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Phytochemical screening and antibacterial activities of Momordica charantia and Vernonia amygdalina extracts on some selected enteric isolates

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TMR Modern Herbal Medicine 2024年第1期7卷 11-18页

作者： seyi-samson enitan Zaynab-Aderonke Ojubanire Temiloluwa-Femi Oyedele Nwachi-Idume Ogbonna Adekunle-Totoola Adeyemi Jamiu-Monsur Olalekan Ayomide-Oluwatobiloba Okuneye Department of Medical Laboratory Science Babcock University Ilishan-RemoOgun state 121103Nigeria Department of Medical Microbiology Babcock University Teaching HospitalIlishan-RemoOgun State 121103Nigeria Department of Education Medical Laboratory Science Council of NigeriaFCT-Abuja 900110Nigeria Clinical Laboratory Department Central Medical Diagnostic CentreIbadan 200113Nigeria

Background:This research focuses on herbal medicine,an ancient healthcare practice,exploring the antibacterial attributes of fresh and dried leaf extracts from Momordica charantia(commonly known as Bitter melon)and Vernonia amygdalina(Bitter leaf).The study specifically investigates their effects on different bacterial strains associated with ***:Four enteric bacterial isolates-Klebsiella pneumoniae,Salmonella typhi,Escherichia coli,and Proteus mirabilis-were obtained from the Medical Laboratory Unit at Babcock University Teaching Hospital in Ilishan-Remo,Ogun *** screening and antibacterial testing were conducted using standard biochemical techniques and the Punch-hole agar diffusion method,***:Qualitative phytochemical screening of the plant extracts revealed the presence of flavonoids,glycosides,and saponin in both plants,excluding *** were identified only in Vernonia *** these phytochemicals,neither plant displayed inhibitory effects on the tested bacterial isolates(Escherichia coli,Proteus mirabilis,Klebsiella pneumoniae,and Salmonella typhi)when tested individually or in ***,combining the fresh and dried leaf extracts of Momordica charantia and Vernonia amygdalina with a standard drug resulted in smaller mean zone diameters of inhibition(Escherichia coli range:14 mm–16 mm,Proteus mirabilis range:31 mm–35 mm,Klebsiella pneumoniae range:13 mm–22 mm,and Salmonella typhi range:35 mm–38 mm)compared to the drug tested alone(16 mm–45 mm).Conclusion:Despite previous indications of antibacterial properties in various extracts of *** and *** leaves,our study presents contradictory results,prompting the need for further investigation despite the presence of significant phytochemicals.

关键词： phytochemical screening herbal medicine Momordica charantia Vernonia amygdalina enteric isolates

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Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments

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Clinical Research Communications 2023年第3期6卷 22-29页

作者： seyi samson enitan Esther Ngozi Adejumo John Osaigbovoh Imaralu Ayodele Ademola Adelakun Oluwakemi Anike Ladipo Comfort Bosede enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Gynaecology and Obstetrics Babcock University Teaching HospitalIlishan-Remo 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis has emerged as a significant health issue among postmenopausal *** this concern necessitates a multifaceted approach encompassing genetics,pharmacogenomics,bone turnover markers,lifestyle factors,concurrent medical conditions,biomarkers,and advanced imaging ***,challenges in terms of cost-effectiveness and ethical considerations do ***,the convergence of technological progress and research endeavors offers a promising *** integration of genetic testing and pharmacogenomics into clinical practice holds substantial *** integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility,thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes–personalized *** the intricate nature of osteoporosis,personalized strategies stand to greatly benefit women grappling with this *** research and collaborative efforts are imperative to propel advancements within this domain,paving the way for further breakthroughs.

关键词： osteoporosis management personalized medicine pharmacogenomics women

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Assessment of d ifferent f ormalin c oncentrations on the h istochemical s taining of l iver,k idneys and l ungs of Wistar r ats

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Toxicology Advances 2023年第3期5卷 22-27页

作者： Gideon Taiwo Oluwaloye Ochuko Fortunate Jenakevwe Kenneth Chukwudi Onyegbula Julius Kayode Bankole seyi samson enitan Department of Medical Laboratory Science Babcock UniversityIlisan-Remo121103Ogun StateNigeria Department of Biomedical Laboratory Science University of IbadanIbadan200005Oyo StateNigeria Department of Medical Laboratory Science Ambrose Alli UniversityEkpoma310006Edo StateNigeria

