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Journal of Environmental Sciences 2011年第10期23卷 1714-1720页

作者： Jamel Jebali sana ben-khedher Jihene Ghedira Nawel Kamel Hamadi Boussetta Laboratory of Biochemical and Environmental Toxicology Higher Institute of AgricultureChott-Mariem4042-SousseTunisia

The biochemical response of Mediteranean Crab （Carcinus maenas） collected at five stations of Monastir Bay and from Kuriat station as control was studied using a set of complementary biomarkers. The catalase, glutathione S-transferase, lactate dehydrogenase, acetycholinesterase activities; and metallothionein and malonediladehyde levels in gills were evaluated. Results revealed differences among sites in relation to each specific biomarker. Hence, a suite of biomarkers can be used to discriminate sampling sites according to types of pollution, reflecting differing conditions of anthropogenic impact. Based on Integrated Biomarker Response, the highest values and critical biochemical alteration were observed at Khniss and Ksibat in response to urban and industrial discharges and the lowest IBR value was found at reference site. The current study has shown clearly that a biomarker-based index is usefulness tool in the monitoring Tunisian coast using C. maenas as sentinel specie. Further studies in progress to investigate the seasonal variations of IBR levels and its relationship to pollutants concentrations in the sediment, gills and digestive gland of Carcinus maenas from Monastir Bay.

关键词： Carcinus maenas acetycholinesterase metallothionein glutathione S-transferase lactate dehydrogenase catalase malonedialdehyde

Towards Securing Machine Learning Models Against Membership Inference Attacks

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Computers, Materials & Continua 2022年第3期70卷 4897-4919页

作者： sana ben Hamida Hichem Mrabet sana Belguith Adeeb Alhomoud Abderrazak Jemai Departement of STIC Higher Institute of Technological Studies of GabesGeneral Directorate of Technological StudiesRades2098Tunisia Research Team on Intelligent Machines National Engineering School of GabesGabes UniversityGabes6072Tunisia SERCOM-Lab. Tunisia Polytechnic SchoolCarthage UniversityTunis1054Tunisia Department of IT College of Computing and InformaticsSaudi Electronic UniversityMedina42376Saudi Arabia School of Science Engineering and EnvironmentUniversity of SalfordManchesterM54WTUK Department of Science College of Science and Theoretical StudiesSaudi Electronic UniversityRiyadh11673Saudi Arabia INSAT SERCOM-Lab.Tunisia Polytechnic SchoolCarthage UniversityTunis1080Tunisia

From fraud detection to speech recognition,including price prediction,Machine Learning(ML)applications are manifold and can significantly improve different ***,machine learning models are vulnerable and are exposed to different security and privacy ***,these issues should be addressed while using ML models to preserve the security and privacy of the data *** is a need to secure ML models,especially in the training phase to preserve the privacy of the training datasets and to minimise the information *** this paper,we present an overview of ML threats and vulnerabilities,and we highlight current progress in the research works proposing defence techniques againstML security and privacy *** relevant background for the different attacks occurring in both the training and testing/inferring phases is introduced before presenting a detailed overview of Membership Inference Attacks(MIA)and the related *** this paper,we introduce a countermeasure against membership inference attacks(MIA)on Conventional Neural Networks(CNN)based on dropout and L2 *** experimental analysis,we demonstrate that this defence technique can mitigate the risks of MIA attacks while ensuring an acceptable accuracy of the ***,using CNN model training on two datasets CIFAR-10 and CIFAR-100,we empirically verify the ability of our defence strategy to decrease the impact of MIA on our model and we compare results of five different ***,we present a solution to achieve a trade-off between the performance of themodel and the mitigation of MIA attack.

关键词： Machine learning security and privacy defence techniques membership inference attacks dropout L2 regularization

Antioxidant and ɑ-glucosidase activities and phytochemical constituents of Chrysanthoglossum trifurcatum(Desf.)

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Asian Pacific Journal of Tropical Medicine 2018年第4期11卷 285-291页

作者： Ahlem ben Sassi sana Amroussi Malek Besbes Mahjoub Aouni Fethia Skhiri Laboratory of Transmissible Diseases and Biologically Active Substances Department of Microbiology Faculty of Pharmacy University of Monastir Laboratory of Genetics Biodiversity and Valorisation of Bioresources Higher Institute of Biotechnology University of Monastir

