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Anemia and insomnia: a cross-sectional study and meta-analysis

Chinese Medical Journal 2021年第6期134卷 675-681页

作者： samantha n.neumann Jun-Juan Li Xiao-Dong Yuan Shuo-Hua Chen Chao-Ran Ma Laura E.Murray-Kolb Yun Shen Shou-Ling Wu Xiang Gao Eberly College of Science The Pennsylvania State UniversityUniversity ParkPAUnited States West Virginia School of Osteopathic Medicine LewisburgVWUnited States Department of nephrology Kailuan General HospitalTangshanHebei 063000China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China Department of nutritional Sciences The Pennsylvania State UniversityUniversity ParkPAUnited States Department ot neurology The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu 215000China

Background: Several recent genome-wide association studies suggested insomnia and anemia may share some common genetic components. We thus examined whether adults with anemia had higher odds of having insomnia relative to those without anemia in a cross-sectional study and a ***: Included in this cross-sectional study were 12,614 Chinese adults who participated in an ongoing cohort, the Kailuan Study. Anemia was defined as hemoglobin levels below 12.0 g/dL in women and 13.0 g/dL in men. Insomnia was assessed using the Chinese version of the Athens Insomnia Scale (AIS). A total AIS score ≥6 was considered insomnia. The association between anemia and insomnia was assessed using a logistic regression model, adjusting for potential confounders such as age, sex, chronic disease status, and plasma C-reactive protein concentrations. A meta-analysis was conducted using the fixed effects model to pool results from our study and three previously published cross-sectional studies on this topic in adult ***: Individuals with anemia had greater odds of having insomnia (adjusted odds ratio [OR]: 1.32;95% confidence interval [CI]: 1.03-1.70) compared with individuals without anemia. A significant association persisted after we excluded individuals with chronic inflammation, as suggested by C-reactive protein levels >1 mg/L (adjusted OR: 1.68;95% CI: 1.22-2.32). The meta-analysis results, including 22,134 participants, also identified a positive association between anemia and insomnia (pooled OR: 1.39;95% CI: 1.22-1.57).Conclusions: The presence of anemia was significantly associated with a higher likelihood of having insomnia in adults. Due to the nature of the cross-sectional study design, results should be interpreted with caution.

关键词： Anemia Insomnia C-reactive protein Inflammation Cohort

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nicotine from cigarette smoking and diet and Parkinson disease:a review

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Translational neurodegeneration 2017年第1期6卷 174-180页

作者： Chaoran Ma Yesong Liu samantha neumann Xiang Gao Department of nutritional Sciences The Pennsylvania State UniversityUniversity ParkUniversity ParkPAUSA Department of neurology Kailuan General HospitalTangshanChina Eberly College of Science The Pennsylvania State UniversityUniversity ParkUniversity ParkPAUSA

Evidence from epidemiological studies suggest a relationship between cigarette smoking and low risk of Parkinson disease(PD).As a major component of tobacco smoke,nicotine has been proposed to be a substance for preventing against PD risk,with a key role in regulating striatal activity and behaviors mediated through the dopaminergic *** studies also showed that nicotine could modulate dopamine transmission and reduce levodopa-induced ***,previous clinical trials yield controversial results regarding nicotine *** this review,we updated epidemiological,preclinical and clinical data,and studies on nicotine from *** also reviewed interactions between genetic factors and cigarette *** a small amount of nicotine can saturate a substantial portion of nicotine receptors in the brain,nicotine from other sources,such as diet,could be a promising therapeutic substance for protection against PD.

关键词： nicotine Smoking Diet Gene-environment interactions Parkinson disease

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Reflection of intense laser light from microstructured targets as a potential diagnostic of laser focus and plasma temperature

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High Power Laser Science and Engineering 2019年第1期7卷 10-16页

作者： J.Jarrett M.King R.J.Gray n.neumann L.Dhl C.D.Baird T.Ebert M.Hesse A.Tebartz D.R.Rusby n.C.Woolsey D.neely M.Roth P.McKenna Department of Physics SUPA University of Strathclyde Institut f¨ur Kernphysik Technische Universit?t Darmstadt York Plasma Institute University of York STFC-Rutherford Appleton Laboratory Institut fur Kernphysik Technische Universit?t Darmstadt

The spatial-intensity profile of light reflected during the interaction of an intense laser pulse with a microstructured target is investigated experimentally and the potential to apply this as a diagnostic of the interaction physics is explored numerically. Diffraction and speckle patterns are measured in the specularly reflected light in the cases of targets with regular groove and needle-like structures, respectively, highlighting the potential to use this as a diagnostic of the evolving plasma surface. It is shown, via ray-tracing and numerical modelling, that for a laser focal spot diameter smaller than the periodicity of the target structure, the reflected light patterns can potentially be used to diagnose the degree of plasma expansion, and by extension the local plasma temperature, at the focus of the intense laser light. The reflected patterns could also be used to diagnose the size of the laser focal spot during a high-intensity interaction when using a regular structure with known spacing.

