检索结果-南通市图书馆

immunoregulatory and Anti-cancer Activities of Combination treatment of Novel Four-Herb Formula and doxorubicin in 4t1-Breast Cancer Bearing Mice

引用

Chinese Journal of integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan ben Chung-Lap Chan Grace Gar-Lee Yue Li Pei-ting Sharon Sze-Man hon HUANG dan-qi Miranda Sin-Man tsang Clara Bik-san Lau Ping-Chung Leung Chun-Kwok Wong institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia international Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li dak Sum Yip Yio Chin R&d Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective to investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(tNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4t1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,Ld 4HF(low dose 4HF),Hd 4HF(high dose 4HF),Ld 4HF+d(low dose and doxorubicin),and d(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4t1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** Ld and Hd groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** Ld 4HF+d group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).the d group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).the treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(Ptered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(Pdoxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analytical computation of magnetic field in coil-dominated superconducting quadrupole magnets based on racetrack coils

引用

Nuclear Science and techniques 2024年第4期35卷 119-135页

作者： Chuang Shen Ying-Shun Zhu Fu-san Chen China Spallation Neutron Source Institute of High Energy PhysicsChinese Academy of Sciences1 Zhongziyuan RoadDongguan 523000China institute of High Energy Physics Chinese Academy of Sciences19B Yuquan RoadBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

Currently,three types of superconducting quadrupole magnets are used in particle accelerators:cos 2θ,CCt,and ***,all three coil configurations have complex spatial geometries,which make magnet manufacturing and strain-sensitive superconductor applications *** with the three existing quadrupole coils,the racetrack quadrupole coil has a simple shape and manufacturing process,but there have been few theoretical *** this paper,the two-dimensional and three-dimensional analytical expressions for the magnetic field in coil-dominated racetrack superconducting quadrupole magnets are *** analytical expressions of the field harmonics and gradient are fully resolved and depend only on the geometric parameters of the coil and current ***,a genetic algorithm is applied to obtain a solution for the coil geometry parameters with field harmonics on the order of 10^(-4).Finally,considering the practical engineering needs of the accelerator interaction region,electromagnetic design examples of racetrack quadrupole magnets with high gradients,large apertures,and small apertures are described,and the application prospects of racetrack quadrupole coils are analyzed.

关键词： Superconducting quadrupole magnet Racetrack coil Multipole field Genetic algorithm Magnetic design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A multi-objective optimization based on machine learning for dimension precision of wax pattern in turbine blade manufacturing

引用

Advances in Manufacturing 2024年第3期12卷 428-446页

作者： Jing dai Song-Zhe Xu Chao-Yue Chen tao Hu san-san Shuai Wei-dong Xuan Jiang Wang Zhong-Ming Ren State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringShanghai UniversityShanghai200444People’s Republic of China

Wax pattern fabrication in the investment casting of hollow turbine blades directly determines the dimension accuracy of subsequent casting,and therefore significantly affects the quality of final *** this work,we develop a machine learning-based multi-objective optimization framework for improving dimension accuracy of wax pattern by optimizing its process *** consider two optimization objectives on the dimension of wax pattern,i.e.,the surface warpage and core *** active learning of Bayesian optimization is employed in data sampling to determine process parameters,and a validated numerical model of injection molding is used to compute objective results of dimension under varied process *** collected dataset is then leveraged to train different machine learning models,and it turns out that the Gaussian process regression model performs best in prediction accuracy,which is then used as the surrogate model in the optimization framework.A genetic algorithm is employed to produce a non-dominated Pareto front using the surrogate model in searching,followed by an entropy weight method to select the most optimal solution from the Pareto *** optimized set of process parameters is then compared to empirical parameters obtained from previous trial-and-error experiments,and it turns out that the maximum and average warpage results of the optimized solution decrease 26.0%and 20.2%,and the maximum and average errors of wall thickness compared to standard part decrease from 0.22 mm and 0.0517 mm using empirical parameters to 0.10 mm and 0.0356 mm using optimized parameters,*** framework is demonstrated capable of addressing the challenge of dimension control arising in the wax pattern production,and it can be reliably deployed in varied types of turbine blades to significantly reduce the manufacturing cost of turbine blades.

关键词： Hollow turbine blade Wax pattern fabrication dimension control Multi-objective optimization Machine learning Numerical simulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arabidopsis photoperiodic regulator CONStANS feeds back to control the circadian clock

引用

Molecular Plant 2024年第9期17卷 1338-1340页

作者： Abril san Martin Marcelo Javier Yanovsky instituto de investigaciones Bioquimicas de Buenos Aires(Fundacion instituto Leloir-CONiCEt) Av.Patricias Argentinas 435Buenos AiresC1405BWE

Human beings live in a world defined by daily cycles of light and darkness caused by the Earth's rotation around its ***,like most living organisms,have evolved internal circadian clocks that time biological processes in anticipation of these daily environmental changes(Young and Kay,2001).the plant clock relies on core genes encoding transcription factors(tFs),which regulate each other's expression through intricate networks of interlocking transcriptional-translational feedback loops(Nohales and Kay,2016).these loops ultimately control the expression of thousands of genes,allowing plants to adapt to daily fluctuations in light,temperature,and humidity(Covington et al.,2008).in addition to daily rhythms,the Earth experiences yearly seasonal cycles marked by longer,warmer days in spring and summer,followed by shorter,cooler days in autumn and *** changes in day length and temperature intensify with distance from the ***,the ability of plants to adjust their growth and development in anticipation of seasonal changes determines their latitudinal distribution(McMillan,1960).

