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Interactive platform for peer review:A proposal to improve the current peer review system

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World Journal of Clinical Cases 2021年第6期9卷 1247-1250页

作者： sameh hany emile General Surgery Department Mansoura University HospitalsMansoura UniversityMansoura 35516Egypt

Peer review is the cornerstone in scientific *** peer review has paramount importance in ensuring the quality of the published literature,it still has a number of *** present manuscript proposes a new method to improve the current peer review system by providing an interactive,dynamic platform that allows direct,anonymous interaction between the authors of submitted manuscripts and the *** real-time interaction may help eliminate any problems related to misunderstanding or misinterpretation of the reviewer’s comments or the authors’response,and would save time while keeping the identity of both parties anonymous.

关键词： Peer Review Interactive Proposal System Improve

Non-operative management of rectal cancer: Highlighting the controversies

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1501-1506页

作者： sameh hany emile Anjelli Wignakumar Department of Colorectal Surgery Cleveland Clinic FloridaWestonFL 33331United States

There remains much ambiguity on what non-operative management(NOM)of rectal cancer truly entails in terms of the methods to be adopted and the best algorithm to *** is clearly shown by the discordance between various national and international guidelines on NOM of rectal *** main aim of the NOM strategy is organ preservation and avoiding unnecessary surgical in-tervention,which carries its own risk of morbidity.A highly specific and sensitive surveillance program must be devised to avoid patients undergoing unnecessary surgical *** many studies,NOM,often interchangeably called the Watch and Wait strategy,has been shown as a promising treatment option when undertaken in the appropriate patient population,where a clinical complete res-ponse is ***,there are no clear guidelines on patient selection for NOM along with the optimal method of surveillance.

关键词： Non-operative Management Rectal cancer Highlighting Controversies

Cellular therapy:A promising tool in the future of colorectal surgery

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World Journal of Gastroenterology 2019年第13期25卷 1560-1565页

作者： Mohammed Mohammed El-Said sameh hany emile Colorectal Surgery Unit General Surgery Department Mansoura University Hospitals Mansoura University

Cellular therapy may be the solution of challenging problems in colorectal surgery such as impaired healing leading to anastomotic leakage and metastatic colorectal cancer(CRC). This review aimed to illustrate the role of cellular therapy in promotion of wound healing and management of metastatic CRC. An organized literature search for the role of cellular therapy in promotion of wound healing and management of metastatic CRC was conducted. Electronic databases including PubMed/Medline, Scopus, and Embase were queried for the search process. Two types of cellular therapy have been recognized, the mesenchymal stem cells(MSCs) and bone marrow-mononuclear cells(BM-MNCs) *** cells have been shown to accelerate and promote healing of various tissue injuries in animal and human studies. In addition, experimental studies have reported that MSCs may help suppress the progression of colon cancer in rat models. This article reviews the possible mechanisms of action and clinical utility of MSCs and BM-MNCs in promotion of healing and suppression of tumor growth in light of the published literature. Cellular therapy has a potentially important role in colorectal surgery, particularly in the promotion of wound healing and management of metastatic CRC. Future directions of cellular therapy in colorectal surgery were explored which may help stimulate futures studies on the role of cellular therapy in colorectal surgery.

关键词： Cellular therapy Future Colorectal surgery Stem cells

Toward less invasive coloproctology: The future is out there

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World Journal of Gastroenterology 2024年第3期30卷 199-203页

作者： sameh hany emile Jonathan Ragheb Department of Colorectal Surgery Cleveland Clinic FloridaWestonFL 33331United States Department of Gastroenterology and Hepatology Cleveland Clinic FloridaWestonFL 33331United States

Medical care has undergone remarkable improvements over the past few *** of the most important innovative breakthroughs in modern medicine is the advent of minimally and less invasive *** trend towards employing less invasive treatment has been vividly shown in the field of gastroenterology,particularly *** to foregut interventions,colorectal surgery has shifted towards a minimally invasive ***,including both medical and surgical management of colorectal diseases,has undergone a remarkable paradigm *** treatment of both benign and malignant colorectal conditions has gradually transitioned towards more conservative and less inva-sive *** interesting paradigm shift was the trend to avoid the need for radical resection of rectal cancer altogether in patients who showed complete response to neoadjuvant *** trend of adopting less invasive appro-aches to treat various colorectal conditions does not seem to be stopping soon as further research on novel,more effective and safer methods is ongoing.

