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Clinical applications of hepatocyte transplantation

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World Journal of Gastroenterology 2009年第17期15卷 2074-2077页

作者： Giada Pietrosi Giovanni Battista Vizzini salvatore Gruttadauria Bruno Gridelli Department of Gastroenterology and Hepatology Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy Department of Surgery Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IsMeTT) University of Pittsburgh Medical Center Palermo 90127 Italy

The shortage of organ donors is a problem worldwide, with approximately 15% of adult patients with lifethreatening liver diseases dying while on the waiting list. The use of cell transplantation for liver disease is an attempt to correct metabolic defects, or to support liver function as a bridge to liver transplantation and, as such, has raised a number of expectations. Most of the available studies briefly reported here focus on adult hepatocyte transplantation (HT), and the results are neither reproducible nor comparable, because the means of infusion, amount of injected cells and clinical variability differ among the studies. To better understand the specif ic role of HT in the management of end-stage liver disease, it is important that controlled studies, designed on the principles of evidence-based medicine, be done in order to guarantee the reproducibility of results.

关键词：肝细胞移植临床应用终末期肝病可重复性世界范围成年患者代谢缺陷肝脏疾病

The importance of being ＂not transplantable＂

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Journal of Geriatric Cardiology 2016年第12期13卷 1002-1004页

作者： Rossana Taravella Marco Caruso Massimo Benedetto Renato Ciofalo Giuliana Pace salvatore Asciutto salvatore Novo Giuseppe Cirrincione Division of Interventional Cardiology Arnas Civico Hospital. Division of Cardiology University Hospital 'Policlinico P. Giaccone ' Palermo Italy Division of lnterventional Cardiology Arnas Civico Hospital Palermo Italy Division of Cardiology University Hospital 'Policlinico P. Giaccone' Palermo Italy

MitraClip therapy for mitral regurgitation (MR) in advanced-end stage heart failure (HF),could open a final bridge to improve symptoms and quality of life in “not transplantable" patients. Functional MR is a complica... 详细信息

关键词： Endstage 心失败心移植 MitraClip 僧帽形的流回 NYHA 功能的班

Role of size and pretreatment of Pd particles on their behaviour in the direct synthesis of H_2O_2

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Journal of Energy Chemistry 2016年第2期25卷 295-303页

作者： salvatore Abate Katia Barbera Gabriele Centi Gianfranco Giorgianni Siglinda Perathoner University of Messina ERIC aisbl and INSTMCASPE Section Industrial Chemistry

Two families of catalysts, based on Pd nanoparticles supported on ceramic asymmetric tubular alumina membranes, are studies in the direct synthesis of H2O2. They are prepared by depositing Pd in two ways：（i） reduction with N2H4 in an ultrasonic bath and（ii） by impregnation-deposition. The first preparation leads to larger particles, with average size of around 11 nm, while the second preparation leads to smaller particles, with average size around 4 nm. The catalytic membranes were tested as prepared, after thermal treatment in air and after further pre-reduction with H2 in mild（100 ℃） conditions. Samples were characterized by TEM, CO-chemisorption monitored by DRIFTS method and TPR, while catalytic tests have been performed in a semi-batch recirculation membrane reactor. Experimental catalytic results were analysed using two kinetics models to derive the reaction constants for the parallel and consecutive reactions of the kinetic network. Smaller particles of Pd show lower selectivity due to the higher rate of parallel combustion, even if the better dispersion of Pd and thus higher metal surface area in the sample lead to a productivity in H2O2 similar or even higher than the sample with the larger Pd particles. Independently on the presence of smaller or larger Pd nanoparticles, an oxidation treatment leads to a significant enhancement in the productivity, although the catalyst progressively reduces during the catalytic process. The inhibition of the parallel combustion reaction（to water） induced from the calcination treatment remains after the in-situ reduction of the oxidized Pd species formed during the *** is likely due to the elimination of defect sites which dissociatively activate oxygen, and tentatively attributed to Pd sites able to give three- and four-fold coordination of CO.

关键词： H2O2 direct synthesis Pd nanoparticles Kinetics of H2O2 synthesis Pd role in H2O2 synthesis

Hericium erinaceus,a medicinal fungus with a centuries-old history:Evidence in gastrointestinal diseases

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World Journal of Gastroenterology 2023年第20期29卷 3048-3065页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino salvatore Auletta Giovanna Palladino Giovanni Brandimarte Rossella D'Onofrio Giusi Arboretto Giuseppe Imperio Andrea Ventura Marina Cipullo Marco Romano Alessandro Federico Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Division of Internal Medicine and Gastroenterology Cristo Re HospitalRome 00167Italy

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for *** studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel *** addition,some components of this mushroom appear to possess strong antineoplastic capabilities against gastric and colorectal *** review aims to analyse all available evidence on the digestive therapeutic potential of this fungus as well as the possible underlying molecular mechanisms.

