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Secular decreasing trends in gastric cancer incidence in Taiwan:A population-based cancer registry study

World Journal of Gastroenterology 2021年第34期27卷 5764-5774页

作者： Yen-Tzeng lin Chun-Ju Chiang Ya-Wen Yang Shih-Pei Huang san-lin you School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei City 242008TaiwanChina Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan UniversityTaipei 10617TaiwanChina Department of Medical Education&Bioethics Graduate Institute of Medical Education&BioethicsNational Taiwan University College of MedicineTaipei 10051TaiwanChina School of Medicine&Big Data Research Center Fu Jen Catholic UniversityNew Taipei City 242008TaiwanChina

BACKGROUND Gastric cancer remains a leading cause of cancer death *** Taiwan,gastric cancer is the sixth leading cause of cancer mortality in both males and *** To evaluate secular trends in gastric cancer incidence according to age,sex,and Helicobacter pylori(***)treatment in *** In this population-based study,we used the national Taiwan Cancer Registry *** percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in ***’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for *** *** The annual percent changes showed continuously decreasing rates of gastric cancer among both males and ***,the decreasing trends differed by sex,with an annual percent change of-2.58%in males and-2.14%in *** age-specific incidence rates increased with *** the same age group,more recent time periods showed lower incidence rates than greater time ***,the sex ratio was lower in later birth cohorts than in earlier birth ***-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for *** infection during 2005 to 2016(r=0.72).CONCLUSION We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in *** results support *** eradication programs in Taiwan.

关键词： Gastric cancer Population-based study Taiwan Cancer Registry Sex difference Helicobacter pylori Helicobacter pylori eradication

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Secular trends of intrahepatic cholangiocarcinoma in a high endemic area:A population-based study

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World Journal of Gastroenterology 2022年第28期28卷 3695-3705页

作者： Chun-Ru lin Yu-Kwang Lee Chun-Ju Chiang Ya-Wen Yang Hung-Chuen Chang san-lin you School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei City 242008Taiwan Department of Surgery National Taiwan University HospitalTaipei 100229Taiwan Graduate Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan UniversityTaipei 10055Taiwan Division of Gastroenterology Department of Internal MedicineShin Kong Wu Ho-Su Memorial HospitalTaipei 111045Taiwan School of Medicine and Data Science Center Fu Jen Catholic UniversityNew Taipei City 242008Taiwan

BACKGROUND Intrahepatic cholangiocarcinoma(ICC)is one of the most aggressive ***,because of its scarcity there are limited population-based data available for investigations into its epidemiologic *** Taiwan,we have a national cancer registry database that can be used to evaluate the secular trends of *** To evaluate secular trends of ICC according to age,sex,and risk factors in *** In this population-based study,we used the national Taiwan Cancer Registry ***-standardized and relative percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of ICC in *** The age-standardized ICC incidence rate among males increased from 1.51 per 100000 in 1993-1997 to 4.07 per 100000 in 2013-2017 and among female from 1.73 per 100000 to 2.95 per *** incidence in females tended to plateau after *** males,the ICC incidence increased as age *** the long-term incidence trend of ICC in females,the incidence of the four age groups(40-44,45-49,50-54 and 55-59 years)remained stable in different years;although,the incidence of the 60-64 group had a peak in 2003-2007,and the peak incidence of the 65-69 and 70-74 groups occurred in *** males,beginning at the age of 65,there were increases in the incidence of ICC for the period of 2003-2017 as compared with females in the period of *** Increased incidence of ICC occurred in Taiwan over the past two *** increased incidence has progressively shifted toward younger people for both males and females.

