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In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites

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Bioactive Materials 2020年第4期5卷 891-901页

作者： Yee-Hsien Ho Kun Man sameehan s.joshi Mangesh V.Pantawane Tso-Chang Wu Yong Yang Narendra B.Dahotre Laboratory for Laser Aided Additive and subtractive Manufacturing Department of Materials Science and EngineeringUniversity of North Texas1150 Union Circle 305310DentonTX76203-5017USA Department of Biomedical Engineering University of North Texas1150 Union Circle 305310DentonTX76203-5017USA

The present study aims to evaluate effect of hydroxyapatite(HA,Ca10(PO4)6OH2),a ceramic similar to natural bone,into AZ31B Mg alloy matrix on biomineralization and *** novel friction stir processing additive manufacturing route was employed to fabricate Mg-HA *** HA contents(5,10,20 wt%)were incorporated into Mg *** observation and chemical composition analysis revealed that refined Mg grains and dispersion of HA particles at micro/nanoscales were achieved in Mg-HA composites after the friction stir *** biomineralization evaluation were carried out using immersion experiments in simulated body fluid followed by mineral morphology observation and chemical composition *** wettability measurements were conducted to correlate the biomineralization *** results showed improvement in wettability and bone-like Ca/P ratio in apatite deposit on the composites compared to as-received *** addition,the increase of blood compatibility,cell viability and spreading were found in the higher HA content composites,indicating the improved ***,friction stir processed Mg-20 wt%HA composite exhibited the highest wettability and better cell adhesion among other composites due to the effect of increased HA content within Mg matrix.

关键词： Friction stir processing Magnesium alloy Hydroxyapatite Additive manufacturing Biomineralization Contact angle measurement Blood compatibility Cell culture

Microstructure and surface texture driven improvement in in-vitro response of laser surface processed AZ31B magnesium alloy

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Journal of Magnesium and Alloys 2021年第4期9卷 1414-1426页

作者： Tso-Chang Wu sameehan sjoshi Yee-Hsien Ho Mangesh VPantawane subhasis sinha Narendra B.Dahotre Department of Materials science and Engineering University of North Texas3940 N Elm StDentonTX 76207USA Center for Agile and Adaptive Additive Manufacturing University of North Texas3940 N Elm StDentonTX 76207USA Department of Metallurgical Engineering Indian Institute of Technology(BHU)VaranasiUttar Pradesh 221005India

The present work explored effects of laser surface melting on microstructure and surface topography evolution in AZ31B magnesium *** effects experienced by the material during laser surface melting were simulated using a multiphysics finite element *** and phase evolution were examined using scanning electron microscopy,X-ray diffraction,and electron back scatter *** topography was evaluated using white light *** interaction of surface melted samples with simulated body fluid was monitored by contact angle measurements and immersion studies up to 7 *** surface melting led to formation of a refined microstructure with predominantly basal crystallographic ***,the amount ofβphase(Mg_(17)Al_(12))increased with an increase in the laser fluence.βphase preferentially decorated the cell *** terms of topography,the surface became progressively rougher with an increase in laser *** a result,upon immersion in simulated body fluid,the laser surface melted samples showed an improved wettability,corrosion resistance,and precipitation of mineral having composition closer to the hydroxyapatite bone mineral compared to the untreated sample.

关键词： Laser surface melting Magnesium alloy Laser surface engineering Biomineralization

Three-stage Transfer Learning with AlexNet50 for MRI Image Multi-Class Classification with Optimal Learning Rate

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Computer Modeling in Engineering & sciences 2025年第1期142卷 155-183页

作者： suganya Athisayamani A.Robert singh Gyanendra Prasad joshi Woong Cho school of Computing Sastra Deemed to be UniversityThanjavur613401India Department of Computational Intelligence SRM Institute of Science and TechnologyKattankulathur603203India Department of AI and software Engineering Kangwon National UniversitySamcheok25913Republic of Korea Department of Electronics Information and Communication EngineeringKangwon National UniversitySamcheok25913Republic of Korea

