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Topical tacrolimus in anterior segment inflammatory disorders

Eye and Vision 2017年第1期4卷 30-36页

作者： samir s.shoughy The Eye Center and the Eye Foundation for Research in Ophthalmology PO Box 55307Riyadh 11534Saudi Arabia

Immune mediated inflammatory anterior segment diseases are variable and their management requires intense *** with topical steroids is associated with serious ocular side *** order to overcome the potentially blinding complications of topical steroids,immunomodulatory drugs are being used more *** is a calcineurin inhibitor that induces suppression of T lymphocytes activity and reduction of ocular *** was recently investigated for application in various anterior segment inflammatory *** this review,we will discuss the therapeutic application of topical tacrolimus as a steroid-sparing agent in treating T cell mediated anterior segment inflammation.

关键词： Tacrolimus Topical Ocular Immune-mediated T cells

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selective and complementary use of Optical Coherence Tomography and Fluorescein Angiography in retinal practice

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Eye and Vision 2016年第1期3卷 202-210页

作者： samir s.shoughy Igor Kozak The Eye Center and The Eye Foundation for Research in Ophthalmology PO Box 55307Riyadh 11534Saudi Arabia King Khaled Eye specialist Hospital RiyadhSaudi Arabia

The current field of posterior pole and retinal imaging of the human eye has expanded into detailed analyses of the macula,retinal periphery,individual retinal layers,vitreoretinal interface,imaging of the choroid and the optic nerve *** challenge in retinal imaging is the enduring pursuit of deeper penetration into tissues,increased resolution to the cellular level,and interpretation of *** much deeper can we go and with what resolution and reproducibility?These are fundamental questions for experts in search of novel imaging *** discoveries may resolve existing controversies,but inevitably stimulate new *** technologies in retinal imaging include adaptive optics retinal imaging and optical coherence tomography-based retinal *** this review,the focus of our discussion will be the discrepancy between the findings(interpretation)of one imaging technology that do not agree or are not even found with a complementary *** a clearly seen abnormality is present with one technology but absent in another,what are the possible explanations?Following is a summary of key concepts of retinal and optic nerve imaging modalities and current controversies regarding their interpretation and/or limitations.

关键词： Retina Imaging Optical coherence tomography Fluorescein angiography

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Clinical manifestations and outcomes of ocular sarcoidosis in saudi Arabia

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International Journal of Ophthalmology(English edition) 2015年第6期8卷 1261-1263页

作者： samir s.shoughy Mahmoud O.Jaroudi Khalid F.Tabbara Igor Kozak The Eye Center the Eye Foundation for Research in Ophthalmology Department of Ophthalmology College of Medicine King Saud University The Wilmer Eye Institute of the Johns Hopkins University school of Medicine King Khaled Eye specialist Hospital

Dear sir,We write to report on the clinical manifestations and outcomes of ocular sarcoidosis in patients presenting to uveitis referral centers in the Kingdom of saudi *** is the first report focused solely on ocular... 详细信息

关键词： Clinical manifestations and outcomes of ocular sarcoidosis in saudi Arabia CNV

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Updates in uveitic macular edema

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World Journal of Ophthalmology 2014年第3期4卷 56-62页

作者： samir s shoughy Igor Kozak The Eye Center and The Eye Foundation for Research in Ophthalmology Vitreoretinal and Uveitis Division King Khaled Eye Specialist Hospital

Macular edema is one of the most common visionthreatening complications of uveitis noted in one third of patients with uveitis. The release of a number of inflammatory mediators induces retinal vascular hyperpermeability leading to uveitic macular edema(UME)which most commonly is of cystoid shape. Fluorescein angiography and non-invasive spectral-domain optical coherence tomography are standard procedures for diagnosis and follow-up of UME with some innovations such as scanning laser ophthalmoscope retro-mode imaging. Effective management of UME requires thorough understanding of the individual case. Proper control of intraocular inflammation is mandatory before targeting macular edema itself. Mainstay of treatment is immunosuppressive therapy with various drug delivery routes including topical, local subconjunctival, peribulbar and sub-Tenon's, intravitreal and systemic. Clinical trials with biologics are under way to study the efficacy of these agents in suppressing intraocular inflammation and resolution of UME. Visual prognosis in UME depends on numerous factors. Younger age and better visual acuity at baseline are associated with more favorable visual outcome in most

关键词： Intraocular inflammation Uveitic macular edema Fluorescein angiography Optical coherence tomography Corticosteroid therapy Drug delivery Clinical trials

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