlexandria UniversityAlexandria 21561Egypt

BACKGROUND Portal hypertension,a common complication associated with liver cirrhosis,can result in variceal bleeding,which greatly impacts patient ***,β-arrestin-2 has been shown to predict the acute hemodynamic response to nonselectiveβ-blocker therapy for cirrhotic portal ***,more data is needed on the long-term effects of and changes inβ-arrestin-2 following nonselectiveβ-blocker *** To investigate the expression and role ofβ-Arrestin-2 in predicting the long-term response to nonselectiveβ-blockers in cirrhotic portal hypertensive *** We prospectively enrolled 91 treatment-naïve patients with cirrhotic portal *** clinical and laboratory data were *** was performed for grading and treating varices and obtaining gastric antral *** measured the serum and antral expression ofβ-arrestin-2 and obtained Doppler measurement of the portal vein congestion *** with nonselectiveβ-blockers was then *** patients were followed up for 18 mo,after which they have undergone a repeat antral biopsy and re-evaluation of the portal vein congestion *** A higher serum level and antral expression ofβ-arrestin-2 was associated with longer bleedingfree intervals,greater reduction in the portal vein congestion index,and improved grade of *** patients with a lowβ-arrestin-2 expression,17.6%were nonselectiveβ-blocker responders,whereas,among those with high expression,95.1%were responders(Pmβ-arrestin-2 value≥2.23 ng/mL was associated with a lower likelihood of variceal bleeding(90%sensitivity and 71%specificity).β-arrestin-2 expression significantly decreased after nonselectiveβ-blocker ***β-arrestin-2 expression in cirrhotic portal hypertension predicts the clinical response to long-term nonselectiveβ-blocker ***β-arrestin-2 is a potential noninvasive biomarker for selecting the candidate patients for nonselectiveβ-bl

关键词： β-arrestin-2 Portal hypertension Variceal bleeding Nonselective beta-blockers Portal congestion index Variceal ligation