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Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

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journal of Integrative Medicine 2019年第2期17卷 132-140页

作者： Carlos R.Oliveira Daniel G.Spindola Daniel M.Garcia Adolfo Erustes Alexandre Bechara Caroline Palmeira-dos-Santos Soraya S.Smaili Gustavo j.S.Pereira André Hinsberger Ezequiel P.Viriato Maria Cristina Marcucci Alexandra C.H.F.Sawaya samantha L.Tomaz Elaine G.Rodrigues Claudia Bincoletto Departamento de Farmacologia Escola Paulista de Medicina (EPM) Universidade Federal de Sao Paulo (UNIFESP) Grupo de Fitocomplexos e Sinalizacao Celular Escola de Ciências da Saúde Universidade Anhembi Morumbi Faculdade de Ciências Farmacêuticas e Bioquímicas Oswaldo Cruz Laboratório de Produtos Naturais e Quimiometria Programa de pós-graduacao em Farmácia e Biotecnologia Universidade Anhanguera de Sao Paulo Faculdade de Ciências Farmacêuticas Universidade Estadual de Campinas (UNICAMP) Unidade de Oncologia Experimental EPM Universidade Federal de Sao Paulo (UNIFESP)

Objective: Although Angelica archangelica is a medicinal and aromatic plant with a long history of use for both medicinal and food purposes, there are no studies regarding the antineoplastic activity of its *** study aimed to evaluate the cytotoxicity and antitumor effects of the crude extract of A. archangelica root(CEAA) on breast ***: The cytotoxicity of CEAA against breast adenocarcinoma cells(4T1 and MCF-7) was evaluated by a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide(MTT) assay. Morphological and biochemical changes were detected by Hoechst 33342/propidium iodide(PI) and annexin V/PI staining. Cytosolic calcium mobilization was evaluated in cells staining with FURA-4 NW. Immunoblotting was used to determine the effect of CEAA on anti-and pro-apoptotic proteins(Bcl-2 and Bax, respectively).The 4 T1 cell-challenged mice were used for in vivo ***: Using ultra-high-performance liquid chromatography–mass spectrometry analysis, angelicin, a constituent of the roots and leaves of A. archangelica, was found to be the major constituent of the CEAA evaluated in this study(73 mg/mL). The CEAA was cytotoxic for both breast cancer cell lines studied but not for human fibroblasts. Treatment of 4 T1 cells with the CEAA increased Bax protein levels accompanied by decreased Bcl-2 expression, in the presence of cleaved caspase-3 and cytosolic calcium mobilization, suggesting mitochondrial involvement in breast cancer cell death induced by the CEAA in this cell line. No changes on the Bcl-2/Bax ratio were observed in CEAA-treated MCF7 cells. Gavage administration of the CEAA(500 mg/kg) to 4T1 cell-challenged mice significantly decreased tumor growth when compared with untreated ***: Altogether, our data show the antitumor potential of the CEAA against breast cancer cells in vitro and in vivo. Further research is necessary to better elucidate the pharmacological application of the CEAA in breast cancer therapy.

关键词： Angelica archangelica Umbelliferae Apoptosis Cell death Breast cancer Angelicin

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采用隧道二极管鑑别器的高速磁存貯讀出放大器(上)

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计算机研究与发展 1964年第4期 19-25页

作者： B.A.Kaufman j.S.hammond 徐正春

由于許多要求相互矛盾,在大容量高速存貯器中,讀出放大器的設計可能是最困难的线路問题。对讀出放大器的这些要求包括:对信息分布不敏感、輸入阻抗可控制、寬的通频带、增益稳定、共式信号抑制強、可放大双向信号、参考电平稳定、高速... 详细信息

