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Anti-aging based on stem cell therapy:A scoping review

World Journal of Experimental Medicine 2024年第3期14卷 57-63页

作者： Nassar El Assaad Alain Chebly Rawad Salame Robert Achkar Nour Bou Atme Khalil Akouch Paul Rafoul Colette Hanna samer.abou zeid Marwan Ghosn Charbel Khalil Faculty of Medicine Saint Joseph UniversityBeirut 961Lebanon Centre Jacques Loiselet for Medical Genetics and Genomics(CGGM) Faculty of MedicineSaint Joseph UniversityBeirut 961Lebanon Higher Institute of Public Health Saint Joseph UniversityBeirut 961Lebanon Stem Cell Therapy Lab Reviva Regenerative Medicine CenterBeirut 961Lebanon Poz Pozan University of Medical Sciences Pozan 034Poland Department of Epidemiology and Biostatistics Faculty of Public HealthLebanese UniversityBeirut 961Lebanon School of Medicine Lebanese American UniversityBeirut 961Lebanon Bone Marrow Transplant Unit Burjeel Medical CityAbu Dhabi 999041United Arab Emirates

Stem cells are present in the tissues and organs and remain in a quiescent and undifferentiated state until it is physiologically necessary to produce new descendant *** to their multipotency property,mesenchymal stem cells have attracted considerable attention worldwide due to their immunomodulation and therapeutic function in tissue *** cells secrete components such as paracrine factors,extracellular vesicles,and exosomes which have been shown to have anti-inflammatory,anti-aging,reconstruction and wound healing potentials in many in vitro and in vivo *** pluripotency and immunomodulatory features of stem cells could potentially be an effective tool in cell therapy and tissue *** affects the capacity for self-renewal and differentiation of stem cells,decreasing the potential for regeneration and the loss of optimal functions in organisms over *** progress in the field of cellular therapy and regenerative medicine has facilitated the evolution of particular guidelines and quality control approaches,which eventually lead to clinical *** therapy could potentially be one of the most promising therapies to control aging due to the fact that single stem cell transplantation can regenerate or substitute the injured *** understand the involvement of stem cells not only in tissue maintenance and disease but also in the control of aging it is important to know and identify their properties,functions,and regulation in vivo,which are addressed in this review.

关键词： Mesenchymal stem cell Anti-aging Telomerase Regenerative medicine Stem cell therapy

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Anal fistula: Intraoperative difficulties and unexpected findings

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World Journal of Gastroenterology 2011年第28期17卷 3272-3276页

作者： Ahmed A abou-zeid Department of Surgery El Demerdash HospitalAin Shams University

Anal fistula surgery is a commonly performed *** diverse anatomy of anal fistulae and their proximity to anal sphincters make accurate preoperative diagnosis essential to avoid recurrence and fecal *** the fact that proper preoperative diagnosis can be reached in the majority of patients by simple clinical examination,endoanal ultrasound or magnetic resonance imaging,on many occasions,unexpected findings can be encountered during surgery that can make the operation difficult and correct decision-making *** this article we discuss the difficulties and unexpected findings that can be encountered during anal fistula surgery and how to overcome them.

关键词： Anal Cryptogenic Fistula Surgery

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In vitro anticancer activity of polysaccharide extracted from red alga Jania rubens against breast and colon cancer cell lines

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Asian Pacific Journal of Tropical Medicine 2018年第10期11卷 583-589页

作者： Saly Gheda Mostafa El-Sheekh Alaa abou-zeid Botany Department Faculty of Science Tanta University

Objective: To evaluate the potential role of the polysaccharides of the marine algae as an anticancer agent in vitro against colon cancer cell line(CoCa2) and breast cancer(MCF7) cell lines and to measure lactate dehydrogenase enzyme(LDH) activity as biomarker of membrane integrity of the cells. Methods: The cells of breast cancer(MCF7) and colon cancer(CoCa2)were used to evaluate the potential anticancer role of the polysaccharides of marine algae. Antiproliferative activity against MCF7 and CoCa2 cell lines were evaluated in vitro by the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2 H-tetrazolium bromide(MTT) assay. Results: The in vitro assay of the antioxidant activity of eight marine seaweed species showed that the red seaweed Jania rubens(J. rubens) had the highest DPPH(2,2 diphenyl-1-picrylhydrazyl) free radical scavenging activity. The extracted polysaccharides with concentrations 0.1–40.0 mg/mL from J. rubens were tested for its anticancer potentiality and cytotoxic effects against the cell lines of human breast(MCF7) and colon cancer(CoCa2) cell lines by MTT assay. The inhibitory concentration at 50 (IC_(50)) value the of J. rubens polysaccharide extract was 0.312 5 mg/mL for MCF7 and 20 mg/mL for CoCa2. LDH activity and annexin V concentration were higher in the treated MCF7 and CaCo2 cells than in the untreated ones. Quantitative polymerase chain reaction technique indicated that the polysaccharide treatments caused up-regulation of Bax, caspase 8 and P53 genes expression in CoCa2 cells, and up-regulation of caspase 3 and down-regulation of Bcl2 genes expression in MCF7 cells. Conclusions: The polysaccharides of the red marine alga J. rubens could be a potential candidate for the natural compounds as antioxidant and anticancer therapy.

