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Influence of hospital volume and outcomes of adult structural heart procedures

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World Journal of Cardiology 2016年第4期8卷 302-309页

作者： Sidakpal S Panaich Nilay Patel Shilpkumar Arora Nileshkumar J Patel samir V Patel Chirag Savani Vikas Singh Rajesh Sonani Abhishek Deshmukh Michael Cleman Abeel Mangi John K Forrest Apurva O Badheka Interventional Cardiology Borgess Medical Center Internal Medicine Saint Peter’s University Hospital Internal Medicine Mount Sinai St.Luke’s Roosevelt Hospital Department of Cardiology University of Miami Miller School of Medicine Internal Medicine Western Reserve Health Education Internal Medicine New York Medical College Public Health Department Emory University School of Medicine Department of Cardiology Mayo Clinic Department of Cardiology Yale School of Medicine Department of Cardiology the Everett Clinic

Hospital volume is regarded amongst many in the medical community as an important quality metric. This is especially true in more complicated and less commonly performed procedures such as structural heart disease interventions. Seminal work on hospital volume relationships was done by Luft et al more than 4 decades ago, when they demonstrated that hospitals performing > 200 surgical procedures a year had 25%-41% lower mortality than those performing fewer procedures. Numerous volume-outcome studies have since been done for varied surgical procedures. An old adage "practice makes perfect" indicating superior operator and institutional experience at higher volume hospitals is believed to primarily contribute to the volume outcome relationship. Compelling evidence from a slew of recent publications has also highlighted the role of hospital volume in predicting superior post-procedural outcomes following structural heart disease interventions. These included transcatheter aortic valve repair, transcatheter mitral valve repair, septal ablation and septal myectomy for hypertrophic obstructive cardiomyopathy, left atrial appendage closure and atrial septal defect/patent foramen ovale closure. This is especially important since these structural heart interventions are relatively complex with evolving technology and a steep learning curve. The benefit was demonstrated both in lower mortality and complications as well as better economics in terms of lower length of stay and hospitalization costs seen at high volume centers. We present an overview of the available literature that underscores the importance of hospital volume in complex structural heart disease interventions.

关键词： Hospital volume Transcatheter mitral valve repair Septal ablation Septal myectomy Transcatheter aortic valve repair Left atrial appendage closure

他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退

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美国医学会杂志（中文版） 2007年第3期26卷 152-160页

作者： Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿（译） Departments of Cardiovascular Medidne Cleveland Clinic Cleveland Ohio. Cell Biology Cleveland Clinic Cleveland Ohio. Diagnostic Radiology Cleveland Clinic Cleveland Ohio. Center for Cardiovascular Diagnostics and Prevention Cleveland Clinic Cleveland Ohio. 不详

背景：他汀类药物可以降低低密度脂蛋白胆固醇（low—density lipoprotein cholesterol，LDL—C）水平并减缓冠状动脉粥样硬化的进展。然而，对于他汀类药物所致高密度脂蛋白胆固醇（high—density lipoprotein cholesterol，HDL—C）... 详细信息

背景：他汀类药物可以降低低密度脂蛋白胆固醇（low—density lipoprotein cholesterol，LDL—C）水平并减缓冠状动脉粥样硬化的进展。然而，对于他汀类药物所致高密度脂蛋白胆固醇（high—density lipoprotein cholesterol，HDL—C）变化与疾病进展的关系，目前仍无相关数据描述。目的：了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者：对4项前瞻性随机试验（1999～2005年在美国、北美、欧洲和澳大利亚进行）的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗（18个月或24个月）时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标：脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果：他汀治疗期间，LDL—C平均（SD）水平从124．0（38．3）mg,／dL（3．2[0．99]mmol／L）降至87．5（28．8）mg,／dL（2．3[0．75]mmol／L）（下降23．5％；P〈0．001），HDL—C水平从42．5（11．0）mg／dL（1．1[0．28]mmol／L）升至45．1（11．4）mg／dL（1．2[0．29]mmol／L）（上升7．5％；P〈0．001）。LDL—C与HDL—C比值从平均（SD）3．0（1．1）降至2．1（0．9）（下降26．7％；P〈0．001）。这些变化同时伴随平均（SD）百分粥样斑块体积的增加（从39．7％[9．8％]增至40．1％[9．7％]）（增加0．5％[3．9％]；P=0．001）以及平均（SD）总粥样斑块体积的减小（2．4[23．6]mm^3；P〈0．001）。在单变量分析中，LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关，而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中，平均LDL—C水平（β系数，0．11[95％可信区间，0．07～0．15]）以及HDL—C升高（β系数，-0．26[95％可信区间，-0．41--0．10]）依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退（动脉粥样斑块体积减少≥5％）见于治疗期间LDL—C水平低于均值（87．5mg／dL）和HDL—C升高百分比大于均值（7．5％；P〈0．001）的患者。临床事件的发生未见显著差异。结论：在LDL—C显著降低以及HDL上升〉7．5％时，他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL．C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关，但是后者是否可以转化为临床事件的显著减少，并改善临床预后仍有待进一步研究确定。

