检索结果-南通市图书馆

F-box only protein 2 exacerbates non-alcoholic fatty liver disease by targeting the hydroxyl CoA dehydrogenase alpha subunit

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第28期29卷 4433-4450页

作者： Zhi Liu Ning-Yuan Chen Zhao Zhang Sai Zhou san-Yuan hu Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Shandong Provincial Qian Foshan HospitalShandong UniversityJinan 250014Shandong ProvinceChina Department of General Surgery Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117Shandong ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a major health burden with an increasing global ***,the unavailability of knowledge underlying NAFLD pathogenesis inhibits effective preventive and therapeutic *** To explore the molecular mechanism of *** Whole genome sequencing(WGS)analysis was performed on liver tissues from patients with NAFLD(n=6)and patients with normal metabolic conditions(n=6)to identify the target genes.A NAFLD C57BL6/J mouse model induced by 16 wk of high-fat diet feeding and a hepatocyte-specific F-box only protein 2(FBXO2)overexpression mouse model were used for in vivo *** transfection,co-immunoprecipitation-based mass spectrometry assays,and ubiquitination in HepG2 cells and HEK293T cells were used for in vitro *** A total of 30982 genes were detected in WGS analysis,with 649 up-regulated and 178 *** of FBXO2,an E3 ligase,was upregulated in the liver tissues of patients with ***-specific FBXO2 overexpression facilitated NAFLD-associated phenotypes in *** of FBXO2 aggravated odium oleate(OA)-induced lipid accumulation in HepG2 cells,resulting in an abnormal expression of genes related to lipid metabolism,such as fatty acid synthase,peroxisome proliferator-activated receptor alpha,and so *** contrast,knocking down FBXO2 in HepG2 cells significantly alleviated the OA-induced lipid accumulation and aberrant expression of lipid metabolism *** hydroxyl CoA dehydrogenase alpha subunit(HADHA),a protein involved in oxidative stress,was a target of FBXO2-mediated ***2 directly bound to HADHA and facilitated its proteasomal degradation in HepG2 and HEK293T *** with HADHA alleviated lipid accumulation caused by FBXO2 overexpression in HepG2 *** FBXO2 exacerbates lipid accumulation by targeting HADHA and is a potential therapeutic target for NAFLD。

关键词： F-box only protein 2 Nonalcoholic fatty liver disease The hydroxyl CoA dehydrogenase alpha subunit Liver steatosis Ubiquitination Lipid accumulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

依兰香气组分鉴定与对比分析

中国热带农业 2024年第2期 44-52页

作者：白亭玉张志烽周冰秦晓威王珏胡荣锁中国热带农业科学院香料饮料研究所/海南省热带香辛饮料作物遗传改良与品质调控重点实验室/农业农村部香辛饮料作物遗传资源利用重点实验室海南万宁571533 云南农业大学热带作物学院云南普洱665000 长江师范学院重庆涪陵408107

为鉴定依兰挥发性香气组分,应用水蒸气蒸馏法(SD)、超声—微波辅助萃取法(UMAE)、快速溶剂萃取法(ASE)3种方式,并利用GC-MS对比分析其风味组成和含量差异。结果表明:3种方法共检测出41种组分,其中SD和UMAE检出29种香气,而ASE检出香气最... 详细信息

为鉴定依兰挥发性香气组分,应用水蒸气蒸馏法(SD)、超声—微波辅助萃取法(UMAE)、快速溶剂萃取法(ASE)3种方式,并利用GC-MS对比分析其风味组成和含量差异。结果表明:3种方法共检测出41种组分,其中SD和UMAE检出29种香气,而ASE检出香气最少,为16种;3种方法香气组分存在差异,其中SD以烯烃类挥发性组分为主,UMAE以烯烃类和酯类香气组分为主,ASE以烯烃类和酸类为主。研究为今后依兰挥发性香气组分提取提供方法参考。

关键词：依兰香气成分

Competitive analysis of online inventory problem with interrelated prices

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2017年第2期32卷 237-252页

作者： HAN Shu-guang GUO Jiu-ling ZHANG Lu-ping hu jue-liang JIANG Yi-wei ZHOU Di-wei Department of Mathematics Zhejiang Sci-Tech University School of Computing Engineering and Mathematics University of Brighton

This paper investigates the online inventory problem with interrelated prices in which a decision of when and how much to replenish must be made in an online fashion even without concrete knowledge of future prices. Four new online models with different price corre- lations are proposed in this paper, which are the linear-decrease model, the log-decrease model, the logarithmic model and the exponential model. For the first two models, the online algo- rithms are developed, and as the performance measure of online algorithm, the upper and lower bounds of competitive ratios of the algorithms are derived respectively. For the exponential and logarithmic models, the online algorithms are proposed by the solution of linear programming and the corresponding competitive ratios are analyzed, respectively. Additionally, the algorithm designed for the exponential model is optimal, and the algorithm for the logarithmic model is optimal only under some certain conditions. Moreover, some numerical examples illustrate that the algorithms based on the dprice-conservative strategy are more suitable when the purchase price fluctuates relatively flat.