In radiology,magnetic resonance imaging(MRI)is an essential diagnostic tool that provides detailed images of a patient’s anatomical and physiological *** is particularly effective for detecting soft tissue ***,radiologists manually interpret these images,which can be labor-intensive and time-consuming due to the vast amount of *** address this challenge,machine learning,and deep learning approaches can be utilized to improve the accuracy and efficiency of anomaly detection in MRI *** manuscript presents the use of the Deep AlexNet50 model for MRI classification with discriminative learning *** are three stages for learning;in the first stage,the whole dataset is used to learn the *** the second stage,some layers of AlexNet50 are frozen with an augmented dataset,and in the third stage,AlexNet50 with an augmented dataset with the augmented *** method used three publicly available MRI classification datasets:Harvard whole brain atlas(HWBA-dataset),the school of Biomedical Engineering of southern Medical University(sMU-dataset),and The National Institute of Neuroscience and Hospitals brain MRI dataset(NINs-dataset)for *** hyperparameter optimizers like Adam,stochastic gradient descent(sGD),Root mean square propagation(RMs prop),Adamax,and AdamW have been used to compare the performance of the learning ***-dataset registers maximum classification *** evaluated the performance of the proposed classification model using several quantitative metrics,achieving an average accuracy of 98%.

关键词： MRI tumors classification AlexNet50 transfer learning hyperparameter tuning optimizer

Thiamine hydrochloride(VB1):An efficient catalyst for one-pot synthesis of α-aminophosphonates under ultrasonic irradiation

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Chinese Chemical Letters 2011年第5期22卷 563-566页

作者： Priyanka G.Mandhane Ratnadeep s.joshi Deepak R.Nagargoje Charansingh H.Gill Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabadMaharashtra 431004India

An efficient synthesis of novelα-aminophosphonates by the reaction of aldehydes and amines with triethyl phosphite in the presence of the easily available,inexpensive,and nontoxic catalyst thiamine hydrochloride（VB1）.This method affords theα-aminopho-sphonates under the influence of ultrasound irradiation in aqueous medium,in short reaction times（4-6 min）,high yields（85-95%）, with improved *** process is green,mild,inexpensive and excellent yields are the main compensation of this procedure.

关键词： Thiamine hydrochloride(VB1) α-Aminophosphonates Triethyl phosphate Water Ultrasonication Green synthesis

Potassium dihydrogen phosphate catalyzed one-pot synthesis of 2,4,5-triaryl-1H-imidazoles

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Chinese Chemical Letters 2010年第4期21卷 429-432页

作者： Ratnadeep s.joshi Priyanka G.Mandhane Mohammad U.shaikh Rajesh P.Kale Charansingh H.Gill Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabadMaharashtra 431 004India

A simple and efficient method has been developed;benzil/benzoin undergoes smooth condensation with various substituted aldehyde and ammonium acetate in the presence of potassium dihydrogen phosphate（KH;PO;） under mild reaction conditions to afford the corresponding trisubstituted imidazole in excellent *** method for synthesis of product,the reaction mixture was reflux in ethanol for 40-90 *** present method is simple,efficient,and cost-effective.

关键词： Potassium dihydrogen phosphate(KH_2PO_4) 2 4 5-Triaryl-1H-imidazole Benzil Benzoin Aldehyde Ammonium acetate

A novel indocyanine green-based fluorescent marker for guiding surgical tumor resection

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Journal of Innovative Optical Health sciences 2021年第3期4卷 77-87页

作者： Jiawei Ge Justin D.Opfermann Hamed saeidi Katherine A.Huenerberg Christopher D.Badger Jaepyeong Cha Martin J.schnermann Arjun s.joshi Axel Krieger Department of Mechanical Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Mechanical Engineering University of Maryland College Park MD 20742USA sheikh Zayed Institute for Pediatric surgical Innovation Children's National Hospital WashingtonDC 20010USA Department of Pathology George Washington University WashingtonDC 20052USA Division of Otolaryngology-Head and Neck surgery George Washington University Washington DC 20052USA Chemical Biology Laboratory Center for Cancer Research National Cancer InstituteNational Institutes of HealthFrederickMD 21702USA

surgical tumor resection is a common approach to cancer *** Ink tattoos are widely used to aid tumor resection by localizing and mapping the tumor edge at the ***,India Ink tattoos are easily obscured during electrosurgical resection,and fade in intensity over *** this work,a novel near-infrared(NIR)fluorescent marker is introduced as an *** NIR marker was made by mixing indocyanine green(ICG),biocompatible cyanoacrylate,and *** marking strategy was evaluated in a chronic ex vivo feasibility study using porcine tissues,followed by a chronic in vivo mouse study while compared with India *** both studies,signal-to-noise(sNR)ratios and dimensions of the NIR markers and/or India Ink over the study period were calculated and *** was performed on the last day of the mouse study after mice were euthanized,and sNR ratios and dimensions were quantified and *** was performed at all injection sites and slides were examined by a *** proposed NIR marker achieved(i)consistent visibility in the 26-day feasibility study and(ii)improved durability,visibility,and biocompatibility when compared to traditional India Ink over the six-week period in an in vivo mouse *** effects persist after electrocautery whereas the India Ink markers were *** use of a NIR fluorescent presurgical marking strategy has the potential for intraoperative tracking during long-term treatment protocols.

