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坚持以循证医学为基础的指导方针制定非甾体类抗炎药处方的全国性状况

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世界核心医学期刊文摘（胃肠病学分册） 2006年第4期2卷 20-20页

作者： abraham N.S El-Serag H.B Johnson M.L. 陈云茹 Michael E. DeBakey Veterans Affairs Medical Center 2002 Holcombe Boulevard (152) Houston TX 77030 United StatesDr.

Background &Aims: Our objective was to assess adherence to evidence-based guidelines by providers of the Department of Veterans Affairs nationwide. Methods: This was a cross-sectional study among veterans prescribed a nonsteroidal anti-inflammatory drug (NSAID) from January 1, 2002, to December 31, 2002. Prescrip tion data were linked to inpatient and outpatient medical records and death file s. The population was characterized as high risk based on the following: age 65 years or older, concurrent corticosteroid or anticoagulant use, history of pepti c ulcer, and high average daily dose of NSAIDs. Adherence was defined as the pre scription of a traditional NSAID with gastroprotection or a coxib in high-risk NSAID users. Univariate and multivariate analyses assessed the potential predict ors of adherence. Results: Three hundred three thousand seven hundred eighty-se ven met our definition of high risk. Most (97.3%) were male; 55.6%were white, 9.6%black, and 34.8%of other/unknown race. Age 65 years or older was the large st high-risk subset (87.1%). Overall, only 27.2%of highrisk veterans (n = 82, 766) were prescribed an adherent strategy. Among veterans with at least 2 risk f actors, adherence was 39.7%; among those with 3 risk factors, adherence was 41. 8%. Predictors of adherence included history of upper gastrointestinal events, anticoagulant use, rheumatologic disease, high Deyo comorbidity index score, use of low-dose salicylates, and concurrent corticosteroid use. Predictors of nona dherence included prescriptions≥90 days and high average daily dose of NSAIDs. Conclusions: Adherence to evidence-based guidelines for safe prescription of NS AIDs in the Department of Veterans Affairs is low (27.2%). The likelihood of ad herence is further decreased if veterans are prescribed NSAIDs for ≥90 days.

关键词： NSAID 指导方针消化性溃疡研究人群抗凝剂环氧化酶抑制剂保护药横断面研究上消化道日

对晚期慢性心力衰竭患者行心脏再同步化治疗致NYHA分级改善的临床预测因素和时机:多中心InSync随机临床评价(MIRACLE)和多中心InSyncICD随机临床评价(MIRACLE-ICD)试验的结果

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 13-13页

作者： Pires L.A. abraham W.T. Young J.B. Johnson K.M. 刘少伟 Heart Rhythm Center St.John Hospital and Medical Center22101 Moross RdDetroitMI 48236United StatesDr

Background: Based on current patient selection criteria, a significant proportion of recipients of cardiac resynchronization therapy(CRT) do not respond to treatment. The purpose of this analysis is to identify predictors and characterize the timing of response to CRT in patients with advanced heart failure. Methods: Patients randomized to receive CRT in the MIRACLE and MIRACLE-ICD trials, designed to assess the benefit of CRT compared with standard medical therapy in patients with advanced heart failure, left ventricular ejection fraction< 0.35, and QRS ≥130 milliseconds, were included for this analysis. Patients with an improvement of ≥1 New York Heart Association(NYHA)class from baseline to the 6-month follow-up were considered responders and those who had no change or worse NYHA class or died were classified as nonresponders. Responders were subdivided into early(within 1-3 months) and late(6 months). Results: One hundred forty-three(64%) of 224 and 190(61%) of 313 patients in the MIRACLE and MIRACLEICD trials, respectively, responded to therapy, with 81(57%) of 143 and 100(53%) of 190 responding early. Several but differing factors predicted CRT response and timing in the two trials with a high sensitivity(89%-90%) but, owing to a low specificity(31%-49%), a modest predictive accuracy(66%-75%). Conclusions: Based on improvement of ≥1 NYHA class, less than two thirds of patients enrolled in the MIRACLE or MIRACLE-ICD trials responded to CRT, with just more than half responding within the first month. Several factors predicted CRT response and timing, but given their modest predictive accuracy, comparable for both studies, additional methods for selecting candidates most likely to benefit from CRT are needed.

