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Enantioselective Synthesis of Benzimidazole Atropisomers Featuring a N-N Axis

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Chinese Journal of Chemistry 2024年第7期42卷 711-718页

作者： Fang-Bei Ge Qi-Kun Yin Chuan-jun Lu Xuan Xuan jia Feng ren-Rong Liu College of Chemistry and Chemical Engineering Qingdao UniversityQingdaoShandong 266071China School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug EvaluationMinistry of EducationYantai UniversityYantaiShandong 264005China

Atroposelective synthesis of N-N atropisomers is an emerging area but remains underexplored;in particular,the synthesis of N-N benzimidazole atropisomers is still ***,the first enantioselective synthesis of N-N benzimidazole atropisomers via the palladium-catalyzed de novo construction of benzimidazole skeleton is *** readily available palladium catalyst and biphosphine ligand,a broad range of nonbiaryl benzimidazole and indole-benzimidazole atropisomers were conveniently ac-cessed in high yields and with excellent ***,these N-N benzimidazole atropisomers showed great anti-tumor activity and selectivity to breast cancer MCF-7 *** simple catalytic system,broad substrate scope,high enantioselectivi-ty,and good bioactivity make this approach highly attractive.

关键词： Asymmetric synthesis Atropisomerism Palladium Benzimidazole Antitumor

The response and anti-stress mechanisms of nitrifying sludge under long-term exposure to Cd Se quantum dots

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Journal of Environmental Sciences 2024年第1期135卷 174-184页

作者： Linkai Guo Lei Yang Yongxiang ren Shen Cui Xiaotong Li jia Wang jun Lan Haoqi Lu Yuchao Wang Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Key Lab of Northwest Water Resource Environment and EcologyMinistry of EducationXi’an University of Architecture and TechnologyXi’an 710055China

The wide application of CdSe quantum dots(QDs)increases its stress risk to sewage treatment *** study evaluated the response of nitrification performance,floc characteristics and microbial community of nitrifying sludge under long-term exposure to CdSe *** showed CdSe QDs(≥1 mg/L)would decrease the activity of ammonia monooxygenase(AMO).Under the stress of 30 mg/L CdSe QDs,the activity of AMO was reduced by 66%,while the activities of hydroxylamine oxidase and nitrite oxidoreductase were enhanced by 19.1%and 26%,***,the final nitrification effects were not adversely affected,and the production rates of NO_(2)^(-)-N and NO_(3)^(-)-N were ***,CdSe QDs improved biomass concentration in sludge and maintained the stability of sludge *** throughput sequencing analysis showed that CdSe QDs evidently reduced the abundance and diversity of microbial community in nitrifying *** abundances of amino acid metabolism and lipid metabolism were ***,CdSe QDs decreased the fluorescence intensity of tryptophan-like protein from 2,326 to 1,179 *** loosely bound extracellular polymeric substances(EPSs)and from 3,792 to 3,117 *** tightly bound *** relieve CdSe QD stress,the polysaccharide content increased from0.31 to 0.61 mg/g MLSS and intracellular antioxidant defense was *** CdSe QD level increasing to 30 mg/L,the total antioxygenic capacity and the activities of catalase were enhanced up to 411%and 143.2%,***,CdSe QDs had little adverse effects on cell membrane integrity,microbial metabolism and the abundance of Nitrospirae.

关键词： Quantum dots Activated sludge Extracellular polymeric substances Microbial community Antioxidant effect

Bayesian inference of neutron-skin thickness and neutron-star observables based on effective nuclear interactions

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 97-105页

作者： jia Zhou jun Xu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China School of Physics Science and Engineering Tongji UniversityShanghai 200092China

We have obtained the constraints on the density dependence of the symmetry energy from neutron-skin thickness data by parityviolating electron scatterings and neutron-star observables using a Bayesian approach,based on the standard Skyrme-HartreeFock(SHF)model and its extension as well as the relativistic mean-field(RMF)*** the neutron-skin thickness data(neutron-star observables)mostly constrain the symmetry energy at subsaturation(suprasaturation)densities,they may more or less constrain the behavior of the symmetry energy at suprasaturation(subsaturation)densities,depending on the energy-density functional *** showing the final posterior density dependence of the symmetry energy,we also compare the slope parameters of the symmetry energy at 0.10 fm-3as well as the values of the symmetry energy at twice saturation density from three effective nuclear *** present work serves as a comparison study based on relativistic and non-relativistic energy-density functionals,for constraining the nuclear symmetry energy from low to high densities using a Bayesian approach.

关键词： symmetry energy neutron skin neutron star

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New method for multibody dynamics based on unknown constraint force

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Science China(Technological Sciences) 2024年第3期67卷 791-808页

作者： TIAN Ying jia YingHong ZHANG jun School of Astronautics Beihang UniversityBeijing 100191China Beijing Institute of Control Engineering Beijing 100190China National Laboratory of Space Intelligent Control Beijing 100190China

This paper presents a new method for the dynamics of multibody systems based on unknown constraint force. The method can uniformly solve multibody systems with typical configurations, including the system with rigid-flexible coupling, the system in tree topology, and the system with loop constraints. Unlike common methods, the proposed method can model the loop system without “cutting off” loop constraints, leading to the exact same modelling process as the tree-like system performs. Based on graph theory, a topological record matrix M_(rec) is proposed to capture the arbitrary system configuration. Moreover, constraint forces are selected as the key variables in semi-recursive framework. With the recursive kinematics relationship between adjacent bodies, the constraint force equation is further assembled to achieve the full-state system solution. The numerical simulations demonstrate the accuracy of the proposed method.

