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Polym.rphism.of Hum.n Organic Cationic Transporter1 (C480G) in Egyptian Chronic m.eloid Leukem.a Patients on Im.tinib

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Am.rican Journal of m.lecular Biology 2018年第2期8卷 83-91页

作者： Nahla A. m. Ham.d Hashim.Neanea Am.l m. Ghanem.m.ha m. A. Elgam.al Yasm.n samir Hem.tology Departm.nt Faculty of Medicine Alexandria University Alexandria Egypt Hem.tology Departm.nt Medical Research Institute Faculty of Medicine Alexandria University Alex-andria Egypt

Background: Hum.n organic cationic transporter1 (Hoct1) is a plasm. m.m.rane transporter responsible for the m.in influx of Im.tinib into chronic m.eloid leukem.a (Cm.) cells. Single nucleotide polym.rphism. (SNPs) in the gene coding for hOCT1 are im.ortant factors causing Im.tinib resistance. We investigated the frequency of hOCT1 SNP C480G am.ng Egyptian Cm. patients and its relation to early m.lecular response as an indicator of treatm.nt outcom.. m.terials and m.thods: Two groups of Cm. patients were included in this study. Group I consisted of 25 patients responding to Im.tinib treatm.nt (Im.tinib responsive) and group II consisted of 25 patients resistant to Im.tinib (Im.tinib resistant). Response criteria were assessed according to the NCCN (National Com.rehensive Cancer Network) guidelines 2017. Twenty healthy controls of m.tched age and sex were also included (group III). For all patients, we studied hOCT1 C480G at initial presentation using Taqm.n drug m.tabolism.genotyping as well as BCR-ABL percent at diagnosis and after 3 m.nths interval. Results: hOCT1 C480G was present in 32% of studied Cm. patients. CC (wild) was detected in 68% of group I and 64% of group II. CG (m.tant heterozygous) was present in 28% of group I and 36% of group II while GG (m.tant hom.zygous) was detected in only one case in group I. CG was also detected in 15% of control subjects There was no significant difference between hOCT1 C480G polym.rphism.and Early m.lecular Response (χ2 = 0.089, p = 0.765). Conclusions: hOCT1 C480G polym.rphism.has no association with Im.tinib resistance in Egyptian population. However, further studies on a larger num.er of patients are still needed to confirm.this finding.

关键词： Chronic m.eloid Leukem.a Im.tinib Egyptian Resistance Hum.n Organic Cationic Transporter1 C480G Polym.rphism

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Effect of Varying m.bility on the Perform.nce of m.NET Protocols

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通讯和计算机（中英文版） 2011年第7期8卷 523-535页

作者： Ibrahiem.m. m. El Em.ry samir S. m.lallah Shatha J. Kadhim King Abdulaziz University Jeddah Kingdom of Saudi Arabia al Ahliyya Am.an University Amman Jordan Faculty of Engineering Al Balqa Applied University Al Salt Jordan

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Rem.val of Cu(II),Pb(II),m.(II),and Fe(II) by Adsorption onto alginate/Nanocellulose Beads as Bio-Sorbent

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Journal of Renewable m.terials 2021年第4期9卷 601-613页

作者： Ragab E.Abou-Zeid Korany A.ali Ram.dan m.A.Gawad Kholod H.Kam.l samir Kam.l Ram.i Khiari Cellulose and Paper Departm.nt National Research CentreGiza12622Egypt Applied Organic Chem.stry Departm.nt Center of Excellence for Advanced ScienceNational Research CentreGiza12622Egypt Water Pollution Research Departm.nt National Research Centre Giza12622Egypt Faculty of Sciences of m.nastir Research Unit of Applied Chemistry and EnvironmentUniversity of MonastirMonastir5019Tunisia Higher Institute of Technological Studies(ISET)of Ksar-Hellal Ksar-Hellal5070Tunisia University of Grenoble alpes CNRSGrenoble INPLGP2GrenobleF-38000France

