检索结果-南通市图书馆

Low-density lipoprotein receptor genetic polymorphism in chronic hepatitis C virus Egyptian patients affects treatment response

引用

World Journal of Gastroenterology 2015年第39期21卷 11141-11151页

作者： Mazen Naga Mona Amin Dina Algendy Ahmed Elbadry May Fawzi Ayman Foda Serag Esmat Dina Sabry Laila Rashed samia gabal Manal Kamal Division of Gastro-enterology Department of Internal Medicine Faculty of Medicine Cairo University Department of Biochemistry Faculty of Medicine Cairo University Department of Pathology Faculty of Medicine Cairo University Department of Clinical and Chemical pathology Faculty of Medicine Cairo University

AIM: To correlate a genetic polymorphism of the low-density lipoprotein(LDL) receptor with antiviral responses in Egyptian chronic hepatitis C virus(HCV) ***: Our study included 657 HCV-infected patients with genotype 4 who received interferonbased combination therapy. Patients were divided into two groups based on their response to therapy: 356 were responders, and 301 were non-responders. Patients were compared to 160 healthy controls. All patients and controls underwent a thorough physical examination, measurement of body mass index(BMI) and the following laboratory tests: serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, albumin, total bilirubin, direct bilirubin, prothrombin time, prothrombin concentration, INR, complete blood count, serum creatinine, fasting blood sugar, HCV antibody, and hepatitis B surface antigen. All HCV patients were further subjected to the following laboratory tests: HCV-RNA using quantitative polymerase chain reaction(PCR), antinuclear antibodies, thyroid-stimulating hormone, an LDL receptor(LDLR) genotype study of LDLR exon8 c.1171G>A and exon-10 c.1413G>A using real-time PCR-based assays, abdominal ultrasonography, ultrasonographic-guided liver biopsy, and histopathological examination of liver biopsies. Correlations of LDL receptor polymorphisms with HAI, METAVIR score, presence of steatosis, and BMI were performed in all ***: There were no statistically significant differences in response rates between the different types of interferon used or LDLR exon10 c.1413G>A. However, there was a significant difference in the frequency of the LDL receptor exon8 c.1171G>A genotype between cases(AA: 25.9%, GA: 22.2%, GG: 51.9%) and controls(AA: 3.8%, GA: 53.1% and GG: 43.1%)(P A polymorphism between responders(AA: 3.6%, GA: 15.2%, GG: 81.2%) and nonresponders(AA: 52.2%, GA: 30.6%, GG: 17.

关键词： Hepatitis C virus Genetic polymorphisms Low-densit

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LINEAR SEARCH FOR A BROWNIAN TARGET MOTION

引用

Acta Mathematica Scientia 2003年第3期23卷 321-327页

作者： A.B.El-Rayes AbdEl-MoneimA.Mohamed Hamdy M.Abou gabal Military Technical College CairoEgyptMilitary Technical CollegeCairoEgyptDepartment of MathematicsFaculty of ScienceTanta UniversityTantaEgypt

A target is assumed to move according to a Brownian motion on the real line. The searcher starts from the origin and moves in the two directions from the starting point. The object is to detect the target. The purpose of this paper is to find the conditions under which the expected value of the first meeting time of the searcher and the target is finite, and to show the existence of a search plan which made this expected value minimum.

关键词： Brownian process expected value linear search optimal search plan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management of Hepatocellular Carcinoma Patients with Portal Vein Thrombosis Using Three-Dimensional Conformal Radiotherapy

引用

Journal of Cancer Therapy 2017年第6期8卷 579-590页

作者： Ahmed Abo gabal Mohamed Lotayef Hoda Abd Elbaky Maha Hassan Heba Elzawahry Ekram Hamed Department of Radiation Oncology National Cancer Institute Cairo University Cairo Egypt Department of Medical Oncology National Cancer Institute Cairo University Cairo Egypt Department of Radio-Diagnosis National Cancer Institute Cairo University Cairo Egypt

