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Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

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Burns & Trauma 2022年第1期10卷 546-557页

作者： Lucy W.Barrett Vanessa S.Fear Bree Foley Katherine Audsley samantha Barnes Hannah Newnes Alison mcDonnell Fiona m.Wood mark W.Fear Jason Waithman Burn Injury Research Unit School of Biomedical SciencesUniversity of Western AustraliaCrawleyWA6009Australia Telethon Kids Institute University of Western AustraliaNorthern EntrancePerth Children’s Hospital15 Hospital AveNedlandsWA6009Australia Fiona Wood Foundation Fiona Stanley HospitalMNH(B)Main HospitalCD 15Level Burns Unit 102-118 Murdoch DriveMurdochWA6150Australia and 4Burns Service of Western AustraliaWA Department of HealthNedlandsWA6009Australia

Background:Recent evidence suggests that burn patients are at increased risk of hospital admission for infection,mental health conditions,cardiovascular disease and cancer for many years after discharge for the burn injury *** injury has also been shown to induce sustained immune system *** change to immune function may contribute to the increased risk of chronic disease ***,the mechanisms that disrupt long-term immune function in response to burn trauma,and their link to long-term morbidity,remain *** this study we investigated changes to immune function after burn injury using a murine model of non-severe ***:An established mouse model of non-severe burn injury(full thickness burn equivalent to 8%total body surface area)was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and *** that CD8^(+)T cells are important drivers of effective tumour suppression in this model,we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus *** cytometry was used to detect and quantify cell populations of interest and changes in immune ***:We demonstrate that 4 weeks after a non-severe burn injury,mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 *** addition,our results reveal that CD8^(+)T cell expansion,differentiation and memory potential is significantly impaired at 1 month ***:Our data suggests that CD8^(+)T cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn *** studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.

关键词： Immunology Surgery Burn injury T cells Immune dysfunction Cancer

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Book reviews

Fungal Diversity 2013年第2期59卷 179-197页

作者： samantha C.Karunarathna Anupama Daranagama Nilam Fadmaulidha Wulandari Thatsanee Luangharn m.m.Ruvishika S.Jayawardena P.H.m.Anushika K.Herath Asha Janadaree Dissanayake Gayan Dakshitha Abeysinghe I.C.Senanayake Sinang Hongsanan Kevin D.Hyde mae Fah Luang University 333 Moo 1ThasudMuangChiang Rai 57100Thailand

This nicely laid out book which is referred to as“Holy Book of Smut Fungi”is an essential tool in helping the scientific community to identify smut fungi *** wonderful guide contains keys to the genera and species and a host plant–smut fungus list and compiles more than 3,500 micrographs and line drawings into a single *** years of collecting and describing smut fungi species by Dr.Kálmán Vánky,the worldwide authority on the subject,has resulted to a 1,500-page *** book provides complete and detailed presentations of species in 93 genera through descriptions and illustrations and updates our knowledge of valid scientific names and synonyms and provides taxonomic references and the host plant range of each *** excellent illustrations and detailed descriptions complement other guides to aid the lay person in getting the latest information on topics to make identification easier.

关键词： illustration descriptions helping

Forgiveness education in fibromyalgia: A qualitative inquiry

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Pain Studies and Treatment 2014年第1期2卷 11-16页

作者： Loren L. Toussaint Ann Vincent mary O. Whipple samantha J. mcAllister Dawn m. Finnie Julie C. Hathaway Terry H. Oh Kevin C. Fleming Kristin S. Vickers Douglas Department of Psychology Luther College Decorah USA Division of Health Care Policy and Research Mayo Clinic Rochester USA Division of Health Care Policy and Research Mayo Clinic Rochester USA Department of Psychiatry and Psychology Mayo Clinic Rochester USA Fibromyalgia and Chronic Fatigue Clinic Mayo Clinic Rochester USA Patient Education Research Mayo Clinic Rochester USA

The purpose of this qualitative study was to assess perspectives on the acceptability and the potential applicability of a forgiveness education in patients with fibromyalgia. The concept and tools of forgiveness were presented to thirteen women (age: 40 - 54 years) with a previous diagnosis of fibromyalgia. Subjects participated in 1 of 2 focus groups following a 90-minute education session in which forgiveness was presented as an emotion-focused coping strategy to deal with interpersonal stressors. Qualitative assessment of focus group discussions reveals 3 themes: 1) forgiveness is healthy and reduces pain, 2) forgiveness is within a patient’s personal control, and 3) forgiveness education is similar to other types of patient education and is well received. Our results suggest that forgiveness education is acceptable and feasible in patients with fibromyalgia. This justifies further exploration of forgiveness as an emotion-focused self- management strategy to decrease psychological distress.

