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Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders:Advances in 2015

World Journal of Gastroenterology 2015年第42期21卷 11974-11983页

作者： salvatore monaco Sara Mariotto Sergio Ferrari Massimiliano Calabrese Gianluigi Zanusso Alberto Gajofatto Domenico Sansonno Franco Dammacco Department of Neurological and Movement Sciences University of Verona Neurologia B Azienda Ospedaliera Universitaria Integrata Department of Internal Medicine and Clinical Oncology University of Bari Medical School

Since its identification in 1989, hepatitis C virus(HCV) has emerged as a worldwide health problem with roughly 185 million chronic infections, representing individuals at high risk of developing cirrhosis and liver cancer. In addition to being a frequent cause of morbidity and mortality due to liver disease, HCV has emerged as an important trigger of lymphoproliferative disorders, owing to its lymphotropism, and of a wide spectrum of extrahepatic manifestations(HCV-EHMs) affecting different organ systems. The most frequently observed HCV-EHMs include mixed cryoglobulinemia and cryoglobulinemic vasculitis, B-cell non-Hodgkin's lymphoma, nephropathies, thyreopathies, type 2 diabetes mellitus, cardiovascular diseases, and several neurological conditions. In addition, neuropsychiatric disorders and neurocognitive dysfunction are reported in nearly 50% of patients with chronic HCV infection, which are independent of the severity of liver disease or HCV replication rates. Fatigue, sleep disturbance, depression and reduced quality of life are commonly associated with neurocognitive alterations in patients with non-cirrhotic chronic HCV infection, regardless of the stage of liver fibrosis and the infecting genotype. These manifestations, which are the topic of this review, typically occur in the absence of structural brain damage or signal abnormalities on conventional brain magnetic resonance imaging(MRI), although metabolic and microstructural changes can be detected by in vivo proton magnetic resonance spectroscopy, perfusion-weighted and diffusion tensorMRI, and neurophysiological tests of cognitive processing. Several lines of evidence, including comparative and longitudinal neuropsychological assessments in patients achieving spontaneous or treatment-induced viral clearance, support a major pathogenic role for HCV in neuropsychiatric and neurocognitive disorders.

关键词： Extra-hepatic manifestations Hepatitis C virus syn

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Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

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Translational Neurodegeneration 2022年第1期11卷 390-400页

作者： Matilde Bongianni Mauro Catalan Daniela Perra Elena Fontana Francesco Janes Claudio Bertolotti Luca Sacchetto Stefano Capaldi Matteo Tagliapietra Paola Polverino Valentina Tommasini Giulia Bellavita Elham Ataie Kachoie Roberto Baruca Andrea Bernardini Mariarosaria Valente Michele Fiorini Erika Bronzato Stefano Tamburin Laura Bertolasi Lorenzo Brozzetti Maria Paola Cecchini Gianluigi Gigli salvatore monaco Paolo Manganotti Gianluigi Zanusso Department of Neurosciences Biomedicineand Movement SciencesPoliclinico G.B.RossiUniversity of Verona37134 VeronaItaly Neurology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly Neurology Unit University of Udine Academic Hospital33100 UdineItaly Department of Surgical Sciences DentistryGynecology and PediatricsUniversity of Verona37134 VeronaItaly Biocrystallography Laboratory Department of BiotechnologyUniversity of Verona37134 VeronaItaly Otolaryngology Unit Department of MedicineSurgery and Health SciencesOspedale CattinaraUniversity of Trieste34128 TriesteItaly.