由于許多要求相互矛盾,在大容量高速存貯器中,讀出放大器的設計可能是最困难的线路問题。对讀出放大器的这些要求包括:对信息分布不敏感、輸入阻抗可控制、寬的通频带、增益稳定、共式信号抑制強、可放大双向信号、参考电平稳定、高速比較器、低門檻电平,而且还希望价格低些。本文討論一种新线路,它簡单、且能滿足这些要求。打算将这种线路用于大容量(大于1000字)随机磁心和磁膜存貯器中。栈路能放大50毫伏的“1”信号,它具有50毫微秒的傳輸和比較延时。共式信号大至10伏,还不影响鑑别器的性能。线路的两个关鍵性的特点是:采用直接耦合差动前置放大器和隧道二极管鑑別器。直接耦合差动前置放大器的特点是:共式信号抑制强、增益稳定、对信息分布不敏感、并且能夠放大双向信号。隧道二极管构成一个优质鑑别器,因为它工作速度快、門槛电平低、門檻电平可以控制且不随溫度变化。于是,对前置放大器增益的大小和稳定性的要求就不严格了。文中推导了設計公式,并对完整的直流最坏情况进行了分析。叙述了某些应用时的线路变化,并給出了实驗数据。在附录Ⅱ中,討論了与前置放大器結合使用的隧道二极管鑑别器的一般問题。分析了某种輸入“1”“0”比时放大器跨导的允許容差,并且分析了偏流扣隧道二极管峯值电流的容差。

关键词：隧道二极管晶体管直接耦合江畸二极管半导体三极管电子设备放大器收集极

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让时尚“再”时尚

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中国服饰 2021年第2期 10018-10019页

作者： samantha Conti Maggie Liu(编译) j.Stoker(摄影) 不详 WWD

“我接下来四天都在这里,可以随时点进来。”Stella McCartney在最近的线上秀后访谈结束时说道,“就当是在静坐抗议吧。”除却言语间透露的英式幽默,这场放送自McCartney伦敦工作室的访谈Q&A环节。

关键词：工作室时尚英式幽默访谈 Q&A

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Fungal diversity notes 840–928:micro-fungi associated with Pandanaceae

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Fungal Diversity 2018年第6期93卷 1-160页

作者： Saowaluck Tibpromma Kevin DHyde Eric H.C.McKenzie Djayarama Bhat Alan j.L.Phillips Dhanushka N.Wanasinghe Milan C.Samarakoon Ruvishika S.jayawardena Asha j.Dissanayake Danushka S.Tennakoon Mingkwan Doilom Rungtiwa Phookamsak Alvin M.C.Tang jianchu Xu Peter EMortimer Itthayakorn Promputtha Sajeewa S.N.Maharachchikumbura Samiullah Khan samantha C.Karunarathna Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China Centre of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand No.128/1-j Azad Housing SocietyCurcaGoa VelhaIndia Division of Applied Science College of International EducationThe Hong Kong Baptist UniversityHong KongSARPeople’s Republic of China Department of Biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Environmental Science Research Centre Faculty of ScienceChiang Mai UniversityChiang Rai 50200Thailand Universidade de Lisboa Faculdade de CieˆnciasBiosystems and Integrative Sciences Institute(BioISI)Campo Grande1749-016 LisbonPortugal Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 34123 AlkhoudOman College of Animal Science and Technology Yunnan Agriculture UniversityKunmingPeople’s Republic of China

