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神经密码协议模型研究

计算机研究与发展 2009年第8期46卷 1316-1324页

作者：陈铁明 samuel h.huang 刘多蔡家楣北京航空航天大学软件开发环境国家重点实验室北京100191 浙江工业大学计算机科学与技术学院杭州310014 辛辛那提大学智能系统实验室美国俄亥俄州辛辛那提45221

利用离散的神经网络模型构建密码协议是信息安全领域一项新的研究内容.首先介绍了一个基于神经网络的树型奇偶机模型,在综述基于树型奇偶机的神经密码协议研究基础上,分析了神经密码协议的权值同步方案存在模型稳定性和同步判定安全性问... 详细信息

利用离散的神经网络模型构建密码协议是信息安全领域一项新的研究内容.首先介绍了一个基于神经网络的树型奇偶机模型,在综述基于树型奇偶机的神经密码协议研究基础上,分析了神经密码协议的权值同步方案存在模型稳定性和同步判定安全性问题,分别提出在激活函数中增加阈值和利用hash函数判定同步权值的改进方法,并利用方差分析和统计实验给出仿真结果,证实了神经密码协议的可行性,最后讨论了协议模型的安全攻击问题.

关键词：神经网络树型奇偶机权值同步密码协议密钥协商

Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

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Signal Transduction and Targeted Therapy 2019年第1期4卷 592-601页

作者： Simon Vyse Paul h.huang Division of Molecular Pathology The Institute of Cancer ResearchLondon SW36JBUnited Kingdom

Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor(EGFR)gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer(NSCLC).however,unlike the classical EGFR L858R point mutation or exon 19 deletions,which represent the majority of EGFR mutations in NSCLC,low frequency EGFR exon 20 insertion mutations are associated with de novo resistance to targeted EGFR inhibitors and correlate with a poor patient ***,we review the developments over the last 5 years in which pre-clinical studies,including elucidation of the crystal structure of an EGFR exon 20 insertion mutant kinase,have revealed a unique mechanism of kinase activation and steric conformation that define the lack of response of these EGFR mutations to clinically approved EGFR *** recent development of several novel small molecule compounds that selectively inhibit EGFR exon 20 insertions holds promise for future therapeutic options that will be effective for patients with this molecular subtype of NSCLC.

关键词： insertion lung cancer

Elevated NKCC1 transporter expression facilitates early post-traumatic brain injury seizures

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Neural Regeneration Research 2017年第3期12卷 401-402页

作者： Buqing Liang Jason h.huang Department of Neurosurgery Neuroscience InstituteBaylor Scott&White HealthCentral DivisionTempleTXUSA Department of Surgery Texas A&M University Health ScienceCenterCollege of MedicineTempleTXUSA

As a leading cause for morbidity and mortality in young adults,traumatic brain injury（TBI）,along with the poorly understood TBI-related seizures inducing their predispositions,pose a major health and socioeconomic p... 详细信息

关键词： TBI Elevated NKCC1 transporter expression facilitates early post-traumatic brain injury seizures Cl TGF

Transcranial photobiomodulation with near-infrared light:a promising therapeutic modality for Alzheimer's disease

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Neural Regeneration Research 2023年第9期18卷 1944-1945页

作者： hanli Liu Damir Nizamutdinov Jason h.huang Bioengineering Department the University of Texas at ArlingtonArlingtonTXUSA Neurosurgery Neuroscience InstituteBaylor Scott and White HealthTempleTXUSA Neurosurgery College of MedicineTexas A&M UniversityTempleTXUSA

Transcranial photobiomodulation(tPBM) is a noninvasive neuromodulation technique that delivers near-infrared(NIR) light with low irradiance(i.e.,power density in mW/cm2) in the wavelength range of 800-1070 *** recently published books or collected literature(hamblin,2019;GonzalezLima,2021) and papers(Nizamutdinov et al. 2022)offer comprehensive reviews of the mechanism of action and potential clinical translations of tPBM for the treatment of a variety of diseases,including neurodegenerative diseases(Alzheimer’s disease(AD),and Parkinson’s disease),traumatic brain injury.

关键词： Alzheimer diseases

Astrocytic calcium waves:unveiling their roles in sleep and arousal modulation

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Neural Regeneration Research 2024年第5期19卷 984-987页

作者： Erxi Wu Dan Qi Damir Nizamutdinov Jason h.huang Department of Neurosurgery and Neuroscience Institute Baylor Scott&White HealthTempleTXUSA Texas A&M University School of Medicine TempleTXUSA Texas A&M University School of Pharmacy College StationTXUSA LIVESTRONG Cancer Institutes and Department of Oncology Dell Medical Schoolthe University of Texas at AustinAustinTXUSA Department of Neurosurgery Baylor College of MedicineTempleTXUSA

Neuron-astrocyte interactions are vital for the brain’s *** astrocyte activities is crucial for comprehending the complex neural network,particularly the population-level functions of neurons in different cortical states and associated behaviors in *** on animal sleep and wakefulness have revealed distinct cortical synchrony patterns between ***,outnumbering neurons by nearly fivefold,support and regulate neuronal and synaptic *** research on astrocyte activation during cortical state transitions has emphasized the influence of norepinephrine as a neurotransmitter and calcium waves as key components of ion channel *** summary focuses on a few recent studies investigating astrocyte-neuron interactions in mouse models during sleep,wakefulness,and arousal levels,exploring the involvement of noradrenaline signaling,ion channels,and glutamatergic signaling in different cortical *** findings highlight the significant impact of astrocytes on large-scale neuronal networks,influencing brain activity and *** astrocytic signaling pathways shows promise for treating sleep disorders and arousal *** research is needed to understand astrocytic calcium signaling in different brain regions and its implications for dysregulated brain states,requiring future human studies to comprehensively investigate neuron-astrocyte interactions and pave the way for therapeutic interventions in sleep-and arousal-related disorders.