Background: In patients with Parkinson’s disease (PD), real-time quaking-induced conversion (RT-QuIC) detection of pathological α-synuclein (α-syn) in olfactory mucosa (OM) is not as accurate as in other α-synucleinopathies. It is unknown whether these variable results might be related to a different distribution of pathological α-syn in OM. Thus, we investigated whether nasal swab (NS) performed in areas with a different coverage by olfactory neuroepithelium, such as agger nasi (AN) and middle turbinate (MT), might affect the detection of pathological α-syn. Methods: NS was performed in 66 patients with PD and 29 non-PD between September 2018 and April 2021. In 43 patients, cerebrospinal fluid (CSF) was also obtained and all samples were analyzed by RT-QuIC for α-syn. Results: In the first round, 72 OM samples were collected by NS, from AN (NSAN) or from MT (NSMT), and 35 resulted positive for α-syn RT-QuIC, including 27/32 (84%) from AN, 5/11 (45%) from MT, and 3/29 (10%) belonging to the non-PD patients. Furthermore, 23 additional PD patients underwent NS at both AN and MT, and RT-QuIC revealed α-syn positive in 18/23 (78%) NSAN samples and in 10/23 (44%) NSMT samples. Immunocytochemistry of NS prepara-tions showed a higher representation of olfactory neural cells in NSAN compared to NSMT. We also observed α-syn and phospho-α-syn deposits in NS from PD patients but not in controls. Finally, RT-QuIC was positive in 22/24 CSF samples from PD patients (92%) and in 1/19 non-PD. Conclusion: In PD patients, RT-QuIC sensitivity is significantly increased (from 45% to 84%) when NS is performed at AN, indicating that α-syn aggregates are preferentially detected in olfactory areas with higher concentration of olfactory neurons. Although RT-QuIC analysis of CSF showed a higher diagnostic accuracy compared to NS, due to the non-invasiveness, NS might be considered as an ancillary procedure for PD diagnosis.

关键词： Parkinson disease Alpha-synuclein Real-time quaking-induced conversion assay Olfactory mucosa Cerebrospinal fluid

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Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology

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Neural Regeneration Research 2025年第11期20卷 3219-3220页

作者： salvatore Saieva Rodrigo Morales Department of Neurology The University of Texas Health Science Center at HoustonHoustonTXUSA Centro Integrativo de Biologia y Quimica Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiagoChile

Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive *** a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of AD patients considering both clinical manifestations and pathological features.

关键词： amyloid Alzheimer clinical

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Virtual internal thermal work evaluation in the multifield variational statements for the analysis of multilayered structures

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 317-326页

作者： salvatore BRISCHETTO Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi 2410129 TorinoItaly

The principle of virtual displacements(PVDs)extended to elasto-thermo-electric problems includes virtual internal elastic,thermal and electric *** governing equations have displacement vector,temperature and electric potential as primary variables of the problem,and the elasto-thermal,elasto-electric and pure elastic problems are obtained as particular cases by deleting the appropriate contributions in the general elasto-thermo-electric variational *** most sensitive issue is given by thermal coupling because the thermo-elastic and thermo-electric effects change depending on the type of load and analysis considered(mechanical load,temperature or electric potential imposed and free vibration analysis).This feature means that the form of the virtual internal thermal work in such variational statements changes depending on the analysis performed and the load *** about multilayered plates and shells suggest the appropriate extension of the variational statement for each analysis,and they give an exhaustive explanation for several forms of the PVD proposed.

关键词： Principle of virtual displacements(PVDs) Variational statements Elasto-thermo-electric problems Multilayered structures Virtual internal elastic work Virtual internal thermal work Virtual internal electric work

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A Continuum Shell Model Including van derWaals Interaction for Free Vibrations of Double-Walled Carbon Nanotubes

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Computer Modeling in Engineering & Sciences 2015年第4期104卷 305-327页

作者： salvatore Brischetto Department of Mechanical and Aerospace Engineering Politecnico di TorinoCorso Duca degli Abruzzi2410129 TorinoITALY

This paper proposes the free vibration analysis of Double-Walled Carbon NanoTubes(DWCNTs).A continuum elastic three-dimensional shell model is used for natural frequency investigation of simply supported *** 3D shell method is compared with beam analyses to show the applicability limits of 1D beam *** effect of van der Waals interaction between the two cylinders is shown for different Carbon NanoTube(CNT)lengths and vibration *** give the van der Waals interaction effect in terms of frequency *** order to apply the 3D shell continuum model,DWCNTs are defined as two concentric isotropic cylinders(with an equivalent thickness and Young modulus)which can be linked by means of the interlaminar continuity conditions or by means of an infinitesimal fictitious layer which represents the van der Waals interaction.

