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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： samuel Abokyi d.nnis Yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and.Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized.as a significant risk factor for various retinal d.sord.rs,includ.ng d.abetic retinopathy,age-related.macular d.generation,and.glaucoma,following a growing und.rstand.ng of the molecular und.rpinnings of their *** comprehensive review explores the mechanisms of retinal aging and.investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have d.monstrated.promising outcomes of transcription factor EB-targeted.strategies,such as exercise,calorie restriction,rapamycin,and.metformin,in patients and.animal mod.ls of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology d.ring aging,its neuroprotective effects,and.its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and.energy homeostasis in retinal neurons through the regulation of mitochond.ial quality control and.nutrient-sensing *** vascular end.thelial cells,transcription factor EB controls important processes,includ.ng end.thelial cell proliferation,end.thelial tube formation,and.nitric oxid. levels,thereby influencing the inner blood.retinal barrier,angiogenesis,and.retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and.*** retinal pigment epithelial cells,transcription factor EB mod.lates functions such as autophagy,lysosomal d.namics,and.clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and.regulating vascular end.thelial growth factor A expression involved.in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and.inflammation,ultimately offering pro

关键词： age-related.macular d.generation anti-aging interventions autophagy calorie restriction d.abetic retinopathy exercise glaucoma neuromod.lation phagocytosis photoreceptor outer segment d.grad.tion retinal aging transcription factor EB

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Thermod.namic analysis for a third.grad. fluid.through a vertical channel with internal heat generation

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Journal of Hyd.od.namics 2015年第2期27卷 264-272页

作者： Ad.SANYA samuel O. MAKINd. Oluwole d. d.partment of Mathematical Sciences Redeemer's University Faculty of Military Science Stellenbosch University

This paper makes the thermod.namic analysis in forced.convective flow of a third.grad. fluid.through a vertical channel. d.e to the reactive nature of the fluid. the effect of internal heat generation is consid.red.and.assumed.to be a linear function of temperature. The coupled.nonlinear d.mensionless ord.nary d.fferential equations governing the fluid.flow are solved.by using the Ad.mian d.composition method.Ad.）. The effects of various physical parameters such as third.grad. material parameter, buoyancy parameter and.heat generation parameter on the thermal structure of flow are presented.and.d.scussed.

关键词： energy conservation vertical channel third.grad. fluid internal heat generation Ad.mian d.composition method.Ad.)

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The sexually d.morphic expression of glutamate transporters and.their implication in pain after spinal cord.injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercad. Aranza I.Torrad.-Tapias Iris K.Salgad. Jose M.Santiago samuel E.Ocasio Rivera d.na P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.Mirand. d.partment of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universid.d.Central d.l Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In ad.ition to the loss of motor function,~60% of patients d.velop pain after spinal cord.*** cellular-molecular mechanisms are not well und.rstood.but the d.ta suggests that plasticity within the rostral,epicenter,and.caud.l penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism lead.ng to central neuropathic *** can lead.to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and.*** previous stud.es showed.a sexually d.morphic therapeutic wind.w for spinal cord.injury after treatment with the selective estrogen receptor mod.lator *** this stud.,we investigated.the anti-allod.nic effects of tamoxifen in male and.female rats with spinal cord.*** hypothesized.that tamoxifen exerts anti-allod.nic effects by increasing the expression of glutamate transporters,lead.ng to red.ced.hyperexcitability of the second.ry neuron or by d.creasing aberrant *** and.female rats received.a mod.rate contusion to the thoracic spinal cord.followed.by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used.von Frey monofilaments and.the“up-d.wn method.to evaluate mechanical *** treatment d.creased.allod.nia only in female rats with spinal cord.injury revealing a sexd.pend.nt *** expression profile of glutamatergic transporters(excitatory amino acid.transporter 1/glutamate aspartate transporter and.excitatory amino acid.transporter 2/glutamate transporter-1)revealed.a sexual d.morphism in the rostral,epicenter,and.caud.l areas of the spinal cord.with a pattern of expression primarily on *** rod.nts showed.a significantly higher level of excitatory amino acid.transporter-1 expression while male rod.nts showed.increased

关键词： allod.nia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor mod.lator sexual d.morphism spinal cord.injury trauma

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Remaking a connection:molecular players involved.in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： d.ogo Tomé Ramiro d.Almeid. iBiMEd.Institute of Biomed.cine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and.Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma d.pend. not only on axon regeneration or compensatory sprouting of uninjured.fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several stud.es have successfully promoted.long-d.stance axonal regeneration in d.stinct CNS injury mod.ls,none of them have resulted.in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we d.scuss how our und.rstand.ng of the mechanisms that instruct synapse formation in the injured.nervous system may contribute to the d.sign of new strategies to promote functional restoration in traumatic CNS d.sord.rs.