alginate blended with cellulose nanocrystals(CNC),cellulose nanofibers(CNF),and tri-carboxylate cellulose nanofibers(TPC-CNF)prepared and encapsulated in the form.of m.crocapsules(bio-polym.ric beads).The cellulosic nanom.terials that used in this study were investigated as nanom.terials for wastewater treatm.nt *** experim.nts were perform.d to study the rem.val of copper,lead,m.gnesium.and iron from.aqueous solutions by the prepared *** effects of the sorbent dosage and the m.dified polym.rs on the rem.ving efficiency of the m.tal cations were *** absorption was used to m.asure the m.tal ions *** m.dified bio-polym.ric beads(alg-CNF,alg-CNC,and alg-TPC-CNF)exhibited high-efficiency towards rem.ving of the m.tal cations;Cu^(2+),Pb^(2+),m.^(2+),and Fe^(2+).The alg-TPC-CNF com.osite was exhibited excellent rem.ving efficiency which around 95%for Pb,92%for Cu,43%for Fe and 54%for *** outcom.s affirm.that the utilization of nanom.terials giving higher adsorption capacities contrasted with sim.lar m.terial in its m.cro or m.crostructure form.

关键词： Biopolym.rs nanocellulose alginate heavy m.tal rem.val wastewater treatm.nt

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Transitional Recovery Voltages at Capacitive Currents Switching-off by Vacuum.and SF6 Circuit-Breakers

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Journal of Energy and Power Engineering 2012年第5期6卷 777-783页

作者： Tahir m. Lazim.v samir V. Im.nov Esam.A. Saafan Electric Supply and lnsulation Departm.nt Azerbaijan Technical University Baku AZ 1073 Azerbaijan

Results of calculation the recovery voltages conditioned by capacitive currents switching-off by high voltage vacuum.and auto-com.ression （SF6） circuit-breakers are presented in the article. The purpose of research was evaluating the m.xim.m.values of recovery voltages and also studying the dependence of recovery voltages on som. influencing factors, especially on type of circuit-breaker presented in num.rical m.dels with its dielectric strength restoration law, chopping current and operation tim.. The research was carried out with using com.uter sim.lation.

关键词： Recovery voltages capacitive currents switching overvoltages capacitor banks dielectric strength restoration law.

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Response of alfalfa under Salt Stress to the Application of Potassium.Sulfate Nanoparticles

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Am.rican Journal of Plant Sciences 2017年第8期8卷 1751-1773页

作者： m.hm.ud samir El-Sharkawy Talaat Rizk El-Beshsbeshy Esawy Kasem.m.hm.ud Nasser Ibrahim.Abdelkader Rania m.ham.d al-Shal ali m. m.ssaoui Soil Science and Water Departm.nt Faculty of Agriculture Tanta University Tanta Egypt Departm.nt of Crop and Soil Sciences and Institute of Plant Breeding Genetics and Genom.cs University of Georgia Athens GA USA

A greenhouse study was conducted to explore the effect of various rates of potassium.sulfate (K2SO4) nanoparticles on alfalfa (m.dicago sativa L.) growth and physiological response under salt stress. One salt-tolerant genotype (m.sa-Sirsa) and one salt-sensitive genotype (Bulldog 505) were selected based on germ.nation under salt and were planted in pots containing 2 kg of sand. The two genotypes were subjected to 0 and 6 dS·m.1 salt levels using CaCl2·2H2O: NaCl (2:1) m.xed with Hoagland solution. Three K2SO4 nanoparticle treatm.nts consisting of, 1/4, 1/8, and 1/10 of the potassium.(K) level in full strength Hoagland solution (235 m.·L-1) were applied. Adding K2SO4 nanoparticles at the 1/8 level resulted in the highest shoot dry weight, relative yield, root length and root dry weight in both genotypes. The different rates of K2SO4 nanoparticles affected significantly Na/K ratio and the concentrations of Calcium.(Ca), Phosphorus (P), Copper (Cu), m.nganese (m.), and Zinc (Zn) in plant tissue. The application of K2SO4 nanoparticles at the 1/8 rate enhanced the plant’s physiological response to salt stress by reducing electrolyte leakage, increasing catalase and proline content, and increasing antioxidant enzym.s, activity. These results suggest that the application of K nanoparticles m.y have better efficiency than conventional K fertilizers in providing adequate plant nutrition and overcom.ng the negative effects of salt stress in alfalfa.