关键词： high power laser laser-solid interactions plasma temperature diagnosis

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Piling up multidecker pyrgos[n]cages as antibacterial materials

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Science China Materials 2025年第1期 314-316页

作者： Miguel A.Liuzzi-Vaamonde Jackson B.Lancaster samantha A.Mason Yuanning Feng Department of Chemistry and Biochemistry The University of Oklahoma

The development of antibiotics is regarded as one of the most significant scientific advances in modern medicine. Before the commercialization of antibiotics, infectious diseases were catastrophic throughout history [1]. Penicillin was used to treat serious infections in the 1940s, but unfortunately, with the introduction of antibiotics came the emergence of antibiotic resistance [2,3]. Evolved and adapted methicillin-resistant Staphylococcus aureus (MRSA) strains are presently impacting community and healthcare systems across the globe [4].

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A probabilistic estimation model for seismic physical portfolio loss of a water supply pipeline system

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Resilient Cities and Structures 2024年第1期3卷 44-54页

作者： samantha Louise n.Jarder Osamu Maruyama Lessandro Estelito O.Garciano Department of Urban Architecture and Civil Engineering Tokyo City University1-28-7 TamazutsumiSetagaya-kuTokyo 158-8557Japan Department of Civil Engineering De La Salle University2401 Taft AveMalateManilaMetro Manila 1004Philippines

Losses due to hazards are inevitable and numerical simulations for estimations are *** study proposes a model for estimating correlated seismic damages and losses of a water supply pipeline system as an alternative for numerical *** common approach in other research shows average damage spots per mesh estimated statistically independent to one *** distributed lifeline systems,such as water supply pipelines,are interconnected,and seismic spatial variability affects the damages across the region;thus,spatial correlation of damage spots is an important factor in target areas for portfolio loss ***,simulations are used to estimate possible losses;however,these assume each damage behaves independently and *** paper assumed that damages per mesh behave in a Poisson distribution to avoid over-dispersion and eliminate negative losses in *** purpose of this study is to obtain a probabilistic portfolio loss model of an extensive water supply *** proposed model was compared to the numerical simulation data with the correlated Poisson *** application of the normal To Anything(nORTA)obtained correlations for Poisson *** proposed probabilistic portfolio loss model,based on the generalized linear model and central limit theory,estimated the possible losses,such as the Probable Maximum Loss(PML,90%non-exceedance)or normal Expected Loss(nEL,50%non-exceedance).The proposed model can be used in other lifeline systems as well,though additional investigation is needed for *** the estimations,a seismic physical portfolio loss for the water supply system was *** portfolio was made to show possible outcomes for the *** proposed method was tested and analyzed using an artificial field and a location-based scenario of a water supply pipeline *** would aid in pre-disaster planning and would require only a few steps and time.

关键词： Spatial correlation Probable maximum loss Risk management Water supply pipeline Portfolio loss estimation

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Restructuring the lithium-ion battery:A perspective on electrode architectures

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eScience 2023年第4期3卷 12-19页

作者： samantha n.Lauro James n.Burrow C.Buddie Mullins Department of Chemistry The University of Texas at AustinAustinTX78712-1224United States McKetta Department of Chemical Engineering The University of Texas at AustinAustinTX78712-1589United States Texas Materials Institute The University of Texas at AustinAustinTX78712-1591United States

The lithium-ion battery(LIB)has enabled portable energy storage,yet increasing societal demands have moti-vated a new generation of more advanced *** the discovery and optimization of battery active ma-terials has been the subject of extensive study since the 1980s,the most disruptive advancements of commercial LIBs in the past decade stem instead from overall cell design and *** pursuit of higher energy density and fast-charging capability,strategies focused on tuning the properties of composite electrode architectures(e.g.,porosity,conductivity,tortuosity,spatial heterogeneity)by restructuring the inactive component matrix of LIB electrode films have recently garnered *** perspective explores recent advances in electrode design through an applied lens,emphasizing synthetic platforms and future research directions that are scalable,commercially feasible,and applicable to a wide range of active *** introduce and critically assess recently proposed strategies for structuring electrode architectures,including spatial gradients of local compo-sition and microstructure;metal-foil current collector alternatives;and electrode templating techniques,evalu-ating both achievements in battery performance and commercial *** with improved active materials,new electrode architectures hold promise to unlock next generation LIBs.