关键词：高密度脂蛋白胆固醇冠状动脉粥样硬化他汀类药物消退冠状动脉粥样斑块 HDL胆固醇低密度脂蛋白胆固醇水平变化

剪切波弹性成像评估慢性肝病肝纤维化:确定准确和理想的测量位置

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国际医学放射学杂志 2015年第3期 275-275页

作者： A.E.samir M.Dhyani A.Vij A.K.Bhan E.F.Halpern J.MendezNavarro 丁静 Department of Radiology Massachusetts General Hospital Harvard Medical School

目的评估剪切波弹性成像(SWE)对弥漫性肝病病人[包括丙型肝炎病毒(HCV)病人]肝纤维化分期的准确性和确定肝脏不同位置SWE测量对肝纤维化分期的相对准确

关键词：肝纤维化 SWE AUC HCV 肝病病人肝疾病剪切波弹性成像脂肪变性

肝脏肿瘤射频消融治疗术后肿瘤边缘与局部肿瘤进展关系的研究

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国际医学放射学杂志 2010年第3期 302-302页

作者：张竞文 R.S. Arellano R.N. Uppot A.E. samir D.A. Gervais P.R. Mueller Department of Radiology Division of Abdominal Imaging and Interventional Radiology Massachusetts General Hospital

摘要目的回顾性分析原发性肝细胞癌及结直肠癌肝转移瘤行射频消融(RFA)术后肿瘤边缘与局部肿瘤进展的关系。方法将接受

关键词：射频消融射频消融术后肿瘤边缘局部肿瘤进展肝细胞癌结直肠癌肝转移瘤

肝局灶性病变经皮介入的光分子成像前瞻性试验

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国际医学放射学杂志 2015年第3期 276-276页

作者： R.A.Sheth R.S.Arellano R.N.Uppot A.E.samir L.Goyal A.X.Zhu 施益洁 Departments of Radiology Massachusetts General Hospital149 13th St Room 2301Charlestown MA 02129

目的为证明光分子成像(OMI)可临床转化应用于肝局灶性病变经皮介入定位。材料与方法本前瞻性、单中心试验符合HIPAA,获伦理审查委员会批准。入选者为怀疑

关键词：肝局灶性病变分子成像经皮

Assessment of Lung Cancer Risk on the Basis of a Biomarker Panel of Circulating Proteins

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Assessment of Lung Cancer Risk on the Basis of a Biomarker P...

