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Science China Chemistry 2024年

作者： Wenbin li Jie gan Qing Guo Sai Zhang Yongquan Qu School of Chemistry and Chemical Engineering Northwestern Polytechnical University School of Materials and Environmental Engineering Chizhou University Research & Development Institute of Northwestern Polytechnical University in Shenzhen

Acquiring descriptors to guide catalyst design is an ideal but challenging topic in the field of heterogeneous catalysis. Herein, the adsorption energy of H*(Ead（H）) has been established to describe the catalytic activity of dual-active sites of single-atom metals and frustrated lewis pairs （FlPs） on the porous nanorod of CeO2surface （M1/PN-CeO2） for reverse water-gas shift （RWGS）reaction. H2and CO2molecules are adsorbed and activated on single-atom metals and FlP sites, respectively, facilitating the RWGS reaction through the H*spillover from single-atom metals to PN-CeO2supports. Mechanistic investigations illustrate that the generation of H*on the single-atom metals and subsequent migration towards FlP are critical steps, determining the performance of M1/PN–CeO2for RWGS reaction. A volcanic correlation is observed between Ead（H） and catalytic activity of M1/PN–CeO2for RWGS. The Pt1/PN–CeO2catalysts with a minimal deviation of-0.01 eV from the experimentally optimized Ead（H） of-1.88 eV, exhibited an exceptional turnover frequency of 33,605 h-1and surpassed a turnover number of 20,000,000for each Pt active site during a period of 650 h at 600°C. These findings could pave the way for the rational design of highly active and durable catalysts for RWGS reaction.

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： samuel Abokyi Dennis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

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Mitophagy and cGAS-STING crosstalk in neuroinflammation

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3327-3361页

作者： Xiaogang Zhou Jing Wang lu Yu gan Qiao Dalian Qin Betty Yuen-Kwan law Fang Ren Jianming Wu Anguo Wu Sichuan Key Medical laboratory of New Drug Discovery and Drugability Evaluation Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia MedicaKey Laboratory of Medical Electrophysiology of Ministry of EducationSchool of PharmacySouthwest Medical UniversityLuzhou 646000China State Key laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao SAR 999078China Chongqing Key laboratory of Sichuan-Chongqing Co-construction for Diagnosis and Treatment of Infectious Diseases Integrated Traditional Chinese and Western Medicine Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

Mitophagy,essential for mitochondrial health,selectively degrades damaged *** is intricately linked to the cGAS-STING pathway,which is crucial for innate *** pathway responds to mitochondrial DNA and is associated with cellular stress *** review explores the molecular details and regulatory mechanisms of mitophagy and the cGAS-STING *** critically evaluate the literature demonstrating how dysfunctional mitophagy leads to neuroinflammatory conditions,primarily through the accumulation of damaged mitochondria,which activates the cGAS-STING *** activation prompts the production of pro-inflammatory cytokines,exacerbating *** review emphasizes the interaction between mitophagy and the cGAS-STING *** mitophagy may suppress the cGAS-STING pathway,offering protection against ***,impaired mitophagy may activate the cGAS-STING pathway,leading to chronic ***,we explored how this interaction influences neurodegenerative disorders,suggesting a common mechanism underlying these *** conclusion,there is a need for additional targeted research to unravel the complexities of mitophagy-cGAS-STING interactions and their role in *** review highlights potential therapies targeting these pathways,potentially leading to new treatments for neuroinflammatory and neurodegenerative *** synthesis enhances our understanding of the cellular and molecular foundations of neuroinflammation and opens new therapeutic avenues for neurodegenerative disease research.