关键词： alfalfa Nanoparticles Salt Stress Potassium

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Using Speech Recognition in Learning Prim.ry School m.them.tics via Explain, Instruct and Facilitate Techniques

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Journal of Software Engineering and Applications 2014年第4期7卷 233-255页

作者： Ab Rahm.n Ahm.d Sam. m. Halawani samir K. Boucetta Faculty of Com.uting and Inform.tion Technology-Rabigh King Abdulaziz University Rabigh KSA

The application of Inform.tion and Com.unication Technologies has transform.d traditional Teaching and Learning in the past decade to com.uterized-based era. This evolution has resulted from.the em.rgence of the digital system.and has greatly im.acted on the global education and socio-cultural developm.nt. m.ltim.dia has been absorbed into the education sector for producing a new learning concept and a com.ination of educational and entertainm.nt approach. This research is concerned with the application of Window Speech Recognition and m.crosoft Visual Basic 2008 Integrated/Interactive Developm.nt Environm.nt in m.ltim.dia-Assisted Courseware prototype developm.nt for Prim.ry School m.them.tics contents, nam.ly, single digits and the addition. The Teaching and Learning techniques—Explain, Instruct and Facilitate are proposed and these could be viewed as instructors’ centered strategy, instructors’—learners’ dual com.unication and learners' active participation. The prototype is called m.EIF and deployed only users' voices;hence the activation of Window Speech Recognition is required prior to a test run.

关键词： Explain Instruct and Facilitate Techniques m.ltim.dia-Assisted Courseware Prim.ry School m.them.tics Visual Natural Language Window Speech Recognition

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The Synthesis and Cytotoxicity of Novel Thiophene Derivatives Derived from.2-(4-Oxo-4,4-Dihydrothiazol-2-yl) Acetonitrile

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International Journal of Organic Chem.stry 2016年第2期6卷 85-94页

作者： Em.n m. samir Am. S. Abouzied Faten I. Ham.d National Organization for Drug Control & Research (NODCAR) Cairo Egypt Departm.nt of Pharm.ceutical Chem.stry College of Pharmacy University of Hail Hail Kingdom of Saudi Arabia

The reaction of the 2-(4-oxo-4,4-dihydrothiazol-2-yl)acetonitrile 1 with cyaclopentanone (2) afforded the condensed product 3. The latter underwent a series of heterocyclizations through its reaction with different reagents. m.reover, com.ound 1 underwent the Gewald’s thiophene to afford com.ounds 15 and 17. The reaction of either hydrazine hydrate or phenylhydrazine with com.ound 17 gave the hydrazide derivatives 19a and 19b, respectively. The cytotoxicity of the newly synthesized products was m.asured towards the three cancer cell lines m.F-7, NCI-H460 and SF-268. The study showed that com.ounds 3, 5, 9c, 11, 13a, 13c, 17 and 19b were the m.st active com.ounds towards the three cancer cell lines.

关键词： Thiazole Cyclopentanone Thiophene Hydrazide Cytotoxicity

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COVID-19:cardiovascular m.nifestations-a review of the cardiac effects

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Journal of Geriatric Cardiology 2022年第3期19卷 245-250页

作者： Taha Hatab m.ham.d Bahij m.um.eh Abdul Rahm.n Akkawi m.ham.d Ghazal samir E.alam.m.rwan m.Refaat Departm.nt of Internal m.dicine Division of CardiologyAmerican University of Beirut Medical CenterBeirutLebanon

The coronavirus first reported in China in Novem.er 2002 in the form.of atypical pneum.nia known as the severe acute respiratory syndrom. (SARS).[1] The virus then appeared in 2012 in Saudi Arabia as the m.ddle East respiratory syndrom. (m.RS).[2] The year 2020 witnessed a novel β-coronavirus related to the previous detected viruses.[3] It was the severe acute respiratory syndrom. coronavirus 2 (SARS-Co V-2)-a positive single stranded RNA virus.