关键词： Toward Less invasive Minimally invasive Coloproctology Future Colorectal surgery

Short-term outcomes of single-incision compared to multi-port laparoscopic gastrectomy for gastric cancer:A meta-analysis of randomized controlled trials

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第4期6卷 127-133页

作者： sameh hany emile Samer Hani Barsom General Surgery Department Mansoura University HospitalsMansoura Egypt Internal Medicine Department University of South DakotaSanford School of MedicineSouth DakotaUSA

Objective:Single-incision laparoscopic sugery has emerged as a safe and less invasive approach to conventional multi-port *** present meta-analysis aimed to assess the collective outcomes of single-incision laparoscopic gastrectomy(SILG)compared to multi-port laparoscopic gastrectomy(MLG)for gastric ***:A PRISMA-compliant systematic review of randomized controlled trials(RCTs)that compared SILG and MLG for gastric cancer in PubMed and Scopus through January 2023 was *** main outcomes of the review were complications,postoperative pain,conversion to open surgery,hospital stay,and ***:Three RCTs including 301 patients(61.8%male)were incuded.A total of 151 patients underwent SILG,and 150 underwent *** was associated with a shorter operative time(WMD=-16.39,95%CI:=27.38 to=5.40,p=0.003;2=0%)and lower pain scores at postoperative day 3(WMD=-1.18,95%CI:=2.27 to=0.091,p=0.033;I^(2)=99%)than *** were no statistically significant differences between the two groups in es timated blood loss(WMD=-16.95,95%CI:-35.84 to 1.95,p=0.078;I^(2)=82%),complications(OR=0.71,95%Cl:0.36 to 1.42,p=0.337;I^(2)=0%),conversion to open surgery(OR=0.33,95%C:0.01 to 8.38,p=0.504),hospital stay(WMD=0.72,95%CI:-0.92 to 2.36,p=0.056;P=84%),time to first flatus(WMD=0.06,95%CI:=0.14 to 0.26,p=0.566;I^(2)=0%),time to first defecation(WMD=-0.14,95%CI:=0.46 to 0.18,p=0.392;I^(2)=0%),or time to first oral intake(WMD=0.37,95%a:=0.75 to 1.49,p=0.520;I^(2)=94%).Conclusions:SILG is associated with shorter operative times and less early postoperative pain than *** odds of complications,blood loss,hospital stay,and gastrointestinal recovery were similar between the two procedures.

关键词： Single-incision Laparoscopic Gastrectomy Meta-analysis Randomized trials

Literature review of the outcome of and methods used to improve transperineal repair of rectocele

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World Journal of Gastrointestinal Surgery 2021年第9期13卷 1063-1078页

作者： Mohammad Fathy Ahmed Hossam Elfallal sameh hany emile General Surgery Mansoura University Faculty of MedicineMansoura 35516Egypt

BACKGROUND Rectocele is commonly seen in parous women and sometimes associated with symptoms of obstructed defecation syndrome(ODS).AIM To assess the current literature in regard to the outcome of the classical transperineal repair(TPR)of rectocele and its technical *** An organized literature search for studies that assessed the outcome of TPR of rectocele was ***/Medline and Google Scholar were queried in the period of January 1991 through December *** main outcome measures were improvement in ODS symptoms,improvement in sexual functions and continence,changes in manometric parameters,and quality of *** After screening of 306 studies,24 articles were found eligible for inclusion to the *** studies(301 patients)assessed the classical TPR of *** median rate of postoperative improvement in ODS symptoms was 72.7%(range,45.8%-83.3%)and reduction in rectocele size ranged from 41.4%-95.0%.Modifications of the classical repair entailed omission of levatorplasty,addition of implant,concomitant lateral internal sphincterotomy,changing the direction of plication of rectovaginal septum,and site-specific *** The transperineal repair of rectocele is associated with satisfactory,yet variable,improvement in ODS symptoms with parallel increase in quality-of-life *** modifications of the classical TPR were *** modifications include omission of levatorplasty,insertion of implants,performing lateral sphincterotomy,changing the direction of classical plication,and site-specific *** indications for these modifications are not yet fully clear and need further prospective studies to help tailor the technique to rectocele patients.