关键词： Neuroinflammation Mitophagy cGAS-STING Innate immunity Mitochondrial DNA Crosstalk Therapeutic avenues Neurodegenerative diseases

Solid-state non-volatile memories based on vdW heterostructure-based vertical-transport ferroelectric field-effect transistors

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Science China(Information Sciences) 2024年第6期67卷 198-206页

作者： Qiyu YANG Zheng-Dong lUO Fei XIAO Junpeng ZHANG Dawei ZHANG Dongxin TAN Xuetao gan Yan lIU Zhufei CHU Yinshui XIA Genquan HAN Hangzhou Institute of Technology Xidian University State Key Discipline laboratory of Wide Band Gap Semiconductor Technology School of MicroelectronicsXidian University School of Artificial Intelligence Xidian University School of Materials Science and Engineering University of New South Wales (UNSW) Sydney ARC Centre of Excellence in Future low-Energy Electronics Technologies (FlEET) University of New South Wales (UNSW) Sydney Key laboratory of light Field Manipulation and Information Acquisition Ministry of Industry and Information Technologyand Shaanxi Key Laboratory of Optical Information TechnologySchool of Physical Science and TechnologyNorthwestern Polytechnical University Faculty of Electrical Engineering and Computer Science Ningbo University

Driven by the explosive development of data-centric computation applications, it is becoming urgent to develop in-memory computing devices that are beyond the von Neumann architecture with an arrangement of separated logic and memory components. The transistor-type solid-state non-volatile memories,such as ferroelectric field-effect transistors(Fe FETs), have long been regarded as a competitive candidate for future in-memory computing architectures. However, the density scaling towards high-density arrays would require advanced Fe FETs with reduced footprints, which remains a great challenge so far. Here, a vertical-transport(VT) Fe FET that flips the charge transport channel perpendicular to the substrate plane is proposed, in which a ferroelectric gate and a van der Waals(vd W) heterojunction channel are vertically integrated, effectively reducing the device footprints. The proposed VT-Fe FET shows not only the robust binary non-volatile memory states but also several key synaptic functionalities at the device level. An artificial neural network with supervised learning was simulated based on the device conductance switching properties,showing excellent classification accuracy for the MNIST handwritten digits. These findings suggest that the proposed VT-Fe FET could offer a new solution for future non-volatile memories as well as more advanced neuromorphic systems.

关键词： vdW heterostructure non-volatile memory vertical-transport transistor ferroelectric field-effect transistor memristive devices

Dynamical Dark Energy in light of Cosmic Distance Measurements.Ⅱ.A Study Using Current Observations

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Research in Astronomy and Astrophysics 2024年第6期24卷 15-20页

作者： Xiaoma Wang gan Gu Xiaoyong Mu Shuo Yuan Gong-Bo Zhao National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Frontiers in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China

We extract key information on dark energy from current observations of BAO,OHD and H_(0),and find hints of dynamical behavior of dark *** particular,a dynamical dark energy model whose equation of state crosses-1 is f... 详细信息

关键词： Cosmology (cosmology:)dark energy cosmology:observations

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The function of doping nitrogen on removing fluoride with decomposing la-MOF-NH_2:Density functional theory calculation and experiments

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Journal of Environmental Sciences 2024年第1期135卷 118-129页

作者： Hongguo Zhang KuilinWan Jia Yan Qian li Yufang Guo lei Huang samuel Raj Babu Arulmani Jian luo School of Environmental Science and Engineering Guangzhou UniversityGuangzhou 510006China Guangzhou University-linkoping University Research Center on Urban Sustainable Development Guangzhou UniversityGuangzhou 510006China School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

Fluoride is an important pollutant in wastewater,and adsorption is an effective way to remove *** nitrogen plays an important role in adsorbent materials,computational models were developed to understand the changes in work function resulting from nitrogen ***-N-C-800℃,was prepared by pyrolyzing la-MOF-NH_(2)to verify the influence on the performance of removing fluoride by *** and electrochemical performance tests were performed to characterize la-N-C-800℃.Adsorption kinetics,adsorption thermodynamics,initial concentrations,pH,and ions competition were investigated using la-N-C-800℃for fluoride *** addition,density functional theory was applied to evaluate the function of *** nitrogen atoms were added,the density of states,partial density of states,populations,and different orbits of charge were calculated to discover deep *** strengthened the carbon structure and la_(2)O_(3)structure to remove *** addition,nitrogen can also act as an adsorption site in the carbon *** results provide design ideas for improving the performance of adsorbent materials by doping elements.

