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chitin-glucan improves important pathophysiological features of irritable bowel syndrome

World Journal of Gastroenterology 2024年第16期30卷 2258-2271页

作者： caroline Valibouze caroline Dubuquoy Philippe chavatte Michaël Genin Veronique Maquet salvatore Modica Pierre Desreumaux christel Rousseaux Department of Digestive Surgery and Transplantation Lille UniversityLille 59037France Intestinal Biotech Development Facultéde MédicineLille 59045France U1286-INFINITE-Institute for Translational Research in Inflammation Universitéde LilleLille 59000France ULR 2694-METRIcS Évaluation des Technologies de santéet des Pratiques MédicalesUniversity of LilleLille 59000France KitoZyme SA Institution SociétéAnonymeZone 2Parc des Hauts SartsRue de MilmortHerstal 4040Belgium Hepato-Gastroenterology Department Lille University HospitalLille 59037France

BAcKGROUND Irritable bowel syndrome(IBS)is one of the most frequent and debilitating conditions leading to gastroenterological ***,recommended treatments remain limited,yielding only limited therapeutic ***-glucan(cG)is a novel dietary prebiotic classically used in humans at a dosage of 1.5-3.0 g/d and is considered a safe food ingredient by the European Food Safety *** provide an alternative approach to managing patients with IBS,we performed preclinical molecular,cellular,and animal studies to evaluate the role of chitin-glucan in the main pathophysiological mechanisms involved in *** To evaluate the roles of cG in visceral analgesia,intestinal inflammation,barrier function,and to develop computational molecular *** Visceral pain was recorded through colorectal distension(cRD)in a model of long-lasting colon hypersensitivity induced by an intra-rectal administration of TNBS[15 milligrams(mg)/kilogram(kg)]in 33 Sprague-Dawley *** pressure was regularly assessed during the 9 wk-experiment(weeks 0,3,5,and 7)in animals receiving cG(n=14)at a human equivalent dose(HED)of 1.5 g/d or 3.0 g/d and compared to negative control(tap water,n=11)and positive control(phloroglucinol at 1.5 g/d HED,n=8)*** anti-inflammatory effect of cG was evaluated using clinical and histological scores in 30 c57bl6 male mice with colitis induced by dextran sodium sulfate(DSS)administered in their drinking water during 14 ***-29 cells under basal conditions and after stimulation with lipopolysaccharide(LPS)were treated with cG to evaluate changes in pathways related to analgesia μ-opioid receptor(MOR),cannabinoid receptor 2(cB2),peroxisome proliferator-activated receptor alpha,inflammation[interleukin(IL)-10,IL-1b,and IL-8]and barrier function[mucin 2-5Ac,claudin-2,zonula occludens(ZO)-1,ZO-2]using the real-time PcR *** modelling of cG,LPS,lipoteichoic acid(LTA),and phospholipomannan(PLM)was developed,and the abili

关键词： chitin-glucan Irritable bowel syndrome Abdominal pain Inflammation Intestinal barrier Molecular modelling Microbial cell walls chelation

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Epidemiology,therapy and outcome of hepatocellular carcinoma between 2010 and 2019 in Piedmont,Italy

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 761-772页

作者： christian Bracco Marta Gallarate Marco Badinella Martini corrado Magnino salvatore D'Agnano Roberta canta Giulia Racca Remo Melchio cristina Serraino Valentina Polla Mattiot Giovanni Gollè Luigi Fenoglio Department of Internal Medicine Santa Croce e Carle General HospitalCuneo 12100Italy Department of Medical Sciences "City of Health and Science"University HospitalTorino 10100Italy