关键词： online inventory problem interrelated prices competitive analysis.

Prostate cancer identification: quantitative analysis of T2-weighted MR images based on a back propagation artificial neural network model

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2015年第7期58卷 666-673页

作者： ZHAO Kai WANG ChengYan hu Juan YANG XueDong WANG He LI FeiYu ZHANG XiaoDong ZHANG jue WANG XiaoYing Department of Radiology Peking University First Hospital Academy for Advanced Interdisciplinary Studies Peking University

Computer-aided diagnosis(CAD) systems have been proposed to assist radiologists in making diagnostic decisions by providing helpful information. As one of the most important sequences in prostate magnetic resonance imaging(MRI), image features from T2-weighted images(T2WI) were extracted and evaluated for the diagnostic performances by using CAD. We extracted 12 quantitative image features from prostate T2-weighted MR images. The importance of each feature in cancer identification was compared in the peripheral zone(PZ) and central gland(CG), respectively. The performance of the computer-aided diagnosis system supported by an artificial neural network was tested. With computer-aided analysis of T2-weighted images, many characteristic features with different diagnostic capabilities can be extracted. We discovered most of the features(10/12) had significant difference(P<0.01) between PCa and non-PCa in the PZ, while only five features(sum average, minimum value, standard deviation, 10 th percentile, and entropy) had significant difference in CG. CAD prediction by features from T2 w images can reach high accuracy and specificity while maintaining acceptable sensitivity. The outcome is convictive and helpful in medical diagnosis.

关键词： prostate cancer magnetic resonance imaging T2WI diagnosis computer-assisted

Spectrum-effect relationship between HPLC fingerprints and bioactive components of Radix Hedysari on increasing the peak bone mass of rat

在线全文

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第4期9卷 266-273页

作者： Xin-Yue Chen san-hu Gou Zhi-Qiang Shi Zhi-Yuan Xue Shi-Lan Feng School of Pharmacy Lanzhou University

The traditional Chinese medicine of Radix Hedysari plays an important role in invigorating gas for ascending, benefiting blood for promoting production of fluid, and promoting circulation for removing obstruction in collaterals, which is consistent with the principle of treatment for osteoporosis. This study is designed to investigate the bioactive components on increasing peak bone mass (PBM) by exploring the spectrum-effect relationship between chromatography fingerprints and effect. Multiple indicators are selected to evaluate the pharmacological activity. In fingerprints, 21 common peaks are obtained, five of which are identified. Furthermore, gray relational analysis (GRA) is a quantitative method of gray system theory and is used to describe the correlation degree of common peaks and pharmacological activities with relational value. 21 components are then divided into three different regions, of which ononin and calycosin play an extremely significant role in increasing PBM. In addition, factor analysis and hierarchical cluster analysis (HCA) are used to screen the optimal producing area for Radix Hedysari. This provides a comprehensive and efficient method to improve the quality evaluation of Radix Hedysari, confirming the bioactive components for PBM-enhancement and further develop its medicinal value.

关键词： Factor analysis Gray relational analysis Hierarchical cluster analysis Peak bone mass Radix Hedysari Spectrum-effect relationship

Phase-field model of pitting corrosion kinetics in metallic materials

在线全文

学校读者我要写书评

暂无评论

npj Computational Materials 2018年第1期4卷 330-338页

作者： Talha Qasim Ansari Zhihua Xiao Shenyang hu Yulan Li Jing-Li Luo san-Qiang Shi Department of Mechanical Engineering The Hong Kong Polytechnic University11 Yuk Choi RoadHung HomKowloonHong Kong Pacific Northwest National Laboratory RichlandWA 99352USA Department of Chemical and Materials Engineering University of AlbertaEdmontonAB T6G 2R3Canada

Pitting corrosion is one of the most destructive forms of corrosion that can lead to catastrophic failure of *** study presents a thermodynamically consistent phase field model for the quantitative prediction of the pitting corrosion kinetics in metallic *** order parameter is introduced to represent the local physical state of the metal within a metal-electrolyte *** free energy of the system is described in terms of its metal ion concentration and the order *** the ion transport in the electrolyte and the electrochemical reactions at the electrolyte/metal interface are explicitly taken into *** temporal evolution of ion concentration profile and the order parameter field is driven by the reduction in the total free energy of the system and is obtained by numerically solving the governing equations.A calibration study is performed to couple the kinetic interface parameter with the corrosion current density to obtain a direct relationship between overpotential and the kinetic interface *** phase field model is validated against the experimental results,and several examples are presented for applications of the phase-field model to understand the corrosion behavior of closely located pits,stressed material,ceramic particles-reinforced steel,and their crystallographic orientation dependence.

