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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： Christian Bracco Marta Gallarate Marco Badinella Martini Corrado Magnino salvatore d'agnano Roberta Canta Giulia Racca Remo Melchio Cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BACKGROUNd Hepatocellular carcinoma(HCC)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of HCC patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of HCC recorded at"Santa Croce e Carle"Hospital in Cuneo(Italy)between 1 January 2010 and 31 december *** highlight possible changes in HCC patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 HCC patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** C virus infection was the most common HCC risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The Child-Pugh score distribution of the patients was:class A 75%,class B 21%and class C 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the HCC was 4.6±3.1 cm.A total of 204 patients(63%)had more than one noduled 92%(305 patients)had a non-metastatic stage of the *** Barcelona Clinic Liver Cancer(BCLC)staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BCLC stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease diagnosis Etiology Treatment

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The role of acetazolamide in critical care and emergency medicine

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Journal of Geriatric Cardiology 2024年第11期21卷 1085-1095页

作者： Jacopo davide Giamello Gabriele Savioli Yaroslava Longhitano Fiorenza Ferrari salvatore d’agnano Ciro Esposito Manfredi Tesauro Christian Zanza department of Emergency Medicine Azienda Ospedaliera S.Croce e CarleCuneoItaly Emergency Medicine and Surgery IRCCS Fondazione Policlinico San MatteoPaviaItaly department of Anesthesiology and Perioperative Medicine University of PittsburghPittsburghPA 15260USA department of Emergency Medicine-Emergency Medicine Residency Program Humanitas University-Research Hospital20089 RozzanoItaly International Renal Research Institute of Vicenza(IRRIV) Department of NephrologyDialysis and TransplantationSan Bortolo HospitalAzienda ULSS Berica VicenzaItaly department of Anaesthesia Critical Care and EmergencyFoundation IRCCS Ca'Granda Ospedale Maggiore PoliclinicoMilanItaly Unit of Nephrology and dialysis ICS MaugeriUniversity of PaviaPaviaItaly department of Systems Medicine University of Rome"Tor Vergata"RomeItaly Geriatric Medicine Residency Program University of Rome"Tor Vergata"RomeItaly

Acetazolamide is the commonly prescribed oral and intravenous carbonic anhydrase inhibitor;over the years,its use in clinical practice has decreased in favor of more recent ***,it is a rather handy drug,which can be useful in several clinical settings when managing critically ill *** objective of this review is the evaluation of the most recent evidence on the use of acetazolamide in emergency medicine and critical care ***,the safety profile of this drug has been *** is a narrative review on the use of acetazolamide in the main contexts in which this drug can be useful in emergency situations for patients with potential critical *** the timeline 1999–2024,a search was conducted on the main scientific platforms;resources of greatest relevance for the use of acetazolamide in critical care and emergency medicine were *** most common emergency situations in which a critically ill patient could benefit from acetazolamide therapy are acute heart failure,acute mountain sickness,post hypercapnic metabolic alkalosis,idiopathic intracranial hypertension and acute angle-closure *** a few cases,however,randomized controlled clinical trials have been *** are also other less solid indications based mostly on experience or retrospective *** seems to be an overall safe drug;serious side effects are rare and can be avoided by carefully selecting the patients to be *** represents a precious resource for emergency physicians and intensivists;critical patients with different conditions can in fact benefit from it;furthermore,acetazolamide is a safe drug if administered to correctly selected patients.

关键词： critical prescribed furthermore

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Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology

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Neural Regeneration Research 2025年第11期20卷 3219-3220页

作者： salvatore Saieva Rodrigo Morales department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Pathological and clinical variability in Alzheimer's disease(Ad):Ad is clinically cha racterized by progressive memory loss and cognitive *** a pathological point of view,the main features of Ad are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of Ad patients considering both clinical manifestations and pathological features.

关键词： amyloid Alzheimer clinical

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Virtual internal thermal work evaluation in the multifield variational statements for the analysis of multilayered structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 317-326页

作者： salvatore BRISCHETTO department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

The principle of virtual displacements(PVds)extended to elasto-thermo-electric problems includes virtual internal elastic,thermal and electric *** governing equations have displacement vector,temperature and electric potential as primary variables of the problem,and the elasto-thermal,elasto-electric and pure elastic problems are obtained as particular cases by deleting the appropriate contributions in the general elasto-thermo-electric variational *** most sensitive issue is given by thermal coupling because the thermo-elastic and thermo-electric effects change depending on the type of load and analysis considered(mechanical load,temperature or electric potential imposed and free vibration analysis).This feature means that the form of the virtual internal thermal work in such variational statements changes depending on the analysis performed and the load *** about multilayered plates and shells suggest the appropriate extension of the variational statement for each analysis,and they give an exhaustive explanation for several forms of the PVd proposed.