关键词： multibody system dynamic modelling rigid-flexible coupling unknown constraint force graph theory semi-recursive algorithm

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Homochirality in Ferroelectrochemistry

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Chinese Journal of Chemistry 2024年第10期42卷 1133-1144页

作者： Hang Peng jun-Chao Qi Yu-Si Liu jia-Mei Zhang Wei-Qiang Liao ren-Gen Xiong Ordered Matter Science Research Center Nanchang UniversityNanchangJiangxi 330031China

What is the most favorite and original chemistry developed in your research group?We originally proposed the design principle for molecular ferroelectrics:ferroelectrochemistry,including quasi-spherical theory,the introduction of homochirality,and H/F *** changed the blind search for molecular ferroelectrics into targeted chemical design,which will develop into a new discipline.

关键词： Molecular ferroelectrics Homochirality Ferroelectricity Chemical design Point groups

Chimeric Monkey Born Alive with a High Contribution of Donor Cells

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Neuroscience Bulletin 2024年第6期40卷 849-851页

作者： jia Huang jun Wu Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTX75390USA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTX75390USA Cecil H.and Ida Green Center for Reproductive Biology Sciences University of Texas Southwestern Medical CenterDallasTX75390USA

Chimeras,which consist of cells from different individuals or different species,represent an important tool in biological *** in the early twentieth century,studies on chimeras have been focusing on understanding fundamental genetic and cellular developmental *** the advances in genetic engineering and embryonic stem cell(ESC)technology,chimeras have become an important tool for the generation of transgenic animals.

关键词： mechanisms. advances developmental

Two simple memristive maps with adaptive energy regulation and digital signal process verification

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2024年第5期25卷 382-394页

作者： Feifei YANG Lujie ren jun MA Zhigang ZHU College of Electrical and Information Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Physics Lanzhou University of TechnologyLanzhou 730050China School of Information Science and Engineering Dalian Polytechnic UniversityDalian 116034China

Mathematical models can produce desired dynamics and statistical properties with the insertion of suitable nonlinear terms,while energy characteristics are crucial for practical application because any hardware realizations of nonlinear systems are relative to energy *** involvement of memristive terms relative to memristors enables multistability and initial-dependent property in memristive *** this study,two kinds of memristors are used to couple a capacitor or an inductor,along with a nonlinear resistor,to build different neural *** corresponding circuit equations are derived to develop two different types of memristive oscillators,which are further converted into two kinds of memristive maps after linear *** Hamilton energy function for memristive oscillators is obtained by applying the Helmholz theorem or by mapping from the field energy of the memristive *** Hamilton energy functions for both memristive maps are obtained by replacing the gains and discrete variables for the memristive oscillator with the corresponding parameters and *** two memristive maps have rich dynamic behaviors including coherence resonance under noisy excitation,and an adaptive growth law for parameters is presented to express the self-adaptive property of the memristive maps.A digital signal process(DSP)platform is used to verify these *** scheme will provide a theoretical basis and experimental guidance for oscillator-to-map transformation and discrete map-energy calculation.

关键词： Hamilton energy Discrete memristor Self-adaptive regulation Digital signal process(DSP)implementation

From dichotomy to diversity:deciphering the multifaceted roles of tumor-associated macrophages in cancer progression and therapy

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Cancer Biology & Medicine 2024年第2期21卷 132-138页

作者： Xiumei Wang jun Chen Guangshuai jia Department of Immunology and Microbiology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Jinfeng Laboratory Chongqing 401329China GMU-GIBH Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510182China

Macrophages are innate immune cells that are ubiquitously distributed throughout the vertebrate *** orchestrate sophisticated processes in development,homeostasis,immunity,and *** residing in tumor tissues are commonly known as tumor-associated macrophages(TAMs)and promote or inhibit tumor growth depending on the activation state2.

关键词： immunity homeostasis tumor

Microstructure and texture evolution of Cu–Cr–Co–Ti alloys during the two-stage cryorolling

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Rare Metals 2024年第9期43卷 4535-4547页

作者： jia-jun Zhang Long-jian Li Zhi-Feng Liu Zong-Ning Chen En-Yu Guo Hui-jun Kang ren-Geng Li Tong-Min Wang Key Laboratory of Solidification Control and Digital Preparation Technology (Liaoning Province) School of Materials Science and EngineeringDalian University of Technology Center of Hyper-Gravity Experimental and Interdisciplinary Research Zhejiang University Ningbo Institute of Dalian University of Technology！Ningbo315000 China Key Laboratory for Light-Weight Materials Nanjing Tech University

This study entailed an investigation of the mechanical properties, microstructural and texture orientation evolutions of CuDCrDCoDTi alloys prepared via twostage cryorolling and intermediate aging treatment. To this end, X-ray diffraction and electron backscatter diffraction were employed. The results indicate that the two-stage cryorolling and intermediate aging treatments led to the development of profuse twin bundles and significantly enhanced the mechanical properties. The initial cryorolling led to coplanar slip and developed a strong Y({111} ) orientation, accelerating the formation of Goss({011} ) orientation and a Brass-type *** intermediate aging treatment relieved the restriction on dislocation slip and reoriented the grains toward the Copper({112} ) and Z({111} ) *** Z orientation, with a relatively high volume fraction,dominated the macrotexture. Secondary cryorolling intensified twinning and shear banding, transforming the Copper-type shear bands into Brass-type shear bands with rhomboidal prism morphology. The areas inside the Brasstype shear bands exhibited a Y orientation, and the areas outside the shear bands exhibited a stable Brass-type texture. The evident decrease in the weighted Schmid factors demonstrated that the two-stage cryorolling and intermediate aging treatment can modify the texture evolution and aid the design of high-performance Cu alloys.

关键词： Copper alloys Electron backscatter diffraction Macrotexture evolution Schmid factor Two-stage cryorolling