关键词： Intrahepatic cholangiocarcinoma Incidence Secular trend Sex ratio Risk factor

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Fractionated evaluation of immunohistochemical hormone receptor expression enhances prognostic prediction in breast cancer patients treated with tamoxifen as adjuvant therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第1期11卷 1-9页

作者： Ching-hung lin Huang-chun LIEN Fu-chang HU Yen-shen LU Sung-hsin KUO ling-chu WE san-lin you Ann-lii CHENG King-jen CHANG Department of Oncology National Taiwan University Hospital Taiwan Taipei 10016 Department of Pathology National Taiwan University Hospital Taiwan Taipei 10016 National Center of Excellence for General Clinical Trial and Research National Taiwan University Hospital Taiwan Taipei 1001 6 Graduate Institute of Epidemiology College of Public Health National Taiwan University Taiwan Taipei 10055 Department of Surgery National Taiwan University Hospital Taiwan Taipei 10016

Objective： To compare the prognostic prediction between dichotomized and fractionated evaluations of hormone receptor expressions. Methods： Patients with stages Ⅰ-Ⅲ breast cancers, who received adjuvant tamoxifen, were enrolled. The expression of estrogen receptor （ER） and progesterone receptor （PR） was evaluated by immu- nohistochemistry （IHC）. A fractionated score （F score）, the percentage of positive-staining nuclei （0=none, 1=1%-10% 2= 11%-30%, 3=31%-50%, 4=51%-70%, and 5=71%-100%）, was assigned to each case. The dichotomized scoring method defines an F score 〉1 as positive. The prognostic values of both scores were compared by multiple Cox＇s proportional hazard models of disease-free survival （DFS） and overall survival （OS）. Results： Four hundred and six- teen patients with a median follow-up of 78.0 months were included. F scores for ER and PR correlated directly with DFS and OS. Although both the dichotomized and fractionated ER and PR scores were significantly associated with DFS and OS in univariate analyses, only fractionated ER and PR scores remained as independent prognostic factors of DFS and OS in the final multiple Cox＇s proportional hazard models. Conclusion： Fractionated IHC hormone receptor expression evaluation enhances the prognostic prediction compared with a dichotomized assessment.

关键词： Breast cancer Fractionated evaluation Estrogen receptor Progesterone receptor

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Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan

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World Journal of Gastroenterology 2006年第2期12卷 222-227页

作者： Chih-Ching Yeh san-lin you Chien-Jen Chen Fung-Chang Sung Department of Risk Management China Medical University College of Public Health Taichung 404Taiwan China Institutes of Epidemiology National Taiwan University College of Public Health Taipei 100Taiwan China Institute of Environment Health China Medical University College of Public Health Taichung 404 Taiwan and Institute of Environment Health National Taiwan University College of Public Health Taipei 100 Taiwan China

AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.

关键词： Peanuts Colorectal cancer Diet Gender difference Prospective study Taiwan

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Copper-Free Resin-Based Braking Materials:A New Approach for Substituting Copper with Fly-Ash Cenospheres in Composites

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Chinese Journal of Mechanical Engineering 2024年第2期37卷 401-412页

作者： Kaikui Zheng youxi lin Shanmin you Zhiying Ren Jianmeng Huang School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China National United Engineering Laboratory for Advanced Bearing Tribology Henan University of Science and TechnologyLuoyang 471023China

Copper particles emitted from braking have become a significant source of environmental ***,copper plays a crucial role in resin-based braking *** high-performance braking materials without copper has become a significant *** this paper,the resin-based braking materials were filled with flyash cenospheres to develop copper-free braking *** effects of fly-ash cenospheres on the physical properties,mechanical and friction and wear properties of braking materials were ***,the wear mechanism of copper-free resin-based braking materials filled with fly-ash cenospheres was *** results indicate that the inclusion of fly-ash cenospheres in the braking materials improved their thermal stability,hardness and impact strength,reduced their density,effectively increased the friction coefficient at medium and high temperatures,and enhanced the heat-fade resistance of the braking *** inclusion of fly-ash cenospheres contributed to the formation of surface friction film during the friction process of the braking materials,and facilitated the transition of form from abrasive wear to adhesive *** 100-350℃,the friction coefficient of the optimal formulation is in the range of 0.57-0.61,and the wear rate is in the range(0.29-0.65)×10^(-7) cm^(3)·N^(-1)·m^(-1),demonstrating excellent resistance to heat-fade and stability in friction *** research proposes the use of fly-ash cenospheres as a substitute for environmentally harmful and expensive copper in brake materials,which not only improves the performance of braking materials but also reduces their costs.