关键词： Hericium erinaceus Fungus Gastritis Inflammatory bowel diseases Gastric cancer Colorectal cancer

Inflammatory bowel diseases patients suffer from significant low levels and barriers to physical activity:The“BE-FIT-IBD”study

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World Journal of Gastroenterology 2023年第41期29卷 5668-5682页

作者： Antonietta Gerarda Gravina Raffaele Pellegrino Tommaso Durante Giovanna Palladino Rossella D’Onofrio Simone Mammone Giusi Arboretto salvatore Auletta Giuseppe Imperio Andrea Ventura Mario Romeo Alessandro Federico Department of Precision Medicine Hepatogastroenterology UnitUniversity of Campania Luigi VanvitelliNaples 80138Italy Mental Health Department S.Pio HospitalBenevento 82100Italy

BACKGROUND The place regular physical activity(PA)should occupy in managing patients with inflammatory bowel diseases(IBD)is *** To assess PA levels and barriers in a southern Italian IBD *** IBD patients with non-severe disease activity[assessed with partial Mayo score for ulcerative colitis(UC)and Harvey-Bradshaw index for Crohn’s disease]were approached to receive an anonymous online questionnaire to assess PA levels using the International Physical Activity Questionnaire(IPAQ)and to assess disease activity as patient-reported outcomes 2(PRO-2)and finally to assess habits,beliefs and barriers in conducting regular ***,anthropometric and demographic data of patients were also *** was expressed as continuous units of resting metabolic rate(Met)in min/*** PA groups were identified:Inactive(2500 Met min/wk)*** Included patients(219)showed overall PA levels of 834.5 Met min/wk,with a large proportion(94,42.9%)classified as inactive while only a minority(9,4.1%)as health-enhancing *** without dyslipidaemia(P0.05).Active patients expressed the need to discuss PA with their *** barriers(e.g.,diagnosis of IBD and fear of flare-ups after PA)are significantly more reported by inactive *** A significant rate of physical inactivity was recorded in this *** showed good *** should be an element of discussion in IBD visits assessed quickly with non-invasive questionnaires.

关键词： Crohn’s disease Inflammatory bowel disease International Physical Activity Questionnaire Physical activity Ulcerative colitis

Worldwide epidemiology of liver hydatidosis including the Mediterranean area

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World Journal of Gastroenterology 2012年第13期18卷 1425-1437页

作者： Giuseppe Grosso salvatore Gruttadauria Antonio Biondi Stefano Marventano Antonio Mistretta Department"G.F.Ingrassia"Section of Hygiene and Public Health University of Catania95123 CataniaItaly Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione-University of Pittsburgh Medical Center in Italy 90127 PalermoItaly Section of General Surgery and Oncology Department of General SurgeryUniversity of Catania95123 CataniaItaly

The worldwide incidence and prevalence of cystic echinococcosis have fallen dramatically over the past several ***,infection with Echinococcus granulosus(***)remains a major public health issue in several countries and regions,even in places where it was previously at low levels,as a result of a reduction of control programmes due to economic problems and lack of *** distribution differs by country and region depending on the presence in that country of large numbers of nomadic or semi-nomadic sheep and goat flocks that represent the intermediate host of the parasite,and their close contact with the final host,the dog,which mostly provides the transmission of infection to *** greatest prevalence of cystic echinococcosis in human and animal hosts is found in countries of the temperate zones,including several parts of Eurasia(the Mediterranean regions,southern and central parts of Russia,central Asia,China),Australia,some parts of America(especially South America)and north and east *** is currently considered an endemic zoonotic disease in the Mediterranean *** most frequent strain associated with human cystic echinococcosis appears to be the common sheep strain(G1).This strain appears to be widely distributed in all *** purpose of this review is to examine the distribution of *** and the epidemiology of a re-emerging disease such as cystic echinococcosis.