关键词： Fibromyalgia Forgiveness Intervention Pain Patient Education

Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids

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Advances in Bioscience and Biotechnology 2012年第3期3卷 204-218页

作者： Houli Jiang Fiona E. Harrison Kavita Jain samantha Benjamin James m. may Joan P. Graves Darryl C. Zeldin John R. Falck Bruce D. Hammock John C. mcGiff Department of Biochemistry University of Texas Southwestern Medical Center Dallas Texas USA Department of medicine Vanderbilt University Nashville Tennessee USA Department of Pharmacology New York Medical College Valhalla New York USA Entomology and Cancer Center University of California Davis California USA NIH/NIEHS Research Triangle Park North Carolina USA

The cardiovascular effects of vitamin C (VitC) could be mediated by epoxyeicosatrienoic acids (EETs). We aimed to study the mechanism of VitC-dependent microsomal formation of cis- and trans-EETs and the regulation of EET levels in rat isolated perfused kidneys and in vivo. VitC biphasically stimulated rat kidney microsomal cis- and trans-EET formation in a ratio of 1:2, involving the participation of lipid hydroperoxides (LOOHs), Fe2+ , and cytochrome P450 (CyP). Levels of LOOHs correlated with microsomal EET production. LOOH stimulation of CyP isoforms resulted in preferred trans- over cis-EET formation from arachidonic acid and was associated with the cleavage of LOOHs, which indicated a CyP peroxy-genase activity. EETs contributed to VitC-induced vasodilator responses in rat isolated perfused kidneys. VitC (1 mg/ml) given in the drinking water for 9 days doubled rat urinary EET excretion, increased plasma levels of EETs, mostly trans-EETs, by 40%, and reduced plasma levels of 20-hydroxyeicosatetraenoic acid. Depletion of VitC in brain cortex and kidney tissues by more than 20- and 50-fold, respectively, in gulonolactone oxidase-knockout mice was associated with mild increases in tissue EETs. These data suggest that LOOHs are a determinant factor for EET formation in vivo in which VitC exerts a key regulatory effect. VitC-activated CyP peroxygenase activity may represent a CyP interaction with lipoxygenases and cyclooxygenases to mediate the cardiovascular effects of VitC via formation of EETs.

关键词： Vitamin C Epoxyeicosatrienoic Acids Cytochrome P450 Lipid Hydroperoxides Peroxygenase

Taxonomy and phylogeny of hyaline‑spored coelomycetes

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Fungal Diversity 2020年第1期100卷 279-801页

作者： Wen‑Jing Li Eric H.C.mcKenzie Jian‑Kui(Jack)Liu D.Jayarama Bhat Dong‑Qin Dai Erio Camporesi Qing Tian Sajeewa S.N.maharachchikumbura Zong‑Long Luo Qiu‑Ju Shang Jin‑Feng Zhang Narumon Tangthirasunun samantha C.Karunarathna Jian‑Chu Xu Kevin D.Hyde Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China World Agroforestry Centre East and Central AsiaKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Landcare Research manaaki Whenua Private Bag 92170AucklandNew Zealand School of Life Science and Technology University of Electronic Science and Technology of ChinaChengdu 611731People’s Republic of China No.128/1‑J Azad Cooperative Housing SocietyCurcaP.O.Goa VelhaGoa 403108India Center for yunnan Plateau Biological Resources Protection and Utilization College of Biological Resource and Food EngineeringQujing Normal UniversityQujingYunnan 655011People’s Republic of China A.m.B.Gruppo Micologico Forlivese“Antonio Cicognani”Via Roma 18ForlìItaly A.m.B Circolo micologico“Giovanni Carini” C.P.314BresciaItaly Societàper gli Studi Naturalistici della Romagna C.P.143BagnacavalloRAItaly College of Agriculture and Biological Sciences Dali UniversityDali 671003YunnanPeople’s Republic of China Department of Biology Faculty of ScienceKing Mongkut’s Institute of TechnologyLadkrabangChalongkrung Rd.Ladkrabang DistrictBangkok 10520Thailand