关键词： Transperineal repair Rectocele Review Modifications Outcome

Predictors of severe and critical COVID-19:A systematic review

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World Journal of Clinical Infectious Diseases 2020年第2期10卷 24-32页

作者： sameh hany emile Sualeh Muslim Khan General Surgery Department Mansoura University HospitalsMansoura UniversityMansoura City 35516Egypt Dow Medical College Dow University of Health SciencesKarachi 74200Pakistan

BACKGROUND Coronavirus disease 2019(COVID-19)has emerged as a public health crisis that was declared as a global pandemic by the World Health *** most cases have no or mild symptoms,around 10%of patients develop severe or critical illness that necessitates hospitalization and intensive care unit *** To assess the literature for the predictive factors that can identify patients having severe/critical COVID-19 *** A Preferred Reporting Items for Systematic Reviews and Meta-Analysescompliant systematic search of the literature was *** databases including PubMed/MEDLINE,Scopus,and Cochrane Library were *** main outcome measures were the predictors of severe/critical COVID-19 and *** Five studies including 583 patients of a median age of 50.5 years were *** were 346(59.4%)male and 237(40.6%)*** 583 hospitalized patients,242(41.5%)had critical *** respiratory distress disease occurred in 291 patients,accounting for 46.7%of total ***(17.1%)mortalities were *** most commonly reported predictors of severe COVID-19 were older age,medical comorbidities,lymphopenia,elevated C-reactive protein,increased D-dimer,and increased neutrophil *** on computed tomography(CT)scanning predictive of severe disease were bronchial wall thickening,CT score>7,linear opacities,consolidation,right upper lobe affection,and crazy paving *** Several demographic,clinical,laboratory,and radiologic factors can help predict severe and critical COVID-19 along with the potential need for mechanical *** that were more commonly reported were older age,medical comorbidities,lymphopenia,increased neutrophil ratio,elevated C-reactive protein,and increased D-dimer.

关键词： COVID-19 SARS-CoV-2 Predictors Severe Critical Systematic review

A case report on aggressive fibromatosis of the arm and shoulder

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Discussion of Clinical Cases 2020年第4期7卷 1-3页

作者： sameh hany emile Ahmad Sakr Department of General Surgery Mansoura Faculty of MedicineMansoura UniversityEgypt

Background:Aggressive fibromatosis is a locally aggressive tumor that originates from the deep musculo-aponeurotic *** this report,we describe the case of an adolescent male with painless,progressively growing swelling in his right arm necessitated surgical excision and postoperative pathologic examination revealed aggressive *** presentation:A 15-year-old boy presented with a painless,progressively growing swelling of his right *** swelling was firm,non-tender and with restricted *** imaging revealed a well-defined,heterogenous,lobulated swelling extending beneath arm and shoulder *** local excision of the swelling was done under general anesthesia and pathologic examination revealed aggressive fibromatosis of the *** radiotherapy was provided to the patient to reduce the risk of local recurrence of the ***:Aggressive fibromatosis of the upper limb presents as a painless,progressively growing *** with MRI is imperative for making a preliminary *** local excision with safety margin with adjuvant radiotherapy is the main line of treatment to minimize the incidence of recurrence and preserve the limb.

关键词： Aggressive Fibromatosis Arm Shoulder Case report

Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom

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World Journal of Gastrointestinal Surgery 2018年第3期10卷 28-39页

作者： sameh hany emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand Department of General Surgery Mansoura Faculty of Medicine Department of Surgery Hospital Clinic University of Barcelona GENIE Centre University College London Department of Surgery and Interventional Sciences University College London Hospitals NHS Trusts Department of Surgical Oncology Alzahra Cancer Center Al Zahra Hospital

The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are *** evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME.

关键词： Rectal cancer Total mesorectal excision Transanal total mesorectal excision Transanal total mesorectal excision Sphincter sparing surgery Colorectal surgery