关键词： Capacitive deionization Fluoride la-MOFs Doping nitrogen

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Exceptional catalytic effect of novel rGO-supported Ni-Nb nanocomposite on the hydrogen storage properties of MgH_(2)

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Journal of Materials Science & Technology 2024年第5期172卷 83-93页

作者： samuel Guemou liuting Zhang Shuai li Yiqun Jiang Tao Zhong Zichuan lu Ren Zhou Fuying Wu Qian li School of Energy and Power Instrumental Analysis CenterJiangsu University of Science and TechnologyZhenjiang 212003China National Engineering Research Center for Magnesium Alloys&National Key laboratory of Advanced Casting Technologies&College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Chongqing Institute of New Energy Storage Materials and Equipment Chongqing 401135China Max Planck Institute for Iron Research Düsseldorf 40237Germany

The design of an excellent active catalyst to improve the sluggish kinetic and thermodynamic properties of magnesium hydride(MgH_(2))remains a great challenge to achieve its practical *** this study,a novel Ni-Nb/rGO nanocomposite catalyst was successfully prepared by one-spot hydrothermal and sub-sequent calcination *** novel Ni-Nb/rGO nanocomposite exhibits an exceptional catalytic effect on improving MgH_(2) sorption ***,the onset desorption temperature of MgH_(2)+10 wt%Ni-Nb/rGO composite is reduced to 198℃,much lower than that of undoped MgH_(2)(330℃).In-terestingly,the composite can release 5.0,5.9,and 6.0 wt%H_(2) within 10 min at 245,260,and 275℃,***,the dehydrogenated MgH_(2)+10 wt%Ni-Nb/rGO composite starts to absorb hydrogen even at room temperature with approximate 2.75 wt%H_(2) uptake at 75℃under 3 MPa H_(2) pressure within 30 min and exhibits excellent stability by maintaining 6.0 wt%hydrogen content after 20 cycles at 300℃.Chou’s model suggests that the de/hydrogenation kinetics of Ni-Nb/rGO-modified MgH_(2) switches from surface penetration model to diffusion model at lower ***,the ac-tivation energies(E a)for the de/hydrogenation of MgH_(2)+10 wt%Ni-Nb/rGO are reduced to 57.8 kJ/mol and 33.9 kJ/mol,which are significantly lower than those of undoped MgH_(2).The work demonstrates that the addition of a novel ternary Ni-Nb/rGO catalyst is an effective strategy to not only boost the sorption kinetics of MgH_(2) but also maintain its cycling property.

关键词： Hydrogen storage materials Magnesium hydride Ni-Nb/rGO Kinetic analysis Catalytic mechanism

The“depict”strategy for discovering new compounds in complex matrices:lycibarbarspermidines as a case

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Journal of Pharmaceutical Analysis 2024年第3期14卷 416-426页

作者： Chen Han Zhixin Zhang Zhiyang Feng Chuanjia Zhai Xuejiao li Yulian Shi Xiang li Miao li Ying Wang gan luo Xiaoyan Gao Department of Chinese Medicine Analysis School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijing102488China

The comprehensive detection and identification of active ingredients in complex matrices is a crucial *** chromatography coupled with high-resolution mass spectrometry(lC-HRMS)is the most prominent analytical platform for the exploration of novel active compounds from complex ***,the lC-HRMS-based analysis workflow suffers from several bottleneck issues,such as trace content of target compounds,limited acquisition for fragment information,and uncertainty in interpreting relevant MS2 *** are vital antioxidant active ingredients in lycii Fructus,while the reported structures are merely focused on dicaffeoylspermidines due to their low *** comprehensively detect the new structures of lycibarbarspermidine derivatives,a“depict”strategy was developed in this ***,potential new lycibarbarspermidine derivatives were designed according to the biosynthetic pathway,and a comprehensive database was established,which enlarged the coverage of lycibarbarspermidine ***,the polarity-oriented sample preparation of potential new compounds increased the concentration of the target ***,the construction of the molecular network based on the fragmentation pathway of lycibarbarspermidine derivatives broadened the comprehensiveness of ***,the weak response signals were captured by data-dependent scanning(DDA)followed by parallel reaction monitoring(PRM),and the efficiency of acquiring MS2 fragment ions of target compounds was significantly *** on the integrated strategy above,210 lycibarbarspermidine derivatives were detected and identified from lycii Fructus,and in particular,170 potential new compounds were structurally *** integrated strategy improved the sensitivity of detection and the coverage of low-response components,and it is expected to be a promising pipeline for discovering new compounds.