细胞核内m6A读码器YTHDC1调控mRNA选择性剪接机制研究

2019年中国肿瘤标志物学术大会暨第十三届肿瘤标志物青年科学家论坛

作者： sun,nan Florence,Guida Bantis,LeonidasE. Muller,DavidC. Li,Peng Taguchi,Ayumu Dhillon,Dilsher Kundnani,DeepaliL. Patel,NikulJ. Yan,Qingxiang Byrnes,Graham Moons,KarelG.M. Tj?nneland,Anne Panico,Salvatore Claudia ,Agnoli Vineis,Paolo Palli,Domenico Bueno-de-Mesquita,Bas Peeters,PetraH. Agudo,Antonio Huerta,JoseM. Dorronsoro,Miren Barranco,MiguelRodriguez Ardanaz,Eva Travis,RuthC. Byrne,KarlSmith Boeing,Heiner Steffen,Annika Kaaks,Rudolf Hüsing,Anika Trichopoulou,Antonia Lagiou,Pagona LaVecchia,Carlo Severi,Gianluca Boutron-Ruault,Marie-Christine Sandanger,TorkjelM. Weiderpass,Elisabete N?st,ThereseH. Tsilidis,Kostas Riboli,Elio Grankvist,Kjell Johansson,Mikael Goodman,GaryE. Feng,Ziding Brennan,Paul Johansson,Mattias Hanash,samir M. The University of Texas MD Anderson Cancer Center Genetic Epidemiology Group International Agency for Research on Cancer Department of Biostatistics The University of Texas MD Anderson Cancer Center Department of Epidemiology and Biostatistics Imperial College London School of Public Health Laboratory of Population Health Max Planck Institute for Demographic Research Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer Center Environment and Radiation Section International Agency for Research on Cancer Department of Epidemiology Julius Center for Health Sciences and Primary CareUniversity Medical Center Unit of Diet Genesand EnvironmentDanish Cancer Society Research Center Department of Clinical Medicine and Surgery Federico Ⅱ University Epidemiology and Prevention Unit Fondazione IRCCS Istituto Nazionale dei Tumori Molecular and Genetic Epidemiology Unit Human Genetics Foundation Cancer Risk Factors and Life-Style Epidemiology Unit Cancer Research and Prevention Institute-Istituto per lo Studio ela Prevenzione Oncologica Department for Determinants of Chronic Diseases National Institute for Public Health and the Environment Unit of Nutirition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of OncologyBellvitge Institute for Biomedical Research (IDIBELL)L’Hospitalet de Llobregat Department of Epidemiology Murcia Regional Health Council Biomedical Research Institute of Murcia(IMIB-Arrixaca) Centro de Investigación Biomédica en Red Epidemiología y Salud Pública (CIBERESP) Public Health Direction and Biodonostia Research Institute-CIBERESP Escuela Andaluza de Salud Pública Instituto de Investigación Biosanitaria Hospitales Universitarios de Granada/Universidad de Granada Epidemiology Preventionand Promotion Health ServiceNavarra Public Health Institute Instituto de Investigación Sanitaria de Navarra (IdiSNA) Navarra Institute for Health Research Cancer Epidemiology Unit Nuffield Department of Population HealthUniversity of Oxford Department of Epidemi

IMPORTANCE:There is an urgent need to improve lung cancer risk assessment because current screening criteria miss a large proportion of ***:To investigate whether a lung cancer risk prediction model based on a panel of selected circulating protein biomarkers can outperform a traditional risk prediction model and current US screening criteria.

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科学新闻 2017年第4期 81-81页

作者： Wen Xiao samir Adhikari Ujwal Dahal Yu-Sheng Chen Ya-Juan Hao Bao-Fa Sun Hui-Ying Sun Ang Li Xiao-Li Ping Wei-Yi Lai Xing Wang Hai-Li Ma Chun-Min Huang Ying Yang Niu Huang Gui-Bin Jiang Hai-Lin Wang Qi Zhou Xiu-Jie Wang Yong-Liang Zhao 杨运桂中国科学院北京基因组研究所

文章简介6-甲基腺嘌呤（m6A）对RNA加工代谢起着多方面的调控作用,如影响mRNA的翻译和稳定性等。然而,m6A的细胞核内读码器YTHDC1如何调控前体mRNA的加工尚不清楚。本研究通过串联亲和沉淀的方法筛选YTHDC1的互作蛋白,发现了与其相互作... 详细信息

文章简介6-甲基腺嘌呤（m6A）对RNA加工代谢起着多方面的调控作用,如影响mRNA的翻译和稳定性等。然而,m6A的细胞核内读码器YTHDC1如何调控前体mRNA的加工尚不清楚。本研究通过串联亲和沉淀的方法筛选YTHDC1的互作蛋白,发现了与其相互作用的两个m RNA剪接因子SRSF3和SRSF10。结合转录组和光交联-RNA测序及

关键词：选择性剪接 m~6A YTHDC1 mRNA 细胞核核(细胞学) 读码调控调节控制