关键词： corrosion pitting steel

Influence of desulfurization slag containing oxides of vanadium and titanium on semi-steel pre-desulfurization

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2022年第6期29卷 939-950页

作者： Bi-wen Yang Yi-hang hu san-ping Liu Xue-dong Zhang Chao-zhen Zheng Hai-bei Wang Research and Design Institute of Metallurgical BGRIMM Technology GroupBeijing 100160China College of Engineering Peking UniversityBeijing 100871China

The desulfurization and resulfurization of slag containing oxides of vanadium and titanium(CaO–SiO_(2)–MgO–Al_(2)O_(3)–V_(2)O_(3)–TiO_(2)–FeO)in the pretreatment of semi-steel desulfurization at 1623 K were *** on the ionic structure theory of slag,it could be concluded that V_(2)O_(3) and TiO_(2) combined with(O_(2)–)to form complex anions including VO_(3)^(3–),TiO_(4)^(4–),etc.,which reduced the activity of(O_(2)–)and decreased the sulfur partition ratio(LS).And FeO enhanced the activity of[O]at the slag–metal interface,which decreased the desulfurization capacity of the *** to the binary basicity,the presented basicity expression containing V_(2)O_(3) and TiO_(2) described the relationship between LS and basicity more *** the problems of dilute slag,a large amount of residual slag and much resulfurization in the slagging-off process after pretreatment,the effect of CaO+C-based slag modifier on the resulfurization,melting point and viscosity of the desulfurization slag was *** was proposed that adding 5%–10%of the slag modifier to the desulfurization slag after desulfurization decreased the resulfurization *** the added modifier adjusted the slag viscosity well,which helped to reduce iron loss and residual slag.

关键词： Semi-steel Desulfurization Resulfurization Vanadium oxide Titanium oxide Slag modifier

A Thermochemical Study on Complex Nickel(Ⅱ) L-α-Histidine

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2003年第2期19卷 227-230页

作者： GAO Sheng li CHEN san ping hu Rong zu SHI Qi zhen Shaanxi Key Laboratory of Physico Inorganic Chemistry Department of ChemistryNorthwest UniversityXi′an 710069P.R.China

The formation enthalpy of complex nickel(Ⅱ) histidine(His) in water was determined by means of microcalorimetry in the temperature range of 298 15-323 15 K. The standard enthalpy of the formation of Ni(His) 2+ 2(aq) was calculated. On the basis of the experimental and the calculated results, three thermodynamic parameters(the activation enthalpy, the activation entropy and the activation free energy), the rate constants, three kinetic parameters(the apparent activation energy, the pre exponential constant and the reaction order) of the formation reaction of the title complex were obtained.

关键词： Nickel chloride L-α-Histidine Complex Formation reaction Thermokinetics

Vibration attenuation of meta-mortar with spring-mass resonators

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2023年第2期20卷 11-23页

作者： san-feng Liu Hai-long Chen Yang Liu hu-guang He Xi-yue An Feng-nian Jin hua-lin Fan State Key Laboratory for Disaster Prevention&Mitigation of Explosion&Impact Army Engineering University of PLANanjing210007China Research Center of Lightweight Structures and Intelligent Manufacturing State Key Laboratory of Mechanics and Control of Mechanical StructuresNanjing University of Aeronautics and AstronauticsNanjing210016China

Metamaterial based on local resonance has excellent vibration attenuation ability in low *** this research,an attempt was performed to make meta-mortar with spring-mass resonators to attenuate vibration and shock ***-spring-mass resonators and dual-spring-mass resonators were designed and made using lead or aluminum blocks and SWPB springs encased by PMMA(polymethyl methacrylate)or aluminum *** resonators were placed into mortar blocks to make metamortar *** attenuation effect was investigated by sweeping vibration with frequency from 50 Hz to 2000 *** these meta-mortar blocks exhibit excellent vibration attenuation ability in the designed band *** dual-spring-mass resonators,meta-mortar blocks have two distinct vibration attenuation bands.

关键词： Meta-mortar Vibration attenuation Spring-mass resonators