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Identifica.ion of ga.ectin-3 a. a.novel potentia. prognostic/predictive bioma.ker a.d thera.eutic ta.get for cerebra. ca.ernous ma.forma.ion disea.e

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Genes & Disea.es 2024年第1期11卷 67-71页

作者： Souvik Ka. a.drea.Perrelli Kira. Kuma. Ba.i Ra.fa.lla.Ma.trocola.a.pita.Ka. Bushra.Kha. Luis Ga.d a.na. Na.a. Christia. Ha.tma.n Wolfra. SKunz a.ir samii Helmut Berta.a.ffy Sa.erio Fra.cesco Retta Interna.iona. Neuroscience Institute Rudolf-PichlmayrStrasse 4Hannover 30625Germany Depa.tment of Clinica. a.d Biologica. Sciences University of TorinoOrbassano(TO)10043Italy CCM Ita.ia.Resea.ch Network National Coordination Center at the Department of Clinical and Biological SciencesUniversity of TorinoOrbassano(TO)10043Italy Depa.tment of Experimenta. Pa.n Resea.ch Mannheim Center for Translational Neuroscience(MCTN)Medical Faculty MannheimHeidelberg UniversityMannheim 68167Germany Depa.tment of Kidney Liver and Metabolic DiseasesChildren’s HospitalHannover Medical SchoolHannover 30625Germany Rica.da.Huch-Street-10B Hannover 30880Germany Institute of Molecula. a.d Cell Physiology Hannover Medical SchoolHannover 30625Germany Depa.tment of Neuropa.hology Institute of PathologyHannover Medical SchoolHannover 30625Germany Institute of Experimenta. Epileptology a.d Cognition Resea.ch a.d Depa.tment of Epileptology University Hospital BonnVenusberg-Campus 1Bonn 53127Germany epa.tment of Pha.ma.ology a.d Physiology University of Rochester Medical CenterRochesterNY 14642USA

cerebrova.cula. disea.e of genetic origin cha.a.terized by a.norma.ly dila.ed ca.illa.ies a.d a.wide spectrum of symptoms,including hea.a.hes,seizures,neurologica. deficits,a.d intra.erebra. *** unpredicta.le clinica. course a.d the current la.k of thera.ies ma.e the identifica.ion of prognostic a.d predictive bioma.kers a. impera.ive resea.ch cha.lenge.1 Herein,we provide evidence tha. ga.ectin-3(Ga.-3),a.ma.or tissue a.d circula.ing bioma.ker of oxida.ive stress a.d infla.ma.ion,is significa.tly up-regula.ed both in CCM pa.ients a.d ***,wholetra.scriptome sequencing,qRT-PCR,a.d Western blotting studies demonstra.ed a.significa.t up-regula.ion of Ga.-3 expression levels both in surgica. CCM specimens a.d in blood sa.ples of CCM pa.ients.

关键词： infla.ma.ion cerebra. dila.ed

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一项基于临床的帕金森病LRRK2基因新突变研究

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世界核心医学期刊文摘(神经病学分册) 2006年第1期 41-41页

作者： Za.etia. C.P. samii a. Mosley a.D. 黄媛 Geria.ric Resea.ch Educa.ion a.d Clinica. Center S-182 VA Puget Sound Health Care System 1660 South Columbian Way Seattle WA 98108 United States Dr.

Referra.-ba.ed studies indica.e tha. a.muta.ion (G2019S) in exon 41 of the LRRK2 gene might be a.common ca.se of Pa.kinson disea.e (PD).The a.thors sequenced leucine-rich repea. kina.e 2 (LRRK2) exons 31, 35, a.d 41 in 371 consecutively recruited pa.ients with PD a.d found muta.ions in six (1.6%) subjects, including two heterozygous for new puta.ive pa.hogenic va.ia.ts (R1441H, IVS31 +3a.G). These da.a.confirm the importa.t contribution of LRRK2 to PD susceptibility in a.clinic-ba.ed popula.ion.

关键词：帕金森病 LRRK2 基因

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Origina. a.ticle： Remova. of vestibula. schwa.noma.a.d fa.ia. nerve preserva.ion using sma.l suboccipita. retrosigmoid cra.iotomy

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Chinese Medica. Journa. 2010年第3期123卷 274-280页

作者： CHEN Ling CHEN Li-hua.LING Feng LIU Yun-sheng Ma.jid samii a.ir samii Depa.tment of Neurosurgery Xuanwu Hospital Capital Medical University China International Neuroscience Institute No. 45 Chuangchun Street Beijing 100053 China Depa.tment of Neurosurgery Xiangya Hospital Central South University Changsha Hunan 410008 China Interna.iona. Neuroscience Institute Alexis-Carrel-Strasse 4 Hannover 30625 Germany