Coelomycete is a general term used for asexual fungi which produce conidia in fruiting bodies:pycnidial,acervular,cupulate,pycnothyria or stromatic *** group contains numerous plant pathogenic,saprobic and endophytic species associated with a wide range of ***,morphological characters and host associations have been used as criteria to identify and classify coelomycetes,and this has resulted in a poor understanding of their generic and species *** based taxonomic studies have provided a better outlook of the phylogenetic and evolutionary trends in ***,the present outcomes represent only a preliminary step towards the understanding of *** genera have not been revisited since they were first *** present study revises the classification of the hyaline-spored coelomycetes and provides a modern taxonomic framework based on both morphology and *** total,248 genera were investigated,of which less than 100 are known to have sequence ***-locus sequence data analyses of 28S nrDNA,18S nrDNA,ITS,RNA polymerase II second largest subunit(rpb2),and part of the translation elongation factor 1-alpha gene(tef1)andβ-tubulin(tub2)gene regions were *** a result,three new genera and 23 new species are *** addition,three new links between sexual and asexual genera are *** are 138 genera that lack sequence data,and these are treated as Ascomycota,genera incertae *** drawings and descriptions are provided based on the examination of types and fresh collections and on the literature.

关键词： 26 new taxa Ascomycota Asexual morphs Basidiomycota

Current trends of liver cirrhosis in mexico: Similitudes and differences with other world regions

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World Journal of Clinical Cases 2018年第15期6卷 922-930页

作者： Nahum méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-martínez samantha Cabrera-Palma Guillermo Cabrera-álvarez Liver Research Unit Medica Sur Clinic and Foundation Department of Gastroenterology Hospital "Juárez" of México Department of molecular Biology in me-dicine Civil Hospital of Guadalajara "Fray Antonio Alcalde" Department of Internal medicine "Christus Muguerza "Super Specialty" Hospital" Monterrey Department of Gas-troenterology "University Hospital "Jose Eleuterio González" Monterrey Department of Gastroenterology "General Hospital of Mexico "Dr.Eduardo Liceaga" Department of Gastroenterology "Central Military Hospital" Faculty of medicine and Nutrition Juárez University of the State of Durango Liver Clinic Regional General Hospital IMSS 1

AIm To investigate the main current etiologies of cirrhosis in *** We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in mexico.

关键词： Alcoholic liver disease Hepatitis C virus Nonalcoholic steatohepatitis Liver cirrhosis

Fungal diversity notes 840–928:micro-fungi associated with Pandanaceae

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Fungal Diversity 2018年第6期93卷 1-160页

作者： Saowaluck Tibpromma Kevin DHyde Eric H.C.mcKenzie DJayarama Bhat Alan J.L.Phillips Dhanushka N.Wanasinghe milan C.Samarakoon Ruvishika S.Jayawardena Asha J.Dissanayake Danushka S.Tennakoon mingkwan Doilom Rungtiwa Phookamsak Alvin m.C.Tang Jianchu Xu Peter Emortimer Itthayakorn Promputtha Sajeewa S.N.maharachchikumbura Samiullah Khan samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand No.128/1-J Azad Housing SocietyCurcaGoa VelhaIndia Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong KongSARPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Environmental Science Research Centre Faculty of ScienceChiang Mai UniversityChiang Rai 50200Thailand Universidade de Lisboa Faculdade de CieˆnciasBiosystems and Integrative Sciences Institute(BioISI)Campo Grande1749-016 LisbonPortugal Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 34123 AlkhoudOman College of Animal Science and Technology Yunnan Agriculture UniversityKunmingPeople’s Republic of China