BAcKGROUND Hepatocellular carcinoma(Hcc)is the most common primary liver malignancy and the second leading cause of cancer deaths *** is often diagnosed at an advanced stage and therefore its prognosis remains poor with a low 5-year survival *** patients have increasingly complex and constantly changing characteristics,thus up-to-date and comprehensive data are *** To analyze the epidemiology and main clinical characteristics of Hcc patients in a referral center hospital in the northwest of Italy between 2010 and *** In this retrospective study,we analyzed the clinical data of all consecutive patients with a new diagnosis of Hcc recorded at"Santa croce e carle"Hospital in cuneo(Italy)between 1 January 2010 and 31 December *** highlight possible changes in Hcc patterns over the 10-year period,we split the population into two 5-year groups,according to the diagnosis period(2010-2014 and 2015-2019).RESULTS Of the 328 Hcc patients who were included(M/F 255/73;mean age 68.9±11.3 years),154 in the first period,and 174 in the *** c virus infection was the most common Hcc risk factor(41%,135 patients).The alcoholic etiology rate was 18%,the hepatitis B virus infection etiology was 5%,and the non-viral/non-alcoholic etiology rate was 22%.The child-Pugh score distribution of the patients was:class A 75%,class B 21%and class c 4%.The average Mayo end-stage liver disease score was 10.6±3.7.A total of 55 patients(17%)were affected by portal vein thrombosis and 158(48%)by portal *** average nodule size of the Hcc was 4.6±3.1 cm.A total of 204 patients(63%)had more than one nodulestatic.stage of the *** Barcelona clinic Liver cancer(BcLc.staging distribution of all patients was:4%very early,32%early,23%intermediate,34%advanced,and 7%*** survival rate was 1.6±0.3 *** 20%of the patients underwent ***,presence of ascites,BcLc.stage and therapy w

关键词： Hepatocellular carcinoma Hepatitis virus Alcoholic hepatitis Non-alcoholic fatty liver disease Diagnosis Etiology Treatment

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Effects of AG1 and AG2 QTLs on Nonstructural carbohydrate and Seed Management Options for Rice Seedling Growth and Establishment under Flooding Stress

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Rice science 2020年第6期27卷 515-528页

作者： Satyen MONDAL M.Jamil Hasan Tofayel Ahmed M.Giashuddin Miah Pompe c.sta cruz Abdel M.ISMAIL International Rice Research Institute DAPO Box 7777Metro Manilathe Philippines Bangladesh Rice Research Institute Gazipur 1701Bangladesh University of the Philippines Los Banos CollegeLaguna 4031the Philippines Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur 1706Bangladesh

Rice(Oryza sativa)plants acquired excess photosynthates in the form of nonstructural carbohydrates(NScs)in their stems and *** keen interest in rice NSc,the dynamics of NSc accumulation,translocation and re-accumulation have not yet been well ***1 and AG2 QTLs associated with flooding tolerance through catalyzing starch into soluble sugar in germinating *** we conducted three experiments,greenhouse and field to lay the groundwork for large-scale diversity studies on grain NSc and some agronomic traits under direct-seeded rice(DSR)system,using elite lines incorporating AG1,AG2 and AG1-AG2 QTLs into the popular varieties PSB Rc82 and ciherang-Sub1 along with the donors Kho Hlan On(AG1)and Ma-Zhan Red(AG2).In germinating seedlings,soluble sugars increased,while starch concentration decreased gradually especially in the tolerant checks and AG1-AG2 introgression lines under flooded *** sugar accumulation in stem started to increase from the vegetative stage and peaked at the panicle initiation stage then gradually decreased towards the maturity *** Sub1-AG lines had higher sugar and starch concentrations at different growth stages than other genotypes in wet season 2016 and dry season *** survival rate was positively correlated with the stem NSc at the early vegetative stage(21 days after sowing),and stem NSc was positively associated with plant height at different growth *** the tested seeding rate,the most suitable seeding rate,4 g/m2 with shallow burial depth(0.5 cm),resulted in better seedling establishment,relatively higher seedling vigor index and higher leaf area index under flooding in DSR *** of AG1-AG2 QTLs had no any negative impact on nonstructural carbohydrate,germination rate,and growth and biomass production.

关键词： anaerobic germination crop establishment direct-seeded rice flooding nonstructural carbohydrate seeding rate seeding depth

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ARBITRARILY SMALL NODAL SOLUTIONS FOR PARAMETRIc ROBIN(p,q)-EQUATIONS PLUS AN INDEFINITE POTENTIAL

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Acta Mathematica Scientia 2022年第2期42卷 561-574页

作者： salvatore LEONARDI Nikolaos S.PAPAGEORGIOU Dipartimento di Matematica e Informatica Viale A.Doria695125 CataniaItaly Technical University Department of MathematicsZorografou CampusAthens 15780Greece

We consider a nonlinear Robin problem driven by the(p,q)-Laplacian plus an indefinite potential term and with a parametric reaction *** minimal conditions on the reaction function,which concern only its behavior near zero,we show that,for all λ>0 small,the problem has a nodal solution y_(λ)∈c^(1)(Ω)and we have y_(λ)→0 in c^(1)(Ω)asλ→0^(+).