Background:Formaldehyde is a chemical substance used to preserve the biochemical and physiological components of a tissue by preventing autolysis and putrefaction,leaving the tissue in a life-like ***:This study aims to assess the effect of formalin concentrations on the histochemical staining in liver,kidneys and lungs of Wistar ***:A total of ten(10)Wistar rats were purchased and allowed to acclimatize for a period of 2 weeks in plastic cages with iron netting at the Animal House facility,Babcock *** animals were placed on standard rat feeds and water *** rats were randomly sacrificed by cervical dislocation,following mild anaesthesia using chloroform *** histological examination,the liver,lungs,and kidneys of Wistar rats were removed and preserved in neutral buffered formalin at 2%,4%,6%,8%,and 10%*** were stained in Haematoxylin and Eosin(Vector Laboratories,***,US).The quality of the nuclei,cytoplasm and cell membrane were graded on a scale of 1(poor)to 5(excellent).Results:Six percent(6%)formalin was observed to produce excellent results in liver tissues with a total grade of sixteen(16).10%formalin produced excellent results in lung tissues with a total grade or nineteen(19).Interestingly,2%,6%and 10%formalin concentrations produced excellently results in kidney tissues with the highest total grade fourteen(14).Conclusion:This study concludes that 6%formalin produced better section and staining qualities more than the commonly used 10%formalin according to the observations from the stained *** implies that the concentration of formalin affects the histochemical staining in liver,kidneys and lungs of Wistar rats.

关键词： fixation kidney liver lungs neutral buffered formalin Wistar rats

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Occupational exposure to flour dust among bakery workers:prevalence,potential hazards and promising interventions

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Toxicology Advances 2023年第4期5卷 33-44页

作者： seyi-samson enitan Osareniro-Eguagie Osakue Esther-Ngozi Adejumo Temitope-Oyewole Olusanya Emmanuel-Olusegun Ileoma Comfort-Bosede enitan Nwachi-Idume Ogbonna Department of Medical Laboratory Science Babcock University Ilishan-RemoOgun state 121103Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-RemoOgun state 121103Nigeria Department of Education Medical Laboratory Science Council of NigeriaFCT-Abuja 900110Nigeria

Occupational exposure to flour dust within bakery environments presents significant health hazards to bakery *** dust,generated as a byproduct during baking,becomes airborne during the baking process,thus constituting a respiratory *** health consequences include respiratory diseases,skin irritation,allergic reactions,and potential long-term health *** indicates that a broad segment of bakery workers encounters exposure to flour dust,with specific subgroups,such as bakers and dough mixers,being particularly *** factors to this exposure encompass insufficient ventilation and a lack of *** is vital to assess exposure levels through air quality monitoring and health *** interventions encompass engineering solutions(e.g.,ventilation systems,dust extraction),administrative measures(including training and the use of personal protective equipment),and the implementation of occupational health and safety *** efforts with healthcare professionals and regulatory authorities are paramount for achieving *** studies underscore the effectiveness of such interventions,resulting in improved worker health,thus underscoring the advantages of protective *** in this endeavor include industry resistance to change,financial considerations,and issues related to *** recommendations entail further research,policy enhancements,and the involvement of industry stakeholders and labor unions in advocating for worker safety.

关键词： flour dust bakery workers occupational exposure interventions health hazards

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Empowering women to combat osteoporosis:unveiling the causes,consequences,and control strategies

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Aging Communications 2023年第3期5卷 8-17页

作者： seyi samson enitan Babatunde Ishola Gabriel Adejumo Esther Ngozi Adejumo Temitope Oyewole Olusanya Eguagie Osareniro Osakue Oluwakemi Anike Ladipo Comfort Bosede enitan Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Department of Medical Laboratory Science University of BeninBenin City 300213Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Osteoporosis is a common bone disease in women worldwide, leading to decreased bone density and an accelerated risk of fractures. The causes of osteoporosis in women include age (senile osteoporosis), menopause-associated hormonal changes, deficiencies in calcium and vitamin D, genetics, lifestyle factors, medical conditions, and some type of medications. The consequences of osteoporosis are colossal, consisting of fractures, decreased quality of life, psychological impacts, and economic burden. To effectively control the menace of osteoporosis in women, numerous strategies are advocated. Adequate calcium and vitamin D consumption through diet or supplements is vital. Regular weight-bearing activities and strength training that promote bone density. Maintaining a healthy life-style through avoiding smoking, limiting alcohol in-take and maintaining a wholesome body weight is essential. Hormone replacement therapy and some medications may be recommended in certain cases. Early detection through regular bone density and blood tests is crucial to lowering its impact. Creating a supportive network through educational programs and resources fosters awareness and empowerment. By engaging these strategies, women can be empowered to combat osteoporosis, reduce fracture risk, and build stronger bones for their overall well-being.