关键词： circadian seasonal Arabidopsis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ion and electron motions in the outer electron diffusion region of collisionless magnetic reconnection

引用

Earth and Planetary Physics 2024年第3期8卷 472-478页

作者： Cong Chang QuanMing Lu san Lu Kai Huang RongSheng Wang deep Space Exploration Laboratory School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences(CAS)Center for Excellence in Comparative Planetology CAS Key Laboratory of Geospace EnvironmentHefei 230026China Collaborative innovation Center of Astronautical Science and technology Harbin 150001China

two-dimensional particle-in-cell simulations are performed to study the coupling between ion and electron motions in collisionless magnetic *** electron diffusion region(EdR),where the electron motions are demagnetized,is found to have a two-layer structure:an inner EdR near the reconnection site and an outer EdR that is elongated to nearly 10 ion inertial lengths in the outflow *** the inner EdR,the speed of the electron outflow increases when the electrons move away from the X *** the outer EdR,the speed of the electron outflow first increases and then decreases until the electrons reach the boundary of the outer *** the boundary of the outer EdR,the magnetic field piles up and forms a depolarization *** the perspective of the fluid,a force analysis on the formation of electron and ion outflows has also been *** the X line,the electrons are accelerated by the reconnection electric field in the out-of-plane *** the electrons move away from the X line,we find that the Lorentz force converts the direction of the accelerated electrons to the x direction,forming an electron *** electric field forces and electron gradient forces tend to drag the electron *** acceleration along the x direction is caused by the Lorentz force,whereas the pressure gradient force tends to decelerate the ion *** these two terms are important,their effects on ions are almost *** Hall electric field force does positive work on ions and is not *** ions are continuously accelerated,and the ion and electron outflow velocities are almost the same near the depolarization front.

关键词： collisionless magnetic reconnection electron diffusion region force analysis particle-in-cell simulation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A regression approach for seismic first-break picking

引用

Petroleum Science 2024年第3期21卷 1584-1596页

作者： Huan Yuan san-Yi Yuan Jie Wu Wen-Jing sang Yu-He Zhao CNPC Key Laboratory of Geophysical Exploration China University of Petroleum(Beijing)Beijing 102249China Research institute of Petroleum Exploration&development—Northwest(NWGi) Key Laboratory of reservoir characterization of CNPCPetroChinaLanzhou 730020GansuChina

the picking efficiency of seismic first breaks(FBs)has been greatly accelerated by deep learning(dL)***,the picking accuracy and efficiency of dL methods still face huge challenges in low signal-to-noise ratio(SNR)*** address this issue,we propose a regression approach to pick FBs based on bidirectional long short-term memory(Bi LStM)neural network by learning the implicit Eikonal equation of 3d inhomogeneous media with rugged topography in the target *** employ a regressive model that represents the relationships among the elevation of shots,offset and the elevation of receivers with their seismic traveltime to predict the unknown FBs,from common-shot gathers with sparsely distributed *** from image segmentation methods which automatically extract image features and classify FBs from seismic data,the proposed method can learn the inner relationship between field geometry and *** addition,the predicted results by the regressive model are continuous values of FBs rather than the discrete ones of the binary *** picking results of synthetic data shows that the proposed method has low dependence on label data,and can obtain reliable and similar predicted results using two types of label data with large *** picking results of9380 shots for 3d seismic data generated by vibroseis indicate that the proposed method can still accurately predict FBs in low SNR *** subsequent stacked profiles further illustrate the reliability and effectiveness of the proposed *** results of model data and field seismic data demonstrate that the proposed regression method is a robust first-break picker with high potential for field application.

关键词： First-break picking Low signal-to-noiseratio Regression BiLStM traveltime Geometry Noisy seismic data

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epigenetic modifications of placenta in women with gestational diabetes mellitus and their offspring

引用

World Journal of diabetes 2024年第3期15卷 378-391页

作者： Yan Yi tao Wang Wei Xu san-hong Zhang department of Ultrasonography The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina Clinical Molecular immunology Center Yangtze UniversityJingzhou 434023Hubei ProvinceChina department of Pediatric Xiantao First People’s HospitalXiantao 433000Hubei ProvinceChina

Gestational diabetes mellitus(GdM)is a pregnancy-related complication characterized by abnormal glucose metabolism in pregnant women and has an important impact on fetal *** a bridge between the mother and the fetus,the placenta has nutrient transport functions,endocrine functions,etc.,and can regulate placental nutrient transport and fetal growth and development according to maternal metabolic *** by means of placental transmission can changes in maternal hyperglycemia affect the *** are many reports on the placental pathophysiological changes associated with GdM,the impacts of GdM on the growth and development of offspring,and the prevalence of GdM in offspring after *** epigenetic changes in GdM are involved in the programming of fetal development and are involved in the pathogenesis of later chronic *** paper summarizes the effects of changes in placental nutrient transport function and hormone secretion levels due to maternal hyperglycemia and hyperinsulinemia on the development of offspring as well as the participation of changes in placental epigenetic modifications due to maternal hyperglycemia in intrauterine fetal programming to promote a comprehensive understanding of the impacts of placental epigenetic modifications on the development of offspring from patients with GdM.