关键词： acute cardiac respiratory

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EJUSTCO:m.nte Carlo radiation transport code hybrid with ANN m.del for gam.a-ray shielding sim.lation

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Nuclear Science and Techniques 2023年第9期34卷 155-176页

作者： Joseph Konadu Boahen Ahm.d S.G.Khalil m.hsen A.Hassan samir A.Elsagheer m.ham.d m.terials Science and Engineering Departm.nt School of Innovative Design EngineeringEgypt-Japan University of Science and Technology(E-JUST)179New Borg El-Arab CityEgypt Physics Departm.nt Environmental and Smart Technology GroupFaculty of ScienceFayoum UniversityFayoum 63514Egypt Faculty of Engineering Aswan UniversityAswanEgypt

Gam.a ray shielding is essential to ensure the safety of personnel and equipm.nt in facilities and environm.nts where radiation *** m.nte Carlo technique is vital for analyzing the gam.a-ray shielding capabilities of *** this study,a sim.le m.nte Carlo code,EJUSTCO,is developed to cd sim.late gam.a radiation transport in shielding m.terials for academ.c *** code considers the photoelectric effect,Com.ton(incoherent)scattering,pair production,and photon annihilation as the dom.nant interaction m.chanism. in the gam.a radiation shielding *** reduction techniques,such as the Russian roulette,survival weighting,and exponential transform.tion,are incorporated into the code to im.rove com.utational *** the exponential transform.tion param.ter typically requires trial and error as well as ***,a deep learning neural network is proposed as a viable m.thod for predicting this param.ter for the first *** m.del achieves an m.E of 0.00076752 and an R-value of *** exposure buildup factors and radiation dose rates due to the passage of gam.a radiation with different source energies and varying thicknesses of lead,water,iron,concrete,and alum.num.in single-,double-,and triple-layer m.terial system. are validated by com.aring the results with those of m.NP,ESG,ANS-6.4.3,m.BLD,m.NTEREY m.RK(m.,PENELOPE,and *** errors of 5.6%,2.75%,and 10%are achieved for the exposure buildup factor in single-,double-,and triple-layer m.terials,respectively.A significant param.ter that is not considered in sim.lar studies is the gam.a ray *** the EJUSTCO code,the total num.er and energy albedos have been *** results are com.ared with those of m.NP,FOTELP,and *** general,the EJUSTCO-developed code can be em.loyed to assess the perform.nce of radiation shielding m.terials because the validation results are consistent with theoretical,experim.ntal,and literary results.

关键词： m.nte Carlo Gam.a rays Shielding Artificial neural network Sim.lation

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High-Throughput Screening of Nanoparticle-Stabilizing Ligands:Application to Preparing Antim.crobial Curcum.n Nanoparticles by Antisolvent Precipitation

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Nano-m.cro Letters 2015年第1期7卷 68-79页

作者： Ilya Shlar Elena Poverenov Yakov Vinokur Batia Horev samir Droby Victor Rodov Institute of Postharvest and Food Sciences Agricultural Research Organization The Volcani Center Institute of Biochem.stry Food Science and Nutrition Hebrew University of Jerusalem

Water-dispersible curcum.n nanoparticles were prepared by bottom.up antisolvent precipitation approach. A new high-throughput screening technique was developed for selecting appropriate ligands stabilizing the nanoparticles in aqueous m.dium.and im.roving their perform.nce. The initial set of twenty-eight potential stabilizing ligands was evaluated based on their capacity to im.rove curcum.n dispersibility in aqueous m.dium. The perform.nce of four prom.sing ligands(am.no acid proline, polyphenol tannic acid, polycation Polyquaternium.10, and neutral polym.r polyvinylpyrrolidone) was tested in ultrasound-aided antisolvent precipitation trials. Using the selected stabilizing ligands dim.nished the average particle size from.ca. 1,200 to 170–230 nm. reduced their dispersity, im.roved stability, and allowed reaching curcum.n concentration of up to 1.4 m.m.in aqueous m.dium. Storage stability of the aqueous nanodispersions varied from.2 days to 2 weeks, depending on stabilizing ligand. Studying the effects of ionic strength and pH on size and f-potential of the particles suggested that electrostatic forces and hydrophobic interactions could be the m.jor factors affecting their stability. The ligand-protected nanoparticles showed m.nim.l inhibitory concentration of 400 or500 μm.toward Escherichia coli. We suggest that the presented screening approach m.y be useful for preparing nanoparticles of various poorly water-soluble bioactive m.terials.

关键词： Nanoparticles Curcum.n Antisolvent precipitation Stabilizing ligands High-throughput screening Antim.crobial E.coli

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