关键词： Electrodes Composite films Batteries Microstructure Lithium-ion

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noninvasive ventilation for pediatric interfacility transports:a retrospective study

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World Journal of Pediatrics 2020年第4期16卷 422-425页

作者： samantha Holbird Tanya Holt Adam Shaw Gregory Hansen College of Medicine University of SaskatchewanSaskatoonSKCanada Division of Pediatric Critical Care Jim Pattison Children’s Hospital103 Hospital DriveSaskatoonSKS7N 0W8Canada

Background To characterize pediatric patients supported with continuous positive airway pressure and bilevel positive airway pressure(CPAP/BiPAP)or high-flow nasal cannula(HFnC)during interfacility transport(IFT).Methods A retrospective study with a provincial pediatric transport team from a tertiary hospital pediatric intensive care *** patients aged 28 days ton January 2017 and December 2018,were identified through a transport registry and were included in the *** A total of 118(26.7%)patients received CPAP/BIPAP or HFnC support for *** most common respiratory diagnosis was bronchiolitis(46%).These patients were placed on respiratory support,31.4 minutes after the transport team’s *** required intubation during their IFT,despite mean transport times of 163 *** This study may provide important information for programs with large catchment areas,in which large distances and transport times should not be barriers to nIV implementation.

关键词： Children Critical illness Intubation noninvasive ventilation Transportation of patients

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Optogenetic inhibition of medial prefrontal cortex projections to the nucleus accumbens core and methyl supplementation via L-Methionine attenuates cocaine-primed reinstatement

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Integrative Zoology 2018年第6期13卷 795-803页

作者： Katherine n.WRIGHT Amanda M.DOSSAT Caroline E.STROnG Lindsay L.SAILER samantha M.PAVLOCK Mohamed KABBAJ Department of Biomedical Sciences and Program in neuroscience Florida State UniversityTallahasseeFloridaUSA national Institute on Drug Abuse BaltimoreMarylandUSA Department of Biomedical Sciences College of MedicineFlorida State UniversityTallahasseeFloridaUSA

DnA methylation has been identified as a powerful and activity-dependent regulator of changes in the brain that may underlie neuroadaptations in response to various types of stimuli,including exposure to drugs of ***,the medial prefrontal cortex(mPFC)projections to the nucleus accumbens(nAc)are critically important for reinstated cocaine-seeking in a rodent model of cocaine *** circuitry undergoes several epigenetic modifications following cocaine exposure,including changes in DnA methylation that are associated with drug-seeking *** have previously shown that methyl supplementation via L-Methionine(MET)administration attenuates cocaine-seeking behavior and reverses expression and methylation patterns of the immediate early gene c-fos,suggesting that MET may act by altering the excitability of this circuitry during cocaine *** the current study,male rats were microinjected with an adeno-associated virus overexpressing halorhodopsin in the mPFC,optical fibers were surgically implanted into the nAc,and the rats were given injections of MET *** underwent acquisition of cocaine self-administration(0.75 mg/kg/infusion,2-h sessions)followed by extinction training in the absence of drug-paired *** reinstatement tests were conducted:cue-induced reinstatement without optogenetic manipulations and cocaine-primed reinstatement with optogenetic inhibition of mPFC-to-nAc *** were no group differences before the cocaine-primed reinstatement session,and all groups showed robust cue-induced *** rats treated with MET and rats that received mPFC-to-nAc inhibition showed an abolishment of cocaine-primed reinstatement,suggesting that systemic methyl supplementation may act through this critical circuity.

