检索结果-南通市图书馆

Effect of alternative antibiotics in treatment of cefotaxime resistant spontaneous bacterial peritonitis

World Journal of Gastroenterology 2013年第8期19卷 1271-1277页

作者： Ahmed Abouelkhair Badawy Tarik Ibrahim Zaher samar mahmoud sharaf Mohamed Hassan Emara Noha Elsaid Shaheen Talaat Fathy Aly Department of Tropical Medicine Zagazig University Faculty of MedicineZagazig 44519Egypt Department of Clinical Pathology Zagazig University Faculty of MedicineZagazig 44519Egypt

AIM:To evaluate effective alternative antibiotics in treatment of cefotaxime-resistant spontaneous bacterial ***:One hundred cirrhotic patients with spontaneous bacterial peritonitis [ascitic fluid polymorphonuclear cell count(PMNLs) ≥ 250 cells/mm 3 at admission] were empirically treated with cefotaxime sodium 2 g/12 h and volume expansion by intravenous human *** patients were subjected to history taking,complete examination,laboratory tests(including a complete blood cell count,prothrombin time,biochemical tests of liver and kidney function,and fresh urine sediment),chest X-ray,a diagnostic abdominal paracentesis,and the sample subjected to total and differential cell count,chemical examination,aerobic and anaerobic *** were divided after 2 d by a second ascitic PMNL count into group Ⅰ;patients sensitive to cefotaxime(n = 81),group Ⅱ(n = 19);cases resistant to cefotaxime(less than 25% decrease in ascitic PMNL count).Patients of group Ⅱ were randomly assigned into meropenem(n = 11) or levofloxacin(n = 8) *** patients performed an end of treatment ascitic PMNL *** were considered improved when:PMNLs decreased to < 250 cells/mm 3,no growth in previously positive culture cases,and improved clinical manifestations with at least 5 d of antibiotic ***:Age,sex,and Child classes showed no significant difference between group Ⅰ and group Ⅱ.Fever and abdominal pain were the most frequent manifestations and were reported in 82.7% and 80.2% of patients in group Ⅰ and in 94.7% and 84.2% of patients in group Ⅱ,*** in group Ⅱ had a more severe ascitic inflammatory response than group Ⅰ and this was demonstrated by more ascitic lactate dehydrogenase(LDH) [median:540 IU/L(range:150-1200 IU/L) vs median:240 IU/L(range:180-500 IU/L),P = 0.000] and PMNL [median:15 000 cell/mm 3(range:957-23 822 cell/mm 3) vs 3400 cell/mm 3(range:695-26 400 cell/mm 3),P = 0.000] *** fluid culture was po

关键词： Spontaneous bacterial peritonitis Cefotaxime Ascitic polymorphonuclear count Cirrhosis Meropenem Levofloxacin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phosphoric Acid Pretreatment and Saccharification of Paper Sludge as a Renewable Material for Cellulosic Fibers

引用

Journal of Renewable Materials 2024年第9期12卷 1573-1591页

作者： samar El-Mekkawi Wafaa Abou-Elseoud Shaimaa Fadel Enas Hassan Mohammad Hassan Chemical Engineering and Pilot Plant Department National Research CentreDokkiGiza12622Egypt Cellulose and Paper Department National Research CentreDokkiGiza12622Egypt

Recycling of paper sludge waste is crucial for establishing a sustainable green industry. This waste contains valuable sugars that can be converted into important chemicals such as ethanol, poly hydroxybutyrate, and lactic acid. However, the main challenge in obtaining sugars in high yield from paper sludge is the high crystallinity of cellulose, which hinders hydrolysis. To address this, pretreatment using phosphoric acid was optimized using response surface methodology to facilitate cellulose hydrolysis with minimal energy and chemicals. The created prediction model using the response surface method considered factors such as acid concentration (ranging from 60% to 85%), consistency (ranging from 4% to 10%), temperature (ranging from 25°C to 80°C), and time (ranging from 0.5 to 4 h). The results revealed that the model’s significant factors affecting the yield were acid concentration, reaction time, temperature, and the product of acid concentration and temperature, while the model’s significant factors affecting the crystallinity were the consistency, the temperature, and their product. The results showed that the optimum conditions for pretreatment were using an acid concentration of 64%, temperature of 25°C, consistency of 10%, and time of 30 min. The hydrolysis of the conditionally pretreated paper sludge resulted in a weight loss of 42%, compared to only 18% weight loss in non-pretreated paper sludge. Furthermore, the optimized conditions led to low levels of furfurals and acetic acid, which are undesirable by-products that can interfere with sugar fermentation. The total sugar obtained under the optimized conditions was 0.43 g glucose/g sample (10.46 g/L), while the contents of methyl furfural, furfural, and acetic acid were 21.65, 235.7, and 4.57 mg/L, respectively. This study demonstrates the potential of phosphoric acid for pretreatment and hydrolysis of paper sludge, enabling efficient saccharification and the production of sugars with minimal undesired