关键词： Marine algae Antioxidant activity Cytotoxicity Apoptosis Lactate dehydrogenase Polymerase chain reaction

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Acid-treated carbon nanotubes and their effects on mortar strength

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Frontiers of Structural and Civil Engineering 2016年第2期10卷 180-188页

作者： M. ELKASHEF K. WANG M.N. abou-zeid Civil Construction and Environmental Engineering Department Iowa State University Ames IA 50011-2151 USA Construction and Architectural Engineering Department The American University in Cairo Egypt

In the present study, multi-walled carbon nanotubes （MWCNTs） were treated in an acidic mixture solution, made with nitric and sulfuric acids in a ratio of 3：1 by volume. The durations of the treatment were 100 and 180 min. The defects of these treated MWCNTs were examined using Raman spectroscopy. The attachment of hydroxyl functional groups to the walls of the MWCNTs were verified using FTIR spectroscopy. The dispersion of CNTs with acid treatment is assessed using UV-Vis spectroscopy and Scanning Electron Microscopy （SEM）. The results indicate that the duration of the acid treatment has significant effect on both the degree of defects and functionality of the MWCNT. The compressive strength of mortar increased with the addition of the acid-treated MWCNTs; however, no appreciable difference was noted for the two treatment durations under this study.

关键词： carbon nanotubes concrete composites nanomaterials cement

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Preparation and Characterization of Eco-friendly Carboxymethyl Cellulose Antimicrobial Nanocomposite Hydrogels

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Journal of Renewable Materials 2018年第5期6卷 536-547页

作者： Sawsan Dacrory Hussein abou-Yousef Ragab E.abou-zeid Samir Kamel Mohamed S.Abdel-Aziz Mohamed Elbadry Cellulose and Paper Department National Research Centre33 El Buhouth St.DokkiGiza 12622Egypt Microbial Chemistry Department National Research Centre33 El Buhouth St.DokkiGiza 12622Egypt Department of Chemistry Faculty of ScienceAin Shams UniversityAbbassiaCairo 11566Egypt

Carboxymethyl cellulose hydrogels were developed through crosslinking process using eco-friendly crosslinkers such as maleic,succinic,and citric *** cellulose was prepared from the cellulosic fraction of olive industry residues.A series of hydrogels with varying crosslinker acid concentrations,reaction times,and reaction temperatures was produced to study the swelling capacities and gel fraction of the obtained *** study pertains to the preparation of antimicrobial nanocomposite hydrogels through in-situ incorporation of the silver nanoparticles during the crosslinking *** nanoparticles were prepared by reduction of AgNO3 with leaves of Ricinus *** particle size of prepared silver nanoparticles was detected by transmission electron microscopy(TEM).Chemical structure and morphological characterizations of the prepared hydrogels were performed using Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM),and energy-dispersive X-ray spectroscopy(EDX).Finally,the antimicrobial activity of the loaded silver hydrogels against Gram negative(G-ve),Gram positive(G+ve),and Candida albicans yeast was demonstrated.

关键词： Hydrogel crosslinked carboxymethyl cellulose silver nanoparticles antibacterial activity

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Surfactant-Assisted Poly(lactic acid)/Cellulose Nanocrystal Bionanocomposite for Potential Application in Paper Coating

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Journal of Renewable Materials 2018年第4期6卷 394-401页

作者： Ragab E.abou-zeid Mohamed A.Diab Salah A.A.Mohamed Ahmed Salama Hind Abdullah Aljohani Kamel Rizq Shoueir Cellulose and Paper Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Packing and Packaging Materials Department National Research Centre33 El-Bohouth St.DokkiP.O.12622GizaEgypt Tabuk University Chemistry DepartmentCollege of Al WajhAl WajhSaudi Arabia Institute of Nanoscience&Nanotechnology Chemistry departmentKafr Elsheikh University33516 Kafr ElsheikhEgypt