This paper provides illustrated descriptions of micro-fungi newly found on Pandanaceae in China and *** fungi are accommodated in 31 *** taxa described include a new family,seven new genera,65 new species,16 previously known species.A new family:malaysiascaceae(Glomerellales).New genera are Acremoniisimulans(Plec-tosphaerellaceae),Pandanaceomyces,Pseudoachroiostachy(Nectriaceae),Pseudohyaloseta(Niessliaceae),Pseudoor-natispora(Stachybotriaceae)and yunnanomyces(Sympoventuriaceae).New species are Acremoniisimulans thailandensis,Beltrania krabiensis,Beltraniella pandanicola,***,Canalisporium krabiense,***,Clonostachys krabiensis,Curvularia chonburiensis,***,***,***,Cylindrocladiella xishuangbannaensis,Dictyochaeta pandanicola,Dictyocheirospora nabanheensis,***,***-sis,Dictyosporium appendiculatum,***,***,***,***,Distoseptispora thailandica,***,Helicoma freycinetiae,Hermatomyces biconisporus,Lasiodiplodia chonburiensis,***,Lasionectria krabiense,menisporopsis pandanicola,montagnula krabiensis,musicillium pandanicola,Neofusicoccum pandanicola,Neohelicomyces pandanicola,Neooccultibambusa thailandensis,Neopestalotiopsis chiang-maiensis,***,***,Pandanaceomyces krabiensis,Paracylindrocarpon nabanheensis,***-danicola,***,Parasarcopodium hongkongensis,Pestalotiopsis krabiensis,***,Polyplosphaeria nabanheensis,***,***,Pseudoachroiostachys krabiense,Pseu-doberkleasmium pandanicola,Pseudochaetosphaeronema pandanicola,Pseudohyaloseta pandanicola,Pseudoornatispora krabiense,Pseudopithomyces pandanicola,Rostriconidium pandanicola,Sirastachys phangngaensis,Stictis pandanicola,Terriera pandanicola,Thozetella pandanicola,Tubeufia freycinetiae,***,***,Vermiculariopsiella hongkongensis,Volutella krabiense,*** a

关键词： 65 new taxa Ascomycota Dothideomycetes Freycinetia Lecanoromycetes Leotiomycetes Pandanus Saprobic Sordariomycetes

Preliminary evaluation of the VIsion PERformance(VIPER) simulator

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military medical Research 2020年第3期7卷 312-323页

作者： Denise S.Ryan Rose K.Sia Jennifer B.Eaddy Lorie A.Logan Jide O.Familoni Hind Beydoun samantha B.Rodgers Bruce A.Rivers Warfighter Refractive Eye Surgery Program and Research Center Fort Belvoir Community HospitalFort BelvoirVA 22060USA Night Vision and Electronic Sensors Directorate Fort BelvoirVA 22060USA Department of Research Programs Fort Belvoir Community HospitalFort BelvoirVA 22060USA

Background:This study evaluated the VIsion PERformance(VIPER)simulator’s ability to assess the functional visual performance in warfighters conducting civilian and military ***:Thirty service members,aged 25–35 years old with a best corrected distance visual acuity(VA)better than or equal to 20/20 or logarithm of the minimum angle of resolution(logmAR)0.00,were randomized to locate and identify road signs and mock improvised explosive devices(IEDs)under either daytime conditions or with infrared imagery,with(cc)and without(sc)wearing their habitual *** also underwent binocular uncorrected(UDVA)and corrected(CDVA)visual assessment,refraction,contrast sensitivity testing and wavefront ***:The mean age was 28.47 *** manifest spherical equivalent was–3.16±1.75 diopters(D),the UDVA in both eyes(OU)was logmAR 0.83±0.47,and the CDVA OU was–0.11±*** VIPER,the mean difference in the detection distance(DD)for road signs ccDD *** was(76.7±52.8)m(Pm(Pmean accuracies were 83.5%and 27.9%for cc and sc,respectively(Pysis indicated that a 1.6 m change in the distance accounts for a 1%change in the accuracy(P=0.002).Without correction,a 4.1 m change accounts for a 1%change in the accuracy(Pm,and that for scDD was(13.2±13.6)m(Pm and that for the scID was(7.4±10.3)m(Pmean IED identification accuracy was 46.7 and 11.4%for cc and sc,respectively(Pminary results reflect VIPER’s ability to assess functional visual performance when detecting and identifying signs and ***,VIPER is able to detect performance changes with and without correction.

关键词： Functional visual performance military task performance

Changes to cadmium associations in canal sediments on drying and oxidation

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Chinese Journal Of Geochemistry 2006年第B8期25卷 247-247页

作者： samantha R. Cook John m. Chamock Andrew Parker School of Environmental Sciences University of Reading Reading UK Daresbury Laboratory Daresbury UK