关键词： (p,q)-Laplacian indefinite potential nonlinear regularity extremal constant sign solutions nodal solutions

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Assessing tree crown fire damage integrating linear spectral mixture analysis and supervised machine learning on Sentinel-2 imagery

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International Journal of Digital Earth 2023年第1期16卷 3162-3198页

作者： Giandomenico De Luca Giuseppe Modica Joao M.N.Silva salvatore Praticò JoséM.c.Pereira Dipartimento di Agrari1 Universitàdegli Studi Mediterranea di Reggio Calabri1Reggio Calabri1Italy Dipartimento di Scienze veterinarie Universitàdegli Studi di Messin1Messin1Italy Forest Research centre School of AgricultureUniversity of LisbonLisbonPortugal

crown fire damage is a mixture of three principal fire-related components:charred material,scorched foliage,and unaltered green *** study estimated the abundance of these physical alterations in two immediate post-fire Mediterranean forest contexts(Portugal and Italy)by applying linear spectral mixture analysis(LSMA)on Sentinel-2 *** tree crowns fire damage was subsequently mapped,integrating fractional abundance information in a random forest(RF)algorithm,comparing the accuracy resulting from the adoption of generic or image spectral libraries as the primary investigative *** image-derived endmembers resulted in more effectiveness in terms of fire-related components abundance quantification(LMSAderived RMSEcores always were≥90%whether generic endmembers or image endmembers derived information was *** environmental heterogeneity of the two study areas affected the fire severity gradients,with a prevalence of the charred(PT)(45–46%)and green class(IT)(44–53%).Post-fire temporal monitoring was initialized by applying the proposed strategies,and the preliminary results showed a positive recovery trend in forest vegetation from the first year following the fire event,with a reduced charcoal predominance and an increasing proportion of green components.

关键词： Post-fire assessment fire severity post-fire vegetation recovery random forest(RF) scikit-learn fraction image extraction spectral unmixing endmembers crown fire damage mapping fully constrained least squares pixel purity index

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Age stability of La(Fe,Si)_(13) hydrides with giant magnetocaloric effects

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Rare Metals 2022年第3期41卷 992-1001页

作者： He Zhou Yi Long salvatore Miraglia Florence Porcher Hu Zhang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Tianjin college University of Science and Technology BeijingTianjin 301830China cNRS Institut NeelUniversite Grenoble Alpes25 Rue des Martyrs38042 GrenobleFrance Laboratoire Leon Brillouin UMR12 CEA-CNRSBat.563 CEA Saclay91191 Gif sur Yvette CedexFrance

The curie temperatures(T_(c))of La_(0.7)ce_(0.3)Fe_(13-x-y)Mn_(x)Si_(y)compounds that are hydrogenated to saturation are raised to near room *** age stability was inves-tigated for the fully hydrogenated La_(0.7)ce_(0.3)Fe_(11.5-x)Mn_(x)Si_(1.5) *** result indicates that the H content will slowly decrease in the hydrides,leading to a decrease in T_(c).However,no age splitting is observed after the hydrides are held at room temperature for two years,indicating the excellent age stability of the *** structural analysis by neutron diffrac-tion shows that Mn atoms preferentially substitute Fe in the 96i *** T_(c)of La_(0.7)ce_(0.3)Fe_(11.55-y)Mn_(y)Si_(1.45)hydrides can be adjusted to the desired working temperature by regulating Mn content based on the linear relationship between T_(c)and Mn ***,the La_(0.7)ce_(0.3)Fe_(11.55-y)Mn_(y)Si_(1.45)hydrides exhibit a giant magnetic entropy change of 15 J·kg^(-1)·K^(-1) under a low magneticfield change of 0-1 *** a result,the giant magnetocaloric effect,linearly adjustable T_(c),and excel-lent age stability make the La_(0.7)ce_(0.3)Fe_(11.55-y)Mn_(y)Si_(1.45)hydrides be one of the ideal candidates for room temperature magnetic refrigerants.