Objective: To investigate the antioxidant and ɑ-glucosidase properties and phytochemical constituents of roots, stems, leaves and flowers extracts and aerial parts oil of Chrysanthoglossum trifurcatum(Desf.)(C. trifurcatum). Methods: For extraction from roots, stems, leaves and flowers of C. trifurcatum, methanol, ethyl acetate and petroleum ether solvents were used. Phenols, flavonoids, flavonols and tannins contents were evaluated. More, C. trifurcatum aerial parts oil composition was determined using chromatography/mass spectrometry. The antioxidant effect was estimated by DPPH, ABTS and reducing power test systems. The ɑ-glucosidase inhibition was determined by colorimetric assay using the enzyme from Aspergillus niger and the p-nitrophenyl glucopyranoside(pNPG) as substrate. Results: The highest amounts of polyphenols, flavonoids, flavonols and tannins were shown by the methanolic extract of leaves. The main components of the aerial parts oil were limonene(29.21%), γ-terpinene(12.96%), 4-terpenyl acetate(12.18%) and ɑ-pinene(5.76%). The activity evaluated by DPPH, ABTS and reducing power tests was important for stems(IC_(50)=0.68 mg/mL) and flowers(IC_(50)=0.67 mg/mL) methanolic extracts and essential oil(IC_(50)=0.72 mg/mL). Findings of ɑ-glucosidase activity revealed that petroleum ether extracts of leaves and roots together with aerial parts oil showed a highest activity with IC_(50) of 0.044, 0.045 and 0.049 mg/m L, respectively. Conclusions: Observed antioxidant and ɑ-glucosidase activities of oil and extracts are attributed to the presence of the active phytochemicals in C. trifurcatum organs. Thus, the C. trifurcatum can be used as a source of antioxidant compounds and dietary supplement to treat patients with type 2 diabetes.

关键词： Antioxidant ɑ-glucosidase Phenolic content Oil Chrysanthoglossum trifurcatum

具有幂律纳米流体流动的导管内辐射热传递的计算评估

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Journal of Central South University 2023年第8期30卷 2642-2656页

作者： Sohail REHMAN Syed Inayat Ali SHAH HASHIM sana ben MOUSSA School of Materials Sciences Georgia Institute of TechnologyAtlanta 30318GeorgiaUSA Department of Mathematics Islamia College PeshawarPeshawarPakistan Department of Mathematics&Statistics The University of HaripurHaripur 22620Pakistan Faculty of Science and Arts Mohail AsserKing Khalid UniversitySaudi Arabia

利用因热源作用而收缩和膨胀的导管研究一阶化学反应和热辐射对幂律Carreau流体热质传输的影响。考虑了以热辐射形式产生热量的流体流动的体积热源和非线性热辐射。采用基于射击简单算法的RK-4方法对径向模式下的质量、动量、能量和物... 详细信息

利用因热源作用而收缩和膨胀的导管研究一阶化学反应和热辐射对幂律Carreau流体热质传输的影响。考虑了以热辐射形式产生热量的流体流动的体积热源和非线性热辐射。采用基于射击简单算法的RK-4方法对径向模式下的质量、动量、能量和物种浓度等基本守恒方程进行了重构和数值求解。考虑粒子的布朗性和热泳性,纳米粒子存在的模型是现象模型。将动量方程与扩展Jaffrey-Hamel问题的Carreau模型组合在一起。不同幂律指数对流体摩擦传热、传热量和传质的影响主要表现在流变性能上,说明剪切增稠型流体比剪切减薄型流体更有效。热传输率在热源处最大,在幂指数最大化时最小。这些研究可能有助于开发一种物理上合理的方法,用于系统化评估收缩/扩张通道中的流体流动和能量使用。

关键词：热传导热辐射发热 Jaffrey-Hamel流幂律Carreau流体数值结果

Tracking Students’ Mental Engagement Using EEG Signals during an Interaction with a Virtual Learning Environment

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Journal of Intelligent Learning Systems and Applications 2019年第1期11卷 1-14页

作者： Asma ben khedher Imène Jraidi Claude Frasson Department of Computer Science and Operations Research University of Montreal Montreal Canada

Monitoring students’ level of engagement during learning activities is an important challenge in the development of tutoring interventions. In this paper, we explore the feasibility of using electroencephalographic signals (EEG) as a tool to monitor the mental engagement index of novice medicine students during a reasoning process. More precisely, the objectives were first, to track students’ mental engagement evolution in order to investigate whether there were particular sections within the learning environment that aroused the highest engagement level among the students, and, if so, did these sections have an impact on learners’ performance. Experimental analyses showed the same trends in the different resolution phases as well as across the different regions of the environments. However, we noticed a higher engagement index during the treatment identification phase since it aroused more mental effort. Moreover statistically significant effects were found between mental engagement and students’ performance.