关键词：心脏再同步化治疗慢性心力衰竭患者 NYHA分级晚期心力衰竭预测因素 InSync 随机分配 D试验

急性失代偿性心力衰竭院内死亡率的危险分层:分类回归树分析

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世界核心医学期刊文摘（心脏病学分册） 2005年第6期1卷 24-24页

作者： Fonarow G.C. Adams Jr. K.F. abraham W.T. 张迎捷 Dr.Division of Cardiology University of California 10833 Le Conte Ave Los Angeles CA 90095 United States

Context: Estimation of mortality risk in patients hospitalized with acute decompensated heart failure(ADHF) may help clinicians guide care. Objective: To develop a practical user-friendly bedside tool for risk stratification for patients hospitalized with ADHF. Design, Setting, and Patients: The Acute Decompensated Heart Failure National Registry(ADHERE) of patients hospitalized with a primary diagnosis of ADHF in 263 hospitals in the United States was queried with analysis of patient data to develop a risk stratification model. The first 33 046 hospitalizations(derivation cohort; October 2001-February 2003) were analyzed to develop the model and then the validity of the model was prospectively tested using data from 32 229 subsequent hospitalizations(validation cohort; March-July 2003). Patients had a mean age of 72.5 years and 52%were female. Main Outcome Measure: Variables predicting mortality in ADHF. Results: When the derivation and validation cohorts are combined, 37 772(58%) of 65 275 patient-records had coronary artery disease. Of a combined cohort consisting of 52 164 patient-records, 23 910(46%) had preserved left ventricular systolic function. In-hospital mortality was similar in the derivation(4.2%) and validation(4.0%) cohorts. Recursive partitioning of the derivation cohort for 39 variables indicated that the best single predictor for mortality was high admission levels of blood urea nitrogen(≥43 mg/dL [15.35 mmol/L]) followed by low admission systolic blood pressure(< 115 mm Hg) and then by high levels of serum creatinine(≥2.75 mg/dL [243.1 μmol/L]). A simple risk tree identified patient groups with mortality ranging from 2.1%to 21.9%. The odds ratio for mortality between patients identified as high and low risk was 12.9(95%con-fidence interval, 10.4-15.9) and similar results were seen when this risk stratification was applied prospectively to the validation cohort. Conclusions: These results suggest that ADHF patients at low, intermediate, and high r

关键词：危险分层左室收缩功能病例记录血清肌酐水平临床医生比值比注册登记生命征单项预测列时

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各向异性纳米晶复合稀土磁体的研制

磁性材料及器件 2007年第4期38卷 1-10页

作者：刘世强李东黄美清金娥实沈玉辉何阳生陈红兵代顿大学磁学试验室美国俄亥俄州代顿市45469 UES公司美国俄亥俄州代顿市45432 FutureTek USA公司美国俄亥俄州代顿市45419

作者成功地开发了全密度各向异性纳米晶复合稀土永磁体,其制备技术新颖,工艺成本低。采用粉末混合技术,纳米磁体的(BH)max可以达到 320～400kJ/m3(40～50MGOe)。而采用粉末镀膜技术,(BH)max可达360～440kJ/m3(45～55MGOe)。这样,制备各... 详细信息

作者成功地开发了全密度各向异性纳米晶复合稀土永磁体,其制备技术新颖,工艺成本低。采用粉末混合技术,纳米磁体的(BH)max可以达到 320～400kJ/m3(40～50MGOe)。而采用粉末镀膜技术,(BH)max可达360～440kJ/m3(45～55MGOe)。这样,制备各向异性纳米晶复合稀土磁体的主要技术困难就得到了克服。此外,作者观察到纳米晶粒复合磁体中软磁相的尺寸可达数十微米。这一尺寸是目前的界面交换耦合模型所建议的软磁相尺寸上限的一千倍以上。继续减小软磁相的尺寸并改善其分布将会进一步改善纳米晶粒复合磁体的磁性能。

