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Preoperative functional MR imaging localization of language and motor areas： effect on therapeutic decision making in patients with potentially resectable brain tumors

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中国神经肿瘤杂志 2006年第2期4卷 133-133页

作者： Petrella JR Shah LM Harris KM Friedman AH George TM sampson jh Pekala JS Voyvodic JT Department of Radiology Division of Neuroradiology Brain Imaging and Analysis Center and Department of Surgery Division of Neurosurgery Duke University Medical Center Box 3808 Durham NC 27710-3808.

Purpose: To prospectively evaluate the effect of preoperative functional magnetic resonance (MR) imaging localization of language and motor areas on therapeutic decision making in patients with potentially resectable brain tumors。Materials and Methods: The Institutional Review Board approved this HIPAA-compliant study, and each patient gave written informed consent。Thirty-nine consecutive patients (19 male, 20 female; mean age, 42.2 years) referred for functional MR imaging for possible tumor resection were prospectively evaluated。A preoperative diagnosis of brain tumor was made in all patients。

关键词： MR功能检查手术治疗脑肿瘤病理机制

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重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤（英文）

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中华神经外科疾病研究杂志 2018年第4期17卷 375-375页

作者： Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D sampson jh Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD

Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective *** conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor *** We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion *** From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of *** level-1(5.0×107TCID50)was identified as the phase 2 *** dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was *** mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 *** the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or *** survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 *** Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent *** survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls.

关键词： WHO

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