关键词： Principle of virtual displacements(PVds) Variational statements Elasto-thermo-electric problems Multilayered structures Virtual internal elastic work Virtual internal thermal work Virtual internal electric work

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A Continuum Shell Model Including van derWaals Interaction for Free Vibrations of double-Walled Carbon Nanotubes

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Computer Modeling in Engineering & Sciences 2015年第4期104卷 305-327页

作者： salvatore Brischetto department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi2410129 TorinoITALY

This paper proposes the free vibration analysis of double-Walled Carbon NanoTubes(dWCNTs).A continuum elastic three-dimensional shell model is used for natural frequency investigation of simply supported *** 3d shell method is compared with beam analyses to show the applicability limits of 1d beam *** effect of van der Waals interaction between the two cylinders is shown for different Carbon NanoTube(CNT)lengths and vibration *** give the van der Waals interaction effect in terms of frequency *** order to apply the 3d shell continuum model,dWCNTs are defined as two concentric isotropic cylinders(with an equivalent thickness and Young modulus)which can be linked by means of the interlaminar continuity conditions or by means of an infinitesimal fictitious layer which represents the van der Waals interaction.

关键词： Exact solution three-dimensional shell model double-walled carbon nanotube van der Waals interaction free vibration

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Further studies on “magnetosensitive bacteria”

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Chinese Journal of Oceanology and Limnology 2009年第1期27卷 6-12页

作者： salvatore BELLINI Institute of Microbiology University of Pavia

Various experimental techniques for study of magnetosensitive bacteria are described and the experimental results are presented and discussed.

关键词： magnetosensitive bacteria biomagnetic microerophilic oxygen

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SUSY QM in a One-dimensional Box and Local Observable Quantities

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Chinese Physics Letters 2006年第8期23卷 1969-1972页

作者： salvatore de Vincenzo Escuela de Fisica Facultad de Ciencias Universidad Central de Venezuela A.P. 47145 Caracas 1041-A Venezuela

We investigate several Hamiltonians for a free particle in a one-dimensional box, in the context of supersymmetric quantum mechanics. Specifically, we study this problem with the Neumann boundary condition, the periodic and antiperiodic boundary condition, and some mixed and complex boundary conditions. This is achieved by using an approach recently proposed which expresses the factorization of the partner Hamiltonians in terms of the probability density and current for the ground-state eigenfunction of one of them.

关键词： SUPERSYMMETRIC QUANTUM-MECHANICS BOUNdARY-CONdITIONS ENERGY-SPECTRA SUPERPOTENTIALS FACTORIZATION POTENTIALS PARTICLE SYSTEMS

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New insight in a new entity:the mitochondrial permeability transition pore arises from the Ca^(2+) -activated F_1F_O-ATPases

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Science Bulletin 2018年第3期63卷 143-145页

作者： salvatore Nesci department of Veterinary Medical Sciences (dIMEVET) University of Bologna

The mitochondrial permeability transition pore(MPTP)is linked to pathways leading to different variant of cell death and the molecular mechanism of MPTP opening is considered a promising approach from structure to med... 详细信息

关键词：毛孔渗透实体 Ca MPTP

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On a unique behavior of freshwater bacteria

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Chinese Journal of Oceanology and Limnology 2009年第1期27卷 3-5页

作者： salvatore BELLINI Institute of Microbiology University of Pavia

Magnetic sensitivity has been found in bacteria from freshwater sites around Pavia, Italy.

关键词： magnetosensitivity biomagnetism freshwater geomagnetic

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Rheumatic manifestations of hepatitis C virus chronicinfection:Indications for a correct diagnosis

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World Journal of Gastroenterology 2016年第4期22卷 1405-1410页

作者： Carlo Palazzi Emilio d’Amico salvatore d’Angelo Michele Gilio Ignazio Olivieri Rheumatology department of Basilicata San Carlo HospitalPotenza and Madonna delle Grazie Hospital75100 MateraItaly division of Internal Medicine San Massimo Hospital86027 PenneItaly

Hepatitis C virus(HCV) is a hepato- and lymphotropicagent that is able to induce several autoimmune rheumatic disorders: vasculitis, sicca syndrome, arthralgias/arthritis and fibromyalgia. The severity of clinical manifestations is variable and sometimes lifethreatening. HCV infection can mimic many primitive rheumatic diseases, therefore, it is mandatory to distinguish HCV-related manifestations from primitive ones because the prognosis and therapeutic strategies can be fairly dissimilar. The new direct-acting antivirals drugs can help to avoid the well-known risks of worsening or new onset of autoimmune diseases during the traditional interferon-based therapies.

关键词： Arthritis Cryoglobulinemia diagnosis Hepatitis C virus Hepatitis C Rheumatic Sicca syndrome Vasculitis

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