This paper provides illustrated descriptions of micro-fungi newly found on Pandanaceae in China and *** fungi are accommodated in 31 *** taxa described include a new family,seven new genera,65 new species,16 previously known species.A new family:Malaysiascaceae(Glomerellales).New genera are Acremoniisimulans(Plec-tosphaerellaceae),Pandanaceomyces,Pseudoachroiostachy(Nectriaceae),Pseudohyaloseta(Niessliaceae),Pseudoor-natispora(Stachybotriaceae)and Yunnanomyces(Sympoventuriaceae).New species are Acremoniisimulans thailandensis,Beltrania krabiensis,Beltraniella pandanicola,***,Canalisporium krabiense,***,Clonostachys krabiensis,Curvularia chonburiensis,***,***,***,Cylindrocladiella xishuangbannaensis,Dictyochaeta pandanicola,Dictyocheirospora nabanheensis,***,***-sis,Dictyosporium appendiculatum,***,***,***,***,Distoseptispora thailandica,***,Helicoma freycinetiae,Hermatomyces biconisporus,Lasiodiplodia chonburiensis,***,Lasionectria krabiense,Menisporopsis pandanicola,Montagnula krabiensis,Musicillium pandanicola,Neofusicoccum pandanicola,Neohelicomyces pandanicola,Neooccultibambusa thailandensis,Neopestalotiopsis chiang-maiensis,***,***,Pandanaceomyces krabiensis,Paracylindrocarpon nabanheensis,***-danicola,***,Parasarcopodium hongkongensis,Pestalotiopsis krabiensis,***,Polyplosphaeria nabanheensis,***,***,Pseudoachroiostachys krabiense,Pseu-doberkleasmium pandanicola,Pseudochaetosphaeronema pandanicola,Pseudohyaloseta pandanicola,Pseudoornatispora krabiense,Pseudopithomyces pandanicola,Rostriconidium pandanicola,Sirastachys phangngaensis,Stictis pandanicola,Terriera pandanicola,Thozetella pandanicola,Tubeufia freycinetiae,***,***,Vermiculariopsiella hongkongensis,Volutella krabiense,*** a

关键词： 65 new taxa Ascomycota Dothideomycetes Freycinetia Lecanoromycetes Leotiomycetes Pandanus Saprobic Sordariomycetes

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想要更有智慧? 请化身第三者

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新东方英语（中英文版） 2017年第7期 54-57页

作者： Claudia hammond 夏丹

俗话说：“当局者迷，旁观者清。”在我们追求智慧之时，这句话也同样适用。智慧关乎选择。我们有时做出一些愚蠢的决定，并非是因为我们缺乏智慧，而是因为我们未能从当时的情境中抽身，从更客观、理性的角度看待问题。所以，智慧其实... 详细信息

俗话说：“当局者迷，旁观者清。”在我们追求智慧之时，这句话也同样适用。智慧关乎选择。我们有时做出一些愚蠢的决定，并非是因为我们缺乏智慧，而是因为我们未能从当时的情境中抽身，从更客观、理性的角度看待问题。所以，智慧其实离你并不遥远，你如果想变得更有智慧，不妨从化身第三者开始。

关键词：第三者智慧化身旁观者

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胰腺癌

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英国医学杂志中文版 2012年第4期15卷 222-228页

作者： Giles Bond-Smith Need Banga Toby M hammond Charles j lmber hepatopancreatic-biliary and liver transplantsurgeon

2008年，全球诊断新发胰腺癌病例大约有21．7万例，而在英国每年有8000例胰腺癌新发病例。世界范围内，胰腺癌的发病率位于第13位，但在癌症中其病死率排第8位。在英国，胰腺癌是排名第11位的常见癌症，且在男性和女性中均为由癌症导致... 详细信息

2008年，全球诊断新发胰腺癌病例大约有21．7万例，而在英国每年有8000例胰腺癌新发病例。世界范围内，胰腺癌的发病率位于第13位，但在癌症中其病死率排第8位。在英国，胰腺癌是排名第11位的常见癌症，且在男性和女性中均为由癌症导致死亡的第5位常见死因。

关键词：胰腺癌常见癌症新发病例世界范围发病率病死率英国

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Numerical Analysis of Neodymium Magnet Influence in Relation Induction/Weight Structures of Sumo Robots

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journal of Mechanics Engineering and Automation 2015年第3期5卷 197-200页

