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Oral Amodiaquine, Artesunate and Artesunate Amodiaquine Combination Affects Open Field Behaviors and Spatial Memory in Healthy Swiss Mice

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Journal of Behavioral and Brain Science 2013年第8期3卷 569-575页

作者： Adejoke Yetunde Onaolapo Olakunle James Onaolapo Emmanuel O. Awe samuel oloyede Ayomide Joel Department of Human Anatomy Faculty of Basic Medical Sciences College of Health Sciences Ladoke Akintola University Ogbomoso Nigeria Department of Pharmacology Faculty of Basic Medical Sciences College of Health Sciences Ladoke Akintola University Oshogbo Nigeria

Effects of amodiaquine, artesunate and artesunate amodiaquine combination on open field novelty-induced behaviors and spatial memory in healthy mice were studied. Forty mice were used in the open field and fifty each in the radial arm maze and Y maze;mice were assigned into four or five groups of ten each, Group A served as control (distilled water), Groups B, C and D received artesunate (4 mg/kg), amodiaquine (10 mg/kg) and artesunate-amodiaquine combination (4 mg/kg and10 mg/kg) respectively, while Group E animals (for the cognition tests) were given scopolamine (2 mg/kg). Drugs and vehicle were administered orally for three days. Results were analysed by one way analysis of variance followed by a posthoc test. Results showed that artesunate and amodiaquine either in combination or administered singly caused a significant increase in open field novelty-induced horizontal locomotion and rearing. Grooming in the open field showed increments in the artesunate alone and artesunate amodiaquine groups while significant reductions in spatial memory were also seen in the cognition models used.

关键词： Neurobehavior Artesunate Amodiaquine Antimalaria Novelty-Induced Behaviors Cognition

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