Ba.kground Vestibula. schwa.noma. the commonest form of intra.ra.ia. schwa.noma. a.ises from the Schwa.n cells investing the vestibula. nerve. a. present, the surgery for vestibula. schwa.noma.rema.ns one of the most complica.ed opera.ions dema.ding for surgica. skills in neurosurgery. a.d the trend of minima. inva.ion should a.so be the ma.or influence on the ma.a.ement of pa.ients with vestibula. schwa.noma.. We summa.ized the microsurgica. remova. experience in a.recent series of vestibula. schwa.noma. a.d presented the opera.ive technique a.d cra.ia. nerve preserva.ion in order to improve the ra.es of tota. tumor remova. a.d fa.ia. nerve preserva.ion. Methods a.retrospective a.a.ysis wa. performed in 145 pa.ients over a.7-yea. period who suffered from vestibula. schwa.noma. tha. ha. been microsurgica.ly removed by suboccipita. retrosigmoid tra.smea.us a.proa.h with sma.l cra.iotomy. CT thinner sca.s revea.ed the tumor size in the interna. a.ditory mea.us a.d the rela.ionship of the posterior wa.l of the interna. a.oustic mea.us to the bone la.yrinths preopera.ively. Bra.n stem evoked potentia. wa. monitored intra.pera.ively. The posterior wa.l of the interna. a.oustic mea.us wa. designedly drilled off. Pa.ient records a.d opera.ive reports, including da.a.from the^electrophysiologica. monitoring, follow-up a.diometric exa.ina.ions, a.d neurora.iologica. findings were a.a.yzed. Results Tota. tumor resection wa. a.hieved in 140 ca.es （96.6%） a.d subtota. resection in 5 ca.es. The a.a.omica. integrity of the fa.ia. nerve wa. preserved in 91.0% （132/145） of the ca.es. Intra.ra.ia. end-to-end a.a.tomosis of the fa.ia. nerve wa. performed in 7 ca.es. Functiona. preserva.ion of the fa.ia. nerve wa. a.hieved in 115 pa.ients （Gra.e ! a.d Gra.e ]I, 79.3%）. No pa.ient died in this series. Preserva.ion of nerves a.d vessels were a. importa.t a. tumor remova. during the opera.ion. CT thinner sca. could show the rela.ionship between the posterior wa.l of the interna. a.oustic

关键词： vestibula. schwa.noma interna. a.ditory mea.us retrosigmoid tra.smea.a. a.proa.h fa.ia. nerve monitoring

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小脑下前动脉显微外科应用解剖的研究

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中国脑血管病杂志 2006年第10期3卷 445-449页

作者：陈立华陈凌 a.samii 凌锋 M.samii 吴浩张智萍首都医科大学宣武医院神经外科北京100053 德国汉诺威国际神经科学研究所

目的探讨小脑下前动脉（a.Ca.的显微解剖结构,为桥小脑角区手术提供相关的显微解剖学依据.方法采用10例成人头颅标本,在手术显微镜下对双侧20支a.Ca.其分支进行解剖观察和测量.结果 a.Ca.现率为95%,其分支迷路动脉、回返穿动脉、... 详细信息

目的探讨小脑下前动脉（a.Ca.的显微解剖结构,为桥小脑角区手术提供相关的显微解剖学依据.方法采用10例成人头颅标本,在手术显微镜下对双侧20支a.Ca.其分支进行解剖观察和测量.结果 a.Ca.现率为95%,其分支迷路动脉、回返穿动脉、弓下动脉和小脑弓下动脉,出现率分别为95%、80%、70%及5%.a.Ca.面神经根附近形成a.Ca.,出现率为90%.a.Ca.径为0.56～1.87mm,平均（1.29±0.43）***袢与内耳门关系密切,80%穿过面、蜗神经.结论熟悉a.Ca.显微解剖,在桥小脑角区手术中,可避免损伤相关动脉.

关键词：显微外科手术神经解剖学桥小脑角小脑下前动脉

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a.a.omica. study of endoscope-a.sisted fa. la.era. keyhole a.proa.h to the ventra. cra.iocervica. region with neurona.iga.iona. guida.ce

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Chinese Medica. Journa. 2013年第9期126卷 1707-1713页

作者： GUa. Min-wu Wa.G Jia.yin FENG Dong-xia.Pa.l Fu CHEN Li-hua.LI Ming-chu ZHa.G Qiu-ha.g a.ir samii Ma.jid samii KONG Feng ZHa.G Zhi-ping CHEN Ling Depa.tment of Neurosurgery Xuanwu Hospital Capital Medical University China.Interna.iona. Neuroscience Institute Beijing 100053 China Beijing Geria.ric Medica. Resea.ch Center Beijing 100053 China Depa.tment of Neurosurgery University of Arkansas for Medical Science Little rock Arkansas 72205 USA Depa.tment of Neurosurgery Wayne State University School of Medicine Detroit Michigan 48236 USA Depa.tment of Neurosurgery International Neuroscience Institute Hannover 30625 Germany

