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Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease

World Journal of Gastrointestinal Pathophysiology 2019年第5期10卷 54-63页

作者： Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen sam nakat Douglas Grider Kim Love James H Boone Dario Sorrentino IBD Center-Division of Gastroenterology Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Radiology Virginia Tech Carilion School of MedicineRoanokeVA 24016United States Department of Basic Science Education Virginia Tech Carilion School of Medicine and Dominion Pathology Associates RoanokeVA 24016United States K.R.Love Quantitative Consulting and Collaboration AthensGA 30605United States Research and Development TECHLAB IncBlacksburgVA 24060United States Department of Clinical and Experimental Medical Sciences University of Udine School of MedicineUdine 33100Italy

BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively *** To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and *** Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of *** location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were *** In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,Psmall bowel)and the number of inflamed colon *** FL and CRP separated disease severity categories with FL showing lower discriminating *** showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL *** can accurately and timely characterize intestinal inflammation in IBD.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Fecal lactoferrin C-reactive protein White blood cell count Mucosal inflammation

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Determination and assessment of total mercury levels in local, frozen and canned fish in Lebanon

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Journal of Environmental Sciences 2011年第9期23卷 1564-1569页

作者： Pierre J Obeid Bilal El-Khoury Joanne Burger samer Aouad Mira Younis Amal Aoun John Hanna El-nakat University of Balamand Faculty of SciencesDepartment of Chemistry Nelson Biological Laboratory Division of Life SciencesRutgers University

Fish is an important constituent of the Lebanese ***,very little attention in our area is given to bring awareness regarding the effect of the toxicity of mercury （Hg） mainly through fish *** study aimed to report analytical data on total mercury levels in several fish species for the first time in thirty years and to also made individuals aware of the presence and danger from exposure to mercury through fish *** samples were selected from local Lebanese markets and fisheries and included 94 samples of which were fresh,frozen,processed,and canned *** values were reported as microgram of mercury per gram of fish based on wet *** level of mercury ranged from 0.0190 to 0.5700 μg/g in fresh samples,0.0059 to 0.0665 μg/g in frozen samples,and 0.0305 to 0.1190 μg/g in canned *** data clearly showed that higher levels of mercury were detected in local fresh fish as opposed to other types thus placing consumers at higher risk from mercury ***,the data revealed that Mallifa （yellowstripe barracuda/Sphyraena chrysotaenia）,Sargous （white seabream/Diplodus sargus）,Ghobbos （bogue/Boops boops）,and shrimp （Penaeus sp.） were among the types containing the highest amounts of *** the other hand,processed fish such as fish fillet,fish burger,small shrimp and crab are found to contain lower levels of mercury and are associated with lower exposure risks to *** population should therefore,be aware to consume limited amounts of fresh local fish to minimize exposure to mercury.

关键词： total mercury fish Lebanon

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