The current article addresses a new strategy for the preparation of polylactic acid/cellulose nanocrystal(PLA/CNCs)nanobiocomposite films with improved structural morphology,mechanical and barrier properties for food packaging *** addition of hexadecyltrimethylammonium bromide(CTAB)and sodium lauryl sulfate(SLS)as cationic and anionic surfactants respectively,was found to play a crucial role in preventing re-aggregation of the CNCs during drying and improving the dispersion of CNCs in the *** coated paper was characterized using mechanical tests,water vapor permeability(WVP),X-ray diffraction(XRD),scanning electron microscopy(SEM)and air *** results showed that the paper coated with PLA containing 7.5%CNCs and 0.15%CTAB based on weight of PLA,gives the highest measured paper properties,where an increase in tensile strength(+133%),Young’s modulus(+309%),tear index(+183%),burst(+60.8)and a decrease in air permeability(−92%)was obtained.

关键词： Cellulose nanocrystal surfactant paper coating mechanical properties air permeability water vapor permeability

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Removal of Cu(II),Pb(II),Mg(II),and Fe(II) by Adsorption onto Alginate/Nanocellulose Beads as Bio-Sorbent

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Journal of Renewable Materials 2021年第4期9卷 601-613页

作者： Ragab E.abou-zeid Korany A.Ali Ramadan M.A.Gawad Kholod H.Kamal Samir Kamel Ramzi Khiari Cellulose and Paper Department National Research CentreGiza12622Egypt Applied Organic Chemistry Department Center of Excellence for Advanced ScienceNational Research CentreGiza12622Egypt Water Pollution Research Department National Research Centre Giza12622Egypt Faculty of Sciences of Monastir Research Unit of Applied Chemistry and EnvironmentUniversity of MonastirMonastir5019Tunisia Higher Institute of Technological Studies(ISET)of Ksar-Hellal Ksar-Hellal5070Tunisia University of Grenoble Alpes CNRSGrenoble INPLGP2GrenobleF-38000France

Alginate blended with cellulose nanocrystals(CNC),cellulose nanofibers(CNF),and tri-carboxylate cellulose nanofibers(TPC-CNF)prepared and encapsulated in the form of microcapsules(bio-polymeric beads).The cellulosic nanomaterials that used in this study were investigated as nanomaterials for wastewater treatment *** experiments were performed to study the removal of copper,lead,magnesium,and iron from aqueous solutions by the prepared *** effects of the sorbent dosage and the modified polymers on the removing efficiency of the metal cations were *** absorption was used to measure the metal ions *** modified bio-polymeric beads(Alg-CNF,Alg-CNC,and Alg-TPC-CNF)exhibited high-efficiency towards removing of the metal cations;Cu^(2+),Pb^(2+),Mg^(2+),and Fe^(2+).The Alg-TPC-CNF composite was exhibited excellent removing efficiency which around 95%for Pb,92%for Cu,43%for Fe and 54%for *** outcomes affirm that the utilization of nanomaterials giving higher adsorption capacities contrasted with similar material in its micro or macrostructure form.

关键词： Biopolymers nanocellulose alginate heavy metal removal wastewater treatment

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Drug resistance in metastatic castration-resistant prostate cancer:an update on the status quo

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Cancer Drug Resistance 2022年第3期5卷 667-690页

作者： Amani Yehya Fatima Ghamlouche Amin Zahwe Yousef zeid Kevork Wakimian Deborah Mukherji Wassim abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107-2020Lebanon Division of Hematology/Oncology Faculty of MedicineAmerican University of Beirut Medical CenterBeirut 1107-2020Lebanon

Prostate cancer(PCa)is a leading cause of cancer-related morbidity and mortality in men *** improvements in the diagnosis and treatment of PCa,a significant proportion of patients with high-risk localized disease and all patients with advanced disease at diagnosis will experience progression to metastatic castration-resistant prostate cancer(mCRPC).Multiple drugs are now approved as the standard of care treatments for patients with mCRPC that have been shown to prolong *** the majority of patients will respond initially,primary and secondary resistance to these therapies make mCRPC an incurable *** molecular mechanisms underlie the development of mCRPC,with the androgen receptor(AR)axis being the main driver as well as the key drug *** resistance mechanisms is crucial for discovering novel therapeutic strategies to delay or reverse the progression of the *** this review,we address the diverse mechanisms of drug resistance in *** addition,we shed light on emerging targeted therapies currently being tested in clinical trials with promising potential to overcome mCRPC-drug resistance.