关键词：纳米晶复合磁体界面交换耦合 Nd-Fe-B 硬磁相软磁相磁性能

非洲猪瘟病毒pp62蛋白单克隆抗体的制备和鉴定

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中国兽医科学 2022年第5期52卷 579-585页

作者：储珺赵普张婕妮王振忠苗雨润鲍晨沂郑龙三吴晓东钱莺娟戴建君南京农业大学动物医学院教育部动物健康与食品安全国际合作联合实验室和农业部细菌学重点实验室江苏南京210095 中国动物卫生与流行病学中心国家非洲猪瘟参考实验室山东青岛266000

pp62蛋白是非洲猪瘟病毒(ASFV)CP530R基因编码的多聚蛋白前体,可被蛋白水解酶切割形成成熟蛋白p35、p15和p8,与pp220多聚蛋白前体的加工产物组装成病毒核壳。本研究参考ASFV China/2018/AnhuiXCGQ毒株基因序列,分析后选取CP530R基因N端(... 详细信息

pp62蛋白是非洲猪瘟病毒(ASFV)CP530R基因编码的多聚蛋白前体,可被蛋白水解酶切割形成成熟蛋白p35、p15和p8,与pp220多聚蛋白前体的加工产物组装成病毒核壳。本研究参考ASFV China/2018/AnhuiXCGQ毒株基因序列,分析后选取CP530R基因N端(1—612 bp)及C端(784—1593 bp),分别构建原核表达质粒pET-28a-pp62-N和pET-28a-pp62-C;转化Rosetta感受态细胞,IPTG诱导表达pp62蛋白;再用纯化蛋白免疫BALB/c小鼠,经细胞融合和阳性克隆筛选后,获得4株可稳定分泌pp62单克隆抗体的杂交瘤细胞。Western-blot检测ASFV感染PAM细胞中pp62剪切体的结果显示,1株仅识别pp62蛋白,1株仅识别p35蛋白,1株仅识别p15蛋白,1株可识别pp62和p8蛋白。IFA鉴定结果显示,4株均能与ASFV感染PAM细胞产生特异性绿色荧光。本研究为建立ASFV诊断方法和研究pp62的生物学功能奠定了生物材料基础。

关键词：非洲猪瘟病毒 pp62蛋白单克隆抗体

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瑞士日内瓦的性传播疾病发病率增加

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 52-52页

作者： abraham S. Toutous-Trellu L. Pechère M. V. Piguet 党倩丽 Department of Dermatology and Venereology University Hospital of Geneva 24 rue Micheli-du-Crest CH-1211 Geneva 14 Switzerland Dr

Background: Focal outbreaks of sexually transmitted infections (STIs) such as syphilis and gonorrhoea have been reported in the large cities of Western Europe over the past few years. The aim of our study was to determine whether a similar trend is observed in Geneva and the situation with regard to HIV infection. Methods: We review the incidence of syphilis, gonorrhoea, Chlamydia trachomatis and HIV in Geneva from 1999 to 2004. Results: Figures indicate a steady and sustained increase in the incidence of syphilis, gonorrhoea and Chlamydia trachomatis in Geneva since 1999 that is maintained into 2004. As for HIV, the number of positive testings in Switzerland has stabilised and primary infection figures do not indicate an increase in newly acquired infections in Geneva. Conclusion: The situation in Geneva is similar to that observed elsewhere inWestern Europe and indicates the need of public health interventions.

关键词：疾病发病率传播疾病日内瓦瑞士 HIV感染沙眼衣原体感染发病率局部爆发发病趋势初次感染

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艺术的扩张旧金山现代博物馆扩建项目

室内设计与装修 2016年第7期 72-77页

作者： [挪]snohetta violet(编译) Craig Dykers Aaron Dorf Lara Kauiman Jon McNeal Simon Ewings Alan Gordon Marianne Lau Elaine Molinar Kjetil Traedal Thorsen Nick Anderson Behrang Behin sam Brisette Chad Carpenter Michael Cotton Aroussiak Gabrielian Kyle Johnson Nick Koster Mario Mohan Neda Mostafavi Anne-Rachel Schiffmann Carrie Tsang Giancarlo Valle Henrik Kam(摄影) Iwan Baan(摄影) 无不详 Joe Fletcher courtesy SFMOMA

自成立的25年以来,Sn（o）hetta建筑事务所一直致力于大型公共文化空间的设计开发,它们坚持跨学科的设计实践理念,将建筑和周围景观进行融合式设计.2016年5月14日开馆的旧金山当代艺术博物馆（SFMOMA）扩建项目是他们最新的设计力作.

关键词：艺术博物馆扩建项目旧金山建筑事务所设计实践文化空间跨学科