关键词： Magnetocaloric effect La(Fe,Si)_(13) Hydrides stability

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characterization of volatile organic compounds in grafted tomato plants upon potyvirus necrotic infection

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Journal of Integrative Agriculture 2023年第8期22卷 2426-2440页

作者： Roberta SPANò Mariarosaria MASTROcHIRIcO Francesco LONGOBARDI salvatore cERVELLIERI Vincenzo LIPPOLIS Tiziana MAScIA Department of Soil Plant and Food SciencesUniversity of Bari“Aldo Moro”Via Amendola 165/ABari 70126Italy Department of chemistry University of Bari“Aldo Moro”Via Orabona 4Bari 70126Italy National Research council(cNR) Institute of Sciences of Food Production(ISPA)Via Amendola 122/OBari 70126Italy

A headspace solid-phase microextraction-gas chromatography-mass spectrometry(HS-SPME/Gc-MS)method was used to study the volatile organic compounds(VOcs)associated with the differential immune response of tomato plants infected with the recombinant strain of potato virus Y(PVY^(c)-to),necrogenic to *** was carried out in Uc82(Uc),a virus susceptible tomato variety,comparing the same Uc plants grafted or not onto a virus tolerant tomato ecotype,Manduria(Ma);the three types of samples used for the Gc-MS analysis were mock-inoculated Uc/Ma plants,Uc/Ma+PVY^(c)-to and Uc+PVY^(c)-to plants;the VOcs obtained were *** from symptomatic PVY^(c)-to-infected Uc plants showed a VOcs composition enriched in alcohols,fatty acid derivates,benzenoids,and salicylic acid derivatives,while in mock-inoculated Uc/Ma plants VOcs were mainly characterized by methyl ester *** VOc profile was in line with RNAseq data analyses,denoting that PVY^(c)-to viral RNA accumulation and disease symptoms induce the specific transcriptional activation of genes involved in VOcs ***,principal component analysis highlighted that VOcs of PVY^(c)-to-infected and mock-inoculated grafted plants were much closer each other than that of symptomatic PVY^(c)-to-infected non-grafted Uc *** results suggest that VOcs profiles of tomato plants are related to the viral RNA accumulation,disease intensity and graft-derived tolerance to PVY^(c)-to infection.

关键词： tomato potyvirus VOcs defense grafted plants

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Non-invasive ventilation for acute hypoxemic respiratory failure,including cOVID-19

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Journal of Intensive Medicine 2023年第1期3卷 11-19页

作者： Tommaso Rosà Luca salvatore Menga Ambika Tejpal Melania cesarano Teresa Michi Michael c.Sklar Domenico Luca Grieco Department of Emergency Intensive Care Medicine and AnesthesiaFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Istituto di Anestesiologiae Rianimazione UniversitàCattolica del Sacro CuoreRome 00168Italy Division of cardiology Department of MedicineUniversity of TorontoToronto ON M5S 1A1Canada Interdepartmental Division of critical care Medicine University of TorontoToronto ON M5S 1A1Canada Department of Anesthesia and Pain Medicine St.Michael's Hospital–Unity Health TorontoUniversity of TorontoToronto ON M5S 1A1Canada

Optimal initial non-invasive management of acute hypoxemic respiratory failure(AHRF),of both coronavirus disease 2019(cOVID-19)and non-cOVID-19 etiologies,has been the subject of significant *** of endotracheal intubation reduces related complications,but maintenance of spontaneous breathing with intense respiratory effort may increase risks of patients’self-inflicted lung injury,leading to delayed intubation and worse clinical ***-flow nasal oxygen is currently recommended as the optimal strategy for AHRF management for its simplicity and beneficial physiological ***-invasive ventilation(NIV),delivered as either pressure support or continuous positive airway pressure via interfaces like face masks and helmets,can improve oxygenation and may be associated with reduced endotracheal intubation ***,treatment failure is common and associated with poor *** and knowledge of the specific features of each interface are necessary to fully exploit their potential benefits and minimize *** clinical and physiological monitoring is necessary during any treatment to avoid delays in endotracheal intubation and protective *** this narrative review,we analyze the physiological benefits and risks of spontaneous breathing in AHRF,and the characteristics of tools for delivering *** goal herein is to provide a contemporary,evidence-based overview of this highly relevant topic.

关键词： Non-invasive ventilation Hypoxemic respiratory failure Self-inflicted lung injury

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Zr_(2)SeB and Hf_(2)SeB:Two new MAB phase compounds with the cr_(2)Alc-type MAX phase(211 phase)crystal structures

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Journal of Advanced ceramics 2022年第11期11卷 1764-1776页

作者： Qiqiang ZHANG Yanchun ZHOU Xingyuan SAN Wenbo LI Yiwang BAO Qingguo FENG salvatore GRASSO chunfeng HU Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Science and Technology on Advanced Functional composite Laboratory Aerospace Research Institute of Materials&Processing TechnologyBeijing 100076China Hebei Key Lab of Optic–Electronic Information and Materials College of Physics Science and TechnologyHebei UniversityBaoding 071002China state Key Laboratory of Green Building Materials China Building Materials AcademyBeijing 100024China

