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Au,Pd and maghemite nanofunctionalized hydroxyapatite scaffolds for bone regeneration

Regenerative Biomaterials 2020年第5期7卷 461-469页

作者： Giovanna Calabrese salvatore Petralia Claudia Fabbi Stefano Forte Domenico Franco salvatore guglielmino Emanuela Esposito salvatore Cuzzocrea Francesco Traina Sabrina Conoci Department of Chemistry Biology Pharmacy and Environmental Science University of MessinaPiazza Pugliatti198122 MessinaSiciliaItaly Research and Development Applied Chemical WorksPaternoCataniaItaly Department of Chemical Science Fin-Ceramica FaenzaVia Granarolo 177/3Faenza 48018Italy Istituto Oncologico del Mediterraneo Ricerca ViagrandeCatania 95029Italy Dipartimento Biomorf Universita degli Studi di MessinaMessinaItaly Rizzoli Orthopedic Institute IRCSSBolognaItaly Distretto Tecnologico Micro e Nano Sistemi Sicilia CataniaItaly

Nanotechnology plays a key role in the development of innovative scaffolds for bone tissue engineering(BTE)allowing the incorporation of nanomaterials able to improve cell proliferation and *** this study,Mg-HA-Coll type I scaffolds(Mg-HA-based scaffolds)were nanofunctionalized with gold nanorods(Au NRs),palladium nanoparticles(Pd NPs)and maghemite nanoparticles(MAG NPs).Nanofunctionalized Mg-HA-based scaffolds(NF-HA-Ss)were tested for their ability to promote both the proliferation and the differentiation of adipose-derived mesenchymal stem cells(hADSCs).Results clearly highlight that MAG nanofunctionalization substantially improves cell proliferation up to 70% compared with the control(Mg-HA-based scaffold),whereas both Au NRs and Pd NPs nanofunctionalization induce a cell growth inhibition of 94% and 89%,*** evidences were found for the osteoinductive properties showing relevant calcium deposits(25% higher than the control)for MAG nanofunctionalization,while a decreasing of cell differentiation(20% lower than the control)for both Au NRs and Pd NPs *** results are in agreement with previous studies that found cytotoxic effects for both Pd NPs and Au *** excellent improvement of both osteoconductivity and osteoinductivity of the MAG NF-HA-S could be attributed to the high intrinsic magnetic field of superparamagnetic MAG *** findings may pave the way for the development of innovative nanostructured scaffolds for BTE.

关键词： bone regeneration hydroxyapatite scaffold tissue engineering gold nanoroads Pd nanoparticles maghemite nanoparticles

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