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Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis

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World Journal of Gastroenterology 2014年第14期20卷 4093-4101页

作者： Abhishek Choudhary Jessica Winn sameer siddique Murtaza Arif Zainab Arif Ghassan M Hammoud Srinivas R Puli Jamal A Ibdah Matthew L Bechtold Division of Gastroenterology Department of Internal MedicineUniversity of Missouri-Columbia Division of Gastroenterology and Hepatology University of IllinoisPeoria CampusOSF Saint Francis Medical CenterPeoria

AIM: To conduct a systemic review and meta-analysis to investigate the role of early precut technique. Multiple randomized controlled trails (RCTs) have reported conflicting results of the early precut sphincterotomy.

关键词： Early precut Endoscopic retrograde cholangiopancreatography cannulation Post-endoscopic retrograde cholangiopancreatography pancreatitis Randomized controlled trials Meta-analysis

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Hyoscine for polyp detection during colonoscopy: A meta-analysis and systematic review

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World Journal of Gastrointestinal Endoscopy 2014年第11期6卷 549-554页

作者： Imran Ashraf Sohail Ashraf sameer siddique Douglas L Nguyen Abhishek Choudhary Matthew L Bechtold Department of Medicine University of Mis-souri Columbia MO 65212 United States Department of Gastroenterology and Hepatology Central Manchester University Hospitals M139WL Manchester United Kingdom Department of Medicine University of California Irvine CA 92868 United States

AIM: To assess the role of hyoscine for polyp detectionduring ***: Studies(randomized controlled trials orRCTs) that compared the use of hyoscine vs no hyo-scine or placebo for polyp detection during colonoscopywere included in our analysis. A search on multiple da-tabases was performed in September 2013 with searchterms being "hyoscine and colonoscopy", "hyoscineand polyp", "hyoscine and adenoma", "antispasmoticand colonoscopy", "antispasmotic and adenoma", and"antispasmotic and polyp". Jadad scoring was used toassess the quality of studies. The efficacy of hyoscinewas analyzed using Mantel-Haenszel model for polypand adenoma detection with odds ratio(OR). The I2measure of inconsistency was used to assess hetero-geneity(P 50%). Statistical analysis was performed by RevMan 5.1. Funnel plots was used to assess publication ***: The search of the electronic databases identified 283 articles. Of these articles, eight published RCTs performed at various locations in Europe, Asia, and Australia were included in our meta-analysis, seven published as manuscripts and one published as an ab-stract(n = 2307). All the studies included patients with a hyoscine and a no hyoscine/placebo group and were of adequate quality(Jadad score ≥ 2). Eight RCTs as-sessed the polyp detection rate(PDR)(n = 2307). The use of hyoscine demonstrated no statistically significant difference as compared to no hyoscine or placebo for PDR(OR = 1.06; 95%CI: 0.89-1.25; P = 0.51). Five RCTs assessed the adenoma detection rate(ADR)(n = 2015). The use of hyoscine demonstrated no statisti-cally significant difference as compared to no hyoscine or placebo for ADR(OR = 1.12; 95%CI: 0.92-1.37; P = 0.25). Furthermore, the timing of hyoscine admin-istration(given at cecal intubation or pre-procedure) demonstrated no differences in PDR compared to no hyoscine or placebo. Publication bias or heterogeneity was not observed for any of the ***: Hyoscine use in pa

关键词： Hyoscine Antispasmodic Polyp detection Colonoscopy

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