关键词： Waste valorization fermentable sugars response surface methodology acid hydrolysis cellulose crystallinity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Unique presentation of neonatal liver failure:A case report

引用

World Journal of Clinical Pediatrics 2024年第2期13卷 221-226页

作者： Eman Al Atrash Amer Azaz samar Said Mohammad Miqdady Department of Pediatrics Division of Pediatric GastroenterologySheikh Khalifa Medical CityAbu Dhabi 971United Arab Emirates Department of Pathology Mayo ClinicRochesterMN 55905United States

BACKGROUND Acute fulminant liver failure rarely occurs in the neonatal *** etiologies include viral infection(15%),metabolic/genetic disease(10%),hematologic disorders(15%),and ischemic injury(5%).Gestational alloimmune liver disease usually manifests as severe neonatal liver failure,with extensive hepatic and extrahepatic iron overload,sparing the reticuloendothelial *** liver failure is a rare cause of liver failure where a patient presents with liver failure in the neonatal period with no hepatocytes in liver *** SUMMARY A 5-week-old male presented with *** examination revealed an alert but deeply icteric *** data demonstrated direct hyperbilirubinemia,a severely deranged coagulation profile,normal transaminase,and normal *** resonance imaging of the abdomen was suggestive of perinatal *** biopsy showed histiocytic infiltration with an absence of *** hemosiderin deposition was identified in a buccal mucosa *** Neonatal liver failure in the absence of hepatocellular regeneration potentially reflects an acquired or inborn defect in the regulation of hepatic regeneration.

关键词： Liver Hyperbilirubinemia Le foie vide Neonatal hemochromatosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contrast Normalization Strategies in Brain Tumor Imaging:From Preprocessing to Classification

引用

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1539-1562页

作者： samar M.Alqhtani Toufique A.Soomro Faisal Bin Ubaid Ahmed Ali Muhammad Irfan Abdullah A.Asiri Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Electronic Engineering The University of LarkanoLarkanaSindh75660Pakistan Computer Science Department Sukkur IBA UniversitySukkurSindh65200Pakistan Eletrical Engineering Department Sukkur IBA UniversitySukkurSindh65200Pakistan Electrical Engineering Department College of EngineeringNajran UniversityNajran61441Saudi Arabia Radiological Sciences Department College of Applied Medical SciencesNajran UniversityNajran61441Saudi Arabia

Cancer-related to the nervous system and brain tumors is a leading cause of mortality in various *** resonance imaging(MRI)and computed tomography(CT)are utilized to capture brain *** plays a crucial role in the diagnosis of brain tumors and the examination of other brain ***,manual assessment of MRI images by radiologists or experts is performed to identify brain tumors and abnormalities in the early stages for timely ***,early diagnosis of brain tumors is intricate,necessitating the use of computerized *** research introduces an innovative approach for the automated segmentation of brain tumors and a framework for classifying different regions of brain *** proposed methods consist of a pipeline with several stages:preprocessing of brain images with noise removal based on Wiener Filtering,enhancing the brain using Principal Component Analysis(PCA)to obtain well-enhanced images,and then segmenting the region of interest using the Fuzzy C-Means(FCM)clustering technique in the third *** final step involves classification using the Support Vector Machine(SVM)*** classifier is applied to various types of brain tumors,such as meningioma and pituitary tumors,utilizing the Contrast-Enhanced Magnetic Resonance Imaging(CE-MRI)*** proposed method demonstrates significantly improved contrast and validates the effectiveness of the classification framework,achieving an average sensitivity of 0.974,specificity of 0.976,accuracy of 0.979,and a Dice Score(DSC)of ***,this method exhibits a shorter processing time of 0.44 s compared to existing *** performance of this method emphasizes its significance when compared to state-of-the-art methods in terms of sensitivity,specificity,accuracy,and *** enhance the method further in the future,it is feasible to standardize the approach by incorporating a set of classifiers to increase the robustness of the brain classi

关键词： Brain tumor magnetic resonance imaging principal component analysis fuzzy c-clustering support vector machine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroprotective effect of liraglutide and memantine in a rat model of Alzheimer’s disease