The ternary or quaternary layered compounds called MAB phases are frequently mentioned recently together with the well-known MAX ***,MAB phases are generally referred to layered transition metal borides,while MAX phases are layered transition metal carbides and nitrides with different types of crystal structure although they share the common nano-laminated structure *** order to prove that MAB phases can share the same type of crystal structure with MAX phases and extend the composition window of MAX phases from carbides and nitrides to borides,two new MAB phase compounds Zr_(2)SeB and Hf_(2)SeB with the cr_(2)Alc-type MAX phase(211 phase)crystal structure were discovered by a combination of first-principles calculations and experimental verification in this ***-principles calculations predicted the stability and lattice parameters of the two new MAB phase compounds Zr_(2)SeB and Hf_(2)*** they were successfully synthesized by using a thermal explosion method in a spark plasma sintering(SPS)*** crystal structures of Zr_(2)SeB and Hf_(2)SeB were determined by a combination of the X-ray diffraction(XRD),scanning electron microscopy(SEM),and high-resolution transmission electron microscopy(HRTEM).The lattice parameters of Zr_(2)SeB and Hf_(2)SeB are a=3.64398Å,c=12.63223Åand a=3.52280Å,c=12.47804Å,*** the atomic positions are M at 4f(1/3,2/3,0.60288[Zr]or 0.59889[Hf]),Se at 2c(1/3,2/3,1/4),and B at 2a(0,0,0).And the atomic.stacking sequences follow those of the cr_(2)Alc-type MAX *** work opens up the composition window for the MAB phases and MAX phases and will trigger the interests of material scientists and physicists to explore new compounds and properties in this new family of materials.

关键词： Zr_(2)SeB and Hf_(2)SeB MAB phase MAX phase first-principles calculations thermal explosion synthesis

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How acute myeloid leukemia(AML)escapes from FMS-related tyrosine kinase 3(FLT3)inhibitors?Still an overrated complication?

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cancer Drug Resistance 2023年第2期6卷 223-238页

作者： salvatore Perrone Tiziana Ottone Nadezda Zhdanovskaya Matteo Molica Hematology Polo Universitario PontinoS.M.Goretti HospitalLatina 04100Italy Department of Biomedicine and Prevention the University of Rome“Tor Vergata”Rome 00100 Italy Neuro-Oncohematology Santa Lucia FoundationI.R.C.C.S.Rome 00100Italy Hematology Department of Translational and Precision MedicineSapienza UniversityRome 00161Italy Hematology Unit S.Eugenio HospitalASL Roma 2Rome 00144Italy.

FMS-related tyrosine kinase 3(FLT3)mutations,present in about 25%-30%of acute myeloid leukemia(AML)patients,constitute one of the most frequently detected mutations in these *** binding of FLT3L to FLT3 activates the phosphatidylinositol 3-kinase(PI3K)and RAS pathways,producing increased cell proliferation and the inhibition of *** types of FLT3 mutations exist:FLT3-ITD and FLT3-TKD(point mutations in D835 and I836 or deletion of codon I836).A class of drugs,tyrosine-kinase inhibitors(TKI),targeting mutated FLT3,is already available with 1st and 2nd generation molecules,but only midostaurin and gilteritinib are currently ***,the emergence of resistance or the selection of clones not responding to FLT3 inhibitors has become an important clinical dilemma,as the duration of clinical responses is generally limited to a few *** review analyzes the insights into mechanisms of resistance to TKI and poses a particular view on the clinical relevance of this *** resistance been overlooked?Indeed,FLT3 inhibitors have significantly contributed to reducing the negative impact of FLT3 mutations on the prognosis of AML patients who are no longer considered at high risk by the European LeukemiaNet(ELN)***,several ongoing efforts to overcome resistance to FLT3-inhibitors will be presented:new generation FLT3 inhibitors in monotherapy or combined with standard chemotherapy,hypomethylating drugs,or IDH1/2 inhibitors,Bcl2 inhibitors;novel anti-human FLT3 monoclonal antibodies(e.g.,FLT3/cD3 bispecific antibodies);FLT3-cAR T-cells;cDK4/6 kinase inhibitor(e.g.,palbociclib).

关键词： Acute myeloid Leukemia FLT3 gilteritinib midostaurin TKI-inhibitor resistance quizartinib sorafenib crenolanib

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