Objective: To determine the possible therapeutic gain of using three-dimensional conformal radiotherapy (3D-CRT) as a treatment option for portal vein tumor thrombus (PVTT) in patients with hepatocellular carcinoma (HCC) and to evaluate the tolerance and toxicity of using such treatment. Materials and methods: Sixty two patients were enrolled in this prospective study between June 2013 and August 2015. The clinical target volume (CTV) was the PVTT and the prescribed dose was 50 Gy/25 fractions. The median follow-up time was 7.4 months. Results: The thrombus crude response rate was 40.4% and the only significant prognostic factor for response was the thrombus size. Responders had significant better survival compared to non-responders with a median survival of 12.5 and 8 months respectively (P Conclusions: The results of this study suggest that radiotherapy should be considered as a safe treatment option for HCC patients with PVTT. It is effective not only for PVTT local control but also for survival, although prospective randomized trials are needed to confirm these results.

关键词： Hepatocellular Carcinoma Portal Vein Thrombosis 3D Conformal Radiotherapy Portal Vein Tumor Thrombus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Compliant to Warfarin Therapy after Mechanical Heart Valve Replacement

引用

Open Journal of Thoracic Surgery 2014年第2期4卷 39-43页

作者： Ragab S. Shehata Ahmed A. Elassal Ayman A. gabal Lecturer Cardiothoracic Surgery Zagazig University Zagazig Egypt Registrar Cardiothoracic Surgery King Abdul-Aziz University Hospital Jeddah KSA

Introduction: Effective anticoagulation depends on demographic factors, patient education, drug knowledge and compliance. The aim of our study is to determine the factors that influence compliance to warfarin in the mechanical valve patient population and its relationship with thrombo-embolic and bleeding events. Patients and Methods: 113 patients underwent mechanical valve replacement (Aortic, mitral or both) at King Abdul-Aziz University Hospital, from 2006 to 2012, patients divided into two groups according to warfarin compliant. Results: 113 patients reviewed in our study, 69 (61.1%) patients found compliant, 36 (31.9%) patients found non compliant, and 8 (7.1%) patients missed. The mean age for all patients was 39.25 y: 76 (67.3%) ware male, 37 (32.7%) were female. Mean age for compliant patients was 40.19 y versus 33.3 y for noncompliant patients with p value 0.017. Male patient less complaint than female with significant 0.01, the mean frequency of follow up was less (32.32 days) in compliant vs. (67.73 days) in non complaint patient. Conclusion: younger age, female gender, Arabic race, assistance at home, education, and single drug use are factors associated with patient compliant, non compliance are associated with higher mortality and valve related complication.

关键词： Warfarin Compliant Mechanical Valve Replacement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

偏滤器靶板附近氦输运的蒙特卡洛模拟

引用

核聚变与等离子体物理 1992年第4期12卷 218-225页

作者：邓柏权谢中友施汉文 H.H.Abou-gabal G.A.Emmert 核工业西南物理研究院 University of Alexandria Egypt University of Wisconsin U.S.A

本文用Monte Carlo方法模拟了偏滤器扁平抽气收集板附近区域的氦原子输运。考虑了氦原子被电子碰撞电离,氦原子与等离子体离子之间的弹性散射等原子过程以及离子的热运动和沿磁力线的流动。计算表明当偏滤器等离子体密度在7cm距离内从... 详细信息

本文用Monte Carlo方法模拟了偏滤器扁平抽气收集板附近区域的氦原子输运。考虑了氦原子被电子碰撞电离,氦原子与等离子体离子之间的弹性散射等原子过程以及离子的热运动和沿磁力线的流动。计算表明当偏滤器等离子体密度在7cm距离内从里向靶板逐渐增加约4.7倍,而温度分布保持不变时,氦灰返回靶板的几率比密度在7cm内向靶板递减4.7倍的通常正分布提高约45％。磁力线与靶板的交角、靶板的温度,边缘等离子体鞘层电位以及不同的靶材料对氦返回靶板几率的影响作了比较。得到的结果对托卡马克聚变裂变增殖堆孔栏和偏滤器工程设计有参考价值。

关键词：氦输运偏滤器蒙特卡洛模拟

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of serum levels of epidermal growth factor with disease severity in patients with unresectable hepatocellular carcinoma