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 207-214页

作者： Duaa M.Bakhshwin Foziya W.Alhalabi Mohamad Omar Barasheed Ahmed M.Bakhshwin Maha H.Jamal Mohammed A.Bazuhair Fatemah O.Kamel Rania M.Magadmi Zoheir A Damanhouri samar M.Alsaggaf Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Hera General Hospital MakkahSaudi Arabia Department of Pathology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Clinical Anatomy Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia

Objective:To assess the effect of memantine combined with liraglutide on aluminum chloride(AlCl_(3))and D-galactose(D-GAL)-induced neurotoxicity in ***:Male Wistar rats were divided into 5 groups of 5 animals each:the positive control,the negative control,the memantine-treated group,the liraglutide-treated group,and the combination group treated with memantine and ***_(3)and D-GAL were used to induce *** tests,brain beta-amyloid protein,and oxidative stress biomarkers were ***:The Morris water maze test indicated an enhanced memory in the combination ***,the combination treatment of liraglutide and memantine resulted in a remarkable reduction in the beta-amyloid protein level in the brain *** inflammation and oxidative stress biomarkers were significantly reduced,and the levels of antioxidant parameters were ***:The combination of liraglutide and memantine exerts neuroprotective effects and enhances memory and cognitive functions in rats with Alzheimer’s disease.

关键词： Alzheimer’s disease Cognitive function Glucagonlike peptide-1 Liraglutide Memantine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Case Report and Clinical Management of a Case of Osteogenesis Imperfecta Detected in the Prenatal Period

引用

Open Journal of Obstetrics and Gynecology 2024年第7期14卷 996-1002页

作者： Amina Chaieb Oumayma Ben Rejeb samar Knaz Yasmine Ben Ali Syrine Chelly Safia Ernez Mouna Derouiche Department of Gynecology and Obstetrics Farhat Hached University Hospital Sousse Tunisia Faculty of Medicine Ibn Al Jazzar University of Sousse Sousse Tunisia

Osteogenesis imperfecta is a hereditary disease characterized by bone fragility due to a defect in type I collagen synthesis. The diagnosis is typically suspected based on suggestive ultrasound findings and confirmed through genetic studies. We present a case of osteogenesis imperfecta suspected during obstetrical ultrasound at 19 weeks’ gestation, which was later confirmed radiographically through computed tomography. Due to the severity of the condition, therapeutic termination of pregnancy was indicated.

关键词： Osteogenesis Imperfecta Ultrasound Screening Antenatal Diagnosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Spectroscopic Investigations for the Six New Synthesized Complexes of Fluoroquinolones and Quinolones Drugs With Nickel(Ⅱ) Metal Ion:Infrared and Electronic Spectroscopy

引用

光谱学与光谱分析 2021年第6期41卷 1976-1981页

作者： samar O.Aljazzar Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

Quinolone has a broad spectrum of synthetic antibiotics with a strong therapeutic effect and quinolone is a term used for chemical treatments used to treat a powerful *** are divided into 4 generations according to the bacterial spectrum,the majority of quinolones used clinically belong to the sub fluoroquinolones group,which has a fluorine atom linked to the central ring system,usually on its carbon atom 6 or *** in this article,six new nickel(Ⅱ)complexes(Ⅰ—Ⅵ)have been synthesized in aqueous alkaline media at pH ranged 8-9,the chemical reactions take place between levofloxacin(HLEV),lomefloxacin(HLOM),nalidixic acid(HNLA),oxolonic acid(HOXO),pipemidic acid(HPIP),and pefloxacin mesylate(HPEF)with nickel(Ⅱ)nitrate *** microanalytical(percentage of carbon,hydrogen and nitrogen),molar conductance(Λm),Infrared(FTIR)spectra,electronic(UV-Vis)spectra,and effective magnetic moment instrumentals were used to identify the suggested structures and their surface *** the analytical and spectroscopic analyses,the stoichiometry between nickel(Ⅱ)metal ion and drug ligands was found to be 1∶2 with general formula as[Ni(L)_(2)(H_(2)O)_(2)]·x H_(2)O(L=LEV(Ⅰ),LOM(Ⅱ),NAL(Ⅲ),OXO(Ⅳ),PIP(V),and PEF(Ⅵ);x=2 or 4).By the comparison between FTIR spectra of quinolone drugs and their complexes,it can be deduced that all the drug ligands act as a bidentate chelates through oxygen atoms of pyridine ring and carboxylate *** electronic configuration of all synthesized nickel(Ⅱ)complexes were octahedral geometry which confirmed based on the values of magnetic susceptibility and the electronic transition bands.

