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A Hybrid Model for Reliability Aware and Energy-Efficiency in Multicore Systems

Computers, Materials & Continua 2022年第3期70卷 4447-4466页

作者： samar nour Sameh A.Salem Shahira M.Habashy Department of Computer and Systems Engineering Faculty of EngineeringHelwan UniversityCairo11792Egypt Egyptian Computer Emergency Readiness Team(EG-CERT) National Telecom Regulatory Authority(NTRA)Cairo12577Egypt

Recently,Multicore systems use Dynamic Voltage/Frequency Scaling(DV/FS)technology to allow the cores to operate with various voltage and/or frequencies than other cores to save power and enhance the *** this paper,an effective and reliable hybridmodel to reduce the energy and makespan in multicore systems is *** proposed hybrid model enhances and integrates the greedy approach with dynamic programming to achieve optimal Voltage/Frequency(Vmin/F)***,the allocation process is applied based on the *** hybrid model consists of three *** first stage gets the optimum safe voltage while the second stage sets the level of energy efficiency,and finally,the third is the allocation *** results on various benchmarks show that the proposed model can generate optimal solutions to save energy while minimizing the makespan *** with other competitive algorithms show that the proposed model provides on average 48%improvements in energy-saving and achieves an 18%reduction in computation time while ensuring a high degree of system reliability.

关键词： Energy-efficiency safe voltage multicore processors core utilization dynamic voltage/frequency scaling makespan

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Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models

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World Journal of Gastroenterology 2022年第33期28卷 4787-4811页

作者： Alissar Monzer Kevork Wakimian Farah Ballout samar Al Bitar Amani Yehya Mariam Kanso nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir Department of Biology American University of BeirutBeirut 1107-2020Lebanon Department of Anatomy Cell Biology and Physiological SciencesAmerican University of BeirutBeirut 1107-2020Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Pathology and Laboratory Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Internal Medicine American University of Beirut Medical CenterBeirut 1107-2020Lebanon Department of Biology and Center for Drug Discovery American University of BeirutBeirut 1107-2020Lebanon

BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related *** stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon ***, there is limited research on the effects of DIQ on eradicating CSCs in *** To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived *** Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid *** Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil *** This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation.

关键词： Diiminoquinone Anticancer activity Colorectal cancer Cancer stem cells Patient-derived organoids Colonospheres

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