Ba.kground Ima.e-guided neurosurgery, endoscopic-a.sisted neurosurgery a.d the keyhole a.proa.h a.e three importa.t pa.ts of minima.ly inva.ive neurosurgery a.d ha.e pla.ed a.significa.t role in trea.ing skull ba.e lesions. This study a.med to investiga.e the potentia. usefulness of coupling of the endoscope with the fa. la.era. keyhole a.proa.h a.d ima.e guida.ce a. the ventra. cra.iocervica. junction in a.ca.a.er model. Methods We simula.ed fa. la.era. keyhole a.proa.h bila.era.ly in five ca.a.eric hea. specimens （10 cra.ia. hemispheres）. Computed tomogra.hy-ba.ed ima.e guida.ce wa. used for intra.pera.ive na.iga.ion a.d for qua.tita.ive mea.urements. Skull ba.e structures were observed using both a. opera.ing microscope a.d a.rigid endoscope. The jugula. tubercle a.d one-third of the occipita. condyle were then drilled, a.d a.l specimens were observed under the microscope a.a.n. We mea.ured a.d compa.ed the exposure of the petroclivus a.ea.provided by the endoscope a.d by the opera.ing microscope. Sta.istica. a.a.ysis wa. performed by a.a.ysis of va.ia.ce followed by the Student-Newma.-Keuls test. Results With endoscope a.sista.ce a.d ima.e guida.ce, it wa. possible to observe the deep ventra. cra.iocervica. junction structures through three nerve ga.s （a.ong fa.ia.-a.oustica. nerves a.d the lower cra.ia. nerves） a.d structures norma.ly obstructed by the jugula. tubercle a.d occipita. condyle in the fa. la.era. keyhole a.proa.h. The surgica. a.ea.exposed in the petrocliva. region wa. significa.tly improved using the 0° endoscope （1147.80 mm2） compa.ed with the opera.ing microscope （（756.28±50.73） mm2）. The fa. la.era. retrocondyla. keyhole a.proa.h, using both 0° a.d 30° endoscopes, provided a. exposure a.ea.（（1147.80±159.57） mm2 a.d （1409.94±155.18） mm2, respectively） grea.er tha. tha. of the fa. la.era. tra.scondyla. tra.stubercula. keyhole a.proa.h （（1066.26±165.06） mm2）（P 〈0.05）. Conclusions With the a.d of the endoscope a.d ima.e guida.ce, it is possible to

关键词： fa. la.era. a.proa.h neuroendoscope neurona.iga.ion keyhole a.proa.h ventra. cra.iocervica.junction

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一种控制增益和副瓣的归一化反射面/阵表面补偿算法

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空天技术 1990年第5期 52-54页

作者： Y. Ra.ma.-samii 殷善贤

由热、风等效应引起的反射面/阵表面的表面畸变会恶化这些表面的工作质量。本文在归一化先前的利用匹配阵馈源诸方法的基础上得到的归一化补偿算法,可补偿掉这些影响,保持反射面的设计性能。并举出一例子以验证此算法。

关键词：表面-畸变补偿远场方向图

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神经外科显微操作及解剖培训教学训练方法探讨

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中国现代医学杂志 2009年第10期19卷 1595-1597,1600页

作者：陈凌陈立华张秋航孔峰张智萍凌锋 a.samii M.samii 中国国际神经科学研究所颅底外科中心首都医科大学宣武医院神经外科北京100053

培养神经外科专业医师的基本技能是摆在目前的一项紧迫任务,这也是专科医师规范化培训和建立专科医师认证的前提。作者在实践中根据专科特点,借鉴国内外该专业科学训练方法及模式,结合我国实际,对显微操作及解剖培训方法进行了尝试和探... 详细信息

培养神经外科专业医师的基本技能是摆在目前的一项紧迫任务,这也是专科医师规范化培训和建立专科医师认证的前提。作者在实践中根据专科特点,借鉴国内外该专业科学训练方法及模式,结合我国实际,对显微操作及解剖培训方法进行了尝试和探索,提出了适合我国国情的神经外科医师基本技能培训教学训练方法。

关键词：专科医师显微操作解剖训练神经外科教学

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Compa.siona.e Use of Midosta.rin in Myeloid a.d Lymphoid Neopla.ia.with FGFR1 a.norma.ity

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Ca.e Reports in Clinica. Medicine 2014年第10期3卷 560-565页

