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Dietary modification in the treatment of schizophrenia spectrum disorders: A systematic review

World Journal of Psychiatry 2020年第8期10卷 187-201页

作者： Monique Aucoin Laura LaChance sam n clouthier Kieran Cooley Department of Research and Clinical Epidemiology Canadian College of Naturopathic MedicineToronto M2K 1E2Canada Department of Psychiatry McGill UniversityMontreal H3A 0G4Canada Centre for Addiction and Mental Health Toronto M6R 1A1Canada Department of Doctoral Acupuncture and Chinese Medicine Pacific College of Health ScienceSan DiegoCA 92108United States

BACKGROUnD Schizophrenia spectrum disorders impact functioning,reduce quality of life and increase the risk of physical illness and premature *** intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes;however,few studies have explored the impact of interventions designed to modify diet on mental health *** To synthesize the existing experimental studies of adjunctive diet modification as an intervention in the treatment of psychotic disorders,analyze findings related to effectiveness and safety,highlight knowledge gaps and limitations,and set forward recommendations for future research *** An extensive a priori search strategy was developed and the databases Embase,Embase Classic,Ovid MEDLInE were *** and data extraction were completed in *** included in this analysis were experimental studies of an adjunctive dietary intervention(overall dietary pattern or education on dietary change)for treatment of schizophrenia spectrum *** restrictions were placed on control groups or *** studies were required to report a mental health *** Twenty-five clinical trials were identified,along with two additional protocols and two *** of the clinical trials reported improvement in one or more mental health domain including psychosis symptoms,cognition,and quality of life.A high level of heterogeneity was found with respect to patient population,intervention,and study *** of the studies included lifestyle or psychosocial components in addition to dietary *** nutrition advice provided to participants was poorly described overall and compliance was not *** studies that showed benefit tended to have a smaller sample size and were less likely to be randomized but were more likely to use a group delivery *** Further research assessing effectiveness and efficacy of clear

关键词： nutrition Psychosis Schizophrenia Diet

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