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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1450-1455页

作者： Mona Abdelkader sameh saleh Tharwat Mokbel Hossam Abouelkheir Ayman Abd El Ghafar Mansoura Ophthalmic Center Mansoura Medicine Hospital Faculty of Medicine Mansoura University

AIM: To detect whether the combination of vincamine, thioctic acid and lutein will improve the retina and optic nerve functions in cases of an opaque media with an optic nerve and/or a retinal defect or ***: Totally 2000 patients(2000 eyes) of corneal opacities with defects in the optic nerve or/and the retinal functions were studied. Every patient received three types of drugs: thioctic acid with cyanocobalamine, vincamine, and lutein. The drugs were given daily for 3-12 mo according to patient’s responses. Full field flash electroretinogram(ERG) and flash visual evoked potential(VEP) were done before treatment and at 1, 3, 6, and 12 mo sequentially. Patients were followed up for 12 ***: In the 2000 eyes, 1000 eyes had both moderate optic nerve and retinal function defects;and 840 eyes out of the 1000 improved with the medical treatment. Another 500 eyes out of the 2000 eyes had extinguished retinal function with normal optic nerve function and only 125 eyes of them improved. The 290 out of the 2000 eyes had severe defects in optic nerve with normal retinal function and 130 of them improved. Another 210 eyes have mild optic nerve and retinal function defects and 194 ***: The combination of vincamine, thioctic acid with cyanocobalamine, and lutein improved both retina and optic nerve functions mainly in mild and moderate defect than in severe cases.

关键词： retina optic nerve opaque media thioctic acid with cyanocobalamine vincamine lutein

Two-stage procedure in the management of selected cases of keratoconus: clear lens extraction with aspherical IOL implantation followed by WFG-PRK

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1761-1767页

作者： Waleed Abou Samra Tharwat Mokbel Mohammed Elwan sameh saleh Ahmed Elwehidy Mohammed Iqbal Adel Ellayeh Department of Ophthalmology Faculty of Medicine Mansoura University Department of Ophthalmology Faculty of Medicine Sohag University

AIM： To assess the objective and subjective results of a two-stage procedure for management of keratoconus： clear lensectomy with aspherical intraocular lens（IOL） implantation followed by wave front-guided photorefractive keratotomy（WFG-PRK）.METHODS： This prospective interventional non-randomized study included patients aged 35 years old or more with grade I and II stable keratoconus, a clear visual axis, minimal corneal thickness（MCT） 420 μm or more and average keratometric reading（K） less than 54 diopter（D）. Refraction of all selected eyes should be-8.00 D sphere or more with less than-6.00 D cylinder and could be corrected two lines or more with spectacles or contact lenses. All studied eyes underwent a two-stage approach treatment： first refractive lens exchange and aspherical IOL implantation followed, after at least 3 mo, by WFGPRK. Pre and postoperative complete ophthalmological examination were performed. Topographical, visual and aberrometric results were recorded and evaluated during 6 mo follow up period. Moreover, patient satisfaction and other subjective outcomes were also ***： The 13 eyes of 11 patients diagnosed with stable keratoconus and aged from 39 to 49 y（42.4±6.2 y） were enrolled in the study. At baseline, 8 eyes had grade I and 5 eyes had grade II keratoconus. The manifest sphere was-10.3±4.2 D（ranged from-8.0 to-14.0 D） and the manifest cylinder was-4.2±1.2 D（ranged from-1.75 to-5.50 D）. After the two-stage procedure, sphere and cylinder reduced significantly to-0.43±0.22 D and-1.3±0.72 D respectively（P〈0.001）. There was also a highly significant improvement in the mean uncorrected distance visual acuity（UDVA） from logMAR 1.41±0.49 preoperatively to 0.51±0.16 postoperatively（P〈0.001） and the mean corrected distance visual acuity（CDVA） from 0.76±0.24 preoperatively to 0.49±0.13 after the operation（P〈0.001）. All aberrometric and mesopic vision parameters and most of the topographical indices demonstrated highly significant improveme

关键词： keratoconus clear lensectomy wave front guided photorefractive keratotomy

Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 387-392页

作者： Tharwat Mokbel sameh saleh Mona Abdelkader Sherief E.El-khouly Waleed Abou Samra Mohamed Mamdouh Mansoura Ophthlmic Center Faculty of Medicine Mansoura University

AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography(OCT) foveal thickness and multifocal electroretinogram(MF-ERG) ***: The study included two groups. Group 1 included 50 diabetic patients with senile cataract(50 eyes, 30 females, 20 males, aged 55±7 y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract(50 eyes, 22 female, 28 males, aged 53.8±8 y) did not receive nepafenac. All patients were followed up for 3 mo postoperatively. OCT and MF-ERG were done preoperative and at 1 wk, 1, 2 and 3 ***: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema(CMO)(10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness. CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects.