关键词： arousal astrocyte calcium waves locus coeruleus neuron-astrocyte interaction norepinephrine sleep wakefulness

An update–tissue engineered nerve grafts for the repair of peripheral nerve injuries

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Neural Regeneration Research 2018年第5期13卷 764-774页

作者： Nitesh P.Patel Kristopher A.Lyon Jason h.huang Texas A&M College of Medicine Temple TX USA Department of Neurosurgery Baylor Scott & White Healthcare Temple TX USA

Peripheral nerve injuries（PNI） are caused by a range of etiologies and result in a broad spectrum of disability. While nerve autografts are the current gold standard for the reconstruction of extensive nerve damage, the limited supply of autologous nerve and complications associated with harvesting nerve from a second surgical site has driven groups from multiple disciplines, including biomedical engineering, neurosurgery, plastic surgery, and orthopedic surgery, to develop a suitable or superior alternative to autografting. Over the last couple of decades, various types of scaffolds, such as acellular nerve grafts（ANGs）, nerve guidance conduits, and non-nervous tissues, have been filled with Schwann cells, stem cells, and/or neurotrophic factors to develop tissue engineered nerve grafts（TENGs）. Although these have shown promising effects on peripheral nerve regeneration in experimental models, the autograft has remained the gold standard for large nerve gaps. This review provides a discussion of recent advances in the development of TENGs and their efficacy in experimental models. Specifically, TENGs have been enhanced via incorporation of genetically engineered cells, methods to improve stem cell survival and differentiation, optimized delivery of neurotrophic factors via drug delivery systems（DDS）, co-administration of platelet-rich plasma（PRP）, and pretreatment with chondroitinase ABC（Ch-ABC）. Other notable advancements include conduits that have been bioengineered to mimic native nerve structure via cell-derived extracellular matrix（ECM） deposition, and the development of transplantable living nervous tissue constructs from rat and human dorsal root ganglia（DRG） neurons. Grafts composed of non-nervous tissues, such as vein, artery, and muscle, will be briefly discussed.

关键词： peripheral nerve injury peripheral nerve repair tissue engineered nerve graft nerve conduit stem cells Schwann cells dorsal root ganglia neurons axon stretch-growth autologous tissue graft

Pazopanib in advanced soft tissue sarcomas

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Signal Transduction and Targeted Therapy 2019年第1期4卷 538-547页

作者： Alex T.J.Lee Robin L.Jones Paul h.huang Division of Molecular Pathology The Institute of Cancer ResearchLondonUK Sarcoma Unit The Royal Marsden NHS Foundation TrustLondonUK Division of Clinical Studies Institute of Cancer ResearchLondonUK

Pazopanib is the first and only tyrosine kinase inhibitor currently approved for the treatment of multiple histological subtypes of soft tissue sarcoma(STS).Initially developed as a small molecule inhibitor of vascular endothelial growth factor receptors,preclinical work indicates that pazopanib exerts an anticancer effect through the inhibition of both angiogenic and oncogenic signaling *** the establishment of optimal dosing and safety profiles in early phase studies and approval for the treatment of advanced renal cell carcinoma,pazopanib was investigated in STS.A landmark phase III randomized study demonstrated improved progression-free survival with pazopanib compared to that with placebo in pretreated patients with STS of various *** efficacy of pazopanib in specific STS subtypes has been further described in real-world-based case series in both mixed and subtype-specific STS *** present,there are no clinically validated predictive biomarkers for use in selecting patients with advanced STS for pazopanib therapy,limiting the clinical effectiveness and cost-effectiveness of the *** this review,we summarize the preclinical and clinical data for pazopanib,outline the evidence base for its effect in STS and explore reported studies that have investigated putative biomarkers.

关键词： sarcoma clinical approval

Repairing peripheral nerve injury using tissue engineering techniques

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Neural Regeneration Research 2015年第9期10卷 1393-1394页

作者： Ernest W.Wang Jun Zhang Jason h.huang Department of Neurosurgery Baylor Scott & White Department of Neurosurgery PLA General Hospital

Each year approximately 360,000 people in the United States suffer a peripheral nerve injury （PNI）, which is a leading source of lifelong disability （Kelsey et al., 1997; Noble et al., 1998）. The most frequent cause of PNIs is motor vehicle accidents, while gunshot wounds, stabbings, and birth trauma are also common factors. Patients suffering from disabilities as a result of their PNIs are also burdensome to the healthcare system, with aver- age hospital stays of 28 days each year （Kelsey et al., 1997; Noble et al., 1998）.

关键词： PNI Repairing peripheral nerve injury using tissue engineering techniques DRG

Grown-in Defects of InSb Crystals:Models and Computation

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Communications in Computational Physics 2006年第3期1卷 511-527页

作者： N.Vaidya h.huang D.Liang Department of Mathematics and Statistics York UniversityToronto M3J 1P3Canada

In this paper,we present a model for grown-in point defects inside indium antimonide crystals grown by the Czochralski(CZ)*** model is similar to the ones used for silicon crystal,which includes the Fickian diffusion and a recombina-tion *** type of models is used for the first time to analyze grown-in point defects in indium antimonide *** temperature solution and the advance of the melt-crystal interface,which determines the time-dependent domain of the model,are based on a recently derived perturbation *** propose a finite difference method which takes into account the moving *** study the effect of thermal flux on the point defect patterns during and at the end of the growth *** results show that the concentration of excessive point defects is positively correlated to the heat flux in the system.

关键词： Crystal growth Czochralski technique point defects recombination thermal flux finite difference method