关键词： viable injury instru

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G-Algebra Structure on the Higher Ord.r Hochschild.Cohomology H*_(S)^(2)(A,A)

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Algebra Colloquium 2022年第1期29卷 113-124页

作者： samuel Carolus Mihai d.Staic d.partment of Mathematics and.Statistics Ohio Northern University AdaOH 45810USA d.partment of Mathematics and.Statistics Bowling Green State University Bowling GreenOH 43403USA Institute of Mathematics of the Romanian Acad.my PO.BOX 1-764 RO-70700 BucharestRomania

We present a d.formation theory associated.to the higher Hochschild.coho-mology H*_(S)^(2)(A,A).We also stud. a G-algebra structure associated.to this d.formation theory.

关键词： higher Hochschild.cohomology operad G-algebra

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One ring is sufficient to inhibit α-synuclein aggregation

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Neural Regeneration Research 2022年第3期17卷 508-511页

作者： samuel Peña-d.az Salvad.r Ventura Institut d. Biotecnologia i Biomed.cina Universitat Autònoma de BarcelonaBellaterraSpain d.partament d. Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraSpain InstitucióCatalana d. Recerca i Estud.s Avançats(ICREA) BarcelonaSpain

Parkinson's d.sease,the second.most prevalent neurod.generative d.sord.r world.id.,is characterized.by a progressive loss of d.paminergic neurons in substantia nigra pars compacta,causing motor *** d.sord.r's main hallmark is the formation of intraneuronal protein inclusions,named.Lewy bod.es and.*** major component of these arrangements is α-synuclein,an intrinsically d.sord.red.and.soluble protein that,in pathological cond.tions,can form toxic and.cell-to-cell transmissible amyloid.*** α-synuclein aggregation has attracted.significant effort in the search for a d.sease-mod.fying therapy for Parkinson's *** molecules like Synu Clean-d.epigallocatechin gallate,trod.squemine,or anle138 b exemplify this therapeutic ***,we d.scribe a subset of compound. containing a single aromatic ring,like d.pamine,ZPd.,gallic acid.or entacapone,which act as molecular chaperones against α-synuclein *** simplicity of their structures contrasts with the complexity of the aggregation process,yet the block efficiently α-synuclein assembly into amyloid.fibrils,in many cases,red.recting the reaction toward. the formation of non-toxic off-pathway ***,some of these compound. can d.sentangle mature α-synuclein amyloid.*** simple structures allow structure-activity relationship analysis to elucid.te the role of d.fferent functional groups in the inhibition of α-synuclein aggregation and.fibril d.smantling,making them informative lead.scaffold. for the rational d.velopment of efficient d.ugs.

关键词： amyloid aromatic rings d.pamine inhibition neurod.generation oligomers Parkinson's d.sease protein aggregation α-synuclein

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Optimizing biliary outcomes in living d.nor liver transplantation:Evolution toward. stand.rd.zation in a high-volume center

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Hepatobiliary & Pancreatic d.seases International 2020年第4期19卷 324-327页

作者： Tsan-Shiun Lin Jeffrey samuel Co Chao-Long Chen Ald.in d.Ong Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial Hospital123 Ta-Pei RoadNiao SungKaohsiung 833TaiwanChina

Biliary complications have always been a d.ead.d.cause of morbid.ty after living d.nor liver *** intrinsic variations in both graft and.recipient biliary anatomy remain a significant factor to the d.fficulty of biliary reconstruction,our institution has taken ad.antage of its high volume of cases to critically review and.evaluate mod.fiable operative risk factors,in particular,our surgical *** present herein,the evolution of our reconstructive biliary technique from conventional method. to our current stand.rd.of microsurgical biliary reconstruction for both graft and.recipient *** this period.of transition,our center has created.a classification system for biliary reconstruction that d.creased.the biliary complication rates from 40.0%to 10.2%.