作者： Mylena samantha Ferreira Mendes Lucas Silva Soares William Cunha Rezende Medeiros Tavares Mechanical Engineering Department Universidade Estadual do Para Sao Luis 66613-115 Brazil Mechanical Engineering Department Universidade Estadual do Maranhao Sao Luis 65063-510 Brazil Mechanical Engineering Department Universidade Estadual do Maranhao Sao Luis 65074-862 Brazil

Since neodymium magnet possesses an extremely strong magnetic field, resulting from the combination of neodymium, iron and boron, it has become the most used in designing autonomous sumo robots. When it is mounted under the structure of this robot, the magnet produces a large amount of normal force resulting from the interaction between its field lines and the steel frame of the arena, reducing the risk of slipping its wheels. Thus, the heavier a robot, the greater the difficulty for the opponent to remove it from the arena. This article explains the properties of Nd-Fe-Br magnets and analyzes the influence of these characteristics in the relation induction/weight. Additionally, to a comparative analysis, this research analyzes the positioning, geometry and polarization of the magnets under study, based on numerical results obtained using Inventor and K ＆ j Magnets Calculator software, given that these factors influence in their energetic product generation. Furthermore, more than just working with what we believe is a subject of great interest for sumo robot＇s teams, this study encourages their competitiveness, an essential factor for the competition.

关键词： Neodymium induction weight.

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Refinement of saliva microRNA biomarkers for sports-related concussion

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journal of Sport and Health Science 2023年第3期12卷 369-378页

作者： Steven D.Hicks Cayce Onks Raymond Y.Kim Kevin j.Zhen jayson Loeffert Andrea C.Loeffert Robert P.Olympia Gregory Fedorchak samantha DeVita Zofia Gagnon Callan McLoughlin Miguel M.Madeira Scott L.Zuckerman Timothy Lee Matthew Heller Chuck Monteith Thomas R.Campbell Christopher Neville Elise Fengler Michael N.Dretsch Department of Pediatrics College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Orthopaedics and Rehabilitation College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Family Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Emergency Medicine College of MedicinePennsylvania State UniversityHersheyPA 17033USA Department of Research and Development Quadrant Biosciences Inc.SyracuseNY 13210USA Department of Biology Marist CollegePoughkeepsieNY 12601USA Sports Concussion Center College of MedicineVanderbilt UniversityNashvilleTN 37212USA Department of Family Medicine College of Osteopathic MedicineNew York Institute of TechnologyOld WestburyNY 11568USA Department of Athletic Training Colgate UniversityHamiltonNY 13346USA Department of Rehabilitation Sciences Old Dominion UniversityNorfolkVA 23529USA Department of Physical Therapy Education Orthopedicsand NeuroscienceCollege of MedicineSUNY Upstate Medical UniversitySyracuseNY 13210USA Department of Exercise Science Syracuse UniversitySyracuseNY 13210USA Department of Medical Research—West Walter Reed Army Institute of ResearchUS Army Joint Base Lewis-McChordHillhurstWA 98433USA

Background:Recognizing sport-related concussion(SRC)is challenging and relies heavily on subjective symptom *** objective,biological marker could improve recognition and understanding of *** is emerging evidence that salivary micro-ribonucleic acids(miRNAs)may serve as biomarkers of concussion;however,it remains unclear whether concussion-related miRNAs are impacted by *** sought to determine whether40 miRNAs previously implicated in concussion pathophysiology were affected by participation in a variety of contact and non-contact *** goal was to refine a miRNA-based tool capable of identifying athletes with SRC without the confounding effects of ***:This case-control study harmonized data from concussed and non-concussed athletes recruited across 10 *** of salivary miRNAs within 455 samples from 314 individuals were measured with RNA ***-subjects testing was used to identify and exclude miRNAs that changed with either(a)a single episode of exercise(166 samples from 83 individuals)or(b)season-long participation in contact sports(212 samples from 106 individuals).The miRNAs that were not impacted by exercise were interrogated for SRC diagnostic utility using logistic regression(172 samples from 75 concussed and 97 non-concussed individuals).Results:Two miRNAs(miR-532-5p and miR-182-5p)decreased(adjusted p0.50;adjusted pjusted p0.70)to identify concussion.A