关键词： cocaine-primed reinstatement corticolimbic DnA methylation methionine optogenetics

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Polarity,intramolecular charge transfer,and hydrogen bond comediated solvent effects on the optical properties of graphene quantum dots

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nano Research 2023年第1期16卷 45-52页

作者： Yalei Hu Christof neumann Lena Scholtz Andrey Turchanin Ute Resch-Genger Siegfried Eigler Institute of Chemistry and Biochemistry Freie Universität BerlinTakustraße 314195 BerlinGermany Institute of Physical Chemistry and Abbe Center of Photonics Friedrich Schiller University JenaLessingstraße 1007743 JenaGermany Federal Institute for Materials Research and Testing(BAM) Division BiophotonicsRichard Willstätter Straße 1112489 BerlinGermany

Graphene quantum dots(GQDs)have attracted increasing attention due to their favorable optical properties and have been widely used,e.g.,in the biomedical ***,the properties related to the chemical structure of GQDs,resulting in solventdependent optical properties,still remain ***,we present the synthesis of long-wavelength emitting GQDs with a size of about 3.6 nm via a solvothermal method using oxo-functionalized graphene(oxo-G)and p-phenylenediamine as precursors and their structural and surface chemical analysis by transmission electron and atomic force microscopy(TEM;AFM)as well as Fourier-transform infrared,Raman,and X-ray photoelectron spectroscopy(FTIR;Raman;XPS).Subsequently,the influence of solvent polarity and proticity on the optical properties of the as-prepared GQDs bearing–OH,–nH_(2),–COOH and pyridine surface groups was *** on the results of the absorption and fluorescence(FL)studies,a possible luminescence mechanism is *** observed solvent-induced changes in the spectral position of the FL maximum,FL quantum yield,and FL decay kinetics in protic and aprotic solvents of low and high polarity are ascribed to a combination of polarity effects,intramolecular charge transfer(ICT)processes,and hydrogen ***,the potential of GQDs for the optical sensing of trace amount of water was *** results of our systematic spectroscopic study will promote the rational design of GQDs and shed more light on the FL mechanism of carbon-based fluorescent nanomaterials.

关键词： graphene quantum dots(GQDs) polarity intramolecular charge transfer(ICT) hydrogen bond optical properties

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Evolution of non‑lichenized,saprotrophic species of Arthonia(Ascomycota,Arthoniales)and resurrection of naevia,with notes on Mycoporum

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Fungal Diversity 2020年第3期102卷 205-224页

作者： Vinodhini Thiyagaraja Robert Lücking Damien Ertz Dhanushka n.Wanasinghe samantha C.Karunarathna Erio Camporesi Kevin D.Hyde CAS Key Laboratory for Plant Biodiversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50002Thailand World Agro Forestry Centre East and Central Asia Kunming 650201YunnanPeople’s Republic of China Botanischer Garten und Botanisches Museum Freie Universitat BerlinKonigin‑Luise‑Str.6-814195 BerlinGermany Research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service Général de l’Enseignement Supérieur et de la Recherche Scientifique Fédération Wallonie-BruxellesRue A.Lavallée 11080 BrusselsBelgium A.M.B.G.Gruppo Micologico Forlivese“Antonio Cicognani” Via Roma 18ForliItaly A.M.B Circolo Micologico“Giovanni carini”C.P.314BresciaItaly Societa per gli Studi naturalistici della Romagna C.P.144BagnacavalloRAItaly

Fungi that are barely lichenized or non-lichenized and closely related to lichenized taxa,the so-called borderline fungi,are an important element in reconstructing the evolutionary history of lichenized *** is a prime example including non-lichenized,saprotrophic lineages which potentially were precursors to lichenized *** this study,we focused on saprotrophic species of Arthonia sensu lato,including new sequence data for Arthonia *** obtained fresh material of this taxon from a living branch of Fraxinus ornus in Italy to assess its taxonomic status and to elucidate its phylogenetic relationships within *** sections of the thallus and ascomata of *** confirmed the absence of a *** likelihood and Bayesian analyses of combined mtSSU,nuLSU and RPB2 sequence data placed the species close to ***(barely lichenized or non-lichenized)and ***(non-lichenized)in a clade closely related to Arthonia sensu stricto,and the *** clade is here resurrected under the name *** character state analysis within a broader context of Arthoniales does not support the saprotrophic lifestyle to be a plesiomorphic feature,but suggests loss of lichenization in naevia,as well as loss and possible regain in a second clade containing saprotrophic species and including taxa resembling Mycoporum,underlining the evolutionary plasticity of *** two clades constitute model taxa to further investigate the evolution of alternative biological lifestyles within the context of chiefly lichenized taxa.

关键词： Arthonia susa Arthothelium Evolution Lichenization Mycarthonia Pseudoarthonia Saprobes

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