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城市环境设计 2020年第4期126卷 200-211页

作者：沃尔夫·狄·普瑞克斯 Jessie Castro Jessie Chen Jasmin Dieterle Luis Ferreira Peter Grell Paul Hoszowsky Dimitar Ivanov Ivana Jug Zhu Yuang Kang Alexander Karaivanov Nam La-Chi Rodelle Lee Feng Lei Megan Lepp samuel liew Thomas Margaretha Jens Mehlan Ivo de Nooijer Reinhard Platzl Vincenzo Possenti Pete Rose Ana Santos Jutta Sch?dler Jaclyn L. Spokojny Günther Weber Chen Yue Markus Pillhofer COOP HIMMELB(L)AU Szeto Wing Duccio Malagamba ShuHe Julien Lanoo

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition （1st Prize）:2007规划设计起始时间/Start of Planning:2008动工/Start of Construction:2013竣工/Completion:2016项目参数/PROJECT DATA用地面积/Site Area:21 688m2建筑毛面积/Gross Floor Area:80 000m2建筑高度-长度-宽度/Building Height-Length-Width:40m-160m-140m层数/Number of Storeys:7

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Use of blood based biomarkers in the evaluation of Crohn's disease and ulcerative colitis

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World Journal of Gastrointestinal Endoscopy 2015年第17期7卷 1233-1237页

作者： Edward L Barnes Choong-Chin liew samuel Chao Robert Burakoff Division of Gastroenterology Hepatologyand EndoscopyBrigham and Women’s Hospital Golden Health Diagnostics Inc. GeneNews

Despite significant improvements in our understanding of Crohn's disease(CD) and ulcerative colitis(UC) in recent years, questions remain regarding the best approaches to assessment and management of these chronic diseases during periods of both relapse and remission. Various serologic biomarkers have been used in the evaluation of patients with both suspected and documented inflammatory bowel disease(IBD), and while each has potential utility in the assessment of patients with IBD, potential limitation remain with each method of assessment. Given these potential shortcomings, there has been increased interest in other means of evaluation of patients with IBD, including an expanding interest in the role of gene expression profiling. Among patients with IBD, gene expression profiles obtained from whole blood have been used to differentiate active from inactive CD, as well as to differentiate between CD, UC, and non-inflammatory diarrheal conditions. There are many opportunities for a non-invasive, blood based test to aid in the assessment of patients with IBD, particularly when considering more invasive means of evaluation including endoscopy with biopsy. Furthermore, as the emphasis on personalized medicine continues to increase, the potential ability of gene expression analysis to predict patient response to individual therapies offers great promise. While whole blood gene expression analysis may not completely replace more traditional means of evaluating patients with suspected or known IBD, it does offer significant potential to expand our knowledge of the underlying genes involved in the development of these diseases.

关键词： Inflammatory bowel disease Ulcerative colitis Gene

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