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Versatile subtypes of pericytes and their roles in spinal cord injury repair,bone development and repair

Bone Research 2022年第2期10卷 253-264页

作者： Sipin Zhu Min Chen Yibo Ying Qiuji Wu Zhiyang Huang Wenfei Ni Xiangyang Wang Huazi Xu samuel bennett Jian Xiao Jiake Xu Department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China Molecular Pharmacology Research Centre School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhouZhejiang 325035China Molecular Laboratory School of Biomedical SciencesThe University of Western AustraliaPerthWA 6009Australia

Vascular regeneration is a challenging topic in tissue repair. As one of the important components of the neurovascular unit(NVU),pericytes play an essential role in the maintenance of the vascular network of the spinal cord. To date, subtypes of pericytes have been identified by various markers, namely the PDGFR-β, Desmin, CD146, and NG2, each of which is involved with spinal cord injury(SCI) repair. In addition, pericytes may act as a stem cell source that is important for bone development and regeneration, whilst specific subtypes of pericyte could facilitate bone fracture and defect repair. One of the major challenges of pericyte biology is to determine the specific markers that would clearly distinguish the different subtypes of pericytes, and to develop efficient approaches to isolate and propagate pericytes. In this review, we discuss the biology and roles of pericytes, their markers for identification, and cell differentiation capacity with a focus on the potential application in the treatment of SCI and bone diseases in orthopedics.

关键词： CD146 pericyte injury

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The Pregnancy Heart Team Approach for the Adult with Hypertrophic Cardiomyopathy and Severe Left Ventricular Outflow Tract Obstruction

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Maternal-Fetal Medicine 2021年第1期3卷 71-74页

作者： Sihong Huang bennett P.samuel Marcos Cordoba Vivian C.Romero Laurie Chalifoux David R.Fermin Stephen C.Cook Congenital Heart Center Spectrum Health Helen DeVos Children's HospitalGrand RapidsMichigan 49503USA Pediatric and Human Development Michigan State University College of Human MedicineGrand RapidsMichigan 49503USA Maternal Fetal Medicine Spectrum Health Medical GroupGrand RapidsMichigan 49503USA Obstetrics Gynecology&Reproductive Biology Michigan State University College o f Human MedicineGrand RapidsMichigan 49503USA West Michigan Anesthesia PC Grand RapidsMichigan 49525USA Michigan State University College of Human Medicine Grand RapidsMichigan 49503USA Hypertrophic Cardiomyopathy Program Spectrum HealthGrand RapidsMichigan 49503USA Medicine Michigan State University College of Human MedicineGrand RapidsMichigan 49503USA

Hypertrophic cardiomyopathy (HCM), the most common single-gene cardiovascular disease, is associated with increased risk for arrhythmias, heart failure, and sudden cardiac death. The hemodynamic changes known to occur during pregnancy can exacerbate heart failure and arrhythmias in women with HCM. We present a 30-year-old woman with HCM to illustrate the benefits of multidisciplinary team management of severe left ventricular outflow tract obstruction (peak gradient >100 mmHg) for optimal maternal and fetal outcomes.

关键词： Cardiomyopathy hypertrophic Left ventricular outflow tract obstruction Pregnancy Pregnancy heart team

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