关键词： Biomarker Contact sports Football RNA Traumatic brain injury

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钛合金的物理冶金

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稀有金属 1979年第6期 66-74页

作者： C.hammond j.Nutting 陈海珊唐仕生

一、钕合金的物理冶金纯钛有同素异晶相转变,在882℃从低温的α相(密排六方)转变为高温的β相(体心立方)。根据合金元素在α相和β相中有不同的溶解度,或是根据它们对相变温度的影响,可将合金元素大致分为α稳定元素及β稳定元素。铝... 详细信息

一、钕合金的物理冶金纯钛有同素异晶相转变,在882℃从低温的α相(密排六方)转变为高温的β相(体心立方)。根据合金元素在α相和β相中有不同的溶解度,或是根据它们对相变温度的影响,可将合金元素大致分为α稳定元素及β稳定元素。铝及间隙元素氧、氮和碳是很强的α稳定元素,而锡、锆和硅对相变温度仅有很微弱的作用(稍稍降低相变点)。

关键词：稳定元素钛合金轻稀有金属合金马氏体片溶质元素超塑性变形错配度沉淀强化强化(金属学) 合金元素共格蠕变强度蠕变极限应变速率敏感性显微组织金相组织交叉滑移间隙元素铝当量

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Ocular image-based deep learning for predicting refractive error:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 164-172页

作者： samantha Min Er Yew Yibing Chen jocelyn Hui Lin Goh David Ziyou Chen Marcus Chun jin Tan Ching-Yu Cheng Victor Teck Chang Koh Yih Chung Tham Department of Ophthalmology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Centre for Innovation and Precision Eye Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Department of Ophthalmology National University HospitalSingapore Ophthalmology and Visual Sciences(Eye ACP) Duke-NUS Medical SchoolSingapore

ackground:Uncorrected refractive error is a major cause of vision impairment worldwide and its increasing prevalent necessitates effective screening and management ***,deep learning,a subset of Artificial Intelligence,has significantly advanced ophthalmological diagnostics by automating tasks that required extensive clinical *** recent studies have investigated the use of deep learning models for refractive power detection through various imaging techniques,a comprehensive systematic review on this topic is has yet be *** review aims to summarise and evaluate the performance of ocular image-based deep learning models in predicting refractive *** text:We search on three databases(PubMed,Scopus,Web of Science)up till june 2023,focusing on deep learning applications in detecting refractive error from ocular *** included studies that had reported refractive error outcomes,regardless of publication *** systematically extracted and evaluated the continuous outcomes(sphere,SE,cylinder)and categorical outcomes(myopia),ground truth measurements,ocular imaging modalities,deep learning models,and performance metrics,adhering to PRISMA *** studies were identified and categorised into three groups:retinal photo-based(n=5),OCT-based(n=1),and external ocular photo-based(n=3).For high myopia prediction,retinal photo-based models achieved AUC between 0.91 and 0.98,sensitivity levels between 85.10%and 97.80%,and specificity levels between 76.40%and 94.50%.For continuous prediction,retinal photo-based models reported MAE ranging from 0.31D to 2.19D,and R^(2) between 0.05 and *** OCT-based model achieved an AUC of 0.79–0.81,sensitivity of 82.30%and 87.20%and specificity of 61.70%–68.90%.For external ocular photo-based models,the AUC ranged from 0.91 to 0.99,sensitivity of 81.13%–84.00%and specificity of 74.00%–86.42%,MAE ranges from 0.07D to 0.18D and accuracy ranges from 81.60%to 96.70%.The reported papers colle

关键词： Deep Learning Artificial Intelligence Refractive Error Retinal images Optical Coherence Tomography Photorefraction Ocular images Prediction

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