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Lipopeptides in promoting signals at surface/interface of micelles:Their roles in repairing cellular and nuclear damages

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Food Bioscience 2022年第2期46卷 73-90页

作者： sami saadi Nazamid Saari Hasanah Mohd Ghazali Abdulkarim Sabo Mohammed Azizah Abdul-Hamid Nor Elhouda Nacer Farooq Anwar Institut de la Nutrition de l’Alimentation et des Technologies Agro-alimentaires INATAA 25017Universit´e Fr`eres Mentouri Constantine 1Algeria Faculty of Food Science and Technology University Putra Malaysia43400SerdangSelangorMalaysia Department of Microbiology and Biotechnology Federal University DutseNigeria D´epartement de Biologie Universit´e de Batna 2Algeria Institute of Chemistry University of SargodhaSargodha40100Pakistan

Lipopeptides are recognized as a structurally diverse group of functional biopeptides.They possess multiple biological,biotechnological and therapeutic applications and are able to affect cell membrane integrity and permeability.It is widely accepted that suppressing the interaction of redooxidation is mainly aimed by inserting functional biopeptides on form alpha-helical peptides or on form antibody.Such types of structured biomaterials have great potential in promoting signal transductions to the most organelles having geometrical and spacial structures similar to endogenous liposome forms such as lysosomes,ribosomes,mitochondria and platelets..Thus,inserting radioactive trace-elements along with biopeptides is necessary in tracing the trajectory of those radioactive micelles that are destined in targeting further complicated disease and growth factor propagation.These techniques are important in determining structure-symmetry and asymmetry leading to meso-spherical crystal-packing modes or to copolymer vesiculization.The main objective of this review is to highlight and elucidate the potential role of lipopeptides in promoting signals at surface/interface of micelles along with their functionalities in repairing cellular and nuclear damages.Moreover,state-of-the-art scientific knowledge is reviewed regarding bioconjugation and structuring charged-mono-layer and/or bi-layer phospholipidic membranes in adherent to signal-biopeptides using some advanced techniques such as ultra-sound probe based polydispersity of radioactive trace-elements assisted microdialysis as micro-separating techniques in between those miscible and immiscible compounds.

关键词： Lipopeptides Biopeptides Biomaterials Spacial structure Transduction signal

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Rare Tumors of Ovary: Case Report and Literature Review

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Open Journal of Pathology 2012年第3期2卷 81-84页

作者： El Fatemi Hinde Hammas Nawal saadi Hannane Brahmi sami Amarti Afaf Bannani Abdelaziz Mesbahi Omar Department of Gynecology Hassan II Teaching Hospital Fez Morocco Department of Oncology Hassan II Teaching Hospital Fez Morocco Department of Pathology Hassan II Teaching Hospital Fez Morocco

Introduction: Large cell neuroendocrine carcinoma (LCNEC) or non small cell neuroendocrine carcinoma the ovary is a rare entity and is frequently associated with ovarian surface epithelial tumors. However, its association with serous carcinoma is rarer, in our knowledge tree cases has been described in international literature and the first case in Moroccan literature. Case Report: A 54-year-old woman presented with a pelvic mass measuring 15 cm in diameter. She underwent an exploratory laparotomy with resection of the pelvic mass. Diffuse and nodular intra-abdominal disseminations were observed. Immunohistochemistry stain confirmed the diagnosis of large cell neuroendocrine carcinoma with serous carcinoma. The patient received three courses of carboplatin and paclitaxel and she's still alivewith a decline of 6 months. Its clinicopathologic association is discussed and the literature is reviewed. Conclusion: In summary, ovarian LCNEC is an aggressive tumor with a tendency to present at advanced stage and cause death within a mean of 17 months after diagnosis;however, some patients, particularly those with stage I disease and/or those who have received platinum-based therapy, may have a more favorable prognosis.

关键词： Ovary Neuroendocrine Carcinoma Non-Small Cell Type Serous Carcinoma Immunohistochemistry

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