关键词： Prostate cancer mCRPC androgen receptor drug resistance novel targeted therapeutics

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Flavonoid chemical composition and antidiabetic potential of Brachychiton acerifolius leaves extract

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Asian Pacific Journal of Tropical Biomedicine 2017年第5期7卷 389-396页

作者： Aisha Hussein abou zeid Mohamed Ali Farag Manal Abdel Aziz Hamed Zeinab Abdel Aziz Kandil Radwa Hassan El-Akad Hanaa Mohamed El-Rafie Pharmacognosy Department National Research Centre Pharmacognosy Department College of PharmacyCairo University Therapeutic Chemistry Department National Research Centre

Objective:To evaluate Brachychiton acerifolius leaf extracts as antidiabetic potential agent and to identify the main active constituents using bioactivity guided ***:In vitro antioxidant activity was evaluated for *** different extracts using DPPH assay and vitamin C as *** activity was then determined using STZ-induced rats treated daily with ethyl acetate and 70% ethanol leaf extracts for4 weeks at a dose of 200 g/kg body weight against gliclazide reference *** glucose,a-amylase,lipid profile,liver function enzymes and oxidative stress markers were assessed along with histopathological study for liver and pancreatic *** and structural elucidation of active compounds were made using Diaion and Sephadex followed by spectral ***:The results indicated that ethyl acetate and ethanol leaf extracts exhibited the strongest antioxidant activity compared to that of vitamin C(IC500.05,0.03 and 12 mg/m L,respectively).Both extracts showed potent anti-hyperglycemic activity evidenced by a significant decrease in serum glucose levels by 82.5% and 80.9% and a-amylase by45.2% and 53.6%,as compared with gliclazide 68% and 59.4%,*** of ethanol extract resulted in the isolation of 9 flavonoids including apigenin-7-O-arhamnosyl(1/2)-b-D-glucuronide,apigenin-7-O-b-D-glucuronide,apigenin-7-O-b-Dglucoside and ***:This study highlights the potential use of *** leaf extract enriched in flavones for the treatment of diabetes that would warrant further clinical trials investigation.

关键词： STZ-induced diabetes Diaion fractionation Flavonoid glucuronides Brachychiton acerifolius

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Complete rectal prolapse in young Egyptian males: Is schistosomiasis really condemned?

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World Journal of Gastrointestinal Surgery 2016年第12期8卷 779-783页

作者： Ahmed A abou-zeid Islam H El Abbassy Ahmed M Kamal Dina A Somaie Unit of Colorectal Surgery Department of General Surgery El Demerdash Hospital Ain Shams University

AIM To investigate the assumption that schistosomiasis is the main cause of rectal prolapse in young Egyptian males. METHODS Twenty-one male patients between ages of 18 and 50 years with complete rectal prolapse were included in the study out of a total 29 patients with rectal prolapse admitted for surgery at Colorectal Surgery Unit, Ain Shams University hospitals between the period of January 2011 and April 2014. Patients were asked to fill out a specifically designed questionnaire about duration of the prolapse, different bowel symptoms and any past or present history of schistosomiasis. Patients also underwent flexible sigmoidoscopy and four quadrant midrectal biopsies documenting any gross or microscopic rectal pathology. Data from questionnaire and pathology results were analyzed and patients were categorized according to their socioeconomic *** Twelve patients(57%) never contracted schistosomiasis and were never susceptible to the disease, nine patients(43%) had history of the disease but were properly treated. None of the patients had gross rectal polypsand none of the patients had active schistosomiasis on histopathological examination. Fifteen patients(71%) had early onset prolapse that started in childhood, majority before the age of 5 years. Thirteen patients(62%) were habitual strainers, and four of them(19%) had straining dating since early childhood. Four patients(19%) stated that prolapse followed a period of straining that ranged between 8 mo and 2 years. Nine patients(43%) in the present study came from the low social class, 10 patients(48%) came from the working class and 2 patients(9%) came from the low middle social class. CONCLUSION Schistosomiasis should not be considered the main cause of rectal prolapse among young Egyptian males. Childhood prolapse that continues through adult life is likely involved. Childhood prolapse probably results from malnutrition, recurrent parasitic infections and diarrhea that induce straining and prolaps

关键词： Rectal prolapse Schistosomiasis Young Egyptian males Low socioeconomic status Chronic straining

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