关键词： Mass spectrometric detection Weak response signals Complex matrices Novel lycibarbarspermidines

Synergetic PVA degradation and H2 evolution in photocatalytic fuel cells using Ag@Fe_(2)O_(3) cathode

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Frontiers of Chemical Science and Engineering 2024年第1期18卷 85-93页

作者： likun Sun Kesi Xiong Baoning Zhang Jinghong Fang Yingchao He Min Wang Zhixing gan Fanglin Du Qiong Sun liyan Yu lifeng Dong College of Materials Science and Engineering Qingdao University of Science and TechnologyQingdao 266042China Center for Future Optoelectronic Functional Materials School of Computer and Electronic InformationNanjing Normal UniversityNanjing 210023China Department of Physics Hamline UniversitySt.Paul 55104USA

In a dual-chamber photocatalytic fuel cell device,polyvinyl alcohol degradation and H2 evolution were concurrently *** setup involved commercial P25 as the photoanode and Ag@Fe_(2)O_(3) nanoparticles as the ***,the feasibility of a Fentonlike reaction in the cathode,utilizing Fe^(2+)ions and pumped O_(2),was *** cathode materials,polyvinyl alcohol types,and pH values’effects were assessed on device *** tests highlighted photoinduced holes(h+)and OH·radicals as pivotal contributions to polyvinyl alcohol ***-term stability of the device was established through cycling experiments.

关键词： photocatalytic fuel cell PVA Ag@Fe_(2)O_(3) cathode materials Fenton-like reaction

Bismuth clusters pinned on TiO_(2) porous nanowires boosting charge transfer for CO_(2) photoreduction to CH_(4)

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Nano Research 2024年第3期17卷 1190-1198页

作者： Jiazhi Meng Kaiwen Wang Yang Wang Jiangping Ma Chaogang Ban Yajie Feng Bin Zhang Kai Zhou liyong gan Guang Han Danmei Yu Xiaoyuan Zhou College of Physics and Institute of Advanced Interdisciplinary Studies Chongqing UniversityChongqing 401331China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing 401331China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China Beijing Key lab of Microstructure and Properties of Advanced Materials Beijing University of TechnologyBeijing 100124China Analytical and Testing Center Chongqing UniversityChongqing 401331China

Artificial photosynthesis in carbon dioxide(CO_(2))conversion into value-added chemicals attracts considerable attention but suffers from the low activity induced by sluggish separation of photogenerated carriers and the kinetic bottleneck-induced unsatisfied ***,we prepare a new-style Bi/TiO_(2) catalyst formed by pinning bismuth clusters on TiO_(2) nanowires through being confined by pores,which exhibits high activity and selectivity towards photocatalytic production of CH_(4) from CO_(2).Boosted charge transfer from TiO_(2) through Bi to the reactants is revealed via in situ X-ray photon spectroscopy and time-resolved photoluminescence(Pl).Further,in situ Fourier transform infrared results confirm that Bi/TiO_(2) not only overcomes the multi-electron kinetics challenge of CO_(2) to CH_(4) via boosting charge transfer,but also facilitates proton production and transfer as well as the intermediates*CHO and*CH_(3)O generation,ultimately achieving the tandem catalysis towards *** calculation also underlies that the more favorable reaction step from*CO to*CHO on Bi/TiO_(2) results in CH_(4) production with higher *** work brings new insights into rational design of photocatalysts with high performance and the formation mechanism of CO_(2) to CH_(4) for solar energy storage in future.

关键词： carbon dioxide(CO_(2))photoreduction charge transfer tandem catalysis methanation