关键词：地中海地区流行病学包虫病公共卫生问题大肠杆菌感染中间宿主人畜共患病控制方案

Hollow micro- and nano-particles by gas foaming

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Nano Research 2014年第7期7卷 1018-1026页

作者： Silvia Orsi Ernesto Di Maio salvatore lannace Paolo A. Netti Center for Advanced Biomaterials for Health Care Istituto Italiano di Tecnologia (IIT@CRIB) Largo Barsanti e Matteucci 50 Napoli 80125 Italy Dipartimento di Ingegneria Chimica dei Materiali e della Produzione Industfiale and Interdisciplinary Research Centre on Biomaterials (CRIB) Universita degli Studi di Napoli Federico II P.le Tecchio 80 Napoli 80125 Italy Institute for Polymers Composites and Biomaterials Consiglio Nazionale delle Ricerche P.le E. Fermi 1 Portici (Na) 80055 Italy

This paper presents the results of a first successful attempt to produce hollow micro- and nano-particles of a large variety of materials, dimensions, shapes and hollow attributes by using an environmentally friendly and cheap technology, common in polymer processing and known as gas foaming. The central role played by ad hoc polymeric hollow micro- and nano-particles in a variety of emerging applications such as drug delivery, medical imaging, advanced materials, as well as in fundamental studies in nanotechnology highlights the wide relevance of the proposed method. Our key contribution to overcome the physical lower bound in the micro- and nano-scale gas foaming was to embed, prior to foaming, bulk micro- and nano-particles in a removable and deformable barrier film, whose role is to prevent the loss of the blowing agent, which is otherwise too fast to allow bubble formation. Furthermore, the barrier film allows for non-isotropic deformation of the particle and/or of the hollow, affording non-spherical hollow particles. In comparison with available methods to produce hollow micro- and nano-particles, our method is versatile since it offers independent control over the dimensions, material and shape of the particles, and the number, shape and open/closed features of the hollows. We have gasfoamed polystyrene and poly-(lactic-co-glycolic) acid particles 200 μm to 200 nm in size, spherical, ellipsoidal and discoidal in shape, obtaining open or closed, single or multiple, variable in size hollows.

关键词：纳米粒子气体发泡微米空心中空颗粒聚合物加工先进材料纳米颗粒

Deep Learning and Time Series-to-Image Encoding for Financial Forecasting

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IEEE/CAA Journal of Automatica Sinica 2020年第3期7卷 683-692页

作者： Silvio Barra salvatore Mario Carta Andrea Corriga Alessandro Sebastian Podda Diego Reforgiato Recupero Department of Mathematics and Computer Science University of CagliariCagliari 09121Italy

In the last decade,market financial forecasting has attracted high interests amongst the researchers in pattern ***,the data used for analysing the market,and then gamble on its future trend,are provided as time series;this aspect,along with the high fluctuation of this kind of data,cuts out the use of very efficient classification tools,very popular in the state of the art,like the well known convolutional neural networks(CNNs)models such as Inception,Res Net,Alex Net,and so *** forces the researchers to train new tools from *** operations could be very time *** paper exploits an ensemble of CNNs,trained over Gramian angular fields(GAF)images,generated from time series related to the Standard&Poor's 500 index future;the aim is the prediction of the future trend of the ***.A multi-resolution imaging approach is used to feed each CNN,enabling the analysis of different time intervals for a single observation.A simple trading system based on the ensemble forecaster is used to evaluate the quality of the proposed *** method outperforms the buyand-hold(B&H)strategy in a time frame where the latter provides excellent *** quantitative and qualitative results are provided.

关键词： Convolutional neural networks(CNNs) ensemble of CNNs financial forecasting Gramian angular fields(GAF)imaging

Screening for pancreatic cancer-a compelling challenge

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Hepatobiliary Surgery and Nutrition 2021年第2期10卷 264-266页

作者： Gabriele Capurso salvatore Paiella Massimo Falconi Pancreato-Biliary Endoscopy and Endosonography Division Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSMilanItaly General and Pancreatic Surgery Unit Pancreas InstituteUniversity of VeronaVeronaItaly Pancreatic Surgery Unit Pancreas Translational&Clinical Research CenterSan Raffaele Scientific Institute IRCCSUniversitàVita-SaluteMilanItaly

Efficacy of pancreatic cancer surveillance programs The publication of the American Gastroenterology Association(AGA)Clinical Practice Update on Pancreas Cancer Screening in High-Risk Individuals(HRIs)underlines the increasing attention for this topic(1).Secondary prevention(surveillance)for pancreatic ductal adenocarcinoma(PDAC),however,remains a challenge with many unsolved questions(Table 1).

关键词： prevention cancer Cancer