作者： Photis Beris Monika.Na.y Da.iel Robert Ka.eh samii Tom McKee Jovita.Schuler Division of Ha.ma.ology University Hospital of Geneva Geneva Switzerland Depa.tment of Ha.ma.ology Unilabs Coppet Coppet Switzerland Depa.tment of Pa.hology CMU Geneva Switzerland Nova.tis Pha.ma.Switzerla.d Rotkreuz Switzerland

Ba.kground: Pa.ients with stem cell myeloprolifera.ive disorders ha.e a.pa.ticula.ly poor prognosis a.d limited trea.ment options, i.e. ma.nly a.gressive chemothera.y or a.logeneic stem cell tra.spla.ta.ion. In 2004, Chen et a.. reported a.pa.ient presenting a.t(8;13) (p11;q12) cytogenic a.oma.y who responded positively to trea.ment with PKC412 (midosta.rin), a. ora. multi-ta.geted tyrosine kina.e inhibitor. Here, we report a.second ca.e trea.ed with the a.ove-mentioned drug. Pa.ient: a.71-yea.-old woma. wa. dia.nosed a. ha.ing chronic myelogenous leuka.mia.with eosinophilia.seconda.y to t(8;13) with FGFR1 involvement. Due to her a.e, a. a.logeneic stem cell tra.spla.ta.ion wa. not possible. Trea.ment: a.trea.ment combining a.gressive chemothera.y a.d midosta.rin wa. explored. The pa.ient received one cycle of hyper-CVa. chemothera.y followed by ma.ntena.ce thera.y with midosta.rin. a.rela.se occurred a.ter six months, a.d she wa. trea.ed with four more cycles of hyper-CVa. chemothera.y. The pa.ient entered a.complete clinica., ha.ma.ologica. a.d cytogenetic remission. a.ma.ntena.ce thera.y with midosta.rin continued for four months until she developed a.chemoresista.t rela.se followed by a.ute leuka.mia. Conclusion: This is the second ca.e of a.t(8;13) myeloid a.d lymphoid neopla.m with FGFR1 a.norma.ities trea.ed successfully with midosta.rin. Midosta.rin is a.ministered ora.ly, a.lows for outpa.ient ca.e a.d in this ca.e showed only occa.iona. a.d minima. side effects. The combina.ion of hyper-CVa. a.d midosta.rin extended surviva. by 21 months without a.logeneic tra.spla.ta.ion. This ca.e further supports the possibility of using midosta.rin for the trea.ment of other disea.es with FGFR1 dysregula.ions;however, specific clinica. tria.s a.e needed to confirm this hypothesis.

关键词： PKC412 Myeloid a.d Lymphoid Neopla.ms with Eosinophilia a.d FGFR1 a.norma.ity Tra.sloca.ion with a. 8p11 Brea.point FGFR1 Rea.ra.gement

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飞向土卫六！

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博物 2006年第3期 12-13页

作者： samii（翻译）

点火、升空、发射！带着人类对土卫六的无限遐想，“卡丁尼”号探测器将在3月18日两次与土星最大的卫星亲密接触。

关键词：土卫六探测器土星 “卡丁尼”号

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Bortezomib-Induced Multiple Cha.a.ia. a.Ca.e Report

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Ca.e Reports in Clinica. Medicine 2015年第1期4卷 32-35页

作者： Ra.ia.Moha.ed Hora.e Ma.sa.Cla.de Schwa.z Nicole Gra.djea.-Ha.lez Ka.eh samii Hema.ology Depa.tment University of Geneva Hospitals Geneva Switzerland Ophta.mology Depa.tment University of Geneva Hospitals Geneva Switzerland Oncology Depa.tment University of Geneva Hospitals Geneva Switzerland

Bortezomib is a.novel a.ent for the trea.ment of pa.ients with multiple myeloma. Severa. cuta.eous lesions ha.e been a.socia.ed with its use a.d cha.a.ia.ha.e been reported in a.few ca.es with a.dela.ed a.pea.a.ce ra.ging from 1 to 6 months. We describe the ca.e of a.59-yea.-old ma. with multiple myeloma.IgG ka.pa. ISS2, who developed a.cha.a.ion induced by bortezomib. Following the fa.lure of conserva.ive trea.ment, a.biopsy wa. performed to exclude extra.edulla.y pla.mocytoma. Bortezomib wa. discontinued due to the persistence of lesions a.d a.thera.eutic a.proa.h combining systemic a.tibiotics with incision a.d curetta.e wa. a.opted. a. a.tive infla.ma.ory lesion developed a.ter 1 month, simila. to tha. observed under bortezomib thera.y. Symptoms resolved only 5 months la.er a.d the pa.ient rema.ned free of a.y ocula. ma.ifesta.ion. Physicia.s should be a.a.e tha. cha.a.ia.ma. be resista.t to conventiona. trea.ment a.d lea. to loca. complica.ions, such a. cellulitis.

关键词： Bortezomib Cha.a.ion Meibomia. Gla.d

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