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Modified Advanced Life Support in Obstetrics course: Feasibility, trainee satisfaction, and sustainability potential

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Family Medicine and Community Health 2017年第1期5卷 71-77页

作者： Anjali Aggarwal Jason L.Salemi Bernice Yap Jennifer L.Matas sameer naik Roger J.Zoorob Hamisu M.Salihu Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA College of Public Health University of South FloridaTampaFLUSA

Objective:The main objective of this initiative was to present evaluation results from an inno-vative adaptation of the Advanced Life Support in Obstetrics(ALSO)training *** modified the traditional ALSO curriculum in our institution by adding hands-on training in laceration repairs and simulation scenarios on acute maternity ***:The modified ALSO provider course was designed to enhance cognitive and proce-dural skills of health care professionals in managing obstetric ***-nine participants attended this course and completed a posttraining *** statistics were used to de-scribe the participant-reported assessment scores for the ALSO course on three domains(subject knowledge,organization and clarity,and teaching effectiveness)for each of 12 course ***:Evaluation of the results showed a high rate of trainee satisfaction as evidenced by the mean assessment scores across all topics ranging from 4.80 to 4.98(out of 5.00).All trainees said they would refer others to the *** modified ALSO course effectively addressed the important needs of primary care physicians involved in maternity care,especially in underserved communities where specialized obstetric care is not readily *** simulation scenarios and workshops using simulated human tissue provide a better foundation before formal ***:Given the changing legal and regulatory climate,we expect that learning to treat complex obstetric situations on the job will become increasingly *** this in mind,both simulation scenarios and workshops using simulated human tissue will provide a better foundation before formal training.

关键词： Advanced Life Support in Obstetrics(ALSO) training hands-on laceration re-pair simulated human tissue

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Noscapine shows antimalarial activity against Plasmodium falciparum 3D7,its clinical isolate Pf140/SS,and Plasmodium berghei ANKA

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Asian Pacific Journal of Tropical Biomedicine 2024年第8期14卷 350-358页

作者： Swaraj Kumar Babu sameer Maharana Satyaranjan Chhatria Dibya Ranjan Sahoo Ashirbad Nanda Satish Kanhar Prativa KBehera Sanjib Mohanty Pradeep Kumar naik Praveen Kishore Sahu Centre of Excellence in Natural Products and Therapeutics Department of Biotechnology and BioinformaticsSambalpur UniversityJyoti ViharSambalpur OdishaIndia Department of Molecular Biology and Infectious Diseases Community Welfare Society HospitalRourkelaOdishaIndia Molecular&Immunology Laboratory Infectious Disease Biology UnitIspat General HospitalRourkelaOdishaIndia Department of Pharmacy Centurion University of Technology and ManagementBhubaneswarOdishaIndia

Objective:To evaluate the antimalarial activity of noscapine against Plasmodium falciparum 3D7 strain(Pf3D7),its clinical isolate(Pf140/SS),and Plasmodium berghei ANKA(PbA).Methods:Using ring-stage survival assay,phenotypic assessments,and SYBR-green-based fluorescence assay,the antimalarial activities of noscapine were assessed compared with dihydroartemisinin(DHA)in in vivo and in vitro *** addition,hemolysis and cytotoxicity tests were carried out to evaluate its ***-PCR assay was also conducted to determine the effect of noscapine on papain-like cysteine protease Plasmodium falciparum falcipain-2(PfFP-2).Results:The antimalarial efficacy of noscapine against Pf3D7 and Pf140/SS was comparable to DHA,with IC50 values of(7.68±0.88)and(5.57±0.74)nM/mL,respectively,and>95%inhibition of PbA infected *** also showed a safe profile,as evidenced by low hemolysis and cytotoxicity even at high ***,PfFP-2 expression was significantly inhibited in both noscapine-treated Pf3D7 and Pf140/SS(P<0.01).Conclusions:Noscapine has antimalarial properties comparable to standard antimalarial DHA with better safety profiles,which may be further explored as a therapeutic candidate for the treatment of malaria.

关键词： Malaria Plasmodium falciparum Plasmodium berghei Noscapine Antimalarial Dihydroartemisinin Cytotoxicity Falcipain-2

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