关键词： Fly-ash cenospheres Braking materials Friction and wear Heat-fade resistance Wear form

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Capacity Market Mechanism Design,Considering Network Optimization and Energy Transition

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1676-1687页

作者： Nan Shang Yihang Song Xiang Zhang you lin China Southern Power Grid Co. Ltd.Guangzhou 510663China Southern Methodist University Junkins 3086251 Airline Road DallasTX 75205US

The coordination of enrgy transition,fixed cost recovery,and sufficient generation supply leads to a new challenge for a traditional capacity market ***,in order to better match network expansion at the same time,it is crucial to redesign the capacity market mechanism considering system *** this paper,a novel capacity market mechanism is proposed considering spot market operations,network expansion,and energy transition,which can minimize the total cost of capacity investment,network expansion,and generation operations,while satisfying the energy transition constraints and topology ***,the capacity market mechanism co-ordinated with spot market operations is illustrated,in which the energy transition and network constraints are ***,a bi-level optimization model is established where the trade organizers minimize the total cost of both investment and operations,subject to the spot power market simultaneously minimizing the local dispatching *** numerical results of a test system show that more economical capacity portfolios can be obtained by constructing reasonable transmission lines,thereby obtaining a more optimal market cost.A detailed multi-scenario simulation is further analyzed to verify the effectiveness of the proposed market mechanism.

关键词： Capacity market energy transition network expansion spot market operation

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High-power,electrically-driven continuous-wave 1.55-μm Si-based multi-quantum well lasers with a wide operating temperature range grown on wafer-scale InP-on-Si(100)heterogeneous substrate

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Light(Science & Applications) 2024年第8期13卷 1512-1523页

作者： Jialiang Sun Jiajie lin Min Zhou Jianjun Zhang Huiyun Liu Tiangui you Xin Ou National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information TechnologyCASShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina College of Information Science and Engineering Jiaxing UniversityJiaxing 314001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences100190 BeijingChina Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

A reliable,efficient and electrically-pumped Si-based laser is considered as the main challenge to achieve the integration of all key building blocks with silicon *** the impressive advances that have been made in developing 1.3-μm Si-based quantum dot(QD)lasers,extending the wavelength window to the widely used 1.55-μm telecommunication region remains *** this study,we develop a novel photonic integration method of epitaxial growth of III-V on a wafer-scale InP-on-Si(100)(InPOS)heterogeneous substrate fabricated by the ion-cutting technique to realize integrated lasers on Si *** ion-cutting plus epitaxial growth approach decouples the correlated root causes of many detrimental dislocations during heteroepitaxial growth,namely lattice and domain *** this approach,we achieved state-of-the-art performance of the electrically-pumped,continuouswave(CW)1.55-μm Si-based laser with a room-temperature threshold current density of 0.65 kA/cm-2,and output power exceeding 155mW per facet without facet coating in CW *** lasing at 120℃ and pulsed lasing at over 130℃ were *** generic approach is also applied to other material systems to provide better performance and more functionalities for photonics and microelectronics.

关键词： pumped power quantum

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Multi-environment BSA-seq using large F3 populations is able to achieve reliable QTL mapping with high power and resolution: An experimental demonstration in rice

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The Crop Journal 2024年第2期12卷 549-557页

作者： Yan Zheng Ei Ei Khine Khin Mar Thi Ei Ei Nyein Likun Huang Lihui lin Xiaofang Xie Min Htay Wai lin Khin Than Oo Myat Myat Moe san san Aye Weiren Wu College of Life Sciences Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Key Laboratory of Genetics Breeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Department of Botany Mawlamyine UniversityMon StateMawlamyineMyanmar Department of Botany Dagon UniversityNorth DagonYangonMyanmar

Bulked-segregant analysis by deep sequencing(BSA-seq) is a widely used method for mapping QTL(quantitative trait loci) due to its simplicity, speed, cost-effectiveness, and efficiency. However, the ability of BSA-seq to detect QTL is often limited by inappropriate experimental designs, as evidenced by numerous practical studies. Most BSA-seq studies have utilized small to medium-sized populations, with F2populations being the most common choice. Nevertheless, theoretical studies have shown that using a large population with an appropriate pool size can significantly enhance the power and resolution of QTL detection in BSA-seq, with F_(3)populations offering notable advantages over F2populations. To provide an experimental demonstration, we tested the power of BSA-seq to identify QTL controlling days from sowing to heading(DTH) in a 7200-plant rice F_(3)population in two environments, with a pool size of approximately 500. Each experiment identified 34 QTL, an order of magnitude greater than reported in most BSA-seq experiments, of which 23 were detected in both experiments, with 17 of these located near41 previously reported QTL and eight cloned genes known to control DTH in rice. These results indicate that QTL mapping by BSA-seq in large F_(3)populations and multi-environment experiments can achieve high power, resolution, and reliability.