关键词： Exact solution three-dimensional shell model double-walled carbon nanotube van der Waals interaction free vibration

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Further studies on “magnetosensitive bacteria”

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Chinese Journal of Oceanology and Limnology 2009年第1期27卷 6-12页

作者： salvatore BELLINI Institute of Microbiology University of Pavia

Various experimental techniques for study of magnetosensitive bacteria are described and the experimental results are presented and discussed.

关键词： magnetosensitive bacteria biomagnetic microerophilic oxygen

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SUSY QM in a One-Dimensional Box and Local Observable Quantities

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Chinese Physics Letters 2006年第8期23卷 1969-1972页

作者： salvatore De Vincenzo Escuela de Fisica Facultad de Ciencias Universidad Central de Venezuela A.P. 47145 Caracas 1041-A Venezuela

We investigate several Hamiltonians for a free particle in a one-dimensional box, in the context of supersymmetric quantum mechanics. Specifically, we study this problem with the Neumann boundary condition, the periodic and antiperiodic boundary condition, and some mixed and complex boundary conditions. This is achieved by using an approach recently proposed which expresses the factorization of the partner Hamiltonians in terms of the probability density and current for the ground-state eigenfunction of one of them.

关键词： SUPERSYMMETRIC QUANTUM-MECHANICS BOUNDARY-CONDITIONS ENERGY-SPECTRA SUPERPOTENTIALS FACTORIZATION POTENTIALS PARTICLE SYSTEMS

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New insight in a new entity:the mitochondrial permeability transition pore arises from the Ca^(2+) -activated F_1F_O-ATPases

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Science Bulletin 2018年第3期63卷 143-145页

作者： salvatore Nesci Department of Veterinary Medical Sciences (DIMEVET) University of Bologna

The mitochondrial permeability transition pore(MPTP)is linked to pathways leading to different variant of cell death and the molecular mechanism of MPTP opening is considered a promising approach from structure to med... 详细信息

关键词：毛孔渗透实体 Ca MPTP

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On a unique behavior of freshwater bacteria

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Chinese Journal of Oceanology and Limnology 2009年第1期27卷 3-5页

作者： salvatore BELLINI Institute of Microbiology University of Pavia

Magnetic sensitivity has been found in bacteria from freshwater sites around Pavia, Italy.

关键词： magnetosensitivity biomagnetism freshwater geomagnetic

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Deep convolutional neural network for multi-level non-invasive tunnel lining assessment

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Frontiers of Structural and Civil Engineering 2022年第2期16卷 214-223页

作者： Bernardino CHIAIA Giulia MARASCO salvatore AIELLO Department of Structural Geotechnical and Building EngineeringPolytechnic University of TurinTorino10129Italy

In recent years,great attention has focused on the development of automated procedures for infrastructures *** efforts have aimed at greater speed and reliability compared to traditional methods of assessing structural *** paper proposes a multi-level strategy,designed and implemented on the basis of periodic structural monitoring oriented to a cost-and time-efficient tunnel control *** strategy leverages the high capacity of convolutional neural networks to identify and classify potential critical *** a supervised learning framework,Ground Penetrating Radar(GPR)profiles and the revealed structural phenomena have been used as input and output to train and test such ***-based analysis and integrative investigations involving video-endoscopy,core drilling,jacking and pull-out testing have been exploited to define the structural conditions linked to GPR profiles and to create the *** degree of detail and accuracy achieved in identifying a structural condition is *** a result,this strategy appears of value to infrastructure managers who need to reduce the amount and invasiveness of testing,and thus also to reduce the time and costs associated with inspections made by highly specialized technicians.

关键词： concrete structure GPR damage classification convolutional neural network transfer learning

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