关键词： Quinolone Fluoroquinolone Nickel FTIR Chelates UV-Vis Octahedral geometry

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spectroscopic Characterizations of Metal-Complexes of 4-Hydroxybenzoic Acid With the Ni(Ⅱ),Mn(Ⅱ),and Cu(Ⅱ)Ions

引用

光谱学与光谱分析 2021年第6期41卷 1971-1975页

作者： samar O.Aljazzar Department of Chemistry College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh 11671Saudi Arabia

One of the phenolic acids is 4-hydroxybenzoic acid(HBA)which takes the form of a white crystalline solid with a molecular formula of C 7H 6O 3,a melting point of 214.5℃and a molecular weight of 138.12 g·mol^(-1).It soluble in polar organic solvents like acetone and alcohols,and slightly soluble in chloroform and *** reactions between the metal ions and the HBA were carried out under specific conditions like(molar reaction was 2∶2(ligand to metal),reaction temperature was 60℃,media was neutral(pH 7),and solvent was H 2O∶MeOH(1∶1).Under these conditions,the HBA was deprotonated to form(HOC_(6)H_(4)CO^(2);L^(-)).The ligand L-was coordinated to the metal ions forming the metal *** reaction of 4-hydroxybenzoic acid(HOC 6H 4CO 2H;HL)with the Ni(Ⅱ),Mn(Ⅱ)and Cu(Ⅱ)ions afford metal-complexes with gross formula of[Ni_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],[Mn_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)]and[Cu_(2)L_(2)(NO_(3))_(2)(H_(2)O)_(4)],*** complexes were characterized by elemental analysis(CHN),magnetic susceptibility,UV-Vis spectra,infrared(IR),and X-ray powder diffraction(XRD)*** complexes of HBA are insoluble in common solvents and hence molar conductance could not be measured,but this very insolubility indicates that the complexes are *** has demonstrated that the ligand(L^(-))was coordinated to the metal ion by bidentate bridging carboxylate group(COO^(-)),with an octahedral ***,HBA is expected to act as bidentate uninegative ions and the coordination number of the metal ions is *** results showed that the complexes possess uniform and organized microstructures in the nanometer range with a main diameter in the range of 11~28 nm.

关键词： 4-hydroxybenzoic acid Metal-complex Spectral analysis Nanostructure

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel technique of insulin loading into porous carriers for oral delivery

引用

Asian Journal of Pharmaceutical Sciences 2018年第4期13卷 297-309页

作者： Sarah Y.Eilleia mahmoud E.Soliman samar Mansour Ahmed.S.Geneidi Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyAin Shams University

The increasing demand for oral macromolecule delivery encouraged the development of mi-croencapsulation technologies to protect such drugs against gastric and enzymatic degra-dation. However, microencapsulation often requires harsh conditions that may jeopardizetheir biological activity. Accordingly, many trials attempted to load macromolecules intoporous drug carriers to bypass any formulation induced instability. In this study, we pre-pared chitosan coated porous poly(d, l-lactide-co-glycolide)(PLGA) microparticles(MPs)loaded with insulin using a novel loading technique; double freeze-drying. The resultsshowed a significant increase in drug loading using only 5 mg/ml initial insulin concen-tration and conveyed a sustained drug release over uncoated MPs. Furthermore, SEM andconfocal microscopy confirmed pore blocking and insulin accumulation within the MPs re-spectively. The oral pharmacodynamic data on rats also proved the preservation of insulinbioactivity after formulation. Finally, the new coating technique proved to be efficient inproducing robust layer of chitosan with higher insulin loading while maintaining insulinactivity.

关键词： Porous microparticles PLGA Insulin Freeze-drying Chitosan coating

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Refined rigorous perturbation bounds for the SR decomposition

引用

Applied Mathematics:A Journal of Chinese Universities 2021年第4期36卷 537-553页

作者： Mahvish samar Aamir Farooq Department of Mathematics Shantou University College of Mathematics and Statistics Chongqing University

In this article, some new rigorous perturbation bounds for the SR decomposition under normwise or componentwise perturbations for a given matrix are derived. Also, the explicit expressions for the mixed and componentwise condition numbers are presented by utilizing the block matrix-vector equation approach. Hypothetical and trial results demonstrate that these new bounds are constantly more tightly than the comparing ones in the literature.

关键词： 65F35 15A23 15A57 SR decomposition Rigorous perturbation bound Lyapunov majorant function Banach fixed point theorem Mixed and componentwise condition numbers

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：