关键词： EEG Engagement Index Learners’ Performance Computer-Based Learning Environments

Modeling of Date Palm （Phoenix dactylifera L.） Vegetative Aerial Architecture, Example of Two Tunisian Cultivars

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Journal of Life Sciences 2014年第5期8卷 418-424页

作者： sana Gammoudi René Lecoustre Mohamed ben Salah Arid and Oases Cropping Laboratory Arid Lands Institute Medenine 4119 Tunisia UMR AMAP CIRAD-BIOS Boulevard de la Lironde TA AS1/PS2 - 34398 Montpellier Cedex 5 France

The present study was carried out to verify the statistical relationships between the characteristic parameters in terms of vegetative aerial architecture of the date palms for simulating realistic 3D models. The vegetal material was composed of two Tunisian varieties of Phoenix dactylifera L., ＂Barhi＂ and ＂Rochdi＂. The observations are taken place in Gabes and on one pair of palms per main stem and offshoot for each cultivar. The analysis of the characteristic dimensions of the pinnae and rachis allowed the determination of a minimum sample. The geometrical analysis confirmed the existence of a strong correlation between rotation angles and radial angles. The architectural analysis of the two Tunisian cultivars revealed that the distribution of characteristic parameter values of pinnae was the outcome ofa regionalized variable along the rachis. This statistical study of relationships between the characteristic parameters in terms of vegetative aerial architecture of the two varieties allows executing a new measurement protocol for computing and simulating realistic 3D models.

关键词： Phoenix dactylifera L. modeling architecture minimum sample correlation.

Phenolic composition and antioxidant properties of Eryngium maritimum (sea holly)

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Journal of Coastal Life Medicine 2017年第5期5卷 212-215页

作者： Ilhem Rjeibi Anouar ben Saad sana Ncib Sami Souid Research Unit of Macromolecular Biochemistry and Genetic Faculty of Sciences of GafsaGafsa2112Tunisia Common Services Unit for Research Faculty of Sciences of GafsaGafsa2112Tunisia

Objective: To examine the antioxidant potential of Tunisian Eryngium maritimum (E. maritimum) leaf, root and stems extracts, as well as their phenolic compositions. Methods: The antioxidant activity of different extracts was assessed using DPPH free radical and hydrogen peroxide scavenging assays. Phenolic profiles were determined by means of liquid chromatography (HPLC-DAD). Results: All plant parts were a rich source of phenolics. Polyphenols and flavonoids were present in leaf extracts. E. maritimum leaf extracts displayed the strongest H2O2 scavenging activity (IC50 = 76.83 μg/mL) and the highest DPPH scavenging activity value (IC50 = 47.87 μg/mL) compared to other extracts. Good relationships were observed between antioxidant activities and the total phenolic and flavonoid contents. Nine bioactive compounds were detected in E. maritimum extracts. Conclusions: Our results provided evidence that E. maritimum could be an interesting source of natural antioxidant that can be used to treat divers diseases.

关键词： Eryngium maritimum Phenolic compositions Antioxidant activity

Impact du traitement carcinologique sur le fonctionnement sexuel et l’image du corps des patientes tunisiennes en rémission d’un cancer du sein localiséImpact of Cancer Treatment on Sexual Functioning and Body Image of Tunisian Patients in Remission from Localized Breast Cancer

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Psycho-Oncologie 2024年第3期18卷 241-248页

作者： Nada Charfi Nour Regaieg Ines Ayadi Najeh Smaoui Rim Feki Imen Gassara sana Omri Lobna Zouari Jihène ben Thabet Manel Maâlej Bouali Afef Khanfir Mohamed Maâlej Service de psychiatrie C CHU Hedi ChakerSfax3000Tunisie Service de carcinologie médicale CHU Habib BourguibaSfax3029Tunisie Facultéde médecine de Sfax Universitéde SfaxSfax3029Tunisie

The diagnosis and the management of breast cancer(BC)affect in a complex way women’s sexual lives and touch the symbol of femininity,which is very important in the constitution of the body *** objectives were to assess the sexual functioning and the body image of patients in remission of localized BC,to determine the links between these two parameters,and to study their relationship with the therapeutic *** conducted a cross-sectional,descriptive,and analytical study in the medical oncology and radiotherapy departments of Habib Bourguiba University Hospital Center in Sfax(Tunisia),between February and August *** were assessed based on a clinical information sheet and two psychometric scales exploring sexual functioning and body image:Female Sexual Function Index(FSFI)and Body Image Scale(BIS).The sample comprised 74 patients with a mean age of 51.55 *** were treated by conservative or radical surgery(44.6%and 55.4%,respectively),chemotherapy(87.8%),hormone therapy(79.7%),targeted therapies(36.5%),and radiotherapy(97.3%).A rate of 51.4%of women had sexual dysfunction(SD),87.8%had hypoactive sexual desire and 36.5%had body image *** body image disorder was significantly associated with DS(p=0.001).The total FSFI score(p=0.001)as well as the subscores of desire(p=0.005),arousal(p=0.003),orgasm(p=0.002),satisfaction(p<0.001),and pain(0.03)were significantly lower in patients with body image *** presence of a SD was not associated with any therapeutic *** contrast,the presence of body image disorder was significantly associated with the radical type of surgery(p=0.003)and chemotherapy(p=0.001).Our results showed a relatively high frequency of SD and body image disorder in women in remission from *** two parameters seem to be closely linked,and this link would be maintained by mastectomy and chemotherapy,which appear to be therapeutic modalities incriminated in the disturbance of body *** the importan