引用

Hepatoma Research 2016年第1期2卷 18-25页

作者： Mohamed Ahmed Samy Kohla Om Kolsoum Al-Haddad Ali Nada Mohamed Al-Warraky Manar Obada Mohamed Amer Sameera Ezzat Ashraf Abou gabal Department of Hepatology National Liver InstituteMenoufia University32511 MenoufiaEgypt Department of Radiology National Liver InstituteMenoufia University32511 MenoufiaEgypt Department of Clinical Biochemistry National Liver InstituteMenoufia University32511 MenoufiaEgypt Department of Epidemiology National Liver InstituteMenoufia University32511 MenoufiaEgypt

Aim:Epidermal growth factor(EGF)is a mitogen for hepatocyte grown in vitro,and its expression is up-regulated during liver *** also plays an important role in tumor initiation and *** goal of this study is to assess whether EGF is associated with advanced hepatocellular carcinoma(HCC)and also whether it is a predictive factor of shortened ***:Serum EGF levels were evaluated in a total of 151 subjects:51 patients with unresectable HCC,(21 of them were eligible for transarterial chemoembolization(TACE)and serum EGF levels were measured before and 1 week after TACE),40 patients with chronic hepatitis without cirrhosis,40 patients with cirrhosis,and 20 healthy *** demographic and laboratory variables were evaluated as predictive factors of survival in a Cox regression multivariate analysis using SPSS ***:The mean serum level of EGF in patients with HCC was 784.49 pg/mL,which was significantly higher(P<0.05)than all other *** EGF level in cirrhotic patients was 144.69 pg/mL;in those with chronic hepatitis C without cirrhosis,it was 338.64 pg/mL;and in healthy controls,it was 297.15 pg/*** group Ia patients who underwent TACE,the mean serum level of EGF was 759.76±287.88 pg/mL before TACE,and 801.14±276.12 pg/mL 1 week after treatment(P=0.34).On multivariate Cox regression analysis only age(P=0.03)and higher serum EGF level(P=0.005),were inversely correlated with overall ***:EGF levels were found to be significantly higher in HCC patients and together with age were the only predictors of poor survival in these *** was an increase in EGF levels 1 week after TACE in response to hypoxia;however,this increase was not statistically significant.

关键词： Cirrhosis epidermal growth factor hepatocellular carcinoma survival transarterial chemoembolization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment Outcome of Pharmacokinetics-Based Dosing of Docetaxel and Fluorouracil in Advanced Head and Neck Cancer Patients

引用

Journal of Cancer Therapy 2018年第12期9卷 998-1010页

作者： Abdelhamid M. Fouad Magdy M. Saber Yahia M. Ismail Yasser A. Sallam Tarek M. Shouman Reham A. A. Elshimy Ahmed Abo gabal Department of Medical Oncology National Cancer Institute Cairo University Cairo Egypt Department of Radiation Oncology National Cancer Institute Cairo University Cairo Egypt Department of Clinical and Chemical Pathology National Cancer Institute Cairo University Cairo Egypt

Introduction: Docetaxel, Cisplatin and 5-Fluorouracil (DPF) became the standard induction chemotherapy in advanced Head and Neck Cancer (HNC) but associated with high toxicity rate. Several studies reported higher response rates with better tolerability when chemotherapy dose is calculated based on Pharmacokinetics (PK) versus conventional Body Surface Area (BSA). Patients and Methods: Thirty nine patients with stage III and IV HNC who received induction DPF were included in the study. Dose of cycle 1 was BSA-based then Docetaxel and 5-FU doses were PK-adjusted starting from cycle 2 whereas Cisplatin dose was BSA-based throughout the study. Results: After median follow up period of 14 months the median overall survival (OS) and progression free survival (PFS) were 15.1 and 10.6 months respectively. Twenty nine patients were available for response assessment. Seven patients (24.1%) achieved complete response while partial response encountered in 19 patients (65.5%) with and Overall response rate of 89.6%. Both treatment related side effects and mortality significantly decreased after the application of PK dose adjustments (p-value 0.007 and 0.01 respectively). Conclusion: PK-guided dose adjustments of 5-FU and Docetaxel in DPF regimen can significantly decrease the treatment related side effects and mortality without compromising the tumor response rate. A randomized clinical trial is needed to compare the PK-guided dose adjustment with the standard BSA based protocol.

关键词： Head and Neck Cancer DPF Docetaxel Fluorouracil Pharmacokinetics Dose Adjustment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：