关键词： nepafenac macular edema cataract surgery diabetes optical coherence tomography multifocal electroretinogram

Does the scleral encircling band provide a protective effect against the progression of diabetic retinopathy?

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1408-1414页

作者： Hossam Youssef Abouelkheir Amani E Badawi Amr M.Abdelkader Amr El-Kanishy sameh saleh Waleed Ali Abou Samra Manal Ali Kasem Tharwat Mokbel Mansoura Ophthalmic Center Faculty of Medicine Mansoura University

AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic ***: The medical records of diabetic patients who underwent unilateral retinal detachment(RD) surgery using scleral buckle and encircling band were reviewed retrospectively. Both eyes of patients were included in the study: one eye in each patient had a scleral buckle with encircling band(the operated eye) and the other one is the non-operated eye. The demographic characters, duration of diabetes and period between surgery and the last recall visit were retrieved from each patient. All the cases underwent fundus photo and fluorescein angiography(when indicated) to confirm the DR ***: Totally 25 patients fulfilled the inclusion and the exclusion criteria were become eligible for the study. A total of 50 eyes of 25 patients were enrolled in this analysis. The mean period of time passed from surgery with encircling band and the last reassessment visit was 12.5±2 y. Even though DR could develop in the operated eyes, it was at a less degree of severity compared to the non-operated eyes of same patients(P=0.027).CONCLUSION: Scleral encircling bands have protective effects against the development and progression of DR.

关键词： diabetic retinopathy scleral encircling bands retinal detachment

Microbial Removal from Secondary Treated Wastewater Using a Hybrid System of Ultrafiltration and Reverse Osmosis

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Journal of Environmental Science and Engineering(A) 2012年第7期1卷 853-869页

作者： Jehad Abbadi Rinad saleh sameh Nusseibeh Muhannad Qurie Mustafa Khamis Rafik Karaman LauraScrano Sabino Aurelio Bufo Department of Biology College of Science and Technology AI-Quds University Jerusalem Palestine Centre for Chemical and Biological Analysis Al-Quds University Jerusalem Palestine Department of Chemistry and Chemical Technology College of Science and Technology Al-Quds University Jerusalem Palestine Department of Bioorganic Chemistry College of Pharmacy A1-Quds University Jerusalem Palestine Department of Agriculture Forestry and Environment University of Basilicata Potenza 85100 Italy

The efficiency of advanced membranes towards removal of general and specific microbes from wastewater was investigated. The treatment included a subsequent system of activated sludge, ultrafiltration (hollow fibre membranes with 100 kDa cut-off, and spiral wound membranes with 20 kDa cut-off), and RO (reverse osmosis). The removal evaluation of screened microbes present in treated wastewater showed that hollow fibre membrane rejected only 1 log (90% rejection) of the TPC (total microbial count), TC (total coliforms), and FC (faecal coliforms). A higher effectiveness was observed with spiral wound, removing 2-3 logs (99%-99.9%) of TPC and complete rejection of TC and FC. The RO system was successful in total rejection of all received bacteria. The removal evaluation of inoculated specific types of bacteria showed that the hollow membranes removed 2 logs (99%) of inoculated E. coli (107-108 cfu/mL inoculum), 2-3 logs (99%-99.9%) of Enterococus spp. (107-1010 cfu/mL inoculum), 1-2 logs (90%-99%) of Salmonella (108-1010 cfu/mL inoculum) and 1-2 logs (90%-99%) of Shigella (105-106 cfu/mL inoculum). The spiral wound was significantly efficient in rejecting further 3 logs of E. coli, 5 logs of Enterococus spp., 4 logs of Salmonella, and a complete rejection of all received bacteria was accomplished by RO membrane. The results indicate that Gram positive bacteria were removed much more efficiently compared to the Gram negative ones, the rationale behind such behaviour is based on cell walls elasticity.

关键词：混合动力系统微生物反渗透废水二级处理超滤中空纤维膜革兰氏阳性细菌