关键词： BSA-seq QTL mapping Large F3 population Multi-environment experiment Cross-validation

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Changes in microstructure and properties of weld heat-affected zone of high-strength low-alloy steel

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Journal of Iron and Steel Research International 2024年第8期31卷 2041-2052页

作者： Shu-jun Jia Qi-lin Ma Yu Hou Ba Li He-song Zhang Qing-you Liu Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Collaborative Innovation Center for Steel Commonality University of Science and Technology BeijingBeijing 100083China Construction Project Management Branch of China National Petroleum Pipeline Network Group Co. Ltd.Langfang 065000HebeiChina

The evolution of the microstructure and toughness of APL5L X80 pipeline steel after thermal welding simulation was investigated by X-ray diffraction,electron backscatter diffraction,and transmission electron *** results indicated that primary heat-affected zones can be divided into weld,coarse-grained,fine-grained,intercritical,and sub-critical *** microstructure of the weld zone is mainly composed of bainitic ferrite and a small amount of granular bainite;however,the original austenite grains are distributed in the columnar *** structure of the coarse-grained zone is similar to that of the weld zone,but the original austenite grains are *** contrast,the microstructure in the fine-grained zone is dominated by fine granular bainite,and the effective grain size is only 8.15μm,thus providing the highest toughness in the entire heat-affected *** intercritical and subcritical zones were brittle valley regions,and the microstructure was dominated by granular ***,the martensite-austenite(M/A)constituents are present in island chains along the grain boundaries,and the coarse size of the M/A constituents seriously reduces the *** results of the crack propagation analyzes revealed that high-angle grain boundaries can significantly slow down crack growth and change the crack direction,thereby increasing the material *** impact toughness of the low-temperature tempering zone was equivalent to that of the columnar grain zone,and the impact toughness was between those of the critical and fine-grained zones.

关键词： Welding thermal simulation Impact toughness Crack propagation Martensite-austenite constituent High-strength low-alloy steel weld Heat-affected zone

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lineaperpetua ***.:a new diatom genus in the Thalassiosirales supported by morphology and molecular data

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Journal of Oceanology and Limnology 2024年第1期42卷 277-290页

作者： Pan YU lin YANG Qingmin you John Patrick KOCIOLEK Kangyu WANG Yonghong BI Quanxi WANG College of Life Sciences Shanghai Normal UniversityShanghai 200234China Institute of Hydrobiology Chinese Academy of SciencesWuhan 430072China Museum of Natural History and Department of Ecology and Evolutionary Biology University of ColoradoUCB 218Boulder CO 80309USA

Based on a combination of morphology and molecular data of ribosomal DNA genes,a new diatom genus lineaperpetua ***,you,Kociolek&Wang is *** features that help define lineaperpetua at the level of genus include:a tangentially undulated valve face;continuous cribra areolae on the valve interior consisting of pores arranged as strips;single rimoportula located inside the ring of marginal ***,phylogenetic analysis based on nuclear small subunit(SSU)rDNA sequences and nuclear large subunit(LSU)rDNA gene placed the three strains of *** in a single,monophyletic clade at a considerable sequence distance from the other genera(Thalassiosira,Conticribra,Planktoniella,Shinodiscus,and other genera)belonging to *** the similarities with some species of Thalassiosira,Conticribra,and Spicaticribra,the suite of features found in lineaperpetua differentiate it from these other *** molecular data and morphological characters suggest an affinity of the new genus to the Thalassiosiraceae.

关键词： diatom morphology new genus phylogeny taxonomy Thalassiosiraceae

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