关键词： Breast cancer sexual dysfunction body image Female Sexual Function Index Body Image Scale

Imidacloprid enhances liver damage in Wistar rats: Biochemical, oxidative damage and histological assessment

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Journal of Coastal Life Medicine 2017年第12期5卷 540-546页

作者： sana Chakroun Intissar Grissa Lobna Ezzi Oumaima Ammar Fadoua Neffati Emna Kerkeni Mohamed Fadhel Najjar Zohra Haouas Hassen ben Cheikh Laboratory of Histology and Cytogenetic(Research Unit of Genetic Genotoxicity and Childhood Illness UR12ES10)Faculty of MedicineUniversity of MonastirStreet AvicenneMonastir 5019Tunisia Laboratory of Biochemistry and Toxicology Fattouma Bourguiba UniversityHospital of MonastirMonastirTunisia

Objective: To investigate the potential adverse effects of imidacloprid on biochemical parameters, oxidative stress and liver damage induced in the rat by oral sub-chronic imidaclopride exposure. Methods: Rats received three different doses of imidacloprid (1/45, 1/22 and 1/10 of LD50) given through gavage for 60 days. Two dozen of male Wistar rats were randomly divided into four experimental groups. Liver damage was determined by measuring aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase leakages. The prooxidant-antioxydant status in hepatic tissue homogenate was evaluated by measuring the degree of lipid peroxidation, the antioxidant enzymes activities such as catalase, superoxide dismutase and glutathione peroxidase (GPx). Results: The relative liver weight was significantly higher than that of control and other treated groups at the highest dose 1/10 of LD50 of imidacloprid. Additionally, treatment of rats with imidacloprid significantly increased liver lipid peroxidation (P ≤ 0.05 or 0.01) which went together with a significant decrease in the levels of superoxide dismutase and catalase activities. Parallel to these changes, imidacloprid treatment enhanced liver damage as evidence by sharp increase in the liver enzyme activities of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and lactate dehydrogenase. These results were also confirmed by histopathology. Conclusions: In light of the available data, it is our thought that after imidacloprid sub-chronic exposure, depletion of antioxidant enzymes is accompanied by induction of potential oxidative stress in the hepatic tissues that might affect the function of the liver which caused biochemical and histopathological alteration.

关键词： Imidacloprid Biochemical parameters Hepatotoxicity Oxidative stress Neonicotinoids

Precocious Puberty in a 5-Year-Old Girl with a Giant Hypothalamic Hamartoma Discovered Perinatally: Case Report

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Open Journal of Endocrine and Metabolic Diseases 2024年第4期14卷 101-106页

作者： Ghita Bourkadi sanae Habibi sana Abourazzak Moustapha Hida Department of Endocrinology Diabetology Metabolic Diseases and Nutrition Hassan II University Hospital Fez Morocco Department of Pediatrics Hassan II University Hospital Fez Morocco Faculty of Medicine and Pharmacy Sidi Mohamed Ben Abdellah University Fez Morocoo

Background: Hypothalamic hamartoma is a rare non-neoplastic lesion, typically identified in early childhood during investigations for precocious puberty and/or gelastic seizures. However, cases of diagnosis even earlier or during fetal development have been documented. Case Presentation: A newborn girl was diagnosed with hydrocephalus during pregnancy. An MRI revealed a large oval hypothalamic process, which suggested a hypothalamic hamartoma. At the age of 2, she experienced alternating crying and laughing seizures, followed by a decrease in visual acuity. Due to involvement of the optic pathways, surgery was not performed and she underwent antiepileptic medicines and gamma knife radiotherapy. At the age of 5 years and 3 months, she presented with breast development and laboratory tests confirmed central precocious puberty. Quarterly injections of GnRH agonists have since been administered with favorable results. Conclusion: Early-diagnosed hypothalamic hamartomas require close monitoring, by an experienced multidisciplinary, to promptly detect and treat potential complications, especially precocious puberty, and prevent any undesirable impact on final height.

关键词： Perinatally-Hypothalamic Hamartoma-Giant-Precocious Puberty