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Non-severe burn injury increases cancer incidence in mice and has long-term impacts on the activation and function of T cells

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Burns & Trauma 2022年第1期10卷 546-557页

作者： Lucy W.Barrett Vanessa S.Fear Bree Foley Katherine Audsley samantha barnes Hannah Newnes Alison McDonnell Fiona M.Wood Mark W.Fear Jason Waithman Burn Injury Research Unit School of Biomedical SciencesUniversity of Western AustraliaCrawleyWA6009Australia Telethon Kids Institute University of Western AustraliaNorthern EntrancePerth Children’s Hospital15 Hospital AveNedlandsWA6009Australia Fiona Wood Foundation Fiona Stanley HospitalMNH(B)Main HospitalCD 15Level Burns Unit 102-118 Murdoch DriveMurdochWA6150Australia and 4Burns Service of Western AustraliaWA Department of HealthNedlandsWA6009Australia

Background:Recent evidence suggests that burn patients are at increased risk of hospital admission for infection,mental health conditions,cardiovascular disease and cancer for many years after discharge for the burn injury *** injury has also been shown to induce sustained immune system *** change to immune function may contribute to the increased risk of chronic disease ***,the mechanisms that disrupt long-term immune function in response to burn trauma,and their link to long-term morbidity,remain *** this study we investigated changes to immune function after burn injury using a murine model of non-severe ***:An established mouse model of non-severe burn injury(full thickness burn equivalent to 8%total body surface area)was used in combination with an orthotopic model of B16 melanoma to investigate the link between burns and *** that CD8^(+)T cells are important drivers of effective tumour suppression in this model,we also investigated potential dysregulation of this immune population using mouse models of burn injury in combination with herpes simplex virus *** cytometry was used to detect and quantify cell populations of interest and changes in immune ***:We demonstrate that 4 weeks after a non-severe burn injury,mice were significantly more susceptible to tumour development than controls using an orthotopic model of B16 *** addition,our results reveal that CD8^(+)T cell expansion,differentiation and memory potential is significantly impaired at 1 month ***:Our data suggests that CD8^(+)T cell-mediated immunity may be dysfunctional for a sustained period after even non-severe burn *** studies in patients to validate these findings may support clinical intervention to restore or protect immunity in patients after burn injury and reduce the increased risk of secondary morbidities observed.

关键词： Immunology Surgery Burn injury T cells Immune dysfunction Cancer

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Biofumigation: An alternative strategy for the control of plant parasitic nematodes

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Journal of Integrative Agriculture 2020年第7期19卷 1680-1690页

作者： Rebecca Jean barnes BRENNAN samantha GLAZE-CORCORAN Robert WICK Masoud HASHEMI University of Massachusetts Amherst Cranberry Station East WarehamMassachusetts 02538USA Stockbridge School of Agriculture University of Massachusetts AmherstAmherstMA 01003USA

Plant-parasitic nematodes wreak havoc on the yield and quality of crops *** from these pests is estimated to exceed US$100 bllion annually but is likely higher due to *** damage may be catastrophic,but historically the solution has been damaging as *** of the synthetic nematicide methyl bromide(MBr)poses risks to the environment and to human ***,the use of plant material and naturally produced compounds to control pests,is an increasingly feasible method of pest *** process acts through the growth or incorporation of plant material into the soil,that,over the course of its degradation,releases glucosinolates that break down into nematotoxic *** secondary plant metabolites exist naturally in commonly grown plants,most of which belong to the Brassicaceae *** endeavors have increasingly explored the potential of *** reaction of target pests,the selection of biofumigant,and ideal environments for efficacy continue to be *** review seeks to provide a cost and benefit assessment of the status of biofumigation for the control of plant-parasitic nematodes as an alternative to conventional methyl bromide usage.

关键词： biofumigation plant-parasitic nematode Brassicaceae isothiocyanate methyl bromide

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三维超高场7T高分辨磁敏感加权像静脉造影(英文)

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磁共振成像 2010年第2期1卷 83-93页

作者： Yulin Ge Samuel barnes samantha Heller Daniel K．Sodickson Lin Tang E．Mark Haacke Jianping Dai Robert I．Grossman Center for Biomedical Imaging Department of Radiology New YorkUniversity Langone Medical CenterNew York NY 10016 USA Department of Radiology The MRIInstitute for Biomedical ResearchDetroit MI 48202 USA Department of Radiology BeijingTiantan Hospital Capital MedicalUniversity Beijing 100050 China

目的超高场磁共振具有高信噪比和独特的磁敏感对比,使其在无创性脑血管造影尤其是对小静脉的检测有明显优势。本文探讨如何在超高场磁共振7T优化和获取高质量的磁敏感加权像(SWI)静脉造影。方法选择10例正常志愿者作为研究对象,采集一系... 详细信息

目的超高场磁共振具有高信噪比和独特的磁敏感对比,使其在无创性脑血管造影尤其是对小静脉的检测有明显优势。本文探讨如何在超高场磁共振7T优化和获取高质量的磁敏感加权像(SWI)静脉造影。方法选择10例正常志愿者作为研究对象,采集一系列7TSWI静脉造影数据并与3T结果作对比。选择参数TR=30～45ms,TE=13～26ms,带宽(BW)=80～140Hz/pixel,翻转角(FA)=10～25?;所有的数据用同样的图像后处理方式得到最小信号叠加投影(mIP)的SWI静脉造影像,并进行定量化分析。结果图像优化后,我们得到高分辨率的7T静脉造影图像。根据静脉血的T2*选择优化TE:16ms(7T),28ms(3T);FA:15?(3T和7T)。相对于3T,7TSWI图像有较高的信噪比和静脉与周围组织的对比度,并显示出更多的微小静脉。结论超高场SWI静脉造影对于显示微小静脉具有明显的优势。

关键词：磁共振成像高场强静脉造影术磁敏感加权成像相位脑

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