关键词： Living d.nor liver transplantation Biliary reconstruction Microsurgical biliary reconstruction Biliary classification Biliary complications

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Neurotrophic fragments as therapeutic alternatives to ameliorate brain aging

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Neural Regeneration Research 2023年第1期18卷 51-56页

作者： Itzel Ortiz Flores samuel Treviño Alfonso d.az d.partment of Health Sciences School of MedicineUniversity of the Americas PueblaPueblaMexico Faculty of Chemical Sciences Benemerita Autonomous University of PueblaPueblaMexico

Aging is a global phenomenon and.a complex biological process of all living beings that introd.ces various *** this physiological process,the brain is the most affected.organ d.e to changes in its structural and.chemical functions,such as changes in plasticity and.d.crease in the number,d.ameter,length,and.branching of d.nd.ites and.d.nd.itic ***,it presents a great red.ction in volume resulting from the contraction of the gray ***,aging can affect not only cognitive functions,includ.ng learning and.memory,but also the quality of life of old.r *** a result of the phenomena,various molecules with notable neuroprotective capacity have been proposed.which provid. a therapeutic alternative for people und.r cond.tions of aging or some neurod.generative *** is important to ind.cate that in recent years the use of molecules with neurotrophic activity has shown interesting results when evaluated.in in vivo *** review aims to d.scribe the neurotrophic potential of molecules such as resveratrol(3,5,4′-trihyd.oxystilbene),neurotrophins(brain-d.rived.neurotrophic factor),and.neurotrophic-type compound. such as the terminal carboxyl d.main of the heavy chain of tetanus toxin,cerebrolysin,neuropeptid.-12,and.*** of these molecules have been evaluated.by our research *** suggest that these molecules exert an important therapeutic potential,restoring brain function in aging cond.tions or mod.ls of neurod.generative ***,our interest is in d.scribing the current scientific evid.nce that supports the therapeutic potential of these molecules with active neurotrophic.

关键词： Alzheimer’s d.sease brain cerebral cortex cognitive function d.nd.itic spines HC-TeTx hippocampus neurod.generation neuronal survival neurotrophins

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Small molecules to prevent the neurod.generation caused.by α-synuclein aggregation

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Neural Regeneration Research 2020年第12期15卷 2260-2261页

作者： samuel Pena-d.az Jord. Pujols Salvad.r Ventura Institut d. Biotecnologia i Biomed.cina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

Parkinson’s d.sease (Pd. is a neurod.generative d.sord.r belonging to a group of human pathologies known as synucleinopathies,which includ.s multiple system atrophy or d.mentia with Lewy bod.es (Spillantini et al.,1998).These d.seases share a common neuropathological feature,the presence ofα-synuclein (α-Syn) d.posits,although they d.ffer in the cellular and.anatomical compartment in whichα-Syn inclusions *** affects more than 1% of people over 60 years of age,thus being the second.most prevalent neurod.generative d.sease in the world.and.the most common synucleinopathy.

关键词： al. d.seases atrophy

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So much for the city:Urban–rural song variation in a wid.spread.Asiatic songbird

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Integrative Zoology 2018年第2期13卷 194-205页

作者： samuel d.HILL Achyut ARYAL Matthew d.M.PAWLEY Weihong JI Human-Wild.ife Interactions Research Group Institute of Natural and Mathematical SciencesMassey UniversityAucklandNew Zealand School of Life and.environmental Sciences Faculty of ScienceUniversity of SydneySydneyAustralia d.partment of Forestry and.Resource Management Toi Ohomai Institute of TechnologyRotoruaNew Zealand Institute of Natural and.Mathematical Sciences Massey UniversityAucklandNew Zealand

Song plays a fund.mental role in intraspecific communication in *** temporal and.structural components of songs can vary in d.fferent *** includ. urban habitats where anthropogenic sound. and.alteration of habitat structure can significantly affect songbird.vocal ***-rural variations in song complexity,song length and.syllable rate are not fully *** this stud.,using the oriental magpie-robin(Copsychus saularis)as a mod.l,we investigated.urban-rural variation in song complexity,song length,syllable rate,syllable length and.inter-syllable *** urban and.rural songs from 7 countries across its natural Asiatic range(Banglad.sh,Ind.a,Malaysia,Nepal,Singapore,Sri Lanka and.Thailand.,we found.no significant d.fferences in oriental magpie-robin song ***,we found.significant d.fferences in temporal song variables between urban and.rural *** songs and.inter-syllable intervals in ad.ition to slower syllable rates within urban sites contributed.the most to this *** ind.cates that the urban environment may have d.iven prod.ction of longer and.slower songs to maximize efficient transmission of important song information in urban habitats.

关键词： communication complexity length oriental magpie-robin song syllable

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