关键词： Near-infrared fluorescent marker surgical tumor resection fluorescence-guided sur-gery electrosurgery India ink

Modelling effect of magnetic field on material removal in dry electrical discharge machining

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Plasma science and Technology 2017年第2期19卷 79-88页

作者： Abhishek GUPTA suhas s.joshi Department of Mechanical Engineering Indian Institute of Technology BombayPowaiMumbai 400 076India

One of the reasons for increased material removal rate in magnetic field assisted dry electrical discharge machining （EDM） is confinement of plasma due to Lorentz forces. This paper presents a mathematical model to evaluate the effect of external magnetic field on crater depth and diameter in single- and multiple-discharge EDM process. The model incorporates three main effects of the magnetic field, which include plasma confinement, mean free path reduction and pulsating magnetic field effects. Upon the application of an external magnetic field, Lorentz forces that are developed across the plasma column confine the plasma column. Also, the magnetic field reduces the mean free path of electrons due to an increase in the plasma pressure and cycloidal path taken by the electrons between the electrodes. As the mean free path of electrons reduces, more ionization occurs in plasma column and eventually an increase in the current density at the inter-electrode gap occurs. The model results for crater depth and its diameter in single discharge dry EDM process show an error of 9%-10% over the respective experimental values.

关键词： electrical discharge machining dry EDM plasma confinement magnetic field

Net Primary Productivity and species Diversity of Herbaceous Vegetation in Banj-oak (Quercus leucotri-chophora ***) Forest in Kumaun Himalaya,India

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Journal of Mountain science 2011年第6期8卷 787-793页

作者： Mukesh joshi Y.s.RAWAT Department of Forestry and Natural Resources Post Box-59H.N.B.Garhwal University Department of Botany Kumaun University

Net primary productivity and species diversity of herbaceous vegetation of banj-oak （Quercus leucotrichophora A. Camus） forest in Kumaun Himalaya, India were analyzed. Across different growth forms （tall forbs, short forbs, cushion and spreading forbs, grasses）, short forbs were most dominant component during rainy season （1VI=152） and winter season （IVI=167） and grasses during the winter season （IVI=148）. Maximum above-ground production occurred during rainy season （132.5 g m-2） and minimum during winter season （2.8 g m-~）. Below-ground production was maximum （85.9 g m-x） during winter season and minimum （14.9 g m-x） during summer season. Annual net shoot production was 15o g m-~ and below-ground production was 138 g m-~. Of the total input 61% was channeled to above- ground parts and 39% to below-ground parts.

关键词： Biomass Diversity Net-primaryproductivity

Estimation of above-ground biomass and carbon stock of an invasive woody shrub in the subtropical deciduous forests of Doon Valley,western Himalaya,India

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Journal of Forestry Research 2015年第2期26卷 291-305页

作者： Gautam Mandal s.P.joshi Ecology Research Laboratory Department of BotanyDAV (PG) College Faculty of science The Lawrence School

This study describes the different parameters used to derive the allometric equation for calculating the biomass of an invasive woody shrub Lantana camara *** the subtropical conditions of western *** identifies the most accurate and convenient method for biomass calculation by comparing destructive with nondestructive *** parameters were measured on a wide range of Lantana from different community levels for the non-destructive calculation of total aboveground *** explanatory variables were identified and measured such as basal diameter either as a single independent variable or in combination with plant *** other suitable combinations of available independent variables include crown length,crown width,crown area,crown volume and coverage of the *** the wide range of allometric equations used with different variables,the equation with D2 H as a variable was found to be the most suitable estimator of biomass calculation for ***,being the most disturbed area due to its high tourist activity round the year,showed maximum coverage（58.57 % ha-1）,highest biomass（13,559.60 kg ha-1） and carbon density（6,373.01 kg ha-1）of *** degree of Lantana’s invasiveness in subtropical conditions was also calculated on the basis of importance value index（IVI）.The maximum IVI（22.77）and mean coverage（26.8 % ha-1） was obtained from the areas near Jolly Grant airport,indicating that physically disturbed areas are more suitable for the growth of Lantana,which may significantly increase shrub *** importance of incorporating allometric equations in calculation of shrub biomass,and its role in atmospheric carbon assimilation has thus been highlighted through the findings of this study.

关键词： Above ground carbon pools Allometric regression equations Carbon density Importance value index(IVI) shrub biomass