关键词： women aging osteoporosis causes consequences control strategies

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A review of complementary and alternative medicine used in cancer care:challenges and prospects

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TMR Integrative Medicine 2023年第21期7卷 1-7页

作者： samson seyi enitan Godwin Avwioro Esther Ngozi Adejumo Oluwakemi Anike Ladipo Chinenye Alaezi Okorochi Gideon Taiwo Oluwaloye Damilola Christianah Ademola-Kemiki Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103Nigeria Faculty of Science Delta State UniversityAbraka 330106Nigeria Department of Chemical Pathology Babcock University Teaching HospitalIlishan-Remo 121103Nigeria

Cancer is a leading cause of death globally,and most patients with cancers frequently seek for complementary and alternative medicine(CAM)to ameliorate their *** of the available CAM care include:acupuncture,aromatherapy,Ayurvedic medicinal drug,cannabis,chelation remedy,homeopathy,hypnotherapy,massage therapy,naturopathic medication,and conventional Chinese remedy amongst *** the growing use of CAM,the evidence-base for its efficacy and safety is *** challenges confronting the efficient deployment of CAM is lack of standardization and regulation;as well as the demand for more extensive studies to validate their safety and *** oncology which is the combination of CAM and conventional cancer care is likewise complicated through the potential adverse interactions between CAM options and most cancers *** article serves as a guide for healthcare providers and patients to determine how CAM can be safely integrated into the cancer care *** into account safety concerns,however,more studies need to be conducted to properly evaluate its ***,CAM can help cancer patients in achieving greater health and well-being.

关键词： alternative medicine cancer care challenges prospects

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Prevalence of hepatitis B virus infection and associated risk factors among adult females infected with Human Immunodeficiency Virus in Ogun State,Nigeria

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Infectious Diseases Research 2023年第3期4卷 1-9页

作者： John Cletus Ihongbe seyi samson enitan Michael Olugbamila Dada Oluchi Ofem Oluchi Gladys Ofem Effiong Joseph Effiong Olalekan Ademola Kemiki Amarachi Favour Ogbonna Department of Medical Laboratory Science Babcock UniversityIlishan-Remo 121103StateNigeria Babcock University Teaching Hospital Molecular and Tissue Culture LaboratoryIlishan-Remo 121103Nigeria

Background:Hepatitis B virus(HBV)infection is prevalent in sub-Saharan Africa,including Nigeria,and is frequently observed in individuals co-infected with human immunodeficiency virus(HIV).Objective:This study aims to evaluate the prevalence of serological markers for hepatitis B virus and identify the associated risk factors among women with HIV undergoing highly active antiretroviral therapy(HAART)in Ogun State,***:Ethical approval was obtained from the Babcock University Health Research Ethics Committee(BUHREC)to recruit a total of 110 adult women infected with HIV,receiving treatment at the HIV clinics of Babcock University Teaching Hospital(BUTH)in Ilishan-Remo and General Hospital in Ijebu-Ode,both located in Ogun State,*** participants’HIV status were confirmed using three rapid diagnostic kits:Determine(Abbott Laboratories,Tokyo,Japan),Unigold HIV(Trinity Biotech Plc Bray,***,Ireland),and 1/2 Stat Pak(Abbott Laboratories,Tokyo,Japan)(Chembio Diagnostic Systems,New York,USA).Additionally,an HBV 5 in 1 Panel manufactured by Innovation Biotechnology Co.,Ltd in Beijing,China,was employed to detect HBV markers qualitatively in serum ***:Out of the 110 subjects that voluntarily participated in the study,4(3.6%)tested positive for HBsAg,2(1.8%)tested positive for HBsAb,81(73.6%)tested positive for HBeAg,3(2.7%)tested positive for HBeAb,and 65(59.1%)tested positive for *** was no significant correlation between the occurrence of HBsAg and the socio-demographic characteristics of the participants(P>0.05).Various risk factors were identified,including lack of knowledge about HBV,absence of HBV vaccination history,history of blood transfusion,organ transplant,and engaging in unprotected sex,among ***:The findings highlight the presence of HBV infection among HIV-positive women undergoing HAART in Ogun State,Nigeria,particularly within the age groups of 18–25 years and 26–30 *** results emphasize the n

关键词： hepatitis B virus serological markers HIV HAART adult females South-West Nigeria

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