关键词： Gestational diabetes mellitus Placental functions Epigenetics Offspring development

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

马克斯·布鲁赫G小调第一小提琴协奏曲演奏分析：探索伟大小提琴家的演奏挑战与诠释选择

马克斯·布鲁赫G小调第一小提琴协奏曲演奏分析：探索伟大小提琴...

引用

作者： d Aung san 成都大学

学位级别：硕士

马克斯·布鲁赫是德国浪漫主义时期的作曲家、小提琴家和指挥家。他的G小调第一小提琴协奏曲被认为是浪漫派时期最重要的协奏曲之一,至今仍是小提琴曲目中最受欢迎的作品之一。这首作品以其抒情的旋律,戏剧性的人物和精湛的独奏段落而... 详细信息

马克斯·布鲁赫是德国浪漫主义时期的作曲家、小提琴家和指挥家。他的G小调第一小提琴协奏曲被认为是浪漫派时期最重要的协奏曲之一,至今仍是小提琴曲目中最受欢迎的作品之一。这首作品以其抒情的旋律,戏剧性的人物和精湛的独奏段落而闻名。此外,这部协奏曲不仅对小提琴家要求了技术挑战和情感深度,而且还要求表演者做出大量不同的音乐诠释。本论文通过对伊扎克·帕尔曼、希拉里·哈恩和马克西姆·文格洛夫等伟大小提琴家们的表演进行分析,探究演奏布鲁赫的G小调第一小提琴协奏曲所涉及的技术挑战和诠释。他们的演奏视频将用于分析每位小提琴家是如何从技术角度处理作品,强调音乐的不同方面并展示他们独特的个人风格和诠释。该研究将重点围绕以下问题:该作品的技术挑战是什么?伟大的小提琴家们在演奏中如何应对这些挑战?不同的小提琴家如何诠释协奏曲的情感表达和音乐表现力?小提琴家以何种方式使用颤音、力度和其他技术来塑造他们对作品的诠释?通过比较和对比这几位伟大小提琴家的演绎,本文将会进一步探究他们在演奏中的差异,并为寻求掌握该作品的表演者提供了解释和帮助。这项研究将深入了解小提琴演奏的细微差别和微妙之处,以及对高水平演奏布鲁赫G小调第一小提琴协奏曲所需的技术和音乐技巧的探究。

关键词：布鲁赫小提琴技巧小提琴演奏诠释

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Optimal aeration management strategy for a small-scale food waste composting

引用

Carbon Resources Conversion 2024年第1期7卷 79-88页

作者： Jia Chi Lai Yi Lung then Siaw san Hwang Chung Sien Lee School of Engineering and Science Faculty of EngineeringComputing and ScienceSwinburne University of Technology93350 KuchingSarawakMalaysia department of Electrical and Electronic Engineering Faculty of EngineeringUniversiti Malaysia Sarawak94300 Kota SamarahanSarawakMalaysia

Food waste is a significant contributor to greenhouse gas emissions when it ends up in *** turns out to be a sustainable solution to this problem,but it requires controlled and continuous airflow for optimal *** study focused on the effect of aeration rates and airflow directions on food waste composting using a closed system with forced *** was entered into the composting vessel in three directions,which were upward,downward,and a combination of both *** direction was run at aeration rates of 0.1,0.4,and 0.7 L/*** findings showed that the compost pile aerated at 0.4 L/min by using two-directional airflow can reach the thermophilic temperature within half of the *** compost pile achieved temperature of 40.94℃ after 10.5 *** the compost experienced slightly high in moisture loss(4.3%),the compost still attained the standard values for *** compost produced from food waste could be applied in soil to improve its fertility.

关键词： Small-scale composting two-directional airflow intermittent aeration Food waste

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

sandwich structures with tapered tubes as core:A quasi-static investigation

引用

defence technology（防务技术） 2024年第3期33卷 447-462页

作者： Xinmei Xiang dehua Shao Xin Zhang Umer Sharif Ngoc san Ha Li Xiang Jing Zhang Jiang Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China Southern Airlines Co. LtdShenzhen BranchShenzhen518000China

in this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3d printing technology was utilized to create the hollow centers of the tapering tubes,with and without *** results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube ***,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their ***,the tapered corrugated tubes'resistance to oblique impacts was *** to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical *** conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall *** and SEA of dtS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to dtS with corrugation number of 10.

关键词： sandwich structure Corrugated tube tapered tube Quasi-static Energy absorption

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：